4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death

Journal of Cell Science

Volumn 113, Issue 4, 2000, Pages 635-641

  Liu, Wei ^a,b   Kato, Masashi ^a   Akhand, Anwaral A ^a   Hayakawa, Akemi ^a   Suzuki, Haruhiko ^a   Miyata, Toshio ^c   Kurokawa, Kiyoshi ^c   Hotta, Yoshihiro ^b   Ishikawa, Naohisa ^b   Nakashima, Izumi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Caspase; Fas; GSH; HNE; Redox

Indexed keywords

4 HYDROXYNONENAL; ACETYLCYSTEINE; ANTIBODY; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CYSTEINE; DITHIOTHREITOL; DNA FRAGMENT; FAS ANTIGEN; GLUTATHIONE; HISTIDINE; LYSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

APOPTOSIS; ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; CYTOTOXICITY; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA CELL LINE; OXIDATION REDUCTION STATE; PRIORITY JOURNAL;

ALDEHYDES; ANTIGENS, CD95; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DNA FRAGMENTATION; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMANS; JURKAT CELLS; K562 CELLS; OXIDATION-REDUCTION; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS;

EID: 0034098451     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Bantel, H., Engels, I. H., Voelter, W., Schulze-Osthoff, K. and Wesselborg, S. (1999). Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis. Cancer Res. 59, 2083-2090.
2. Boggs, S. E., McCormick, T. S. and Lapetina, E. G. (1998). Glutathione levels determine apoptosis in macrophases. Biochem. Bioph. Res. Co. 247, 229-233.
3. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V. and Wallach. D. (1996). Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death. Cell 85, 803-815.
4. Brambilla, G., Sciaba, L., Faggin, P., Maura, A., Marinari, U. M., Ferro, M. and Esterbauer, H. (1986). Cytotoxicity, DNA fragmentation, and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes. Mutat. Res. 171, 169-176.
5. Buckley, C. D., Pilling, D., Henriqucz, N. V., Parsonage, G., Threlfall, K., Scheel-Toellner, D., Simmons, D. L., Akbar, A. N., Lord, J. M. and Salmon, M. (1999). RGD peptides induce apoptosis by direct caspase-3 activation. Nature 397, 534-539.
6. Caricchio, R., Reap, E. A. and Cohen, P. L. (1998). Fas/Fas ligand interactions are involved in ultraviolet-B-induced human lymphocyte apoptosis. J. Immunol. 161, 241-251.