Acidic residues critical for the activity and biological function of yeast DNA polymerase η

Molecular and Cellular Biology

Volumn 21, Issue 6, 2001, Pages 2018-2025

  Kondratick, Christine M ^a   Washington, M Todd ^a   Prakash, Satya ^a   Prakash, Louise ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; DNA DIRECTED DNA POLYMERASE ETA; DNA POLYMERASE; GLUTAMINE; THYMINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INACTIVATION; NONHUMAN; PRIORITY JOURNAL; RESIDUE ANALYSIS; SACCHAROMYCES CEREVISIAE; ULTRAVIOLET RADIATION;

ALANINE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; CELL NUCLEUS; CONSERVED SEQUENCE; DNA-DIRECTED DNA POLYMERASE; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEOTIDES; ULTRAVIOLET RAYS; YEASTS;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0035012235     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.6.2018-2025.2001     Document Type: Article

References (33)

1. Beese, L. S., V. Derbyshire, and T. A. Steitz. 1993. Structure of DNA polymerase I Klenow fragment bound to duplex DNA. Science 260:352-355.
2. Cordeiro-Stone, M., L. S. Zaritskaya, L. K. Price, and W. K. Kaufmann. 1997. Replication fork bypass of a pyrimidine dimer blocking leading strand DNA synthesis. J. Biol. Chem. 272:13945-13954.
3. Creighton, S., L. B. Bloom, and M. F. Goodman. 1995. Gel fidelity assay measuring nucleotide misinsertion, exonucleolytic proofreading, and lesion bypass efficiencies. Methods Enzymol. 262:232-256.
4. Dingwall, C., and R. A. Laskey. 1991. Nuclear targeting sequences - a consensus? Trends Biochem. Sci. 16:478-481.
5. Doublie, S., S. Tabor, A. M. Long, C. C. Richardson, and T. Ellenberger. 1998. Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution. Nature 391:251-258.
6. Gietz, R. D., and A. Sugino. 1988. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74:527-534.
7. Goodman, M. K., S. Creighton, L. B. Bloom, and J. Petruska. 1993. Biochemical basis of DNA replication fidelity. Crit. Rev. Biochem. Mol. Biol. 28: 83-126.
8. h-methylguanine by yeast and human DNA polymerase η. Mol. Cell. Biol. 20:8001-8007.
9. Haracska, L., S.-L. Yu, R. E. Johnson, L. Prakash, and S. Prakash. 2000. Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η. Nat. Genet. 25:458-461.
10. Jacobo-Molina, A., J. Ding, R. G. Nanni, A. D. Clark, X. Lu, C. Tantillo, R. L. Williams, G. Kamer, A. L. Ferris, P. Clark, A. Hizi, S. H. Hughes, and E. Arnold. 1993. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Proc. Natl. Acad. Sci. USA 90:6320-6324.
11. Johnson, R. E., C. M. Kondratick, S. Prakash, and L. Prakash. 1999. hRAD30 mutations in the variant form of xeroderma pigmentosum. Science 285:263-265.
12. Johnson, R. E., S. Prakash, and L. Prakash. 1999. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase. Polη. Science 283:1001-1004.
13. Johnson, R. E., S. Prakash, and L. Prakash. 2000. The human DINB1 gene encodes the DNA polymerase Polθ. Proc. Natl. Acad. Sci. USA 97:3838-3843.
14. Johnson, R. E., S. Prakash, and L. Prakash. 1999. Requirement of DNA polymerase activity of yeast Rad30 protein for its biological function. J. Biol. Chem. 274:15975-15977.
15. Johnson, R. E., M. T. Washington, L. Haracska, S. Prakash, and L. Prakash. 2000. Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions. Nature 406:1015-1019.
16. Johnson, R. E., M. T. Washington, S. Prakash, and L. Prakash. 1999. Bridging the gap: a family of novel DNA polymerases that replicate faulty DNA. Proc. Natl. Acad. Sci. USA 96:12224-12226.
17. Johnson, R. E., M. T. Washington, S. Prakash, and L. Prakash. 2000. Fidelity of human DNA polymerase η. J. Biol. Chem. 275:7447-7450.
18. Joyce, C. M., and T. A. Steitz. 1994. Function and structure relationships in DNA polyrnerases. Annu. Rev. Biochem. 63:777-822.
19. Kohlstaedt, L. A., J. Wang, J. M. Friedman, P. A. Rice, and T. A. Steitz. 1992. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256:1783-1790.
20. Kunkel, T. A., and S. H. Wilson. 1998. DNA polymerases on the move. Nat. Struct. Biol. 5:95-99.
21. Lehmann, A. R., S. Kirk-Bell, C. F. Arlett, M. C. Paterson, P. H. M. Lohman, E. A. de Weerd-Kastelein, and D. Bootsma. 1975. Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation. Proc. Natl. Acad. Sci. USA 72:219-223.
22. Masutani, C., R. Kusumoto, A. Yamada, N. Dohmae, M. Yokoi, M. Yuasa, M. Araki, S. Iwai, K. Takio, and F. Hanaoka. 1999. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η. Nature 399: 700-704.
23. McDonald, J. P., A. S. Levine, and R. Woodgate. 1997. The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism. Genetics 147:1557-1568.
24. Nelson, J. R., C. W. Lawrence, and D. C. Hinkle. 1996. Deoxycytidyl transferase activity of yeast REVI protein. Nature 382:729-731.
25. Pelletier, H., M. R. Sawaya, A. Kumar, S. H. Wilson, and J. Kraut. 1994. Structure of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP. Science 264:1891-1903.
26. Polesky, A. H., M. E. Dahlberg, S. J. Benkovic, N. D. F. Grindley, and C. M. Joyce. 1992. Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli. J. Biol. Chem. 267:8417-8428.
27. Polesky, A. H., T. A. Steitz, N. D. F. Grindley, and C. M. Joyce. 1990. Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli. J. Biol. Chem. 265: 14579-14591.
28. Steitz, T. A. 1999. DNA polymerases: structural diversity and common mechanisms. J. Biol. Chem. 274:17395-17398.
29. Tissier, A., J. P. McDonald, E. G. Frank, and R. Woodgate. 2000. polι, a remarkably error-prone human DNA polymerase. Genes Dev. 14:1642-1650.
30. Wang, Y.-C., V. M. Maher, D. L. Mitchell, and J. J. McCormick. 1993. Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prime replication on a template containing photoproducts. Mol. Cell. Biol. 13:4276-4283.
31. Washington, M. T., R. E. Johnson, S. Prakash, and L. Prakash. 2000. Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase η. Proc. Natl. Acad. Sci. USA 97:3094-3099.
32. Washington, M. T., R. E. Johnson, S. Prakash, and L. Prakash. 1999. Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase η. J. Biol. Chem. 274:36835-36838.
33. Waters, H. L., S. Seetharam, M. M. Seidman, and K. H. Kraemer. 1993. Ultraviolet hypermutability of a shuttle vector propagated in xeroderma pigmentosum variant cells. J. Investig. Dermatol. 101:744-748.