Development of tridentate iron chelators: From desferrithiocin to ICL670

Current Medicinal Chemistry

Volumn 10, Issue 12, 2003, Pages 1065-1076

  Nick, Hanspeter ^a   Acklin, Pierre ^a   Lattmann, René ^a   Buehlmayer, Peter ^a   Hauffe, Suzanne ^a   Schupp, Joachim ^a   Alberti, Daniele ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Desferal; Desferrithiocin; ICL670; Iron chelation; Overload; Pharmacology; Thalassemia

Indexed keywords

AMINOTRANSFERASE; BETA 2 MICROGLOBULIN; CGP 28499; CGP 28500; CGP 50992; CGP 52241; CGP 52547; CGP 52548; CGP 56897; CGP 62258; CGP 62259; CGP 62411; CGP 63370; CGP 69939; CGP 72671; DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; DEFEROXAMINE MESYLATE; DEFERRIFERRITHIOCIN; EDETIC ACID; FERRITIN; HEMOGLOBIN; HYDROXYPHENYL PYRROLINE HYDROXAMATE; IRON; IRON CHELATING AGENT; N,N' BIS(2 HYDROXYBENZYL)ETHYLENEDIAMINE N,N' DIACETIC ACID; PLACEBO; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BETA THALASSEMIA; BLOOD TRANSFUSION; BODY BURDEN; CLINICAL TRIAL; DIARRHEA; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CLASSIFICATION; DRUG DESIGN; DRUG EFFICACY; DRUG ISOLATION; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; HUMAN; IRON CHELATION; IRON OVERLOAD; LIFESPAN; NAUSEA; NEPHROTOXICITY; NONHUMAN; PLASMA HALF LIFE; RASH; REVIEW;

ANIMALS; BENZOIC ACIDS; CALLITHRIX; CHEMISTRY, PHYSICAL; DIHYDROPYRIDINES; DOGS; HUMANS; IRON; IRON CHELATING AGENTS; RATS; THIAZOLES; TRIAZOLES;

EID: 0038324389     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033457610     Document Type: Review

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