A vitamin D3 analog induces a G1-phase arrest in CaCo2 Cells by inhibiting Cdk2 and Cdk6: Roles of cyclin E, p21(Waf1), and p27(Kip1)

Endocrinology

Volumn 141, Issue 11, 2000, Pages 3931-3939

  Scaglione Sewell, B A ^a   Bissonnette, M ^a   Skarosi, S ^a   Abraham, C ^a   Brasitus, T A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1ALPHA,25 DIHYDROXY 16 ENE 23 YNE 26,27 HEXAFLUOROCHOLECALCIFEROL; COLECALCIFEROL DERIVATIVE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 6; CYCLIN E; PROTEIN P21; PROTEIN P27; REGULATOR PROTEIN; UNCLASSIFIED DRUG; 26,26,26,27,27,27-HEXAFLUORO-1,25-DIHYDROXYVITAMIN D3; ANTINEOPLASTIC AGENT; CALCITRIOL; CDK2 PROTEIN, HUMAN; CDK4 PROTEIN, HUMAN; CDK6 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; DRUG DERIVATIVE; ENZYME INHIBITOR; FALECALCITRIOL; MICROTUBULE ASSOCIATED PROTEIN; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; COLON MUCOSA; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; VITAMIN D METABOLISM; CELL DIVISION; CELL STRAIN CACO 2; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANTICARCINOGENIC AGENTS; CACO-2 CELLS; CALCITRIOL; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CELL DIVISION; CELL SURVIVAL; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; G1 PHASE; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 85047678847     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.141.11.7782     Document Type: Article

References (62)

1. 3 and its metabolites/analogs
2. 3 in chemically induced rat colon carcinogenesis
3. 3 on proliferation and differentiation of CaCo-2 cells
4. Vitamin D and its metabolites inhibit cell proliferation in human rectal mucosa and a colon cancer cell line
5. 3 analogs: Potent modulators of proliferation and differentiation of breast cancer cell lines in vitro
6. Vitamin D and prostate cancer
7. 3 stimulates phospholipase C-γ in rat colonocytes: Role of c-src in PLC-γ activation
8. 3 stimulates membrane phosphinositide turnover, activates protein kinase C and increases cytosolic calcium in rat colonic epithelium
9. 3 in promelocytic NB4 leukemia cells: A structure function study
10. 3 and parathyroid hormone on calcium transport in chick intestine
11. 3 on signal transduction in colonic cells
12. Rapid, nongenomic steroid actions: A new age?
13. Novel vitamin D analogs that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone mobilization
14. 1α,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (RO245531), a new deltanoid (vitamin D analog) for prevention of breast cancer in the rat
15. 3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism
16. Biological activity of fluorinated vitamin D analogs at C-26 and C-27 on human promyelocytic leukemia cell HL-60
17. 3 analog (Ro 25-6750) inhibits human colon cancer in vitro via apoptosis
18. 3 an its synthetic analog 1α,25-dihydroxy-16-ene-23yne-26,27 hexafluoro-19-nor-cholecalciferol (RO-25-6760), on a human colon cancer xenograft
19. 3, inhibits azoxymethane-induced colonic tumorigenesis
20. 3 inhibit the growth of human breast cancer cells in vitro and in vivo
21. 3 stimulates activator protein-1-dependent CaCo-2 cell differentiation
22. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line CaCo-2 in culture
23. Cell cycle analysis by flow cytometry
24. Measurement of protein using bicinchoninic acid
25. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
26. Reduction of background in protein kinase assays by electroblotting
27. How to analyze rates and proportions
28. Sulindac sulfide inhibits the proliferation of colon cancer cells: Diminished expression of the proliferation markers PCNA and Ki-67
29. 3 stimulates apoptosis in CaCo-2 cells and alters the expression of BCL-X(L) and the proform of caspase-3
30. CDK inhibitors: Positive and negative regulators of G1-phase progression
31. 3 synergism toward transforming growth factor-β1-induced AP-1 transcriptional activity in mouse osteoblastic cells via its nuclear receptor
32. Positive and negative modulation of vitamin D receptor function by transforming growth factor-β signaling through Smad proteins
33. Convergence of transforming growth factor-β and vitamin D signaling pathways on SMAD transcriptional coactivators
34. p27(Kip1), a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest
35. Vitamin D receptors in breast cancer cell lines
36. 3 on the proliferation of pancreatic cancer cell lines
37. 3 analogs: A novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines
38. 3 on cell cycle kinetics of T47D human breast cancer cells
39. 3-treated HL60 cells
40. 3 in human prostate cancer cell line LNCaP involves reduction of cyclin-dependent kinase 2 activity and persistent G1 accumulation
41. Demystified: Cell cycle
42. p27, A novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related tc p21
43. Cyclin-dependent regulation of G1 in mammalian fibroblasts
44. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/cdk4
45. 3 leads to the induced differentiation of the myelcmonocytic cell line U937
46. Vitamin D analogs, leukemia, and WAF1
47. Prevalence of ras gene mutations in human colorectal cancers
48. Role of transforming growth factor β in human disease
49. 3 analog, EB1089, on HL-60 cells by induction of the TGF-β receptor
50. Transformation of intestinal epithelial cells by chronic TGF-β1 treatment results in down-regulation of the type II TGF-β receptor and induction of cyclooxygenase-2
51. Different roles for cyclins D1 and E in regulation of the G1-to-S transition
52. Cancer cell cycles
53. Mammalian G1 cyclins
54. Cell cycle arrest and reversion of Ras-induced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase
55. Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts
56. Cyclin E-induced S phase without activation of the pRb/E2F pathway
57. Regulation of cyclin E gene expression by the human papillomavirus type 16 E7 oncoprotein
58. The Role of the transcription factor Sp1 in regulating the expression of the Waf1/Cip1 gene in U937 leukemic cells
59. Failure of programmed cell death and differentiation as causes of tumors: Some simple mathematical models
60. Different growth patterns of a cancer cell population as a fraction of its starting growth characteristic: Analysis by mathematical modeling
61. Mutations of mitotic checkpoint genes in human cancers