DNA polymerase active site is highly mutable: Evolutionary consequences

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 10, 2000, Pages 5095-5100

  Patel, Premal H ^a   Loeb, Lawrence A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CHLAMYDIA TRACHOMATIS; DNA LIBRARY; ENZYME ACTIVE SITE; ESCHERICHIA COLI; EVOLUTION; GENETIC COMPLEMENTATION; MUTAGENESIS; MUTATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; THERMUS AQUATICUS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIA; BINDING SITES; CONSERVED SEQUENCE; DNA; DNA POLYMERASE I; DNA-DIRECTED DNA POLYMERASE; EVOLUTION, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; THERMUS;

CHLAMYDIA TRACHOMATIS; ESCHERICHIA COLI; THERMUS AQUATICUS;

EID: 0034625013     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.10.5095     Document Type: Article

References (27)

1. Pelletier, H., Sawaya, M. R., Kumar, A., Wilson, S. H. & Kraut, J. (1994) Science 264, 1891-1903.
2. Beese, L. S., Derbyshire, V. & Steitz, T. A. (1993) Science 260, 352-355.
3. Patel, P. H., Jacobo-Molina, A., Ding, J., Tantillo, C., Clark, A. D., Jr., Raag, R., Nanni, R. G., Hughes, S. H. & Arnold, E. (1995) Biochemistry 34, 5351-5363.
4. Li, Y., Korolev, S. & Waksman, G. (1998) EMBO J. 17, 7514-7525.
5. Reha-Krantz, L. J. & Nonay, R. L. (1994) J. Biol. Chem. 269, 5635-5643.
6. Astatke, M., Grindley, N. D. & Joyce, C. M. (1998) J. Mol. Biol. 278, 147-165.
7. Wang, J., Sattar, A. K., Wang, C. C., Karam, J. D., Konigsberg, W. H. & Steitz, T. A. (1997) Cell 89, 1087-1099.
8. Takehsita, S., Sato, M., Toba, M., Masahashi, W. & Hashimoto-Gotoh, T. (1987) Gene 61, 63-74.
9. Suzuki, M., Baskin, D., Hood, L. E. & Loeb, L. A. (1996) Proc. Natl. Acad. Sci. USA 93, 9670-9675.
10. Grimm, E. & Arbuthnot, P. (1995) Nucleic Acids Res. 23, 4518-4519.
11. Desai, U. J. & Pfaffle, P. K. (1995) BioTechniques 19, 780-782, 784.
12. Patel, P. H. & Preston, B. D. (1994) Proc. Natl. Acad. Sci. USA 91, 549-553.
13. Dube, D. K. & Loeb, L. A. (1989) Biochemistry 28, 5703-5707.
14. Encell, L. P., Landis, D. M. & Loeb, L. A. (1999) Nat. Biatech. 17, 143-147.
15. Drake, J. W. (1991) Proc. Natl. Acad. Sci. USA 88, 7161-7164.
16. Ochman, H. & Wilson, A. C. (1988) J. Mol. Evol. 26, 74-86.
17. Sweasy, J. B. & Loeb, L. A. (1993) Proc. Natl. Acad. Sci. USA 90, 4626-4630.
18. Kim, B., Hathaway, T. R. & Loeb, L. A. (1996) J. Biol. Chem. 271, 4872-4878.
19. Black, M. E., Newcomb, T. G., Wilson, H.-M. P. & Loeb, L. A. (1996) Proc. Natl. Acad. Sci. USA 93, 3525-3529.
20. Landis, D. M. & Loeb, L. A. (1998) J. Biol. Chem. 273, 25809-25817.
21. Christians, F. C. & Loeb, L. A. (1990) Proc. Natl. Acad. Sci. USA 93, 6124-6128.
22. Mao, E. F., Lane, L., Lee, J. & Miller, J. H. (1997) J. Bacteriol. 179, 417-422.
23. LeClerc, J. E., Li, B., Payne, W. L. & Cebula, T. A. (1996) Science 274, 1208-1211.
24. Gibbons, R. J. & Kapsimalis, B. (1967) J. Bacteriol. 93, 510-512.
25. Taddei, F., Radman, M., Maynard-Smith, J., Toupance, B., Gouyon, P. H. & Godelle, B. (1997) Nature (London) 387, 700-702.
26. Ochman, H., Elwyn, S. & Moran, N. A. (1999) Proc. Natl. Acad. Sci. USA 96, 12638-12643.
27. Guttman, D. S. & Dykhuizen, D. E. (1994) Science 266, 1380-1383.