Mobilization of intracellular iron by analogs of pyridoxal isonicotinoyl hydrazone (PIH) is determined by the membrane permeability of the iron-chelator complexes

Biochemical Pharmacology

Volumn 64, Issue 12, 2002, Pages 1689-1701

  Buss, Joan L ^a   Arduini, Emmanuele ^a   Ponka, Prem ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Iron chelators; Membrane permeability of iron chelates; Mobilization of iron from cells; PIH analogs; Pyridoxal isonicotinoyl hydrazone (PIH); Secondary iron overload

Indexed keywords

2 HYDROXY 1 NAPHTHALDEHYDE BENZOYLHYDRAZONE; 2 HYDROXY 1 NAPHTHALDEHYDE ISONICOTINOYLHYDRAZONE; BOVINE SERUM ALBUMIN; HYDRAZONE DERIVATIVE; IRON CHELATING AGENT; PYRIDOXAL BENZOYLHYDRAZONE; PYRIDOXAL ISONICOTINOYLHYDRAZONE; SALICYLALDEHYDE BENZOYLHYDRAZONE; SALICYLALDEHYDE ISONICOTINOYLHYDRAZONE; SUCCINYLACETONE; TRANSFERRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG BINDING; DRUG PENETRATION; ERYTHROCYTE GHOST; ERYTHROCYTE MEMBRANE; HEME SYNTHESIS; IRON KINETICS; ISOMERISM; LIPOPHILICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETICULOCYTE; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE PERMEABILITY; IRON; IRON CHELATING AGENTS; ISONIAZID; MICE; PYRIDOXAL; RETICULOCYTES; SERUM ALBUMIN, BOVINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037114461     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01426-0     Document Type: Article

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