Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells

Journal of Neuroscience

Volumn 17, Issue 6, 1997, Pages 1911-1918

  Troy, Carol M ^a,b   Stefanis, Leonidas ^a   Greene, Lloyd A ^a   Shelanski, Michael L ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NONE   (United States)

Author keywords

apoptosis; cysteine aspartases; Nedd2; neuronal cell death; oxidative stress; trophic factor deprivation

Indexed keywords

INTERLEUKIN 1BETA CONVERTING ENZYME; NERVE GROWTH FACTOR; SUPEROXIDE DISMUTASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CYTOPATHOGENIC EFFECT; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REPRESSION; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SYMPATHETIC NERVE;

EID: 0031018396     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-06-01911.1997     Document Type: Article

References (28)

1. Batistatou A, Greene LA (1991) Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity. J Cell Biol 115:461-471.
2. Brown Jr RH (1995) Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice. Cell 80:687-692.
3. Coyle JT, Puttfarcken P (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262:689-695.
4. Farinelli SE, Park DS, Greene LA (1996) Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism. J Neurosci 16:2325-2334.
5. Ferrari G, Yan CYI, Greene LA (1995) N-acetylcysteine (D-and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci 15:2857-2866.
6. Greene LA (1978) Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. J Cell Biol 78:747-755.
7. Greene LA, Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424-2428.
8. Kumar S (1995) Inhibition of apoptosis by the expression of antisense Nedd2. FEBS Lett 368:69-72.
9. Kumar S, Knioshita M, Noda M, Copeland NG, Jenkins NA (1994) Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes Dev 8:1613-1626.
10. Lindenboim L, Haviv R, Stein R (1995) Inhibition of drug-induced apoptosis by survival factors in PC12 cells. J Neurochem 64:1054-1063.
11. Mesner PW, Winters TR, Green SH (1992) Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons. J Cell Biol 119:1669-1680.
12. Pittman RN, Wang S, DiBenedetto AJ, Mills JC (1993) A system for characterizing cellular and molecular events in programmed neuronal cell death. J Neurosci 13:3669-3680.
13. Rukenstein A, Rydel RE, Greene LA (1991) Multiple agents rescue PC12 cells from serum-free cell death by translation-and transcription-independent mechanisms. J Neurosci 11:2552-2563.
14. Rydel RE, Greene LA (1988) cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor. Proc Natl Acad Sci USA 85:1257-1261.
15. Schapira AHV (1995) Oxidative stress in Parkinson's disease. Neuropathol Appl Neurobiol 21:3-9.
16. Srinivasan A, Foster LM, Testa M-P, Ord T, Keane RW, Bredesen DE, Kayalar C (1996) Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis. J Neurosci 16:5654-5660.
17. Stefanis L, Park DS, Yan CYI, Farinelli SE, Troy CM, Shelanski ML, Greene LA (1996) Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support: dissociation from apoptosis. J Biol Chem 271:30663-30671.
18. Theodore L, Derossi D, Chassaing G, Llirbat B, Kubes M, Jordan P, Chneilweiss H, Godement P, Prochiantz A (1995) Intraneuronal delivery of protein kinasc C pseudosubstrate leads to growth cone collapse. J Neurosci 15:7158-7167.
19. Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Elliston KO, Ayala JM, Casano FJ, Chin J, Ding GJ-F, Egger LA, Gaffney EP, Limjuco G, Palyha OC, Raju SM, Rolando AM, Salley JP, Yamin T-T, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA, Tocci MJ (1992) A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356:768-774.
20. Troy CM, Shelanski ML (1994) Down-regulation of copper/zinc superoxide dismutase (SOD1) causes neuronal cell death. Proc Natl Acad Sci USA 91:6384-6387.
21. Troy CM, Brown K, Greene LA, Shelanski ML (1990) Ontogeny of the neuronal intermediate filament protein, peripherin, in the mouse embryo. Neuroscience 36:217-237.
22. Troy CM, Greene LA, Shelanski ML (1992) Neurite outgrowth in peripherin-depleted PC12 cells. J Cell Biol 117:1085-1092.
23. Troy CM, Derossi D, Prochiantz A, Greene LA, Shelanski ML (1996a) Downregulation of Cu/Zn SOD1 leads to cell death via the nitric oxide-peroxynitrite pathway. J Neurosci 16:253-261.
24. Troy CM, Stefanis L, Prochiantz A, Greene LA, Shelanski ML (1996b) The contrasting roles of ICE family proteases and interleukin-1β in apoptosis induced by trophic factor withdrawal and by SOD1 downregulation. Proc Natl Acad Sci USA 93:5635-5640.
25. Troy CM, Stefanis L, Greene LA, Shelanski ML (1996c) Mechanisms of neuronal degeneration: a final common pathway? In: Neuronal regeneration, reorganization, and repair (Seil F, ed), pp 103-112. New York: Raven.
26. Wang L, Miura M, Bergeron L, Zhu H, Yuan J (1994) Ich-1, an ICE/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78:739-750.
27. Williams LR (1995) Oxidative stress, age-related neurodegeneration, and the potential for neurotrophic. Cerebrovasc Brain Metab Rev 7:55-73.
28. Yamin T-T, Ayala JM, Miller DK (1996) Activation of the native 45 kDa precursor form of interleukin-1-converting enzyme. J Biol Chem 271: 13273-13282.