-
1
-
-
0034958108
-
Defective DNA polymerase-6 proofreading causes cancer susceptibility in mice
-
R.E. Goldsby, N.A. Lawrence, L.E. Hays, E.A. Olmsted, X. Chen, M. Singh, and B.D. Preston Defective DNA polymerase-6 proofreading causes cancer susceptibility in mice Nat. Med. 7 2001 638 639
-
(2001)
Nat. Med.
, vol.7
, pp. 638-639
-
-
Goldsby, R.E.1
Lawrence, N.A.2
Hays, L.E.3
Olmsted, E.A.4
Chen, X.5
Singh, M.6
Preston, B.D.7
-
3
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
A. Trifunovic, A. Wredenberg, M. Falkenberg, J.N. Spelbrink, A.T. Rovio, C.E. Bruder, Y.M. Bohlooly, S. Gidlof, A. Oldfors, R. Wibom, J. Tornell, H.T. Jacobs, and N.G. Larsson Premature ageing in mice expressing defective mitochondrial DNA polymerase Nature 429 2004 417 423
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
Bohlooly, Y.M.7
Gidlof, S.8
Oldfors, A.9
Wibom, R.10
Tornell, J.11
Jacobs, H.T.12
Larsson, N.G.13
-
4
-
-
0034951870
-
Backbone modification of nucleic acids: Synthesis, structure and therapeutic applications
-
J. Micklefield Backbone modification of nucleic acids: synthesis, structure and therapeutic applications Curr. Med. Chem. 8 2001 1157 1179
-
(2001)
Curr. Med. Chem.
, vol.8
, pp. 1157-1179
-
-
Micklefield, J.1
-
5
-
-
0035374671
-
The conserved active site motif a of Escherichia coli DNA polymerase I is highly mutable
-
A. Shinkai, P.H. Patel, and L.A. Loeb The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable J. Biol. Chem. 276 2001 18836 18842
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18836-18842
-
-
Shinkai, A.1
Patel, P.H.2
Loeb, L.A.3
-
7
-
-
0034625013
-
DNA polymerase active site is highly mutable: Evolutionary consequences
-
P.H. Patel, and L.A. Loeb DNA polymerase active site is highly mutable: evolutionary consequences Proc. Natl. Acad. Sci. U.S.A. 97 2000 5095 5100
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 5095-5100
-
-
Patel, P.H.1
Loeb, L.A.2
-
8
-
-
0029845979
-
Random mutagenesis of Thermus aquaticus DNA polymerase I: Concordance of immutable sites in vivo with the crystal structure
-
M. Suzuki, D. Baskin, L.E. Hood, and L.A. Loeb Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure Proc. Natl. Acad. Sci. U.S.A. 93 1996 9670 9675
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 9670-9675
-
-
Suzuki, M.1
Baskin, D.2
Hood, L.E.3
Loeb, L.A.4
-
10
-
-
0037076311
-
Directed evolution of novel polymeerase activities: Mutation of a DNA polymerase into an efficient RNA polymerase
-
G. Xia, L. Chen, T. Sera, M. Fa, P.G. Schultz, and F.E. Romesberg Directed evolution of novel polymeerase activities: mutation of a DNA polymerase into an efficient RNA polymerase Proc. Natl. Acad. Sci. U.S.A. 99 2002 6597 6602
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 6597-6602
-
-
Xia, G.1
Chen, L.2
Sera, T.3
Fa, M.4
Schultz, P.G.5
Romesberg, F.E.6
-
11
-
-
0026541430
-
Mammalian DNA polymerase p can substitute for DNA polymerase I during DNA replication in Escherichia coli
-
J.B. Sweasy, and L.A. Loeb Mammalian DNA polymerase p can substitute for DNA polymerase I during DNA replication in Escherichia coli J. Biol. Chem. 267 1992 1407 1410
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 1407-1410
-
-
Sweasy, J.B.1
Loeb, L.A.2
-
13
-
-
0028050350
-
Rapid evolution of a protein in vitro by DNA shuffling
-
W.P.C. Stemmer Rapid evolution of a protein in vitro by DNA shuffling Nature 370 1994 389 391
-
(1994)
Nature
, vol.370
, pp. 389-391
-
-
Stemmer, W.P.C.1
-
15
-
-
0043194096
-
Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I
-
M. Camps, J. Naukkarinen, B.P. Johnson, and L.A. Loeb Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I Proc. Natl. Acad. Sci. U.S.A. 100 2003 9727 9732
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 9727-9732
-
-
Camps, M.1
Naukkarinen, J.2
Johnson, B.P.3
Loeb, L.A.4
-
16
-
-
0035836707
-
Directed evolution of polymerase function by compartmentalized self-replication
-
F.J. Ghadessy, J.L. Ong, and P. Holliger Directed evolution of polymerase function by compartmentalized self-replication Proc. Natl. Acad. Sci. U.S.A. 98 2001 4552 4557
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 4552-4557
-
-
Ghadessy, F.J.1
Ong, J.L.2
Holliger, P.3
-
17
-
-
0021984004
-
Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP
-
D.L. Ollis, P. Brick, R. Hamlin, N.G. Xuong, and T.A. Steitz Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP Nature 313 1985 762 766
-
(1985)
Nature
, vol.313
, pp. 762-766
-
-
Ollis, D.L.1
Brick, P.2
Hamlin, R.3
Xuong, N.G.4
Steitz, T.A.5
-
18
-
-
0032518398
-
Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 a resolution
-
S. Doublie, S. Tabor, A.M. Long, C.C. Richardson, and T. Ellenberger Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution Nature 391 1998 251 258
-
(1998)
Nature
, vol.391
, pp. 251-258
-
-
Doublie, S.1
Tabor, S.2
Long, A.M.3
Richardson, C.C.4
Ellenberger, T.5
-
19
-
-
0032535528
-
Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: Structural basis for nucleotide incorporation
-
Y. Li, S. Korolev, and G. Waksman Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation EMBO J. 17 1998 7514 7525
-
(1998)
EMBO J.
, vol.17
, pp. 7514-7525
-
-
Li, Y.1
Korolev, S.2
Waksman, G.3
-
20
-
-
0032518524
-
Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal
-
J.R. Kiefer, C. Mao, J.C. Braman, and L.S. Beese Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal Nature 391 1998 304 307
-
(1998)
Nature
, vol.391
, pp. 304-307
-
-
Kiefer, J.R.1
Mao, C.2
Braman, J.C.3
Beese, L.S.4
-
22
-
-
0035997351
-
Active site tightness and substrate fit in DNA replication
-
E.T. Kool Active site tightness and substrate fit in DNA replication Annu. Rev. Biochem. 71 2002 191 219
-
(2002)
Annu. Rev. Biochem.
, vol.71
, pp. 191-219
-
-
Kool, E.T.1
-
23
-
-
0032584219
-
A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides
-
M. Astatke, K. Ng, N.D.F. Grindley, and C.M. Joyce A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides Proc. Natl. Acad. Sci. U.S.A. 95 1998 3402 3407
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 3402-3407
-
-
Astatke, M.1
Ng, K.2
Grindley, N.D.F.3
Joyce, C.M.4
-
24
-
-
0034704124
-
Multiple amino acid substitutions allow DNA polymerises to synthesize RNA
-
P.H. Patel, and L.A. Loeb Multiple amino acid substitutions allow DNA polymerises to synthesize RNA J. Biol. Chem. 275 2000 40266 40272
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40266-40272
-
-
Patel, P.H.1
Loeb, L.A.2
-
25
-
-
0035895911
-
A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity
-
P.J. Patel, H. Kawate, E. Adman, M. Ashbach, and L.A. Loeb A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity J. Biol. Chem. 276 2001 5044 5051
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5044-5051
-
-
Patel, P.J.1
Kawate, H.2
Adman, E.3
Ashbach, M.4
Loeb, L.A.5
-
26
-
-
0035812849
-
Crystal structure of a Y-family DNA polymerse in action: A mechanism for error-prone and lesion-bypass replication
-
H. Ling, F. Boudsocq, R. Woodgate, and W. Yang Crystal structure of a Y-family DNA polymerse in action: a mechanism for error-prone and lesion-bypass replication Cell 107 2001 91 102
-
(2001)
Cell
, vol.107
, pp. 91-102
-
-
Ling, H.1
Boudsocq, F.2
Woodgate, R.3
Yang, W.4
-
27
-
-
0034847259
-
Structure of the catalytic core of S. cerevisiae DNA polymerase eta: Implications for translesion DNA synthesis
-
J. Trincao, R.E. Johnson, C.R. Escalante, S. Prakash, L. Prakash, and A.K. Aggarwal Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis Mol. Cell. 8 2001 417 426
-
(2001)
Mol. Cell.
, vol.8
, pp. 417-426
-
-
Trincao, J.1
Johnson, R.E.2
Escalante, C.R.3
Prakash, S.4
Prakash, L.5
Aggarwal, A.K.6
-
28
-
-
0034857266
-
Crystal structure of a DinB lesion bypass DNA polymerase catalytic fraagment reveals a classic polymerase catalytic domain
-
B.L. Zhou, J.D. Pata, and T.A. Steitz Crystal structure of a DinB lesion bypass DNA polymerase catalytic fraagment reveals a classic polymerase catalytic domain Mol. Cell. 2 2001 427 437
-
(2001)
Mol. Cell.
, vol.2
, pp. 427-437
-
-
Zhou, B.L.1
Pata, J.D.2
Steitz, T.A.3
-
29
-
-
1242314258
-
Expanding the substrate repertoire of a DNA polymerase by directed evolution
-
M. Fa, A. Radeghieri, A.A. Henry, and F.E. Romesberg Expanding the substrate repertoire of a DNA polymerase by directed evolution J. Am. Chem. Soc. 126 2004 1748 1754
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 1748-1754
-
-
Fa, M.1
Radeghieri, A.2
Henry, A.A.3
Romesberg, F.E.4
-
30
-
-
0029023051
-
A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides
-
S. Tabor, and C.C. Richardson A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides Proc. Natl. Acad. Sci. U.S.A. 92 1995 6339 6343
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 6339-6343
-
-
Tabor, S.1
Richardson, C.C.2
-
31
-
-
0026029379
-
A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity
-
S.S. Carroll, M. Cowart, and S.J. Benkovic A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity Biochemistry 30 1991 804 813
-
(1991)
Biochemistry
, vol.30
, pp. 804-813
-
-
Carroll, S.S.1
Cowart, M.2
Benkovic, S.J.3
-
32
-
-
0035804793
-
Enhanced ribonucleotide incorporation by an O-helix mutant of Thermus aquaticus DNA polymerase I
-
M. Ogawa, A. Tosaka, Y. Ito, S. Yoshida, and M. Suzuki Enhanced ribonucleotide incorporation by an O-helix mutant of Thermus aquaticus DNA polymerase I Mutat. Res. 485 2001 197 207
-
(2001)
Mutat. Res.
, vol.485
, pp. 197-207
-
-
Ogawa, M.1
Tosaka, A.2
Ito, Y.3
Yoshida, S.4
Suzuki, M.5
-
33
-
-
0033578332
-
Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation
-
Y. Li, V. Mitaxov, and G. Waksman Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation Proc. Natl. Acad. Sci. U.S.A. 96 1999 9491 9496
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 9491-9496
-
-
Li, Y.1
Mitaxov, V.2
Waksman, G.3
-
34
-
-
0025121103
-
Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli
-
A.H. Polesky, T.A. Steitz, N.D. Grindley, and C.M. Joyce Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli J. Biol. Chem. 265 1990 14579 14591
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 14579-14591
-
-
Polesky, A.H.1
Steitz, T.A.2
Grindley, N.D.3
Joyce, C.M.4
-
35
-
-
0033613841
-
Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment)
-
D.T. Minnick, K. Bebenek, W.P. Osheroff, R.M.J. Turner, M. Astatke, L. Liu, T.A. Kunkel, and C.M. Joyce Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) J. Biol. Chem. 274 1999 3067 3075
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 3067-3075
-
-
Minnick, D.T.1
Bebenek, K.2
Osheroff, W.P.3
Turner, R.M.J.4
Astatke, M.5
Liu, L.6
Kunkel, T.A.7
Joyce, C.M.8
-
36
-
-
0029784881
-
A thumb subdomain mutant of the large fragment of Escherichia coli DNA polymerase I with reduced DNA binding affinity, processivity, and frameshift fidelity
-
D.T. Minnick, M. Astatke, C.M. Joyce, and T.A. Kunkel A thumb subdomain mutant of the large fragment of Escherichia coli DNA polymerase I with reduced DNA binding affinity, processivity, and frameshift fidelity J. Biol. Chem. 271 1996 24954 24961
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24954-24961
-
-
Minnick, D.T.1
Astatke, M.2
Joyce, C.M.3
Kunkel, T.A.4
-
37
-
-
0012768537
-
Presence of 18-A long hydrogen bond track in the active site of Escherichia coli DNA polymerase I (Klenow fragment). Its requirement in the stabilization of enzyme-template-primer complex
-
K. Singh, and M.J. Modak Presence of 18-A long hydrogen bond track in the active site of Escherichia coli DNA polymerase I (Klenow fragment). Its requirement in the stabilization of enzyme-template-primer complex J. Biol. Chem. 278 2003 11289 11302
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11289-11302
-
-
Singh, K.1
Modak, M.J.2
-
38
-
-
0035814929
-
Identification of hydrogen bonds between Escherichia coli DNA polymerase I (Klenow fragment) and the minor groove of DNA by amino acid substitution of the polymerase and atomic substitution of the DNA
-
T.E. Spratt Identification of hydrogen bonds between Escherichia coli DNA polymerase I (Klenow fragment) and the minor groove of DNA by amino acid substitution of the polymerase and atomic substitution of the DNA Biochemistry 40 2001 2647 2652
-
(2001)
Biochemistry
, vol.40
, pp. 2647-2652
-
-
Spratt, T.E.1
-
39
-
-
17144371499
-
Fidelity of mispair formation and mispair extension is dependent on the interaction between the minor groove of the primer terminus and Arg668 of DNA polymerase I of Escherichia coli
-
M.D. McCain, A.S. Meyer, S.S. Schultz, A. Glekas, and T.E. Spratt Fidelity of mispair formation and mispair extension is dependent on the interaction between the minor groove of the primer terminus and Arg668 of DNA polymerase I of Escherichia coli Biochemistry 44 2005 5647 5659
-
(2005)
Biochemistry
, vol.44
, pp. 5647-5659
-
-
McCain, M.D.1
Meyer, A.S.2
Schultz, S.S.3
Glekas, A.4
Spratt, T.E.5
-
40
-
-
18244389209
-
Loss of DNA minor groove interactions by exonuclease-deficient Klenow polymerase inhibits O6-methylguanine and abasic site translesion synthesis
-
E.E. Gestl, and K.A. Eckert Loss of DNA minor groove interactions by exonuclease-deficient Klenow polymerase inhibits O6-methylguanine and abasic site translesion synthesis Biochemistry 44 2005 7059 7068
-
(2005)
Biochemistry
, vol.44
, pp. 7059-7068
-
-
Gestl, E.E.1
Eckert, K.A.2
-
41
-
-
2542525398
-
Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution
-
F.J. Ghadessy, N. Ramsay, F. Boudsocq, D. Loakes, A. Brown, S. Iwai, A. Vaisman, R. Woodgate, and P. Holliger Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution Nat. Biotechnol. 22 2004 755 759
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 755-759
-
-
Ghadessy, F.J.1
Ramsay, N.2
Boudsocq, F.3
Loakes, D.4
Brown, A.5
Iwai, S.6
Vaisman, A.7
Woodgate, R.8
Holliger, P.9
-
42
-
-
0037388383
-
Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations
-
S.J. Johnson, J.S. Taylor, and L.S. Beese Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations Proc. Natl. Acad. Sci. U.S.A. 100 2003 3895 3900
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 3895-3900
-
-
Johnson, S.J.1
Taylor, J.S.2
Beese, L.S.3
-
43
-
-
1642588255
-
Structures of mismatch replication errors observed in a DNA polymerase
-
S.J. Johnson, and L.S. Beese Structures of mismatch replication errors observed in a DNA polymerase Cell 116 2004 803 816
-
(2004)
Cell
, vol.116
, pp. 803-816
-
-
Johnson, S.J.1
Beese, L.S.2
-
44
-
-
13444255987
-
Incorporation of reporter-labeled nucleotides by DNA polymerases
-
J.P. Anderson, B. Angerer, and L.A. Loeb Incorporation of reporter-labeled nucleotides by DNA polymerases Biotechniques 38 2005 257 264
-
(2005)
Biotechniques
, vol.38
, pp. 257-264
-
-
Anderson, J.P.1
Angerer, B.2
Loeb, L.A.3
-
45
-
-
0025040632
-
An attempt to unify the structure of polymerases
-
M. Delarue, O. Poch, N. Tordo, D. Moras, and P. Argos An attempt to unify the structure of polymerases Protein Eng. 3 1990 461 467
-
(1990)
Protein Eng.
, vol.3
, pp. 461-467
-
-
Delarue, M.1
Poch, O.2
Tordo, N.3
Moras, D.4
Argos, P.5
-
46
-
-
0035906661
-
Prokaryotic DNA polymerase I: Evolution, structure, and "base flipping" mechanism for nucleotide selection
-
P.H. Patel, M. Suzuki, E. Adman, A. Shinkai, and L.A. Loeb Prokaryotic DNA polymerase I: evolution, structure, and "base flipping" mechanism for nucleotide selection J. Mol. Biol. 308 2001 823 837
-
(2001)
J. Mol. Biol.
, vol.308
, pp. 823-837
-
-
Patel, P.H.1
Suzuki, M.2
Adman, E.3
Shinkai, A.4
Loeb, L.A.5
-
47
-
-
0028206048
-
Function and structure relationships in DNA polymerases
-
C.M. Joyce, and T.A. Steitz Function and structure relationships in DNA polymerases Annu. Rev. Biochem. 63 1994 777 822
-
(1994)
Annu. Rev. Biochem.
, vol.63
, pp. 777-822
-
-
Joyce, C.M.1
Steitz, T.A.2
-
48
-
-
0035012235
-
Acidic residues critical for the activity and biological function of yeast DNA polymerase eta
-
C.M. Kondratick, M.T. Washington, S. Prakash, and L. Prakash Acidic residues critical for the activity and biological function of yeast DNA polymerase eta Mol. Cell Biol. 21 2001 2018 2025
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 2018-2025
-
-
Kondratick, C.M.1
Washington, M.T.2
Prakash, S.3
Prakash, L.4
|