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Volumn 52, Issue 6, 2005, Pages 1779-1804

A look to the future: Prediction, prevention, and cure including islet transplantation and stem cell therapy

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; BCG VACCINE; CD20 ANTIBODY; CYCLOSPORIN; DACLIZUMAB; HEAT SHOCK PROTEIN 277; HEAT SHOCK PROTEIN 60; IMMUNOSUPPRESSIVE AGENT; INSULIN; INSULIN B [9-23]; INTERLEUKIN 2 RECEPTOR ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD3; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NICOTINAMIDE; OKT 3; PREDNISONE; RAPAMYCIN; RITUXIMAB; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG;

EID: 27844583931     PISSN: 00313955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pcl.2005.07.002     Document Type: Review
Times cited : (13)

References (132)
  • 1
    • 0028779842 scopus 로고
    • The pathogenesis of insulin-dependent diabetes mellitus
    • M.A. Atkinson, and N.K. Maclaren The pathogenesis of insulin-dependent diabetes mellitus N Engl J Med 331 1994 1428 1436
    • (1994) N Engl J Med , vol.331 , pp. 1428-1436
    • Atkinson, M.A.1    MacLaren, N.K.2
  • 2
    • 0022617990 scopus 로고
    • Type I diabetes mellitus: A chronic autoimmune disease
    • G.S. Eisenbarth Type I diabetes mellitus: a chronic autoimmune disease N Engl J Med 314 1986 1360 1368
    • (1986) N Engl J Med , vol.314 , pp. 1360-1368
    • Eisenbarth, G.S.1
  • 3
    • 0028584260 scopus 로고
    • Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives
    • P.J. Bingley, M.R. Christie, and E. Bonifacio Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives Diabetes 43 1994 1304 1310
    • (1994) Diabetes , vol.43 , pp. 1304-1310
    • Bingley, P.J.1    Christie, M.R.2    Bonifacio, E.3
  • 4
    • 0030175880 scopus 로고    scopus 로고
    • Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes
    • C.F. Verge, R. Gianani, and E. Kawasaki Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes J Autoimmun 9 1996 379 383
    • (1996) J Autoimmun , vol.9 , pp. 379-383
    • Verge, C.F.1    Gianani, R.2    Kawasaki, E.3
  • 5
    • 0029995958 scopus 로고    scopus 로고
    • Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
    • C.F. Verge, R. Gianani, and E. Kawasaki Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies Diabetes 45 1996 926 933
    • (1996) Diabetes , vol.45 , pp. 926-933
    • Verge, C.F.1    Gianani, R.2    Kawasaki, E.3
  • 6
    • 0031939509 scopus 로고    scopus 로고
    • Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ-specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus
    • M. Pietropaolo, M. Peakman, and S.L. Pietropaolo Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ-specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus J Autoimmun 11 1998 1 10
    • (1998) J Autoimmun , vol.11 , pp. 1-10
    • Pietropaolo, M.1    Peakman, M.2    Pietropaolo, S.L.3
  • 7
    • 0030982937 scopus 로고    scopus 로고
    • Combined analysis and single-step detection of GAD65 and IA2 autoantibodies in IDDM can replace the histochemical islet cell antibody test
    • U. Wiest-Ladenburger, R. Hartmann, and U. Hartmann Combined analysis and single-step detection of GAD65 and IA2 autoantibodies in IDDM can replace the histochemical islet cell antibody test Diabetes 46 1997 565 571
    • (1997) Diabetes , vol.46 , pp. 565-571
    • Wiest-Ladenburger, U.1    Hartmann, R.2    Hartmann, U.3
  • 8
    • 0016261369 scopus 로고
    • Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
    • G.F. Bottazzo, A. Florin-Christensen, and D. Doniach Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies Lancet 2 1974 1279 1283
    • (1974) Lancet , vol.2 , pp. 1279-1283
    • Bottazzo, G.F.1    Florin-Christensen, A.2    Doniach, D.3
  • 9
    • 27844602873 scopus 로고    scopus 로고
    • Viva ICA: Cytoplasmic islet cell antibodies 30 years later [abstract]
    • M. Pietropaolo, S. Yu, and I. Libman Viva ICA: cytoplasmic islet cell antibodies 30 years later [abstract] Diabetes 53 Suppl 2 2004 A64
    • (2004) Diabetes , vol.53 , Issue.2 SUPPL. , pp. 64
    • Pietropaolo, M.1    Yu, S.2    Libman, I.3
  • 10
    • 0026506615 scopus 로고
    • Distinct cytoplasmic islet cell antibodies with different risks for type 1 (insulin-dependent) diabetes mellitus
    • S. Genovese, E. Bonifacio, and J.M. McNally Distinct cytoplasmic islet cell antibodies with different risks for type 1 (insulin-dependent) diabetes mellitus Diabetologia 35 1992 385 388
    • (1992) Diabetologia , vol.35 , pp. 385-388
    • Genovese, S.1    Bonifacio, E.2    McNally, J.M.3
  • 11
    • 0026548770 scopus 로고
    • Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes
    • R. Gianani, A. Pugliese, and S. Bonner-Weir Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes Diabetes 41 1992 347 353
    • (1992) Diabetes , vol.41 , pp. 347-353
    • Gianani, R.1    Pugliese, A.2    Bonner-Weir, S.3
  • 12
    • 0027529913 scopus 로고
    • Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes
    • M.A. Atkinson, D.L. Kaufman, and D. Newman Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes J Clin Invest 91 1993 350 356
    • (1993) J Clin Invest , vol.91 , pp. 350-356
    • Atkinson, M.A.1    Kaufman, D.L.2    Newman, D.3
  • 13
    • 0028799911 scopus 로고
    • Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase
    • M.A. Myers, D.U. Rabin, and M.J. Rowley Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase Diabetes 44 1995 1290 1295
    • (1995) Diabetes , vol.44 , pp. 1290-1295
    • Myers, M.A.1    Rabin, D.U.2    Rowley, M.J.3
  • 14
    • 0028799010 scopus 로고
    • ICA512 autoantibody radioassay
    • R. Gianani, D.U. Rabin, and C.F. Verge ICA512 autoantibody radioassay Diabetes 44 1995 1340 1344
    • (1995) Diabetes , vol.44 , pp. 1340-1344
    • Gianani, R.1    Rabin, D.U.2    Verge, C.F.3
  • 15
    • 0028258006 scopus 로고
    • A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM
    • C.E. Grubin, T. Daniels, and B. Toivola A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM Diabetologia 37 1994 344 350
    • (1994) Diabetologia , vol.37 , pp. 344-350
    • Grubin, C.E.1    Daniels, T.2    Toivola, B.3
  • 16
    • 0021019885 scopus 로고
    • Insulin antibodies in insulin-dependent diabetics before insulin treatment
    • J.P. Palmer, C.M. Asplin, and P. Clemons Insulin antibodies in insulin-dependent diabetics before insulin treatment Science 222 1983 1337 1339
    • (1983) Science , vol.222 , pp. 1337-1339
    • Palmer, J.P.1    Asplin, C.M.2    Clemons, P.3
  • 17
    • 0030798560 scopus 로고    scopus 로고
    • A novel micro-assay for insulin autoantibodies
    • A.J. Williams, P.J. Bingley, and E. Bonifacio A novel micro-assay for insulin autoantibodies J Autoimmun 10 1997 473 478
    • (1997) J Autoimmun , vol.10 , pp. 473-478
    • Williams, A.J.1    Bingley, P.J.2    Bonifacio, E.3
  • 18
    • 0031812550 scopus 로고    scopus 로고
    • Comparison of a novel micro-assay for insulin autoantibodies with the conventional radiobinding assay
    • H.E. Naserke, N. Dozio, and A.G. Ziegler Comparison of a novel micro-assay for insulin autoantibodies with the conventional radiobinding assay Diabetologia 41 1998 681 683
    • (1998) Diabetologia , vol.41 , pp. 681-683
    • Naserke, H.E.1    Dozio, N.2    Ziegler, A.G.3
  • 19
    • 0023630622 scopus 로고
    • Competitive insulin autoantibody assay: Prospective evaluation of subjects at high risk for development of type I diabetes mellitus
    • P. Vardi, S.A. Dib, and M. Tuttleman Competitive insulin autoantibody assay: prospective evaluation of subjects at high risk for development of type I diabetes mellitus Diabetes 36 1987 1286 1291
    • (1987) Diabetes , vol.36 , pp. 1286-1291
    • Vardi, P.1    Dib, S.A.2    Tuttleman, M.3
  • 20
    • 0037408360 scopus 로고    scopus 로고
    • Diabetes Antibody Standardization Program: First assay proficiency evaluation
    • P.J. Bingley, E. Bonifacio, and P.W. Mueller Diabetes Antibody Standardization Program: first assay proficiency evaluation Diabetes 52 2003 1128 1136
    • (2003) Diabetes , vol.52 , pp. 1128-1136
    • Bingley, P.J.1    Bonifacio, E.2    Mueller, P.W.3
  • 21
    • 0030695027 scopus 로고    scopus 로고
    • Prediction of IDDM in the general population: Strategies based on combinations of autoantibody markers
    • P.J. Bingley, E. Bonifacio, and A.J. Williams Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers Diabetes 46 1997 1701 1710
    • (1997) Diabetes , vol.46 , pp. 1701-1710
    • Bingley, P.J.1    Bonifacio, E.2    Williams, A.J.3
  • 22
    • 0030747073 scopus 로고    scopus 로고
    • Evaluation of ICA512As in combination with other islet cell autoantibodies at the onset of IDDM
    • S.J. Feeney, M.A. Myers, and I.R. Mackay Evaluation of ICA512As in combination with other islet cell autoantibodies at the onset of IDDM Diabetes Care 20 1997 1403 1407
    • (1997) Diabetes Care , vol.20 , pp. 1403-1407
    • Feeney, S.J.1    Myers, M.A.2    MacKay, I.R.3
  • 23
    • 0025039679 scopus 로고
    • Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
    • S. Baekkeskov, H.J. Aanstoot, and S. Christgau Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase Nature 347 1990 151 156
    • (1990) Nature , vol.347 , pp. 151-156
    • Baekkeskov, S.1    Aanstoot, H.J.2    Christgau, S.3
  • 24
    • 10744229400 scopus 로고    scopus 로고
    • Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Abs
    • C.J. Padoa, J.P. Banga, and A.M. Madec Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Abs Diabetes 52 2003 2689 2695
    • (2003) Diabetes , vol.52 , pp. 2689-2695
    • Padoa, C.J.1    Banga, J.P.2    Madec, A.M.3
  • 25
    • 0033574642 scopus 로고    scopus 로고
    • High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase
    • H.L. Schwartz, J.M. Chandonia, and S.F. Kash High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase J Mol Biol 287 1999 983 999
    • (1999) J Mol Biol , vol.287 , pp. 983-999
    • Schwartz, H.L.1    Chandonia, J.M.2    Kash, S.F.3
  • 26
    • 0031953634 scopus 로고    scopus 로고
    • Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes
    • E. Kawasaki, L. Yu, and M.J. Rewers Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes Diabetes 47 1998 733 742
    • (1998) Diabetes , vol.47 , pp. 733-742
    • Kawasaki, E.1    Yu, L.2    Rewers, M.J.3
  • 27
    • 0036106442 scopus 로고    scopus 로고
    • Application of phage display peptide library to autoimmune diabetes: Identification of IA-2/ICA512bdc dominant autoantigenic epitopes
    • L. Farilla, C. Tiberti, and A. Luzzago Application of phage display peptide library to autoimmune diabetes: identification of IA-2/ICA512bdc dominant autoantigenic epitopes Eur J Immunol 32 2002 1420 1427
    • (2002) Eur J Immunol , vol.32 , pp. 1420-1427
    • Farilla, L.1    Tiberti, C.2    Luzzago, A.3
  • 28
    • 27844520895 scopus 로고    scopus 로고
    • Humoral autoimmunity to IA-2 intracellular domain epitopes increases the cumulative risk of type 1 diabetes (T1D) progression [abstract]
    • A. Casu, D.J. Becker, and S. Pietropaolo Humoral autoimmunity to IA-2 intracellular domain epitopes increases the cumulative risk of type 1 diabetes (T1D) progression [abstract] Diabetes 2005 OR121
    • (2005) Diabetes , pp. 121
    • Casu, A.1    Becker, D.J.2    Pietropaolo, S.3
  • 29
    • 0027201783 scopus 로고
    • Islet cell autoantigen 69 kD (ICA69)L: Molecular cloning and characterization of a novel diabetes-associated autoantigen
    • M. Pietropaolo, L. Castano, and S. Babu Islet cell autoantigen 69 kD (ICA69)L: molecular cloning and characterization of a novel diabetes-associated autoantigen J Clin Invest 92 1993 359 371
    • (1993) J Clin Invest , vol.92 , pp. 359-371
    • Pietropaolo, M.1    Castano, L.2    Babu, S.3
  • 30
    • 0036498093 scopus 로고    scopus 로고
    • Antibodies against different epitopes of heat-shock protein 60 in children with type 1 diabetes mellitus
    • L. Horvath, L. Cervenak, and M. Oroszlan Antibodies against different epitopes of heat-shock protein 60 in children with type 1 diabetes mellitus Immunol Lett 80 2002 155 162
    • (2002) Immunol Lett , vol.80 , pp. 155-162
    • Horvath, L.1    Cervenak, L.2    Oroszlan, M.3
  • 31
    • 0242364727 scopus 로고    scopus 로고
    • A comprehensive guide to antibody and T-cell responses in type 1 diabetes
    • S.M. Lieberman, and T.P. DiLorenzo A comprehensive guide to antibody and T-cell responses in type 1 diabetes Tissue Antigens 62 2003 359 377
    • (2003) Tissue Antigens , vol.62 , pp. 359-377
    • Lieberman, S.M.1    Dilorenzo, T.P.2
  • 32
    • 0026603981 scopus 로고
    • Incidence of insulin-dependent diabetes mellitus in Colorado
    • J.N. Kostraba, E.C. Gay, and Y. Cai Incidence of insulin-dependent diabetes mellitus in Colorado Epidemiology 3 1992 232 238
    • (1992) Epidemiology , vol.3 , pp. 232-238
    • Kostraba, J.N.1    Gay, E.C.2    Cai, Y.3
  • 33
    • 0025940439 scopus 로고
    • Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies
    • H. Barmeier, D.K. McCulloch, and J.L. Neifing Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies Diabetologia 34 1991 727 733
    • (1991) Diabetologia , vol.34 , pp. 727-733
    • Barmeier, H.1    McCulloch, D.K.2    Neifing, J.L.3
  • 34
    • 0025011787 scopus 로고
    • A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes
    • W.J. Riley, N.K. Maclaren, and J. Krischer A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes N Engl J Med 323 1990 1167 1172
    • (1990) N Engl J Med , vol.323 , pp. 1167-1172
    • Riley, W.J.1    MacLaren, N.K.2    Krischer, J.3
  • 35
    • 0024266274 scopus 로고
    • How, when, and why to predict IDDM
    • N.K. Maclaren How, when, and why to predict IDDM Diabetes 37 1988 1591 1594
    • (1988) Diabetes , vol.37 , pp. 1591-1594
    • MacLaren, N.K.1
  • 36
    • 0002284160 scopus 로고
    • The Pittsburgh Insulin-Dependent Diabetes Mellitus (IDDM) Registries: The descriptive epidemiology of racial differences
    • G. Mimura Excerpta Medica Amsterdam, The Netherlands*et al.
    • R.E. LaPorte, A.L. Drash, and D. Wagener The Pittsburgh Insulin-Dependent Diabetes Mellitus (IDDM) Registries: the descriptive epidemiology of racial differences G. Mimura Clinico-genetic genesis of diabetes mellitus. International Congress Series 1982 Excerpta Medica Amsterdam, The Netherlands 66 77
    • (1982) Clinico-genetic Genesis of Diabetes Mellitus. International Congress Series , pp. 66-77
    • Laporte, R.E.1    Drash, A.L.2    Wagener, D.3
  • 37
    • 0003777740 scopus 로고    scopus 로고
    • Karlsburg type I diabetes risk study of a general population: Frequencies and interactions of the four major type I diabetes-associated autoantibodies studied in 9419 schoolchildren
    • M. Strebelow, M. Schlosser, and B. Ziegler Karlsburg type I diabetes risk study of a general population: frequencies and interactions of the four major type I diabetes-associated autoantibodies studied in 9419 schoolchildren Diabetologia 42 1999 661 670
    • (1999) Diabetologia , vol.42 , pp. 661-670
    • Strebelow, M.1    Schlosser, M.2    Ziegler, B.3
  • 38
    • 0036514136 scopus 로고    scopus 로고
    • Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: An 8-year follow-up of the Washington State Diabetes Prediction Study
    • J.M. LaGasse, M.S. Brantley, and N.J. Leech Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington State Diabetes Prediction Study Diabetes Care 25 2002 505 511
    • (2002) Diabetes Care , vol.25 , pp. 505-511
    • Lagasse, J.M.1    Brantley, M.S.2    Leech, N.J.3
  • 39
    • 0035136532 scopus 로고    scopus 로고
    • Beta-cell autoimmunity, genetic susceptibility, and progression to type 1 diabetes in unaffected schoolchildren
    • P. Kulmala, J. Rahko, and K. Savola Beta-cell autoimmunity, genetic susceptibility, and progression to type 1 diabetes in unaffected schoolchildren Diabetes Care 24 2001 171 173
    • (2001) Diabetes Care , vol.24 , pp. 171-173
    • Kulmala, P.1    Rahko, J.2    Savola, K.3
  • 40
    • 23444432369 scopus 로고
    • Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives
    • D. Schatz, J. Krischer, and G. Horne Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives J Clin Invest 93 1994 2403 2407
    • (1994) J Clin Invest , vol.93 , pp. 2403-2407
    • Schatz, D.1    Krischer, J.2    Horne, G.3
  • 41
    • 0033020127 scopus 로고    scopus 로고
    • Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (type 1) diabetes in relatives
    • N. Maclaren, M. Lan, and R. Coutant Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (type 1) diabetes in relatives J Autoimmun 12 1999 279 287
    • (1999) J Autoimmun , vol.12 , pp. 279-287
    • MacLaren, N.1    Lan, M.2    Coutant, R.3
  • 42
    • 2542505445 scopus 로고    scopus 로고
    • Brief communication: Early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents
    • M. Hummel, E. Bonifacio, and S. Schmid Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents Ann Intern Med 140 2004 882 886
    • (2004) Ann Intern Med , vol.140 , pp. 882-886
    • Hummel, M.1    Bonifacio, E.2    Schmid, S.3
  • 43
    • 7444253875 scopus 로고    scopus 로고
    • IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes
    • E. Bonifacio, M. Hummel, and M. Walter IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes Diabetes Care 27 2004 2695 2700
    • (2004) Diabetes Care , vol.27 , pp. 2695-2700
    • Bonifacio, E.1    Hummel, M.2    Walter, M.3
  • 44
    • 0031738116 scopus 로고    scopus 로고
    • Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop
    • C.F. Verge, D. Stenger, and E. Bonifacio Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop Diabetes 47 1998 1857 1866
    • (1998) Diabetes , vol.47 , pp. 1857-1866
    • Verge, C.F.1    Stenger, D.2    Bonifacio, E.3
  • 45
    • 0032518421 scopus 로고    scopus 로고
    • Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes: A population-based study. the Childhood Diabetes in Finland Study Group
    • P. Kulmala, K. Savola, and J.S. Petersen Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes: a population-based study. The Childhood Diabetes in Finland Study Group J Clin Invest 101 1998 327 336
    • (1998) J Clin Invest , vol.101 , pp. 327-336
    • Kulmala, P.1    Savola, K.2    Petersen, J.S.3
  • 46
    • 0842288452 scopus 로고    scopus 로고
    • Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics
    • P. Achenbach, K. Warncke, and J. Reiter Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics Diabetes 53 2004 384 392
    • (2004) Diabetes , vol.53 , pp. 384-392
    • Achenbach, P.1    Warncke, K.2    Reiter, J.3
  • 50
    • 0034967803 scopus 로고    scopus 로고
    • Risk assessment, prediction and prevention of type 1 diabetes
    • L.C. Harrison Risk assessment, prediction and prevention of type 1 diabetes Pediatr Diabetes 2 2001 71 82
    • (2001) Pediatr Diabetes , vol.2 , pp. 71-82
    • Harrison, L.C.1
  • 52
    • 0029953008 scopus 로고    scopus 로고
    • The role of HLA class II genes in insulin-dependent diabetes mellitus: Molecular analysis of 180 caucasian, multiplex families
    • J.A. Noble, A.M. Valdes, and M. Cook The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 caucasian, multiplex families Am J Hum Genet 59 1996 1134 1148
    • (1996) Am J Hum Genet , vol.59 , pp. 1134-1148
    • Noble, J.A.1    Valdes, A.M.2    Cook, M.3
  • 53
    • 8944258928 scopus 로고    scopus 로고
    • Newborn screening for HLA markers associated with IDDM: Diabetes autoimmunity study in the young (DAISY)
    • M. Rewers, T.L. Bugawan, and J.M. Norris Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY) Diabetologia 39 1996 807 812
    • (1996) Diabetologia , vol.39 , pp. 807-812
    • Rewers, M.1    Bugawan, T.L.2    Norris, J.M.3
  • 54
    • 0029837733 scopus 로고    scopus 로고
    • Panning for gold: Genome-wide scanning for linkage in type 1 diabetes
    • J.A. Todd, and M. Farrall Panning for gold: genome-wide scanning for linkage in type 1 diabetes Hum Mol Genet 5 Spec No 1996 1443 1448
    • (1996) Hum Mol Genet , vol.5 , Issue.SPEC. NO. , pp. 1443-1448
    • Todd, J.A.1    Farrall, M.2
  • 55
    • 0020568890 scopus 로고
    • The genetic susceptibility to type 1 (insulin-dependent) diabetes: Analysis of the HLA-DR association
    • E. Wolf, K.M. Spencer, and A.G. Cudworth The genetic susceptibility to type 1 (insulin-dependent) diabetes: analysis of the HLA-DR association Diabetologia 24 1983 224 230
    • (1983) Diabetologia , vol.24 , pp. 224-230
    • Wolf, E.1    Spencer, K.M.2    Cudworth, A.G.3
  • 56
    • 0001657878 scopus 로고
    • Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: A family study
    • P.A. Morel, J.S. Dorman, and J.A. Todd Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study Proc Natl Acad Sci U S A 85 1988 8111 8115
    • (1988) Proc Natl Acad Sci U S a , vol.85 , pp. 8111-8115
    • Morel, P.A.1    Dorman, J.S.2    Todd, J.A.3
  • 57
    • 0035807595 scopus 로고    scopus 로고
    • Closing in on type 1 diabetes
    • H. McDevitt Closing in on type 1 diabetes N Engl J Med 345 2001 1060 1061
    • (2001) N Engl J Med , vol.345 , pp. 1060-1061
    • McDevitt, H.1
  • 58
    • 0036165756 scopus 로고    scopus 로고
    • Progression to insulin-requiring diabetes in seronegative prediabetic subjects: The role of two HLA-DQ high-risk haplotypes
    • M. Pietropaolo, D.J. Becker, and R.E. LaPorte Progression to insulin-requiring diabetes in seronegative prediabetic subjects: the role of two HLA-DQ high-risk haplotypes Diabetologia 45 2002 66 76
    • (2002) Diabetologia , vol.45 , pp. 66-76
    • Pietropaolo, M.1    Becker, D.J.2    Laporte, R.E.3
  • 59
    • 4243620949 scopus 로고    scopus 로고
    • Absence of islet autoantibodies at diabetes onset does not rule out type 1A diabetes
    • C.N. Cornell Absence of islet autoantibodies at diabetes onset does not rule out type 1A diabetes Diabetes 49 Suppl 1 2000 A69
    • (2000) Diabetes , vol.49 , Issue.1 SUPPL. , pp. 69
    • Cornell, C.N.1
  • 60
    • 0026465330 scopus 로고
    • Autoimmunity and genetics contribute to the risk of insulin-dependent diabetes mellitus in families: Islet cell antibodies and HLA DQ heterodimers
    • R.B. Lipton, M. Kocova, and R.E. LaPorte Autoimmunity and genetics contribute to the risk of insulin-dependent diabetes mellitus in families: islet cell antibodies and HLA DQ heterodimers Am J Epidemiol 136 1992 503 512
    • (1992) Am J Epidemiol , vol.136 , pp. 503-512
    • Lipton, R.B.1    Kocova, M.2    Laporte, R.E.3
  • 62
    • 0033428551 scopus 로고    scopus 로고
    • Potentials and pitfalls in neonatal screening for type 1 diabetes
    • G. Dahlquist Potentials and pitfalls in neonatal screening for type 1 diabetes Acta Paediatr Suppl 88 1999 80 82
    • (1999) Acta Paediatr Suppl , vol.88 , pp. 80-82
    • Dahlquist, G.1
  • 63
    • 0032961804 scopus 로고    scopus 로고
    • Relationship of beta-cell function and autoantibodies to progression and nonprogression of subclinical type 1 diabetes: Follow-up of the Seattle Family Study
    • C.J. Greenbaum, K.L. Sears, and S.E. Kahn Relationship of beta-cell function and autoantibodies to progression and nonprogression of subclinical type 1 diabetes: follow-up of the Seattle Family Study Diabetes 48 1999 170 175
    • (1999) Diabetes , vol.48 , pp. 170-175
    • Greenbaum, C.J.1    Sears, K.L.2    Kahn, S.E.3
  • 64
    • 85011524269 scopus 로고
    • High risk DQ alleles improve IDDM prediction in ICA + ve first-degree relatives with decreased insulin secretion [abstract]
    • D.J. Becker, N. Cakan, and R.E. Laporte High risk DQ alleles improve IDDM prediction in ICA + ve first-degree relatives with decreased insulin secretion [abstract] Diabetologia 38 Suppl 1 1995 A42
    • (1995) Diabetologia , vol.38 , Issue.1 SUPPL. , pp. 42
    • Becker, D.J.1    Cakan, N.2    Laporte, R.E.3
  • 65
    • 85011525153 scopus 로고    scopus 로고
    • Autoantibodies to GAD65 and ICA512/IA-2 improve IDDM prediction in first-degree relatives with decreased first phase insulin response and ICA positivity [abstract]
    • M. Pietropaolo, M. Trucco, and N. Cakan Autoantibodies to GAD65 and ICA512/IA-2 improve IDDM prediction in first-degree relatives with decreased first phase insulin response and ICA positivity [abstract] Autoimmunity 24 Suppl 1 1996 51
    • (1996) Autoimmunity , vol.24 , Issue.1 SUPPL. , pp. 51
    • Pietropaolo, M.1    Trucco, M.2    Cakan, N.3
  • 66
    • 0031897241 scopus 로고    scopus 로고
    • Dual-parameter model for prediction of type I diabetes mellitus
    • G.S. Eisenbarth, R. Gianani, and L. Yu Dual-parameter model for prediction of type I diabetes mellitus Proc Assoc Am Physicians 110 1998 126 135
    • (1998) Proc Assoc Am Physicians , vol.110 , pp. 126-135
    • Eisenbarth, G.S.1    Gianani, R.2    Yu, L.3
  • 67
    • 0032551674 scopus 로고    scopus 로고
    • The Melbourne Pre-Diabetes Study: Prediction of type 1 diabetes mellitus using antibody and metabolic testing
    • P.G. Colman, P. McNair, and H. Margetts The Melbourne Pre-Diabetes Study: prediction of type 1 diabetes mellitus using antibody and metabolic testing Med J Aust 169 1998 81 84
    • (1998) Med J Aust , vol.169 , pp. 81-84
    • Colman, P.G.1    McNair, P.2    Margetts, H.3
  • 68
    • 0026022192 scopus 로고
    • Predictive value of intravenous glucose tolerance test insulin secretion less than or greater than the first percentile in islet cell antibody positive relatives of type 1 (insulin-dependent) diabetic patients
    • P. Vardi, L. Crisa, and R.A. Jackson Predictive value of intravenous glucose tolerance test insulin secretion less than or greater than the first percentile in islet cell antibody positive relatives of type 1 (insulin-dependent) diabetic patients Diabetologia 34 1991 93 102
    • (1991) Diabetologia , vol.34 , pp. 93-102
    • Vardi, P.1    Crisa, L.2    Jackson, R.A.3
  • 69
    • 0035140996 scopus 로고    scopus 로고
    • Proposed guidelines on screening for risk of type 1 diabetes
    • P.J. Bingley, E. Bonifacio, and A.G. Ziegler Proposed guidelines on screening for risk of type 1 diabetes Diabetes Care 24 2001 398
    • (2001) Diabetes Care , vol.24 , pp. 398
    • Bingley, P.J.1    Bonifacio, E.2    Ziegler, A.G.3
  • 70
    • 0032055459 scopus 로고    scopus 로고
    • Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial: A randomized, controlled trial
    • Group TDC
    • Group TDC Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial: a randomized, controlled trial Ann Intern Med 128 1998 517 523
    • (1998) Ann Intern Med , vol.128 , pp. 517-523
  • 71
    • 0023278491 scopus 로고
    • Effects of age, duration and treatment of insulin-dependent diabetes mellitus on residual beta-cell function: Observations during eligibility testing for the Diabetes Control and Complications Trial (DCCT)
    • Group TDR
    • Group TDR Effects of age, duration and treatment of insulin-dependent diabetes mellitus on residual beta-cell function: observations during eligibility testing for the Diabetes Control and Complications Trial (DCCT) J Clin Endocrinol Metab 65 1987 30 36
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 30-36
  • 72
    • 0037739476 scopus 로고    scopus 로고
    • Therapeutic controversy: Prevention and treatment of diabetes in children
    • A.L. Rosenbloom, D.A. Schatz, and J.P. Krischer Therapeutic controversy: prevention and treatment of diabetes in children J Clin Endocrinol Metab 85 2000 494 522
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 494-522
    • Rosenbloom, A.L.1    Schatz, D.A.2    Krischer, J.P.3
  • 73
    • 0025049497 scopus 로고
    • Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin
    • P.F. Bougneres, P. Landais, and C. Boisson Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin Diabetes 39 1990 1264 1272
    • (1990) Diabetes , vol.39 , pp. 1264-1272
    • Bougneres, P.F.1    Landais, P.2    Boisson, C.3
  • 74
    • 0023709376 scopus 로고
    • Cyclosporin-induced remission of IDDM after early intervention: Association of 1 yr of cyclosporin treatment with enhanced insulin secretion
    • Group TC-ERCT
    • Group TC-ERCT Cyclosporin-induced remission of IDDM after early intervention: association of 1 yr of cyclosporin treatment with enhanced insulin secretion Diabetes 37 1988 1574 1582
    • (1988) Diabetes , vol.37 , pp. 1574-1582
  • 75
    • 0024813410 scopus 로고
    • Double-blind controlled trial of azathioprine in children with newly diagnosed type I diabetes
    • J.J. Cook, I. Hudson, and L.C. Harrison Double-blind controlled trial of azathioprine in children with newly diagnosed type I diabetes Diabetes 38 1989 779 783
    • (1989) Diabetes , vol.38 , pp. 779-783
    • Cook, J.J.1    Hudson, I.2    Harrison, L.C.3
  • 76
    • 0022353991 scopus 로고
    • Increase in remission rate in newly diagnosed type I diabetic subjects treated with azathioprine
    • L.C. Harrison, P.G. Colman, and B. Dean Increase in remission rate in newly diagnosed type I diabetic subjects treated with azathioprine Diabetes 34 1985 1306 1308
    • (1985) Diabetes , vol.34 , pp. 1306-1308
    • Harrison, L.C.1    Colman, P.G.2    Dean, B.3
  • 77
    • 0023735943 scopus 로고
    • Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus
    • J. Silverstein, N. Maclaren, and W. Riley Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus N Engl J Med 319 1988 599 604
    • (1988) N Engl J Med , vol.319 , pp. 599-604
    • Silverstein, J.1    MacLaren, N.2    Riley, W.3
  • 78
    • 0031967886 scopus 로고    scopus 로고
    • Putative environmental factors in type 1 diabetes
    • H.K. Akerblom, and M. Knip Putative environmental factors in type 1 diabetes Diabetes Metab Rev 14 1998 31 67
    • (1998) Diabetes Metab Rev , vol.14 , pp. 31-67
    • Akerblom, H.K.1    Knip, M.2
  • 79
    • 0036080178 scopus 로고    scopus 로고
    • Environmental factors in the etiology of type 1 diabetes
    • H.K. Akerblom, O. Vaarala, and H. Hyoty Environmental factors in the etiology of type 1 diabetes Am J Med Genet 115 2002 18 29
    • (2002) Am J Med Genet , vol.115 , pp. 18-29
    • Akerblom, H.K.1    Vaarala, O.2    Hyoty, H.3
  • 80
    • 0027957328 scopus 로고
    • Cow's milk exposure and type I diabetes mellitus: A critical overview of the clinical literature
    • H.C. Gerstein Cow's milk exposure and type I diabetes mellitus: a critical overview of the clinical literature Diabetes Care 17 1994 13 19
    • (1994) Diabetes Care , vol.17 , pp. 13-19
    • Gerstein, H.C.1
  • 81
    • 0021336406 scopus 로고
    • Dietary protein: A trigger of insulin-dependent diabetes in the BB rat?
    • R.B. Elliott, and J.M. Martin Dietary protein: a trigger of insulin-dependent diabetes in the BB rat? Diabetologia 26 1984 297 299
    • (1984) Diabetologia , vol.26 , pp. 297-299
    • Elliott, R.B.1    Martin, J.M.2
  • 82
    • 0023866258 scopus 로고
    • Dietary prevention of diabetes in the non-obese diabetic mouse
    • R.B. Elliott, S.N. Reddy, and N.J. Bibby Dietary prevention of diabetes in the non-obese diabetic mouse Diabetologia 31 1988 62 64
    • (1988) Diabetologia , vol.31 , pp. 62-64
    • Elliott, R.B.1    Reddy, S.N.2    Bibby, N.J.3
  • 83
    • 20044370128 scopus 로고    scopus 로고
    • Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: A pilot study
    • H.K. Akerblom, S.M. Virtanen, and J. Ilonen Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study Diabetologia 48 2005 829 837
    • (2005) Diabetologia , vol.48 , pp. 829-837
    • Akerblom, H.K.1    Virtanen, S.M.2    Ilonen, J.3
  • 84
    • 0038303174 scopus 로고    scopus 로고
    • Intervening before the onset of type 1 diabetes: Baseline data from the European Nicotinamide Diabetes Intervention Trial (ENDIT)
    • Group ENDIT
    • Group ENDIT Intervening before the onset of type 1 diabetes: baseline data from the European Nicotinamide Diabetes Intervention Trial (ENDIT) Diabetologia 46 2003 339 346
    • (2003) Diabetologia , vol.46 , pp. 339-346
  • 85
    • 1642277657 scopus 로고    scopus 로고
    • European Nicotinamide Diabetes Intervention Trial (ENDIT): A randomised controlled trial of intervention before the onset of type 1 diabetes
    • E.A. Gale, P.J. Bingley, and C.L. Emmett European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes Lancet 363 2004 925 931
    • (2004) Lancet , vol.363 , pp. 925-931
    • Gale, E.A.1    Bingley, P.J.2    Emmett, C.L.3
  • 86
    • 0033001488 scopus 로고    scopus 로고
    • The NOD mouse model of type 1 diabetes: As good as it gets?
    • M.A. Atkinson, and E.H. Leiter The NOD mouse model of type 1 diabetes: as good as it gets? Nat Med 5 1999 601 604
    • (1999) Nat Med , vol.5 , pp. 601-604
    • Atkinson, M.A.1    Leiter, E.H.2
  • 87
    • 0029856169 scopus 로고    scopus 로고
    • A population based strategy to prevent insulin-dependent diabetes using nicotinamide
    • R.B. Elliott, C.C. Pilcher, and D.M. Fergusson A population based strategy to prevent insulin-dependent diabetes using nicotinamide J Pediatr Endocrinol Metab 9 1996 501 509
    • (1996) J Pediatr Endocrinol Metab , vol.9 , pp. 501-509
    • Elliott, R.B.1    Pilcher, C.C.2    Fergusson, D.M.3
  • 88
    • 0025837184 scopus 로고
    • Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
    • Z.J. Zhang, L. Davidson, and G. Eisenbarth Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin Proc Natl Acad Sci U S A 88 1991 10252 10256
    • (1991) Proc Natl Acad Sci U S a , vol.88 , pp. 10252-10256
    • Zhang, Z.J.1    Davidson, L.2    Eisenbarth, G.3
  • 89
    • 0027889561 scopus 로고
    • Antigen-specific immunotherapy: Oral tolerance and subcutaneous immunization in the treatment of insulin-dependent diabetes
    • A. Muir, D. Schatz, and N. Maclaren Antigen-specific immunotherapy: oral tolerance and subcutaneous immunization in the treatment of insulin-dependent diabetes Diabetes Metab Rev 9 1993 279 287
    • (1993) Diabetes Metab Rev , vol.9 , pp. 279-287
    • Muir, A.1    Schatz, D.2    MacLaren, N.3
  • 90
    • 0025890960 scopus 로고
    • Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats
    • P.A. Gottlieb, E.S. Handler, and M.C. Appel Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats Diabetologia 34 1991 296 300
    • (1991) Diabetologia , vol.34 , pp. 296-300
    • Gottlieb, P.A.1    Handler, E.S.2    Appel, M.C.3
  • 91
    • 0027480065 scopus 로고
    • Insulin prophylaxis in individuals at high risk of type I diabetes
    • R.J. Keller, G.S. Eisenbarth, and R.A. Jackson Insulin prophylaxis in individuals at high risk of type I diabetes Lancet 341 1993 927 928
    • (1993) Lancet , vol.341 , pp. 927-928
    • Keller, R.J.1    Eisenbarth, G.S.2    Jackson, R.A.3
  • 92
    • 0037198427 scopus 로고    scopus 로고
    • Effects of insulin in relatives of patients with type 1 diabetes mellitus
    • Group DPTTDS
    • Group DPTTDS Effects of insulin in relatives of patients with type 1 diabetes mellitus N Engl J Med 346 2002 1685 1691
    • (2002) N Engl J Med , vol.346 , pp. 1685-1691
  • 93
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • A. Pugliese, M. Zeller, and A. Fernandez Jr The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes Nat Genet 15 1997 293 297
    • (1997) Nat Genet , vol.15 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez Jr., A.3
  • 94
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • P. Vafiadis, S.T. Bennett, and J.A. Todd Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus Nat Genet 15 1997 289 292
    • (1997) Nat Genet , vol.15 , pp. 289-292
    • Vafiadis, P.1    Bennett, S.T.2    Todd, J.A.3
  • 95
    • 0032402315 scopus 로고    scopus 로고
    • Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens
    • M. Sospedra, X. Ferrer-Francesch, and O. Dominguez Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens J Immunol 161 1998 5918 5929
    • (1998) J Immunol , vol.161 , pp. 5918-5929
    • Sospedra, M.1    Ferrer-Francesch, X.2    Dominguez, O.3
  • 96
    • 0036222578 scopus 로고    scopus 로고
    • Cellular environment and freedom of gene expression
    • M. Pietropaolo, N. Giannoukakis, and M. Trucco Cellular environment and freedom of gene expression Nat Immunol 3 2002 335 [author reply: 336]
    • (2002) Nat Immunol , vol.3 , pp. 335
    • Pietropaolo, M.1    Giannoukakis, N.2    Trucco, M.3
  • 97
    • 0035089893 scopus 로고    scopus 로고
    • Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs
    • A. Pugliese, D. Brown, and D. Garza Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs J Clin Invest 107 2001 555 564
    • (2001) J Clin Invest , vol.107 , pp. 555-564
    • Pugliese, A.1    Brown, D.2    Garza, D.3
  • 98
    • 5444222000 scopus 로고    scopus 로고
    • Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
    • E. Jaeckel, M.A. Lipes, and H. von Boehmer Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes Nat Immunol 5 2004 1028 1035
    • (2004) Nat Immunol , vol.5 , pp. 1028-1035
    • Jaeckel, E.1    Lipes, M.A.2    Von Boehmer, H.3
  • 99
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1
    • J. Skyler, J. Krischer, and J. Wolfsdorf Effects of oral insulin in relatives of patients with type 1 diabetes: the Diabetes Prevention Trial-Type 1 Diabetes Care 28 2005 1068 1076
    • (2005) Diabetes Care , vol.28 , pp. 1068-1076
    • Skyler, J.1    Krischer, J.2    Wolfsdorf, J.3
  • 100
    • 0036300542 scopus 로고    scopus 로고
    • Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide
    • D.G. Alleva, A. Gaur, and L. Jin Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide Diabetes 51 2002 2126 2134
    • (2002) Diabetes , vol.51 , pp. 2126-2134
    • Alleva, D.G.1    Gaur, A.2    Jin, L.3
  • 101
    • 9144268894 scopus 로고    scopus 로고
    • C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: Report of an ADA workshop, 21-22 October 2001
    • J.P. Palmer, G.A. Fleming, and C.J. Greenbaum C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001 Diabetes 53 2004 250 264
    • (2004) Diabetes , vol.53 , pp. 250-264
    • Palmer, J.P.1    Fleming, G.A.2    Greenbaum, C.J.3
  • 102
    • 0037407317 scopus 로고    scopus 로고
    • Guidelines for intervention trials in subjects with newly diagnosed type 1 diabetes
    • C.J. Greenbaum, and L.C. Harrison Guidelines for intervention trials in subjects with newly diagnosed type 1 diabetes Diabetes 52 2003 1059 1065
    • (2003) Diabetes , vol.52 , pp. 1059-1065
    • Greenbaum, C.J.1    Harrison, L.C.2
  • 103
    • 0031569177 scopus 로고    scopus 로고
    • CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice
    • L. Chatenoud, J. Primo, and J.F. Bach CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice J Immunol 158 1997 2947 2954
    • (1997) J Immunol , vol.158 , pp. 2947-2954
    • Chatenoud, L.1    Primo, J.2    Bach, J.F.3
  • 104
    • 0027958044 scopus 로고
    • Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
    • L. Chatenoud, E. Thervet, and J. Primo Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice Proc Natl Acad Sci U S A 91 1994 123 127
    • (1994) Proc Natl Acad Sci U S a , vol.91 , pp. 123-127
    • Chatenoud, L.1    Thervet, E.2    Primo, J.3
  • 105
    • 0027729166 scopus 로고
    • Mycophenolate mofetil can prevent the development of diabetes in BB rats
    • L. Hao, S.M. Chan, and K.J. Lafferty Mycophenolate mofetil can prevent the development of diabetes in BB rats Ann N Y Acad Sci 696 1993 328 332
    • (1993) Ann N Y Acad Sci , vol.696 , pp. 328-332
    • Hao, L.1    Chan, S.M.2    Lafferty, K.J.3
  • 106
    • 27844445221 scopus 로고    scopus 로고
    • TrialNet
    • TrialNet MMF/DZB study Available at: http://www.diabetestrialnet.org/en/ public/ommf.html Accessed May 12, 2005
    • MMF/DZB Study
  • 108
    • 0035944844 scopus 로고    scopus 로고
    • Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
    • I. Raz, D. Elias, and A. Avron Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial Lancet 358 2001 1749 1753
    • (2001) Lancet , vol.358 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3
  • 109
    • 0035479846 scopus 로고    scopus 로고
    • Immunotherapy of insulin-dependent diabetes mellitus
    • J.F. Bach Immunotherapy of insulin-dependent diabetes mellitus Curr Opin Immunol 13 2001 601 605
    • (2001) Curr Opin Immunol , vol.13 , pp. 601-605
    • Bach, J.F.1
  • 110
    • 0033568236 scopus 로고    scopus 로고
    • Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection
    • E.S. Woodle, D. Xu, and R.A. Zivin Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection Transplantation 68 1999 608 616
    • (1999) Transplantation , vol.68 , pp. 608-616
    • Woodle, E.S.1    Xu, D.2    Zivin, R.A.3
  • 111
    • 0036733642 scopus 로고    scopus 로고
    • Modified anti-CD3 therapy in psoriatic arthritis: A phase I/II clinical trial
    • T.O. Utset, J.A. Auger, and D. Peace Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial J Rheumatol 29 2002 1907 1913
    • (2002) J Rheumatol , vol.29 , pp. 1907-1913
    • Utset, T.O.1    Auger, J.A.2    Peace, D.3
  • 112
    • 0037198420 scopus 로고    scopus 로고
    • Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
    • K.C. Herold, W. Hagopian, and J.A. Auger Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus N Engl J Med 346 2002 1692 1698
    • (2002) N Engl J Med , vol.346 , pp. 1692-1698
    • Herold, K.C.1    Hagopian, W.2    Auger, J.A.3
  • 113
    • 0036141438 scopus 로고    scopus 로고
    • Multiple immuno-regulatory defects in type-1 diabetes
    • A. Kukreja, G. Cost, and J. Marker Multiple immuno-regulatory defects in type-1 diabetes J Clin Invest 109 2002 131 140
    • (2002) J Clin Invest , vol.109 , pp. 131-140
    • Kukreja, A.1    Cost, G.2    Marker, J.3
  • 114
    • 0035806276 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade
    • P.A. Taylor, R.J. Noelle, and B.R. Blazar CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade J Exp Med 193 2001 1311 1318
    • (2001) J Exp Med , vol.193 , pp. 1311-1318
    • Taylor, P.A.1    Noelle, R.J.2    Blazar, B.R.3
  • 115
    • 2942537697 scopus 로고    scopus 로고
    • Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
    • J.C. Edwards, L. Szczepanski, and J. Szechinski Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis N Engl J Med 350 2004 2572 2581
    • (2004) N Engl J Med , vol.350 , pp. 2572-2581
    • Edwards, J.C.1    Szczepanski, L.2    Szechinski, J.3
  • 117
  • 118
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • A.M. Shapiro, J.R. Lakey, and E.A. Ryan Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen N Engl J Med 343 2000 230 238
    • (2000) N Engl J Med , vol.343 , pp. 230-238
    • Shapiro, A.M.1    Lakey, J.R.2    Ryan, E.A.3
  • 119
    • 0036303015 scopus 로고    scopus 로고
    • Successful islet transplantation: Continued insulin reserve provides long-term glycemic control
    • E.A. Ryan, J.R. Lakey, and B.W. Paty Successful islet transplantation: continued insulin reserve provides long-term glycemic control Diabetes 51 2002 2148 2157
    • (2002) Diabetes , vol.51 , pp. 2148-2157
    • Ryan, E.A.1    Lakey, J.R.2    Paty, B.W.3
  • 120
    • 13744261497 scopus 로고    scopus 로고
    • Regeneration of the pancreatic beta cell
    • M. Trucco Regeneration of the pancreatic beta cell J Clin Invest 115 2005 5 12
    • (2005) J Clin Invest , vol.115 , pp. 5-12
    • Trucco, M.1
  • 121
    • 11444250320 scopus 로고    scopus 로고
    • Stem cells and diabetes
    • M. Trucco Stem cells and diabetes Pediatr Diabetes 5 Suppl 2 2004 2 4
    • (2004) Pediatr Diabetes , vol.5 , Issue.2 SUPPL. , pp. 2-4
    • Trucco, M.1
  • 122
    • 0036070177 scopus 로고    scopus 로고
    • Pancreatic stem cells
    • S. Bonner-Weir, and A. Sharma Pancreatic stem cells J Pathol 197 2002 519 526
    • (2002) J Pathol , vol.197 , pp. 519-526
    • Bonner-Weir, S.1    Sharma, A.2
  • 123
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Y. Dor, J. Brown, and O.I. Martinez Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation Nature 429 2004 41 46
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3
  • 124
    • 4444320484 scopus 로고    scopus 로고
    • Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
    • R.M. Seaberg, S.R. Smukler, and T.J. Kieffer Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages Nat Biotechnol 22 2004 1115 1124
    • (2004) Nat Biotechnol , vol.22 , pp. 1115-1124
    • Seaberg, R.M.1    Smukler, S.R.2    Kieffer, T.J.3
  • 125
    • 0034068602 scopus 로고    scopus 로고
    • Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
    • S. Ferber, A. Halkin, and H. Cohen Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia Nat Med 6 2000 568 572
    • (2000) Nat Med , vol.6 , pp. 568-572
    • Ferber, S.1    Halkin, A.2    Cohen, H.3
  • 126
    • 0036009120 scopus 로고    scopus 로고
    • Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs
    • Y. Dai, T.D. Vaught, and J. Boone Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs Nat Biotechnol 20 2002 251 255
    • (2002) Nat Biotechnol , vol.20 , pp. 251-255
    • Dai, Y.1    Vaught, T.D.2    Boone, J.3
  • 127
    • 0034669347 scopus 로고    scopus 로고
    • Isolation of the regulatory regions and genomic organization of the porcine alpha1,3-galactosyltransferase gene
    • C. Koike, R.P. Friday, and I. Nakashima Isolation of the regulatory regions and genomic organization of the porcine alpha1,3-galactosyltransferase gene Transplantation 70 2000 1275 1283
    • (2000) Transplantation , vol.70 , pp. 1275-1283
    • Koike, C.1    Friday, R.P.2    Nakashima, I.3
  • 128
    • 0037155815 scopus 로고    scopus 로고
    • Molecular basis of evolutionary loss of the alpha 1,3- galactosyltransferase gene in higher primates
    • C. Koike, J.J. Fung, and D.A. Geller Molecular basis of evolutionary loss of the alpha 1,3-galactosyltransferase gene in higher primates J Biol Chem 277 2002 10114 10120
    • (2002) J Biol Chem , vol.277 , pp. 10114-10120
    • Koike, C.1    Fung, J.J.2    Geller, D.A.3
  • 129
    • 0347367029 scopus 로고    scopus 로고
    • Production of alpha 1,3-galactosyltransferase-deficient pigs
    • C.J. Phelps, C. Koike, and T.D. Vaught Production of alpha 1,3-galactosyltransferase-deficient pigs Science 299 2003 411 414
    • (2003) Science , vol.299 , pp. 411-414
    • Phelps, C.J.1    Koike, C.2    Vaught, T.D.3
  • 130
    • 0025076398 scopus 로고
    • Pancreatic islet transplantation after upper abdominal exenteration and liver replacement
    • A.G. Tzakis, C. Ricordi, and R. Alejandro Pancreatic islet transplantation after upper abdominal exenteration and liver replacement Lancet 336 1990 402 405
    • (1990) Lancet , vol.336 , pp. 402-405
    • Tzakis, A.G.1    Ricordi, C.2    Alejandro, R.3
  • 131
    • 0035987925 scopus 로고    scopus 로고
    • Distinct characteristics and features of allogeneic chimerism in the NOD mouse model of autoimmune diabetes
    • T.D. Zorina, V.M. Subbotin, and S. Bertera Distinct characteristics and features of allogeneic chimerism in the NOD mouse model of autoimmune diabetes Cell Transplant 11 2002 113 123
    • (2002) Cell Transplant , vol.11 , pp. 113-123
    • Zorina, T.D.1    Subbotin, V.M.2    Bertera, S.3
  • 132
    • 0038110577 scopus 로고    scopus 로고
    • Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes
    • T.D. Zorina, V.M. Subbotin, and S. Bertera Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes Stem Cells 21 2003 377 388
    • (2003) Stem Cells , vol.21 , pp. 377-388
    • Zorina, T.D.1    Subbotin, V.M.2    Bertera, S.3


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