Mechanisms underlying the cytotoxic effects of Tachpyr - A novel metal chelator

Biochimica et Biophysica Acta - General Subjects

Volumn 1571, Issue 3, 2002, Pages 211-218

  Samuni, Ayelet M ^a   Krishna, Murali C ^a   DeGraff, William ^a   Russo, Angelo ^a   Planalp, Roy P ^b   Brechbiel, Martin W ^a   Mitchell, James B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Univ of New Hampshire   (United States)

Author keywords

Antioxidant; Cytotoxicity; Redox activity; Superoxide

Indexed keywords

CHELATING AGENT; DNA; FERRIC ION; FERROUS ION; HYDROGEN PEROXIDE; HYDROXIDE; IRON; N,N'N,'' TRIS(2 PYRIDYLMETHYL) 1,3,5 TRIAMINOCYCLOHEXANE; OXYGEN; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL FREE SYSTEM; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA ISOLATION; ELECTRON SPIN RESONANCE; HUMAN; HUMAN CELL; INCUBATION TIME; MAMMAL CELL; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; OXIMETRY; PRIORITY JOURNAL; PROTECTION; REDUCTION; SPECTROPHOTOMETRY; SPIN TRAPPING; ULTRAVIOLET RADIATION;

ANTINEOPLASTIC AGENTS; CARCINOMA; CATALASE; CELL SURVIVAL; CELL-FREE SYSTEM; CHELATING AGENTS; CYCLOHEXYLAMINES; DNA; DNA, SINGLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IRON; LUNG NEOPLASMS; MACROMOLECULAR SUBSTANCES; OXIDATION-REDUCTION; OXYGEN; OXYGEN CONSUMPTION; PLASMIDS; PYRIDINES; SUPEROXIDE DISMUTASE; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

HABER; MAMMALIA;

EID: 0037014639     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(02)00218-0     Document Type: Article

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