Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

Current Biology

Volumn 7, Issue 3, 1997, Pages 202-210

  Sells, Mary Ann ^a   Knaus, Ulla G ^b   Bagrodia, Shubha ^c   Ambrose, Diane M ^a   Bokoch, Gary M ^b   Chernoff, Jonathan ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Department of Population Medicine and Diagnostic Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0031105660     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(97)70091-5     Document Type: Article

References (47)

1. Ridley AJ, Hall A: The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992, 70:389-399.
2. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A: The small GTP-binding protein rac regulates growth factors-induced membrane ruffling. Cell 1992, 70:401-410.
3. Kozma R, Ahmed S, Best A, Lim L: The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 cells. Mol Cell Biol 1995, 15:1942-1952.
4. Nobes CD, Hall A: Rho, Rac, and Cdc42 GTPases regulate the assembly of multi-molecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell 1995, 81:53-62.
5. Drubin DG: Development of cell polarity in budding yeast. Cell 1991, 65:1093-1096.
6. Chant J: Cell polarity in yeast. Trends Genet 1994, 10:328-333.
7. Hall A: Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu Rev Cell Biol 1994, 10:31-54.
8. Ridley AJ: Rho-related proteins: actin cytoskeleton and cell cycle. Curr Opin Genet Dev 1995, 24:24-30.
9. Manser E, Leung T, Salihuddin H, Tan L, Lim L: A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cd42. Nature 1993, 363:364-367.
10. Manser E, Leung T, Salihuddin H, Zhao Z-s, Lim L: A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 1994, 367:40-46.
11. Knaus UG, Morris S, Dong H-J, Chernoff J, Bokoch GM: Regulation of p21 -activated kinases by human leukocyte G protein coupled receptors. Science 1995, 269:221-223.
12. Johnson LN, Noble MEM, Owen DJ: Active and inactive protein kinases - structural basis for regulation. Cell 1996, 85:149-158.
13. Bagrodia S, Taylor S, Creasy CL, Chernoff J, Cerione RA: Identification of a murine p21Cdc42/Rac activated protein kinase (PAK). J Biol Chem 1995, 270:22731-22738.
14. Galisteo ML, Chernoff J, Su Y-C, Skolnik EY, Schlessinger J: The adaptor protein Nek links tyrosine kinases with the serinethreonine kinase Pak1. J Biol Chem 1996, 271:20997-21000.
15. Bokoch GM, Wang Y, Bohl BP, Sells MA, Quilliam LA, Knaus UG: Interaction of Nek adapter protein with p21-activated kinase (PAK1). J Biol Chem 1996, 271:25746-25749.
16. Zhang S, Han J, Sells MA, Chernoff J, Knaus UG, Ulevitch RJ, Bokoch GM: Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem 1995, 270:23934-23936.
17. Bagrodia S, Derijard B, Davis RJ, Cerione RA: Cdc42 and Pakmediated signaling leads to Jun kinase and p38 mitogenactivated protein kinase activation. J Biol Chem 1995, 270:27995-27998.
18. Polverino A, Frost JP, Yang P, Hutchinson M, Neiman AM, Cobb MH, Marcus S: Activation of mitogen-activated protein kinase cascades by p21 -activated protein kinases in cell-free extracts of Xenopus oocytes. J Biol Chem 1995, 270:26067-26070.
19. Brown JL, Stowers L, Maer M, Trejo J, Coughlin S, Chant J: Human Ste20 homologue hPakl links GTPases to the JNK MAP kinase pathway. Curr Biol 1996, 6:598-605.
20. Leeuw T, Fourest-Lieuvin A, Wu C, Chenevert J, Clark K, Whiteway M, Thomas DY, Leberer E: Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin. Science 1995, 270:1210-1213.
21. Chang EC, Barr M, Wang Y, Jung V, Xu H-P, Wigler MH: Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell 1994, 79:131-141.
22. Liu H, Styles CA, Fink GR: Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science 1993, 262:1741-1744.
23. Leberer E, Wu C, Leeuw T, Forest-Lieuvin A, Segall JE, Thomas DY: Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase. EMBO J 1991, 16:83-97.
24. Marcus S, Polverino A, Chang E, Robbins D, Cobb MH, Wigler MH: Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomycespombe. Proc Natl Acad Sci USA 1995, 92:6180-6184.
25. + encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. EMBO J 1995, 14:5908-5919.
26. Mosch H-U, Radclyffe RL, Fink GR: Ras2 signals via the Cdc42/Ste20/mitogen-activated protein kinase module to induce filamentous growth in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 1996, 93:5352-5356.
27. Manser E, Huang H-Y, Loo T-H, Chen XQ, Leung T, Lim L: Expression of constitutively active a-Pak reveals effects of the kinase on actin and focal complexes. Mol Cell Biol, in press.
28. Lamarche N, Tapon N, Stowers L, Burbelo PD, Aspenström P, Bridges T, Chant J, Hall A: Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65Pak and the JNK/SAPK MAP kinase cascade. Cell 1996, 87:519-529.
29. Joneson T, McDonough M, Bar-Sagi D, Van Aelst L: RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science 1996, 274:1374-1376.
30. Fan G, Merritt SE, Kortenjann M, Shaw PE, Holzman LB: Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2. J Biol Chem 1996, 271:24788-24793.
31. Burbelo PD, Dreschel D, Hall A: A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem 1995, 270:29071-29074.
32. Rana A, Gallo K, Godowski P, Hirai S, Ohno S, Zon L, Kyriakis JM, Avruch J: The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J Biol Chem 1996, 271:19025-19028.
33. Teramoto H, Coso OA, Miyata H, Igishi T, Miki T, Gutkind JS: Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway: a role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J Biol Chem 1996, 271:27225-27228.
34. Symons M, Derry JMJ, Kariak B, Jiang S, Lemahieu V, McCormick F, Francke U, Abo A: Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 1996, 84:723-734.
35. Lu W, Katz S, Gupta R, Mayer BJ: Activation of Pak by membrane localization mediated by Nek SH3 domain. Curr Biol 1997, 7:85-94.
36. Brzeska H, Szczepanowska J, Hoey J, Korn ED: The catalytic domain of Acanthamoeba myosin I heavy chain kinase. II. Expression of active catalytic domain and sequence homology to p21 -activated kinase (PAK). J Biol Chem 1996, 271:27056-27062.
37. Lee SF, Egelhoff TT, Mahasneh A, Cote GP: Cloning and characterization of a Dictyostelium myosin I heavy chain kinase activated by Cdc42 and Rac. J Biol Chem 1996, 271:27044-27048.
38. Bement WM, Mooseker MS: TEDS rule: a molecular rationale for differential regulation of myosins by phosphorylation of the heavy chain head. Cell Motil Cytoskeleton 1995, 31:87-92.
39. Brzeska H, Korn ED: Regulation of class I and class II myosins by heavy chain phosphorylation. J Biol Chem 1996, 271:16983-16986.
40. Kelley CA, Seller JR, Gard DL, Bui D, Adelstein RS, Baines IC: Xenopus nonmuscle myosine heavy chain isoforms have different subcellular localizations and enzymatic activities. J Cell Biol 1996, 134:675-687.
41. Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC: Wiskott-Aldrich syndrome protein physically associates with Nek through Src homology 3 domains. Mol Cell Biol 1995, 15:5725-5731.
42. Chen C, Okayama H: High-efficiency transformation of mammalian cell by plasmid DNA. Mol Cell Biol 1987, 7:2745-2752.
43. Elledge SJ, Mulligan JT, Ramer SW, Spottswood M, Davis RW: λYES: A multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations. Proc Natl Acad Sci USA 1991, 88:1731-1735.
44. Smith DB, Johnson KS: Single-step purification of polypeptides expressed in Escherichia colias fusions with glutathione S-transferase. Gene 1988, 67:31-40.
45. Sells MA, Chernoff J: Epitope tagging vectors for eukaryotic protein production. Gene 1995, 152:187-189.
46. Andersson S, Davis DL, Dahlbäck. H, Jörnvall H, Russell DW: Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation. J Biol Chem 1989, 264:8222-8229.
47. Manser E, Leung T, Monfries C, Teo M, Hall C, Lim L: Diversity and versatility of GTPase activating proteins for the p21rho subfamily of ras G proteins detected by anovel overlay assay. J Biol Chem 1992, 267:16025-16028.