The role of Bim, a proapoptotic BH3-only member of the Bcl-2 family, in cell-death control

Annals of the New York Academy of Sciences

Volumn 917, Issue , 2000, Pages 541-548

  Strasser, Andreas ^a   Puthalakath, Hamsa ^a   Bouillet, Philippe ^a   Huang, David C S ^a   O'Connor, Liam ^a   O'Reilly, Lorraine A ^a   Cullen, Leonie ^a   Cory, Suzanne ^a   Adams, Jerry M ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CYSTEINE PROTEINASE; DYNEIN ADENOSINE TRIPHOSPHATASE; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; CELL SURVIVAL; CONFERENCE PAPER; ENZYME ACTIVATION; MICROTUBULE; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY;

ANIMALIA;

EID: 0033665032     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb05419.x     Document Type: Conference Paper

References (51)

1. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
2. Size control: The regulation of cell numbers in animal development
3. An evolutionary perspective on apoptosis
4. The molecular biology of apoptosis
5. The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
6. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
7. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
8. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
9. Apoptosis and its role in human disease
10. Caspases: Enemies within
11. CED-4 - The third horseman of apoptosis
12. Apoptosis signaling
13. Mice deficient in IL-1b-converting enzyme are defective in production of mature IL-1b and resistant to endotoxic shock
14. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
15. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
16. FLICE, a novel FADD homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signaling complex
17. An induced proximity model for caspase-8 activation
18. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHa1) death signal
19. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2
20. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
21. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
22. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
23. The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum and the outer mitochondrial membrane
24. Structure of Bcl-x(L)-Bak peptide complex: Recognition between regulators of apoptosis
25. Inhibition of Bax channel-forming activity by Bcl-2
26. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
27. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
28. Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types
29. Bcl-2, Bcl-X(L) and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death
30. Death cycle and Swiss army knives
31. CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease
32. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
33. A dominant interfering mutant of FADD/Mort1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
34. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
35. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
36. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
37. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
38. Differential requirement for caspase 9 in apoptotic pathways in vivo
39. Apaf-1 (CED-4 homologue) regulates programmed cell death in mammalian development
40. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
41. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
42. Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
43. p53 is required for radiation-induced apoptosis in mouse thymocytes
44. Thymocyte apoptosis induced by p53-dependent and independent pathways
45. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
46. Bim - A novel member of the Bcl-2 family that promotes apoptosis
47. Rapid hybridoma screening method for the identification of monoclonal antibodies to low abundance cytoplasmic proteins
48. Bcl-2 family member Bim required for some apoptotic pathways and to preclude autoimmunity
49. The pro-apoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
50. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
51. The pro-apoptotic BH3-only protein Bim is expressed in hemopoietic, epithelial, neuronal and germ cells