The hexadentate hydroxypyridinonate TREN-(Me-3,2-HOPO) is a more orally active iron chelator than its bidentate analogue

Journal of Pharmaceutical Sciences

Volumn 89, Issue 4, 2000, Pages 545-555

  Yokel, Robert A ^a,b   Fredenburg, Andrea M ^b   Durbin, Patricia W ^c   Xu, Jide ^c   Rayens, Mary Kay ^b   Raymond, Kenneth N ^c  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 1 METHYL 4 (1 PROPYLCARBAMOYL) 2(1H)PYRIDINONE; IRON CHELATING AGENT; PYRIDONE DERIVATIVE; TRIS[(3 HYDROXY 1 METHYL 2 OXO 1,2 DIHYDROPYRIDINE 4 CARBOXYAMIDO)ETHYL]AMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; IRON CHELATION; IRON KINETICS; MALE; NONHUMAN; PARTITION COEFFICIENT; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0033820935     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6017(200004)89:4<545::AID-JPS12>3.0.CO;2-J     Document Type: Article

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