Karlsburg Type I diabetes risk study of a general population: Frequencies and interactions of the four major Type I diabetes-associated autoantibodies studied in 9419 schoolchildren

Diabetologia

Volumn 42, Issue 6, 1999, Pages 661-670

  Strebelow, M ^b   Schlosser, M ^b   Ziegler, B ^b   Rjasanowski, I ^b   Ziegler, M ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b NONE

Author keywords

Autoantibodies; GADA; IA2A; IAA; ICA; Normal population; Prediction; Schoolchildren; Screening approach; Type I (insulin dependent) diabetes

Indexed keywords

AUTOANTIBODY; GLUCOSE; GLUTAMATE DECARBOXYLASE; INSULIN; IODINE 125; PROTEIN TYROSINE PHOSPHATASE;

ADOLESCENT; ANTIBODY BLOOD LEVEL; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; DIAGNOSTIC VALUE; GLUCOSE TOLERANCE TEST; HUMAN; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MAJOR CLINICAL STUDY; MORBIDITY; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK ASSESSMENT; SCHOOL CHILD;

ADOLESCENT; AUTOANTIBODIES; CHILD; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 1; FEMALE; GERMANY; GLUCOSE TOLERANCE TEST; GLUTAMATE DECARBOXYLASE; HUMANS; INSULIN; MALE; PROTEIN-TYROSINE-PHOSPHATASE; RISK FACTORS;

EID: 0003777740     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051213     Document Type: Article

References (34)

1. 1. Castano L, Eisenbarth GS (1990) Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol 8: 647-679
2. 2. Atkinson MA, Maclaren NK (1990) What causes diabetes? Sci Am 7: 62-67
3. 3. Bingley PJ, Bonifacio E, Gale EAM (1993) Can we really predict IDDM? Diabetes 42: 213-220
4. 4. Ellis TM, Schatz DA, Ottendorfer EW et al. (1998) The relationship between humoral and cellular immunity to IA-2 in IDDM. Diabetes 47: 566-569
5. 5. Bonifacio E, Bingley PJ, Shattock M et al. (1990) Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet 335: 147-149
6. 6. Verge CF, Howard NJ, Rowley MJ et al. (1994) Anti-glutamate decarboxylase and other antibodies at the onset of childhood IDDM: a population-based study. Diabetologia 37: 1113-1120
7. 7. Kulmala P, Savola K, Petersen JS et al. (1998) Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. J Clin Invest 101: 327-336
8. + relatives. Diabetes 45: 1720-1728
9. 9. Dittler J, Seidel D, Schenker M, Ziegler AG (1998) GADIA2-combi determination as first-line screening for improved prediction of type 1 diabetes in relatives. Diabetes 47: 592-597
10. 10. Dahlquist G, Blom I, Holmgren G et al. (1985) The epidemiology of diabetes in Swedish children 0-14 years: a six-year prospective study. Diabetologia 28: 802-808
11. 11. Bingley PJ, Bonifacio E, Shattock M et al. (1993) Can islet cell antibodies predict insulin-dependent diabetes in the general population? Diabetes Care 16: 45-50
12. 12. Lévy-Marchal C, Patterson C, Green A (1995) Variation by age group and seasonality at diagnosis of childhood IDDM in Europe. Diabetologia 38: 823-830
13. 13. Hagopian WA, Sanjeevi CB, Kockum I et al. (1995) Glutamate decarboxylase, insulin and islet cell antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 95: 1505-1511
14. 14. Lühder F, Schlosser M, Mauch L et al. (1994) Autoantibodies against GAD65 rather than GAD67 precede the onset of type 1 diabetes. Autoimmunity 19: 71-80
15. 15. Schlosser M, Hahmann J, Lühder F, Strebelow M, Ziegler M (1995) Radioiodination of the 65kD and 67kD isoforms of glutamic acid decarboxylase (GAD) for application in radioimmunoassays. Diabetes Research 29: 17-31
16. 16. Payton MA, Hawkes CJ, Christie MR (1995) Relationship of the 37.000-and 40.000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest 96: 1506-1511
17. 17. Seißler J, Morgenthaler NG, Achenbach P et al. (1996) Combined screening for autoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia 39: 1351-1356
18. 18. Vardi P, Dib SA, Tuttleman M et al. (1987) Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of type I diabetes mellitus. Diabetes 36: 1286-1291
19. 19. Ziegler M, Strebelow M, Lühder F, Schlosser M, Rjasanowski I, Ziegler B (1995) The predictive value of GAD65 autoantibodies is improved by insulin autoantibodies. In: Baba S, Kaneko T (eds) Diabetes 1994: Proc. 15th Intern. Diab. Fed. Congr. Kobe 6-11 November 1994. Elsevier, Amsterdam, Lausanne, New York, Shannon, Tokyo, pp 1041-1046
20. 20. Bottazzo GF, Florin-Christensen A, Doniach D (1974) Islet cell antibodies in diabetes mellitus with autoimmune poly-endocrine deficiency. Lancet ii: 1279-1283
21. 21. Augstein P, Ziegler B, Schlosser M, Flassig S, Strebelow M, Ziegler M (1997) Immunohistochemical differentiation of monoclonal GAD antibodies recognizing linear or conformational epitope regions. Pancreas 15: 139-146
22. 22. Vardi P, Crisa L, Jackson RA et al. (1991) Predictive value of intravenous glucose tolerance test insulin secretion less than or greater than the first percentile in islet cell antibody positive relatives of type I (insulin-dependent) diabetic patients. Diabetologia 34: 93-102
23. 23. Bingley PJ, Colman P, Eisenbarth S et al. (1992) Standardization of IVGTT to predict IDDM. Diabetes Care 15: 1313-1316
24. 24. Verge CF, Gianani R, Kawasaki E et al. (1996) Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45: 926-933
25. 25. Bingley PJ, Bonifacio E, Williams AJK, Genovese S, Bottazzo GF, Gale AM (1997) Prediction of IDDM in the general population. Strategies based on combinations of autoantibody markers. Diabetes 46: 1701-1710
26. 26. Aanstoot HJ, Sigurdsson E, Jaffe M et al. (1994) Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population. Diabetologia 37: 917-924
27. 27. Ziegler B, Augstein P, Lühder F et al. (1994) Monoclonal antibodies specific to the glutamic acid decarboxylase 65 kDa isoform derived from a non-obese diabetic (NOD) mouse. Diabetes Research 25: 47-64
28. 28. Genovese S, Bonifacio E, McNally JM et al. (1992) Distinct cytoplasmic islet cell antibodies with different risks for type 1 (insulin-dependent) diabetes mellitus. Diabetologia 35: 385-388
29. 29. Eisenbarth GS, Gianani R, Liping Y et al. (1998) Dual-parameter model for prediction of Type I diabetes mellitus. Proc Assoc Am Physicians 110: 126-135
30. 30. Schatz D, Krischer J, Horne G et al. (1994) Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives. J Clin Invest 93: 2403-2407
31. 31. Ziegler M, Strebelow M, Jacobi U, Schlosser M, Waßmuth R, Rjasanowski I, Ziegler B (1998) Die Karlsburger Typ-1-Diabetes-Risikostudie bei einer normalen Population von 12 558 Schulkindern zeigt ein Erkrankungsrisiko bei 0,4% der Probanden mit einer Positivität für zwei und mehr Diabetes-assoziierte Autoantikörper. Diabetes und Stoffwechsel [abstract] 7: 22
32. 32. Strebelow M, Schlosser M, Ziegler B, Ziegler M (1997) Karlsburg IDDM risk study in schoolchildren - Initial screening for GADA, IAA, IA2A and ICA. Exp Clin Endocrinol Diabetes [abstract] 105: 74
33. 33. Wiest-Ladenberger U, Hartmann R, Hartmann U, Berling K, Böhm BO, Richter W (1997) Combined analysis and single-step detection of GAD65 and IA2 autoantibodies in IDDM can replace the histochemical islet cell antibody test. Diabetes 46: 565-571
34. 34. Boehm BO, Manfras B, Seissler J et al. (1991) Epidemiology and immunogenetic background of islet-cell antibody-positive non-diabetic schoolchildren. Diabetes 40: 1435-1439