Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene: Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype

Journal of Biological Chemistry

Volumn 280, Issue 36, 2005, Pages 31686-31698

  Weng, Yan ^a   DiRusso, Concetta C ^b   Reilly, Andrew A ^a   Black, Paul N ^b   Ding, Xinxin ^a,c  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b ORDWAY RESEARCH INSTITUTE   (United States)

^c WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ANTIGENS; BIOLOGICAL ORGANS; ENZYMES; MATHEMATICAL MODELS;

CHOLESTEROL; CYTOCHROME; OXYGENASES; SERUM;

GENES;

ANTIOXIDANT; CARNITINE PALMITOYLTRANSFERASE; CYTOCHROME P450; FARNESOID X RECEPTOR; LONG CHAIN FATTY ACID COENZYME A LIGASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PREGNANE X RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; FATTY LIVER; GENE EXPRESSION; LIVER METABOLISM; LIVER MICROSOME; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STEROID METABOLISM; TISSUE SPECIFICITY; UNINDEXED SEQUENCE; VITAMIN METABOLISM;

ANIMALS; CHOLESTEROL; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME REPRESSION; FATTY ACIDS; FATTY LIVER; GENE DELETION; GENE EXPRESSION PROFILING; MICE; MICE, KNOCKOUT; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE;

EID: 24744466284     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504447200     Document Type: Article

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