Functional domains in presenilin 1. The Tyr-288 residue controls γ-secretase activity and endoproteolysis

Journal of Biological Chemistry

Volumn 279, Issue 23, 2004, Pages 23925-23932

  Laudon, Hanna ^a   Karlström, Helena ^a   Mathews, Paul M ^b   Farmery, Mark R ^a   Gandy, Samuel E ^c   Lundkvist, Johan ^a   Lendahl, Urban ^a   Näslund, Jan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; DIMERS; ENZYMES;

ENDOPROTEOLYSIS; HETERODIMERS;

BIOCHEMISTRY;

ALANINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; NOTCH RECEPTOR; PHENYLALANINE; PRESENILIN 1; TYROSINE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING;

ALANINE; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELLS, CULTURED; EMBRYO; ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENES, REPORTER; IMMUNOBLOTTING; LUCIFERASES; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PRECIPITIN TESTS; PRESENILIN-1; PROTEIN STRUCTURE, TERTIARY; STEM CELLS; SUBCELLULAR FRACTIONS; TRANSFECTION; TYROSINE;

ANIMALIA;

EID: 2642513216     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401277200     Document Type: Article

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