메뉴 건너뛰기




Volumn 134, Issue 5, 1999, Pages 510-521

Development of novel aroylhydrazone ligands for iron chelation therapy: 2-pyridylcarboxaldehyde isonicotinoyl hydrazone analogs

Author keywords

[No Author keywords available]

Indexed keywords


EID: 0033230124     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2143(99)90173-7     Document Type: Article
Times cited : (85)

References (52)
  • 1
    • 0031001278 scopus 로고    scopus 로고
    • Iron - Chelating therapy and the treatment of thalassemia
    • 1. Olivieri NF, Brittenham GM. Iron - chelating therapy and the treatment of thalassemia. Blood 1997;89:739-61.
    • (1997) Blood , vol.89 , pp. 739-761
    • Olivieri, N.F.1    Brittenham, G.M.2
  • 2
    • 0031869315 scopus 로고    scopus 로고
    • The development of iron chelators to treat iron overload disease and their use as experimental tools to probe intracellular iron metabolism
    • 2. Richardson DR, Ponka P. The development of iron chelators to treat iron overload disease and their use as experimental tools to probe intracellular iron metabolism. Am J Hematol 1998;58:299-305.
    • (1998) Am J Hematol , vol.58 , pp. 299-305
    • Richardson, D.R.1    Ponka, P.2
  • 4
    • 0018394556 scopus 로고
    • Mobilization of iron from reticulocytes. Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent
    • 4. Ponka P, Borova J, Neuwirt J, Fuchs O. Mobilization of iron from reticulocytes. Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent. FEBS Lett 1979;97:317-21.
    • (1979) FEBS Lett , vol.97 , pp. 317-321
    • Ponka, P.1    Borova, J.2    Neuwirt, J.3    Fuchs, O.4
  • 5
    • 0018798539 scopus 로고
    • A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents
    • 5. Ponka P, Borova J, Neuwirt J, Fuchs O, Necas E. A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents. Biochim Biophys Acta 1979;586:278-97.
    • (1979) Biochim Biophys Acta , vol.586 , pp. 278-297
    • Ponka, P.1    Borova, J.2    Neuwirt, J.3    Fuchs, O.4    Necas, E.5
  • 6
    • 0018567483 scopus 로고
    • Effective iron chelation following oral administration of an isoniazid-pyridoxal hydrazone
    • 6. Hoy T, Humphreys J, Jacobs A, Williams A, Ponka P. Effective iron chelation following oral administration of an isoniazid-pyridoxal hydrazone. Br J Haematol 1979;43:443-9.
    • (1979) Br J Haematol , vol.43 , pp. 443-449
    • Hoy, T.1    Humphreys, J.2    Jacobs, A.3    Williams, A.4    Ponka, P.5
  • 7
    • 0019518135 scopus 로고
    • Mechanisms of in vivo chelation by pyridoxal isonicotinoyl hydrazone and other imino derivatives of pyridoxal
    • 7. Hershko C, Avramovici-Grisaru S, Link G, Gelfand L, Sarel S. Mechanisms of in vivo chelation by pyridoxal isonicotinoyl hydrazone and other imino derivatives of pyridoxal. J Lab Clin Med 1981;98:99-108.
    • (1981) J Lab Clin Med , vol.98 , pp. 99-108
    • Hershko, C.1    Avramovici-Grisaru, S.2    Link, G.3    Gelfand, L.4    Sarel, S.5
  • 8
    • 0032055861 scopus 로고    scopus 로고
    • Pyridoxal isonicotinoyl hydrazone and its analogs. Potential orally effective iron-chelating agents for the treatment of iron overload disease
    • 8. Richardson DR, Ponka P. Pyridoxal isonicotinoyl hydrazone and its analogs. Potential orally effective iron-chelating agents for the treatment of iron overload disease. J Lab Clin Med 1998;131:306-15.
    • (1998) J Lab Clin Med , vol.131 , pp. 306-315
    • Richardson, D.R.1    Ponka, P.2
  • 9
    • 0024920255 scopus 로고
    • Iron chelators of the pyridoxal isonicotinoyl hydrazone class III. Formation constants with calcium(II), magnesium(II) and zinc(II)
    • 9. Richardson DR, Hefter GT, May PM, Webb J, Baker E. Iron chelators of the pyridoxal isonicotinoyl hydrazone class III. Formation constants with calcium(II), magnesium(II) and zinc(II). Biol Metals 1989;2:161-7.
    • (1989) Biol Metals , vol.2 , pp. 161-167
    • Richardson, D.R.1    Hefter, G.T.2    May, P.M.3    Webb, J.4    Baker, E.5
  • 10
    • 0000424901 scopus 로고
    • Iron chelators of the pyridoxal isonicotinoyl hydrazone class part 2. Formation constants with iron(III) and iron(II)
    • 10. Vitolo LMW, Hefter GT, Clare BW, Webb J. Iron chelators of the pyridoxal isonicotinoyl hydrazone class Part 2. Formation constants with iron(III) and iron(II). Inorg Chim Acta 1990;170:171-6.
    • (1990) Inorg Chim Acta , vol.170 , pp. 171-176
    • Vitolo, L.M.W.1    Hefter, G.T.2    Clare, B.W.3    Webb, J.4
  • 11
    • 0020524787 scopus 로고
    • Chelator-mediated iron efflux from reticulocytes
    • 11. Morgan EH. Chelator-mediated iron efflux from reticulocytes. Biochim Biophys Acta 1983;733:39-50.
    • (1983) Biochim Biophys Acta , vol.733 , pp. 39-50
    • Morgan, E.H.1
  • 12
    • 0020050144 scopus 로고
    • Iron utilization in rabbit reticulocytes. A study using succinylacetone as an inhibitor of haem synthesis
    • 12. Ponka P, Wilczynska A, Schulman HM. Iron utilization in rabbit reticulocytes. A study using succinylacetone as an inhibitor of haem synthesis. Biochim Biophys Acta 1982;720:96-102.
    • (1982) Biochim Biophys Acta , vol.720 , pp. 96-102
    • Ponka, P.1    Wilczynska, A.2    Schulman, H.M.3
  • 13
    • 0030846021 scopus 로고    scopus 로고
    • Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin
    • 13. Babcock M, de Silva D, Oaks R, Davis-Kaplan S, Jiralerspong S, Montermini L, et al. Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin. Science 1997;276:1709-12.
    • (1997) Science , vol.276 , pp. 1709-1712
    • Babcock, M.1    De Silva, D.2    Oaks, R.3    Davis-Kaplan, S.4    Jiralerspong, S.5    Montermini, L.6
  • 14
    • 0031567601 scopus 로고    scopus 로고
    • Deletion of the yeast homologue of the human gene associated with friedreich's ataxia elicits iron accumulation in the mitochondrion
    • 14. Foury F, Cazzalini O. Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in the mitochondrion. FEBS Lett 1997;411:373-7.
    • (1997) FEBS Lett , vol.411 , pp. 373-377
    • Foury, F.1    Cazzalini, O.2
  • 15
    • 0031253821 scopus 로고    scopus 로고
    • Aconitase and mitochondrial iron-sulphur protein deficiency in friedreich ataxia
    • 15. Rötig A, de-Lonlay P, Chretien D, Foury F, Koenig M, Sidi D, et al. Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia. Nature Genet 1997;17:215-7.
    • (1997) Nature Genet , vol.17 , pp. 215-217
    • Rötig, A.1    De-Lonlay, P.2    Chretien, D.3    Foury, F.4    Koenig, M.5    Sidi, D.6
  • 16
    • 0026575576 scopus 로고
    • Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture
    • 16. Baker E, Richardson DR, Gross S, Ponka P. Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture. Hepatology 1992;15:492-501.
    • (1992) Hepatology , vol.15 , pp. 492-501
    • Baker, E.1    Richardson, D.R.2    Gross, S.3    Ponka, P.4
  • 17
    • 0028891974 scopus 로고
    • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective anti-proliferative agents
    • 17. Richardson DR, Tran E, Ponka P. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective anti-proliferative agents. Blood 1995;86:4295-306.
    • (1995) Blood , vol.86 , pp. 4295-4306
    • Richardson, D.R.1    Tran, E.2    Ponka, P.3
  • 18
    • 0030894798 scopus 로고    scopus 로고
    • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective anti-proliferative agents II: The mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone
    • 18. Richardson DR, Milnes K. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective anti-proliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone. Blood 1997;89:3025-38.
    • (1997) Blood , vol.89 , pp. 3025-3038
    • Richardson, D.R.1    Milnes, K.2
  • 19
    • 2642709214 scopus 로고    scopus 로고
    • Biliary iron excretion in rats following treatment with analogs of pyridoxal isonicotinoyl hydrazone
    • 19. Bláha K, Cikrt M, Nerudová J, Fornusková H. Ponka P. Biliary iron excretion in rats following treatment with analogs of pyridoxal isonicotinoyl hydrazone. Blood 1998;91:4368-72.
    • (1998) Blood , vol.91 , pp. 4368-4372
    • Bláha, K.1    Cikrt, M.2    Nerudová, J.3    Fornusková, H.4    Ponka, P.5
  • 20
    • 0033566305 scopus 로고    scopus 로고
    • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective anti-proliferative agents III: The effect of the ligands on molecular targets involved in proliferation
    • 20. Darnell G, Richardson DR. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective anti-proliferative agents III: the effect of the ligands on molecular targets involved in proliferation. Blood 1999;94:781-92.
    • (1999) Blood , vol.94 , pp. 781-792
    • Darnell, G.1    Richardson, D.R.2
  • 21
    • 0031436976 scopus 로고    scopus 로고
    • Potential of iron chelators as effective anti-proliferative agents
    • 21. Richardson DR. Potential of iron chelators as effective anti-proliferative agents. Can J Physiol Pharmacol 1997;75:1164-80.
    • (1997) Can J Physiol Pharmacol , vol.75 , pp. 1164-1180
    • Richardson, D.R.1
  • 22
    • 0024241764 scopus 로고
    • Deferoxamine inhibition of human neuroblastoma viability and proliferation
    • 22. Becton DL, Bryles P. Deferoxamine inhibition of human neuroblastoma viability and proliferation. Cancer Res 1988;48: 7189-92.
    • (1988) Cancer Res , vol.48 , pp. 7189-7192
    • Becton, D.L.1    Bryles, P.2
  • 23
    • 0023689207 scopus 로고
    • Mechanism of antineuroblastoma activity of deferoxamine in vitro
    • 23. Blatt J, Taylor SR, Stitely S. Mechanism of antineuroblastoma activity of deferoxamine in vitro. J Lab Clin Med 1988; 112:433-6.
    • (1988) J Lab Clin Med , vol.112 , pp. 433-436
    • Blatt, J.1    Taylor, S.R.2    Stitely, S.3
  • 25
    • 0026683009 scopus 로고
    • Deferoxamine, cyclophosphamide, etoposide, carboplatin, and thiotepa (D-CECat): A new cytoreductive chelation-chemotherapy regimen in patients with advanced neuroblastoma
    • 25. Donfrancesco A, Deb G, Dominici C, Angioni A, Caniglia M, De Sio L, et al. Deferoxamine, cyclophosphamide, etoposide, carboplatin, and thiotepa (D-CECat): a new cytoreductive chelation-chemotherapy regimen in patients with advanced neuroblastoma. Am J Clin Oncol 1992;15:319-22.
    • (1992) Am J Clin Oncol , vol.15 , pp. 319-322
    • Donfrancesco, A.1    Deb, G.2    Dominici, C.3    Angioni, A.4    Caniglia, M.5    De Sio, L.6
  • 26
    • 0029177913 scopus 로고
    • Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumour cell growth in culture and in vivo
    • 26. Cory JG, Cory AH, Rappa G, Lorico A, Liu MC, Lin TS, Sartorelli AC. Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumour cell growth in culture and in vivo. Adv Enzyme Regul 1995;35:55-68.
    • (1995) Adv Enzyme Regul , vol.35 , pp. 55-68
    • Cory, J.G.1    Cory, A.H.2    Rappa, G.3    Lorico, A.4    Liu, M.C.5    Lin, T.S.6    Sartorelli, A.C.7
  • 27
    • 0029441072 scopus 로고
    • Chemical and biological properties of cytotoxic α-(N)-heterocyclic carboxaldehyde thiosemicarbazones
    • 27. Liu M-C, Lin T-S, Sartorelli AC. Chemical and biological properties of cytotoxic α-(N)-heterocyclic carboxaldehyde thiosemicarbazones. Prog Med Chem 1995;32:1-35.
    • (1995) Prog Med Chem , vol.32 , pp. 1-35
    • Liu, M.-C.1    Lin, T.-S.2    Sartorelli, A.C.3
  • 28
    • 0001525013 scopus 로고
    • Cytotoxic chelators and chelates I. Inhibition of DNA synthesis in cultured rodent and human cells by aroylhydrazones and by a copper(II) complex of salicylaldehyde benzoyl hydrazone
    • 28. Johnson DK, Murphy TB, Rose NJ, Goodwin WH, Pickart L. Cytotoxic chelators and chelates I. Inhibition of DNA synthesis in cultured rodent and human cells by aroylhydrazones and by a copper(II) complex of salicylaldehyde benzoyl hydrazone. Inorg Chim Acta 1982;67:159-62.
    • (1982) Inorg Chim Acta , vol.67 , pp. 159-162
    • Johnson, D.K.1    Murphy, T.B.2    Rose, N.J.3    Goodwin, W.H.4    Pickart, L.5
  • 29
    • 0025341256 scopus 로고
    • The uptake of iron and transferrin by the human melanoma cell
    • 29. Richardson DR, Baker E. The uptake of iron and transferrin by the human melanoma cell. Biochim Biophys Acta 1990; 1053:1-12.
    • (1990) Biochim Biophys Acta , vol.1053 , pp. 1-12
    • Richardson, D.R.1    Baker, E.2
  • 30
    • 0028535112 scopus 로고
    • The iron metabolism of the human neuroblastoma cell. Lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis
    • 30. Richardson DR, Ponka P. The iron metabolism of the human neuroblastoma cell. Lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis. J Lab Clin Med 1994;124:660-71.
    • (1994) J Lab Clin Med , vol.124 , pp. 660-671
    • Richardson, D.R.1    Ponka, P.2
  • 31
    • 0032510294 scopus 로고    scopus 로고
    • Characterisation of non-transferrin-bound iron (ferric citrate) uptake by rat hepatocytes in culture
    • 31. Baker E, Baker SM, Morgan EH. Characterisation of non-transferrin-bound iron (ferric citrate) uptake by rat hepatocytes in culture. Biochim Biophys Acta 1998;1380:21-30.
    • (1998) Biochim Biophys Acta , vol.1380 , pp. 21-30
    • Baker, E.1    Baker, S.M.2    Morgan, E.H.3
  • 32
    • 0024121621 scopus 로고
    • Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy-and light-subumit mRNAs
    • 32. Leibold EA, Munro HN. Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy-and light-subumit mRNAs. Proc Natl Acad Sci USA 1988;85:2171-5.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 2171-2175
    • Leibold, E.A.1    Munro, H.N.2
  • 33
    • 0024365045 scopus 로고
    • A specific mrna binding factor regulates the iron-dependent stability of the cytoplasmic transferrin receptor mRNA
    • 33. Müllner EW, Neupert B, Kühn LC. A specific mRNA binding factor regulates the iron-dependent stability of the cytoplasmic transferrin receptor mRNA. Cell 1989;58:373-82.
    • (1989) Cell , vol.58 , pp. 373-382
    • Müllner, E.W.1    Neupert, B.2    Kühn, L.C.3
  • 34
    • 0022549635 scopus 로고
    • Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs
    • 34. Konarska MM, Sharp PA. Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs. Cell 1986;46:845-55.
    • (1986) Cell , vol.46 , pp. 845-855
    • Konarska, M.M.1    Sharp, P.A.2
  • 35
    • 0024644665 scopus 로고
    • Comparison of two different hybridization systems in northern transfer analysis
    • 35. Mahmoudi M, Lin VK. Comparison of two different hybridization systems in northern transfer analysis. Biotechniques 1989;7:331-2.
    • (1989) Biotechniques , vol.7 , pp. 331-332
    • Mahmoudi, M.1    Lin, V.K.2
  • 36
    • 0029758487 scopus 로고    scopus 로고
    • Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
    • 36. Hentze MW, Kühn LC. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci USA 1996;93:8175-82.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8175-8182
    • Hentze, M.W.1    Kühn, L.C.2
  • 37
    • 0029024009 scopus 로고
    • Effect of hydroxyurea on cellular iron metabolism in human leukemic CCRF-CEM cells: Changes in iron uptake and the regulation of transferrin receptor and ferritin gene expression following inhibition of DNA synthesis
    • 37. Chitambar CR, Wereley JP. Effect of hydroxyurea on cellular iron metabolism in human leukemic CCRF-CEM cells: changes in iron uptake and the regulation of transferrin receptor and ferritin gene expression following inhibition of DNA synthesis. Cancer Res 1995;55:4361-6.
    • (1995) Cancer Res , vol.55 , pp. 4361-4366
    • Chitambar, C.R.1    Wereley, J.P.2
  • 40
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip 1 is a potent inhibitor of G1 cyclin-dependent kinases
    • 40. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip 1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993;75:805-16.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 41
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • 41. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997;88:323-31.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 42
    • 0028980494 scopus 로고
    • p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
    • 42. Agarwal ML, Agarwal A, Taylor WR, Stark GR. p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci USA 1995;92:8493-7.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8493-8497
    • Agarwal, M.L.1    Agarwal, A.2    Taylor, W.R.3    Stark, G.R.4
  • 43
    • 0026496885 scopus 로고
    • A mammalian cell cycle check point pathway utilizing p53 and gadd45 is defective in ataxia telangiectasia
    • 43. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, et al. A mammalian cell cycle check point pathway utilizing p53 and gadd45 is defective in ataxia telangiectasia. Cell 1992;71:587-97.
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1    Zhan, Q.2    El-Deiry, W.S.3    Carrier, F.4    Jacks, T.5    Walsh, W.V.6
  • 44
    • 0026782447 scopus 로고
    • Cell cycle synchronization and growth inhibition by 3-hydroxypyridin-4-one iron chelators in leukemic cell lines
    • 44. Hoyes KP, Hider RC, Porter JB. Cell cycle synchronization and growth inhibition by 3-hydroxypyridin-4-one iron chelators in leukemic cell lines. Cancer Res 1992;52:4591-9.
    • (1992) Cancer Res , vol.52 , pp. 4591-4599
    • Hoyes, Kp.1    Hider, R.C.2    Porter, J.B.3
  • 45
    • 0027201502 scopus 로고
    • Neuroblastoma sensitivity to growth inhibition by deferoxamine: Evidence for a block in the G1 phase of the cell cycle
    • 45. Brodie C, Siriwardana G, Lucas J, Schleicher R, Terada N, Szepesi A, et al. Neuroblastoma sensitivity to growth inhibition by deferoxamine: evidence for a block in the G1 phase of the cell cycle. Cancer Res 1993;53:3968-75.
    • (1993) Cancer Res , vol.53 , pp. 3968-3975
    • Brodie, C.1    Siriwardana, G.2    Lucas, J.3    Schleicher, R.4    Terada, N.5    Szepesi, A.6
  • 46
    • 37049125557 scopus 로고
    • Crystal structure and chemical properties of bis(N-picolinylidene-N'-salicyloylhydrazinato)nickle(II)
    • 46. Domiano P, Musatti A, Nardelli M, Pelizzi C. Crystal structure and chemical properties of bis(N-picolinylidene-N'-salicyloylhydrazinato)nickle(II). J Chem Soc Dalton Trans 1975;295-300.
    • (1975) J Chem Soc Dalton Trans , pp. 295-300
    • Domiano, P.1    Musatti, A.2    Nardelli, M.3    Pelizzi, C.4
  • 47
    • 48749140519 scopus 로고
    • 10-metal complexes of pyridine-2-carbaldehyde salicyloylhydrazone and x-ray structure of the zinc derivative
    • 10-metal complexes of pyridine-2-carbaldehyde salicyloylhydrazone and x-ray structure of the zinc derivative. Polyhedron 1984;3:281-6.
    • (1984) Polyhedron , vol.3 , pp. 281-286
    • Domiano, P.1    Pelizzi, C.2    Predieri, G.3    Vignali, C.4    Palla, G.5
  • 49
    • 0023811903 scopus 로고
    • Iron mobilization from hepatocyte monolayer cultures by chelators: The importance of membrane permeability and the iron-binding constant
    • 49. Porter JB, Gyparaki M, Burke LC, Huehns ER, Sarpong P, Saez V, et al. Iron mobilization from hepatocyte monolayer cultures by chelators: the importance of membrane permeability and the iron-binding constant. Blood 1988;72:1497-503.
    • (1988) Blood , vol.72 , pp. 1497-1503
    • Porter, J.B.1    Gyparaki, M.2    Burke, L.C.3    Huehns, E.R.4    Sarpong, P.5    Saez, V.6
  • 50
    • 0028030463 scopus 로고
    • Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Relationship of the lipophilicity of the apochelator to its ability to remove iron from reticulocytes in vitro
    • 50. Ponka P, Richardson DR, Edward JT, Chubb FL. Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Relationship of the lipophilicity of the apochelator to its ability to remove iron from reticulocytes in vitro. Can J Physiol Pharmacol 1994;72:659-66.
    • (1994) Can J Physiol Pharmacol , vol.72 , pp. 659-666
    • Ponka, P.1    Richardson, D.R.2    Edward, J.T.3    Chubb, F.L.4
  • 51
    • 0018337084 scopus 로고
    • The reduction of ribonucleotides
    • 51. Thelander L, Reichard P. The reduction of ribonucleotides. Annu Rev Biochem 1979;48:133-58.
    • (1979) Annu Rev Biochem , vol.48 , pp. 133-158
    • Thelander, L.1    Reichard, P.2
  • 52
    • 0032771646 scopus 로고    scopus 로고
    • Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: An iron chelator with antitumour activity
    • 52. Richardson DR, Bernhardt PV. Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with antitumour activity. J Biol Inorg Chem 1999;4:266-73.
    • (1999) J Biol Inorg Chem , vol.4 , pp. 266-273
    • Richardson, D.R.1    Bernhardt, P.V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.