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Journal of Biological Inorganic Chemistry

Volumn 8, Issue 4, 2003, Pages 427-438

Interactions of the pyridine-2-carboxaldehyde isonicotinoyl hydrazone class of chelators with iron and DNA: Implications for toxicity in the treatment of iron overload disease

(2) Chaston, Timothy B a,b,c Richardson, Des R a,b,c

a CHILDREN S CANCER INSTITUTE AUSTRALIA FOR MEDICAL RESEARCH (Australia)

b Heart Research Institute ^* (Australia)

c HEART RESEARCH INSTITUTE (Australia)

Author keywords

Iron chelators; Pyridine 2 carboxaldehyde isonicotinoyl hydrazone; Pyridoxal isonicotinoyl hydrazone; Redox chemistry

Indexed keywords

ASCORBIC ACID; DEFEROXAMINE; DNA; IRON; IRON CHELATING AGENT; LIGAND; PYRIDINE 2 CARBOXALDEHYDE ISONICOTINOYLHYDRAZONE; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; CONTROLLED STUDY; DNA BINDING; DNA STRAND BREAKAGE; DRUG DESIGN; DRUG DNA BINDING; DRUG EFFICACY; HUMAN; HUMAN CELL; IRON CHELATION; IRON OVERLOAD; OXIDATION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; REDUCTION; TOXICITY;

EID: 0038814301 PISSN: 09498257 EISSN: None Source Type: Journal
DOI: 10.1007/s00775-002-0434-3 Document Type: Article

Times cited : (63)

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