Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid β-protein

Neurobiology of Aging

Volumn 25, Issue 8, 2004, Pages 1057-1066

  Rabacchi, Sylvia A ^a,b   Friedman, Wilma J ^a,c   Shelanski, Michael L ^a   Troy, Carol M ^a  

^a College of Physicians and Surgeons ^*  (United States)

^b BIOGEN   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

4 Hydroxynonenal; Antisense oligonucleotides; APAF 1; CAD cells; Caspase 3; Caspase 7; Caspase 9; Caspases; DIABLO; Hippocampal neurons; HNE; Neuronal apoptosis; Neuronal death; PC12 cells; Sympathetic neurons

Indexed keywords

4 HYDROXYNONENAL; AMYLOID BETA PROTEIN; ANTISENSE OLIGODEOXYNUCLEOTIDE; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 7; CASPASE 9; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL TYPE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; EVOKED RESPONSE; GENETIC VARIABILITY; LIPID PEROXIDATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

ALDEHYDES; AMYLOID BETA-PROTEIN; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CARRIER PROTEINS; CASPASE 3; CASPASE 9; CASPASES; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; MICE; MITOCHONDRIAL PROTEINS; NERVE GROWTH FACTORS; NEURODEGENERATIVE DISEASES; NEURONS; PC12 CELLS; PROTEINS; RATS; SUPEROXIDE DISMUTASE;

EID: 2942750162     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2003.10.003     Document Type: Article

References (49)

1. Bains J.S., Shaw C.A. Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res. Brain Res. Rev. 25(3):1997;335-358
2. Bergeron L., Yuan J. Sealing one's fate: control of cell death in neurons. Curr. Opin. Neurobiol. 8(1):1998;55-63
3. Bruckner S.R., Estus S. JNK3 contributes to c-jun induction and apoptosis in 4-hydroxynonenal-treated sympathetic neurons. J. Neurosci. Res. 70(5):2002;665-670
4. Camandola S., Poli G., Mattson M.P. The lipid peroxidation product 4-hydroxy-2, 3-nonenal increases AP-1-binding activity through caspase activation in neurons. J. Neurochem. 74(1):2000;159-168
5. Chan S.L., Griffin W.S., Mattson M.P. Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease. J. Neurosci. Res. 57(3):1999;315-323
6. Cotman C.W., Su J.H. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol. 6(4):1996;493-506
7. Cotman C.W., Whittemore E.R., Watt J.A., Anderson A.J., Loo D.T. Possible role of apoptosis in Alzheimer's disease. Ann. N. Y. Acad. Sci. 747:1994;36-49
8. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science. 262:1993;689-695
9. Garcia-Calvo M., Peterson E.P., Leiting B., Ruel R., Nicholson D.W., Thornberry N.A. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J. Biol. Chem. 273(49):1998;32608-32613
10. Gervais F.G., Xu D., Robertson G.S., Vaillancourt J.P., Zhu Y., Huang J., et al. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell. 97(3):1999;395-406
11. Greene L.A., Tischler A.S. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. U.S.A. 73(7):1976;2424-2428
12. Greenlund L.J., Deckwerth T.L., Johnson E.M. Jr. Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron. 14(2):1995;303-315
13. Hengartner M.O. The biochemistry of apoptosis. Nature. 407(6805):2000;770-776
14. Ji C., Amarnath V., Pietenpol J.A., Marnett L.J. 4-Hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release. Chem. Res. Toxicol. 14(8):2001;1090-1096
15. Keller J.N., Mark R.J., Bruce A.J., Blanc E., Rothstein J.D., Uchida K., et al. 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes. Neuroscience. 80(3):1997;685-696
16. Krichevsky A.M., Kosik K.S. RNAi functions in cultured mammalian neurons. Proc. Natl. Acad. Sci. U.S.A. 99(18):2002;11926-11929
17. Krohn A.J., Preis E., Prehn J.H. Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector. J. Neurosci. 18(20):1998;8186-8197
18. Kruman I., Bruce-Keller A.J., Bredesen D., Waeg G., Mattson M.P. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J. Neurosci. 17(13):1997;5089-5100
19. Liu W., Kato M., Akhand A.A., Hayakawa A., Suzuki H., Miyata T., et al. 4-Hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death. J. Cell Sci. 113(Pt 4):2000;635-641
20. Margolin N., Raybuck S.A., Wilson K.P., Chen W., Fox T., Gu Y., et al. Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases. J. Biol. Chem. 272(11):1997;7223-7228
21. Markesbery W.R., Carney J.M. Oxidative alterations in Alzheimer's disease. Brain Pathol. 9(1):1999;133-146
22. Mattson M.P., Pedersen W.A. Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease. Int. J. Dev. Neurosci. 16(7/8):1998;737-753
23. Pedersen W.A., Fu W., Keller J.N., Markesbery W.R., Appel S., Smith R.G., et al. Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Ann. Neurol. 44(5):1998;819-824
24. Qi Y., Wang J.K.T., McMillian M., Chikaraishi D.M. Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation. J. Neurosci. 17(4):1997;1217-1225
25. Selkoe D.J. Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues. Science. 248(4959):1990;1058-1060
26. Smith R.G., Henry Y.K., Mattson M.P., Appel S.H. Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis. Ann. Neurol. 44(4):1998;696-699
27. Stefanis L., Burke R.E., Greene L.A. Apoptosis in neurodegenerative disorders. Curr. Opin. Neurol. 10(4):1997;299-305
28. Stefanis L., Troy C.M., Qi H., Shelanski M.L., Greene L.A. Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity. J. Neurosci. 18(22):1998;9204-9215
29. Stefanis L., Park D.S., Yan C.Y., Farinelli S.E., Troy C.M., Shelanski M.L., et al. Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis. J. Biol. Chem. 271(48):1996;30663-30671
30. Subramaniam R., Koppal T., Green M., Yatin S., Jordan B., Drake J., et al. The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease. Neurochem. Res. 23(11):1998;1403-1410
31. Talanian R.V., Quinlan C., Trautz S., Hackett M.C., Mankovich J.A., Banach D., et al. Substrate specificities of caspase family proteases. J. Biol. Chem. 272(15):1997;9677-9682
32. Thornberry N.A., Rano T.A., Peterson E.P., Rasper D.M., Timkey T., Garcia-Calvo M., et al. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 272(29):1997;17907- 17911
33. Troy CM. Diversity of caspase involvement in neuronal cell death. In: Mattson MP, Estus S, editors. Programmed cell death: cellular and molecular mechanisms. Amsterdam: Elsevier; 2000. p. 67-92.
34. Troy CM. Caspase specificity in neuronal death. In: Lo EH, Marwah J, editors. Neuroprotection. Scottsdale: Prominent Press; 2001. p. 281-97.
35. Troy C.M., Shelanski M.L. Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells. Proc. Natl. Acad. Sci. U.S.A. 91(14):1994;6384-6387
36. Troy C.M., Salvesen G.S. Caspases on the brain. J. Neurosci. Res. 69(2):2002;145-1450
37. Troy C.M., Greene L.A., Shelanski M.L. Neurite outgrowth in peripherin-depleted PC12 cells. J. Cell. Biol. 117(5):1992;1085-1092
38. Troy C.M., Friedman J.E., Friedman W.J. Mechanisms of p75-mediated death of hippocampal neurons: role of caspases. J. Biol. Chem. 3:2002;3
39. Troy C.M., Stefanis L., Greene L.A., Shelanski M.L. Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells. J. Neurosci. 17(6):1997;1911-1918
40. Troy C.M., Stefanis L., Prochiantz A., Greene L.A., Shelanski M.L. The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation. Proc. Natl. Acad. Sci. U.S.A. 93(11):1996;5635-5640
41. Troy C.M., Derossi D., Prochiantz A., Greene L.A., Shelanski M.L. Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. J. Neurosci. 16(1):1996;253-261
42. Troy C.M., Rabacchi S.A., Friedman W.J., Frappier T.F., Brown K., Shelanski M.L. Caspase-2 mediates neuronal cell death induced by beta-amyloid. J. Neurosci. 20(4):2000;1386-1392
43. Troy C.M., Rabacchi S.A., Hohl J.B., Angelastro J.M., Greene L.A., Shelanski M.L. Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. J. Neurosci. 21(14):2001;5007-5016
44. Uchida K., Shiraishi M., Naito Y., Torii Y., Nakamura Y., Osawa T. Activation of stress signaling pathways by the end product of lipid peroxidation. 4-Hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J. Biol. Chem. 274(4):1999;2234-2242
45. Vickers T.A., Koo S., Bennett C.F., Crooke S.T., Dean N.M., Baker B.F. Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis. J. Biol. Chem. 278(9):2003;7108-7118
46. Wang X., Zelenski N.G., Yang J., Sakai J., Brown M.S., Goldstein J.L. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J. 15(5):1996;1012-1020
47. Yankner B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 16(5):1996;921-932
48. Yuan J., Yankner B.A. Apoptosis in the nervous system. Nature. 407(6805):2000;802-809
49. Zhang W., He Q., Chan L.L., Zhou F., El Naghy M., Thompson E.B., et al. Involvement of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells. Free Radic. Biol. Med. 30(6):2001;699-706