Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with 1 diabetes

Diabetes

Volumn 47, Issue 5, 1998, Pages 733-742

  Kawasaki, Eiji ^a   Yu, Liping ^a   Rewers, Marian J ^a   Hutton, John C ^a   Eisenbarth, George S ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; EPITOPE;

ANTIBODY DETECTION; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CELL SPREADING; CHIMERA; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; FAMILIAL DISEASE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AUTOANTIBODIES; AUTOANTIGENS; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; EPITOPE MAPPING; FEMALE; HUMANS; INFANT; ISLETS OF LANGERHANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; NEOPLASM PROTEINS; PROTEIN-TYROSINE-PHOSPHATASE; RADIOIMMUNOASSAY; RISK FACTORS;

EID: 0031953634     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.5.733     Document Type: Article

References (22)

1. REFERENCES 1. Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpnti O, Raghu PK, Paquette TL: Insulin antibodies in insulin-dependent diabetics before Insulin treatment. Science 222:1337-1331, 1983
2. Baekkeskov S, Aanstoot H, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F. Richter-Oleson H, De Camilli P: Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347:151-136, 1990
3. Dotta F, Previti M, Lenti L, Dionisi S, Casetta B, D'Erme M, Eisenbarth G, Di Mario U: GM2-1 pancreatic islet ganglioside: identification and clmractcrization of a novel islet-specific molecule. Diabetologia 38:117-1121, 1995
4. Aanstoot H, Kang S, Kim J, Lindsay L, Roll U, Knip M Atkinson M, Mose-Larson P, Fey S, Ludvigsson J, Landin M, Bruining J, Maclaren N, Åkerblom HK, Baekkeskov S: Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD66 and IA2 marks the early phases of autoimmune response in type I diabetes. J Clin Invest 97:2772-2783, 1996
5. Rabin DU, Pleasic SM, Palmer-Crocker R, Shapiro JA: Cloning expression of IDDM-specific human autoantigens. Diabetes 41:183-186, 1992
6. Rabin DU, Pleasic SM, Shapiro JA, Yoo-Warren H, Oles J, Hicks JM, Goldstein DE, Rae PMM: Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol 152:3183-3187, 1994
7. Lan MS, Lu J, Goto Y, Notions AL: Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 13:505-514, 1994
8. Wasmeier C, Hutton JC: Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes. J Biol Chem 271:18161-18170, 1996
9. Kawasaki E, hutton JC, Eisenbarth GS: Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, Phogrin, an autoantigen of type I diabetes. Biochem Biophys Res Commun 227:440-447, 1996
10. Smith P, Barker K, Wang J, Lu Y, Shipley J, Crompton M: ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins. Biochem Biophys Res Commun 229:402-411, 1996
11. Cui L, Yu W, DeAizpurua H, Schmidli T, Pallen C: Cloning and characterization of islet cell antigen-related protein tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes. J Biol Chem 271:24817-24823, 1996
12. Solimena M, Dirkx R, Hermel J, Pleasic-Williams S, Shapiro JA, Caron L, Rabin DU: ICA512, an autoantigen of type I diabetes, is an intrinsic protein of neurosecvetory granules. EMBO J 15:2102-2114, 1995
13. Bonifacio E, Lampasona V, Genovese S, Ferrari M, Bosi E: Identification of protein tyrosine phosphatase-like IA-2 (islet cell antigen 512) as the insulin-dependent diabetes-related 47/40K autoantigen and a target of islet-cell antibodies. J Immunol 155:5419-5426, 1995
14. Kawasaki E, Eisenbarth GS, Wasmeier C, Hutton JC: Autoantibodies to protein tyrosine phosphatase-like proteins in type I diabetes: overlapping specificities to phogrin and ICA512/IA-2. Diabetes 45:1344-1349, 1996
15. Kawasaki E., Yu L, Gianani R, Verge CF, Babu S, Bonifacio E, Eisenbarth GS: Evaluation of islet cell antigen (ICA) 512/IA-2 autoantibody radioassays using overlapping ICA512/IA-2 constructs. J Clin Endocrinol Metab 82:375-380, 1997
16. Verge Cf, Gianani R, Kawasaki E, Yu L, Pietroapolo M, Jackson RA, Chase HP, Eisenbarth GS: Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-933, 1990
17. Yu L, Rewers M, Gianani R, Kawasaki E, Zhang Y, Verge C, Chase P, Klingensmith G, Erlich H, Norris J, Eisonbarth GS: Anti-islet autoantibodies develop sequentially rather than simultaneously. J Clin Endocrinol Metab 81:4264-4267, 1996
18. National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057, 1979
19. Vardi P, Dib SA, Tuttleman M, Connelly JE, Grinbergs M, Rabizadeh A, Riley WJ, Maclaren NK, Eisenbarth GS, Soeldner JS: Competitive insulin autoantibody RIA: prospoctive evaluation of subjects at high risk for development of type I diabetes mellitus. Diabetes 36:1286-1292, 1987
20. Hagopian WA, Michelson B, Karlson AE, Larson F, Moody A, Grubin CE, Rowe R, Petersen J, McEvoy R, Lernmark A: Autoantibodies IDDM primarily recognize the 65,000-Mr rather than the 67,000-Mr isoform of glutamlc acid decarboxylase. Diabetes 42:631-636, 1993
21. Lampasona V, Bearzatto M, Genovese S, Bosi E, Ferrari M, Bonifacio E: Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domain of the protein tyrosine phosphatase-like IA-2 autoantigen. J Immunol 157:2707-2711, 1996
22. Zhang B, Lan M, Notkins A: Autoantibodies to IA-2 in IDDM: location of major antigenic determinants. Diabetes 40:40-43, 1997