Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes

Journal of Autoimmunity

Volumn 9, Issue 3, 1996, Pages 379-383

  Verge, Charles F ^a   Gianani, Roberto ^a   Kawasaki, Eiji ^a   Yu, Liping ^a   Pietropaolo, Massimo ^a   Chase, H Peter ^a   Eisenbarth, George S ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

Autoantibodies; Glutamic acid decarboxylase; IA 2; ICA512; Insulin autoantibodies; Islet cell antibodies; Prediction; Relatives

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE; INSULIN;

ADOLESCENT; ADULT; ANTIBODY DETECTION; CHILD; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET CELL; PREDICTION; PRIORITY JOURNAL; RELATIVE; RISK ASSESSMENT;

EID: 0030175880     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0051     Document Type: Conference Paper

References (25)

1. 1. Bonifacio E., Bingley P.J., Shattock M., Dean B.M., Dunger D., Gale E.A.M., Bottazzo G.F. 1990. Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet 335: 147-149
2. 2. Schatz D., Krischer J., Horne G., Riley W., Spillar R., Silverstein J., Winter W., Muir A., Derovanesian D., Shah S., Malone J., Maclaren N. 1994. Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives. J. Clin. Invest. 93: 2403-2407
3. 3. Palmer J.P., Asplin C.M., Clemons P., Lyen K., Tatpati O., Raghu P.K., Paquette T.L. 1983. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222: 1337-1339
4. 4. Greenbaum C.J., Palmer J.P., Kuglin B., Kolb H., and Participating Laboratories. 1992. Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: results of the fourth international workshop on the standardization of insulin autoantibody measurement. J. Clin. Endocrinol. Metab. 74: 1040-1044
5. 5. Baekkeskov S., Aanstoot H., Christgau S., Reetz A., Solimena M.S., Cascalho M., Folli F., Richter-Olsen H., DeCamilli P. 1990. Identification of the 64K autoantigen in insulin dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347: 151-156
6. 6. Gianani R., Rabin D.U., Verge C.F., Yu L., Babu S., Pietropaolo M., Eisenbarth G.S. 1995. ICA512 autoantibody radioassay. Diabetes 44: 1340-1344
7. 7. Rabin D.U., Pleasic S.M., Shapiro J.A., Yoo-Warren H., Oles J., Hicks J.M., Goldstein D.E., Rae P.M.M. 1994. Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J. Immunol. 152: 3183-3188
8. 8. Lan M.S., Lu J., Goto Y., Notkins A.L. 1994. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell. Biol. 13: 505-514
9. 9. Verge C.F., Kawasaki E., Gianani R., Yu L., Pietropaolo M., Jackson R.A., Chase H.P., Eisenbarth G.S. 1996. Prediction of type I diabetes mellitus in first degree relatives using a combination of insulin, glutamic acid decarboxylase and ICA512 autoantibodies. Diabetes: in press
10. 10. Keller R.J., Eisenbarth G.S., Jackson R.A. Insulin prophylaxis in individuals at high risk of type 1 diabetes. 1993. Lancet 341: 927-928
11. 11. National Diabetes Data Group. 1979. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28: 1039-1057
12. 12. Vardi P., Dib S.A., Tuttleman M., Connelly J.E., Grinbergs M., Radizabeh A., Riley W.J., Maclaren N.K., Eisenbarth G.S., Soeldner J.S. 1987. Competitive insulin autoantibody assay: prospective evaluation of subjects at high risk for development of type I diabetes mellitus. Diabetes 36: 1286-1291
13. 13. Grubin C.E., Daniels T., Toivola B., Landin-Olsson M., Hagopian W.A., Li L., Karlsen A.E., Boel E., Michelsen B., Lernmark A. 1994. A novel radiobinding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 37: 344-350
14. 14. Kawasaki E., Yu L., Gianani R., Verge C.F., Babu S., Bonifacio E., Eisenbarth G.S. 1996. Improved sensitivity of ICA512 autoantibody radioassay and efficiency of islet autoantibody screening. Submitted
15. 15. Swets J.A. 1988. Measuring the accuracy of diagnostic systems. Science 240: 1285-1293
16. 16. Landin-Olsson M. 1990. Precision of the islet-cell antibody assay depends on the pancreas. J. Clin. Lab. Anal. 4: 289-294
17. 17. Greenbaum C.J., Palmer J.P., Nagataki S., Yamaguchi Y., Molenaar J.L., Van Beers W.A.M., Maclaren N.K., Lernmark A., and Participating Laboratories. 1992. Improved specificity of ICA assays in the fourth international immunology of diabetes exchange workshop. Diabetes 41: 1570-1574
18. 18. Kadowaki T., Kadowaki H., Mori Y., Tobe K., Sakuta R., Suzuki Y., Tanabe Y., Sakura H., Awata T., Goto Y., Hayakawa T., Matsuoka K., Kawamori R., Kamada T., Horai S., Nonaka I., Hagura R., Akanuma Y., Yazaki Y. 1994. A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. N. Engl. J. Med. 330: 962-968
19. 19. Froguel P., Zouali H., Vionnet N., Velho G., Vaxillaire M., Sun F., Lesage S., Stoffel M., Takeda J., Passa P., Permutt M.A., Beckmann J.S., Bell G.I., Cohen D. 1993 Familial hyperglycemia due to mutations in glucokinase: definition of a subtype of diabetes mellitus. N. Engl. J. Med. 328: 697-702
20. 20. Bowden D.W., Gravius T.C., Akots G., Fajans S.S. 1992. Identification of genetic markers flanking the locus for maturity-onset diabetes of the young on human chromosome 20. Diabetes 41: 88-92
21. 21. Vaxillaire M., Boccio V., Philippi A., Vigouroux C., Terwilliger J., Passa P., Beckmann J.S., Velho G., Lathrop G.M., Froguel P. 1995. A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Nat. Genet. 9: 418-423
22. 22. Banerji M.A., Chaiken R.L., Huey H., Tuomi T., Norin A.J., Mackay I.R., Rowley M.J., Zimmet P.Z., Lebovitz H.E. 1994. GAD antibody negative NIDDM in adult black subjects with diabetic ketoacidosis and increased frequency of human leukocyte antigen DR3 and DR4. Flatbush diabetes. Diabetes 43: 741-745
23. 23. Polymeropoulos M.H., Swift R.G., Swift M. 1994. Linkage of the gene for Wolfram syndrome to markers on the short arm of chromosome 4. Nat. Genet. 8: 95-97
24. 24. Baisch J.M., Weeks T., Giles R., Hoover M., Stastny P., Capra J.D. 1990. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N. Engl. J. Med. 322: 1836-1841
25. 25. Pugliese A., Gianani R., Moromisato R., Awdeh Z.L., Alper C.A., Erlich H.A., Jackson R.A., Eisenbarth G.S. 1995. HLA-DQB1 * 0602 is associated with dominant protection from diabetes even among islet cell antibody positive first degree relatives of patients with insulin-dependent diabetes. Diabetes 44: 608-613