P53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: Suppression by BAG-1

EMBO Journal

Volumn 17, Issue 10, 1998, Pages 2736-2747

  Matsuzawa, Shu Ichi ^a   Takayama, Shinichi ^a   Froesch, Barbara ^a   Zapata, Juan M ^a   Reed, John C ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

BAG 1; p21(waf 1); p53; Siah; sina

Indexed keywords

BINDING PROTEIN; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CONTROLLED STUDY; DELETION MUTANT; EMBRYO; EPITHELIUM CELL; FIBROBLAST; GENE INDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PLASMID; PRIORITY JOURNAL; REPORTER GENE; TRANSACTIVATION; ULTRAVIOLET IRRADIATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARRIER PROTEINS; CELL CYCLE; CELL DIVISION; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA; DNA-BINDING PROTEINS; DROSOPHILA; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBCELLULAR FRACTIONS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; ULTRAVIOLET RAYS;

EID: 0032525309     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.10.2736     Document Type: Article

References (59)

1. Adachi,M. et al. (1996) IL-2 upregulates BAG-1 gene expression through Serine-rich region within IL-2 receptor βc chain. Blood, 88, 4118-4123.
2. 1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc. Natl Acad. Sci. USA, 92, 8493-8497.
3. Amson,R.B. et al. (1996) Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the Drosphila seven in absentia gene. Proc. Natl Acad. Sci. USA, 93, 3953-3957.
4. Bajrdelli,A., Longati,P., Albero,D., Goruppi,S., Schneider,C., Ponzetto,C. and Comoglio,P.M. (1996) HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J., 15, 6205-6212.
5. Boldin,M.P., Mett,I.L. and Wallach,D. (1995) A protein related to a proteasomal subunit binds to the intacellular domain of the p55 TNF receptor upstream to its 'death domain'. FEBS Lett., 367, 39-44.
6. CIP1/WAF1 gene in normal diploid human fibroblasts. Science, 277, 831-834.
7. Brugarolas,J., Chandrasekaran,C., Gordon,J.I., Beach,D., Jacks,T. and Hannon,G.J. (1995) Radiation-induced cell cycle arrest comprised by p21 deficiency. Nature, 377, 552-551.
8. Buckbinder,L., Talbott,R., Velasco-Miguel,S., Takenaka,I., Faha,B., Seizinger,B.R. and Kley,N. (1995) Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature, 377, 646-649.
9. Carthew,R.W. and Rubin,G.M. (1990) seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Cell, 63, 561-577.
10. Carthew,R.W., Neufeld,T.P. and Rubin,G.M. (1994) Identification of genes that interact with the sina gene in Drosophila eye development. Proc. Natl Acad. Sci. USA, 91, 11689-11693.
11. Chang,H.C., Solomon,N.M., Wassarman,D.A., Karim,F.D., Therrien,M., Rubin,G.M. and Wolff,T. (1995) Phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell. 80, 463-172.
12. Clevenger,C.V., Thickman,K., Ngo,W., Chang,W.-P., Takayama,S. and Reed,J.C. (1997) Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines. Ba/F3 and Nb2. Mol. Endocrinol., 11, 608-618.
13. Della,N.G., Senior,P.V. and Bowtell,D.D. (1993) Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina). Development, 117, 1333-1343.
14. 1 checkpoint control. Cell, 82, 675-684.
15. Deveraux,Q., Takahashi,R., Salvesen,G.S. and Reed,J.C. (1997) X-linked IAP is a direct inhibitor of cell death proteases. Nature, 388, 300-303.
16. Dickson,B.J., Dominguez,M., van der Straten,A. and Hafen,E. (1995) Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. Cell. 80, 453-462.
17. Durfee,T., Becherer,K., Chen,P.-E., Yeh,S.-H., Yang,Y., Kilburn,A.E., Lee,W.H. and Elledge,S.J. (1993) The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev., 1, 555-569.
18. el-Deiry,W.S. et al. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817-825.
19. Elledge,S.J. (1996) Cell cycle checkpoints: preventing an identity crisis. Science, 274, 1664-1667.
20. Estojak,J., Brent,R. and Golemis,E.A. (1995) Correlation of two-hybrid affinity data with in vitro measurements. Mol. Cell. Biol., 15, 5820-5829.
21. 2 exit of the cell cycle: role in DNA damage-induced apoptosis. Oncogene, 10, 2263-2270.
22. Hall,P.A. and Lane,D.P. (1997) Tumour suppressors: a developing role for p53? Curr. Biol., 7, R144-R147.
23. Hanada,M., Aimé-Sempé,C., Sato,T. and Reed,J.C. (1995) Structure-function analysis of Bcl-2 protein: identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax. J. Biol. Chem., 270, 11962-11968.
24. 1 cyclin-dependent kinases. Cell, 75, 805-816.
25. Hartwell,L.H. and Kastan,M.B. (1994) Cell cycle control and cancer. Science, 266, 1821-1828.
26. Höhfeld,J. and Jentsch,S. (1997) GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J., 16, 6209-6216.
27. Hu,G., Zhang,S., Vidal,M., Baer,J.L. and Fearon,E.R. (1997) Mammalian homoiogs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Genes Dev., 11, 2701-2714.
28. Jamal,S. and Ziff,E.B. (1995) Raf phosphorylates p53 in vitro and potentiates p53-dependent transcriptional transactivation in vivo. Oncogene, 10, 2095-2101.
29. Levine,A.J. (1997) p53, the cellular gatekeeper for growth and division. Cell, 88, 323-331.
30. Li,S., Li,Y. Carthew,R. and Lai,Z.-C. (1997) Photoreceptor cell differentiation requires regulated protolysis of the transcriptional represser tramtrack. Cell. 90, 469-478.
31. Lowe,S.W., Ruley,H.E., Jacks,T. and Houseman,D.E. (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74, 957-967.
32. Miyashita,T. and Reed,J.C. (1995) Tumor suppressor p53 is a direct transcriptional activator of human BAX gene. Cell, 80, 293-299.
33. Miyashita,T., Krajewski,S., Krajewska,M. Wang,H.G., Lin,H.K., Hoffman,B., Lieberman,D. and Reed,J.C. (1994) Tumor suppressor p53 is a regulator of BCL-2 and BAX in gene expression in vitro and in vivo. Oncogene, 9, 1799-1805.
34. Nemani, M. et al. (1996) Activation of the human homologue of the Orosophila sina gene in apoptosis and tumor suppression. Proc. Natl Acad. Sci. USA, 93, 9039-9042.
35. Okayama,H., Kawaichi,M., Brownstein,M., Lee,R, Yokota,T. and Arai,K. (1987) High-efficiency cloning of full-length cDNA; construction and screening of cDNA expression libraries for mammalian cells. Methods Enzymol., 154, 3-28.
36. Reed,J.C. et al. (1996) Bcl-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J. Cell. Biochem., 60, 23-32.
37. Régnier,C.H., Tomasetto,C., Moog-Lutz,C., Chenard,M.-P., Wendling,C., Basset,P. and Rio,M.-C. (1995) Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. J. Biol Chem., 270, 25715-25721.
38. Rothe,M., Pan,M.-G., Henzel,W.J., Ayres,T.M. and Goeddel,D.V. (1995) The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 83, 1243-1252.
39. Sato,T. et al. (1994) Interactions among members of the bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl Acad. Sci. USA, 91, 9238-9242.
40. Sato,T., Irie,S. and Reed,J.C. (1995a) Identification of a protein tyrosine phosphatase that associates with Fas/APO-1 (CD95). Science, 268, 411-415.
41. Saurin,A.J., Borden,K.L., Boddy,M.N. and Freemont,P.S. (1996) Does this have a familiar RING? Trends Biochem. Sci., 21, 208-214.
42. Selvakurnaran,M., Lin,H.-K., Miyashita,T., Wang,H.-G., Krajewski,S., Reed,J.C., Hoffman,B. and Liebermann,D. (1994) Immediate early up-regulation of BAX expression by p53 but not TGFß1: a paradigm for distinct apoptotic pathways. Oneogene. 9, 1791-1798.
43. 2/M by p53. Oncogene, 10, 109-115.
44. Takayama,S., Sato,T., Krajewski,S., Kochel,K., Irie,S., Millan,J.A. and Reed,J.C. (1995) Cloning and functional analysis of BAG-1: a novel Bcl-2 binding protein with anti-cell death activity. Cell 80, 279-284.
45. Takayama,S., Kochel,K., Irie,S., Inazawa,J., Abe,T., Sato,T., Druck,T., Huebner,K. and Reed,J.C. (1996) Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. Genomics, 35, 494-498.
46. Takayama,S., Bimston,D.N., Matsuzawa,S., Freeman,B.C., Aime-Sempe,C., Xie,Z., Morimoto,R.J. and Reed,J.C. (1997) BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J., 16, 4887-1896.
47. Tang,A., Neufeld,T., Kwan,E. and Rubin,G. (1997) PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Cell, 90, 459-467.
48. Unger,T., Nau,M.M., Segal,S. and Minna,J.D. (1992) p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer. EMBO J., 11, 1383-1390.
49. Wang,H.-G., Takayama,S., Rapp,U.R. and Reed,J.C. (1996) Bcl-2 interacting protein. BAG-1, binds to and activates the kinase Raf-1. Proc. Natl Acad. Sci. USA, 93, 7063-7068.
50. Wang,Y., Szekely,L., Okan,I., Klein,G. and Wiman,K.G. (1993) Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line. Oncogene, 8, 3427-3431.
51. Webster,N.J., Resnik,J.L., Reichart,D.B., Strauss,B., Haas,M. and Seely,B.L. (1996) Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer. Cancer Res., 56, 2781-2788.
52. Werner,H., Karnieli,E., Rauscher,F.J. and LeRoith,D. (1996) Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc. Natl Acad. Sci. USA, 93, 8318-8323.
53. Wright,D.A., Futcher,B., Ghosh,P. and Geha,R.S. (1996) Association of human fas (CD95) with a ubiquitin-conjugating enzyme (UBC-FAP). J. Biol. Chem., 49, 31037-31043.
54. Yin,C., Knudson,C.M., Korsmeyer,S.J. and Van Dyke,T. (1997) Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature, 385, 637-640.
55. Zeiner,M. and Gehring,U. (1995) A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. Proc. Natl Acad. Sci. USA, 92, 11465-11469.
56. Zeiner,M., Gebauer,M. and Gehring,V. (1997) Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteins. EMBO J., 16, 5483-5490.
57. Zha,H., Fisk,H.A., Yaffe,M.P., Mahajan,N., Herman,B. and Reed,J.C. (1996) Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol. Cell. Biol., 16, 6494-6508.
58. Zhan,Q., Fan,S., Bae,I., Guillouf,C., Liebermann,D.A., O'Connor,P.M. and Fornace,Jr,A.J. (1994) Induction of BAX by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene, 9, 3743-3751.
59. Zhang,L., Kashanchi,F., Zhan,Q., Zhan,S., Brady,J.N., Fornace,A.J., Seth,P. and Helman,L.J. (1996) Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis. Cancer Res., 56, 1367-1373.