Transcriptional regulation of human oxysterol 7α-hydroxylase by sterol response element binding protein

Biochemical and Biophysical Research Communications

Volumn 316, Issue 1, 2004, Pages 158-164

  Norlin, Maria ^a,b   Chiang, John Y L ^a  

^a NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Cholesterol; CYP7B1; Lipid homeostasis; Oxysterol; SREBP; Sterol metabolism

Indexed keywords

BINDING PROTEIN; LUCIFERASE; OXYGENASE; OXYSTEROL 7ALPHA HYDROXYLASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CHEMICAL INTERACTION; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; GENE CONTROL; GENE MAPPING; GENE REPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPORTER GENE;

BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEINS; CYTOCHROME P-450 ENZYME SYSTEM; DNA-BINDING PROTEINS; ENZYME REPRESSION; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; SP1 TRANSCRIPTION FACTOR; STEROID HYDROXYLASES; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROLS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 1542345766     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.02.029     Document Type: Article

References (29)

1. Vlahcevic Z.R., Pandak W.M., Stravitz R.T. Regulation of bile acid biosynthesis. Gastroenterol. Clin. North Am. 28:1999;1-25.
2. Chiang J.Y. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr. Rev. 23:2002;443-463.
3. Crestani M., Karam W.G., Chiang J.Y. Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol. 7α -hydroxylase mRNA and the CYP7 gene in HepG2 cells Biochem. Biophys. Res. Commun. 198:1994;546-553.
4. Chiang J.Y., Kimmel R., Weinberger C., Stroup D. Farnesoid X receptor responds to bile acids and represses cholesterol. 7α -hydroxylase gene (CYP7A1) transcription J. Biol. Chem. 275:2000;10918-10924.
5. Schroepfer G.J. Jr. Oxysterols: modulators of cholesterol metabolism and other processes. Physiol. Rev. 80:2000;361-554.
6. Brown M.S., Goldstein J.L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 89:1997;331-340.
7. Rose K.A., Stapleton G., Dott K., Kieny M.P., Best R., Schwarz M., Russell D.W., Björkhem I., Seckl J., Lathe R. Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids. 7α -hydroxy dehydroepiandrosterone and 7α -hydroxy pregnenolone Proc. Natl. Acad. Sci. USA. 94:1997;4925-4930.
8. Wu Z., Martin K.O., Javitt N.B., Chiang J.Y. Structure and functions of human oxysterol. 7α -hydroxylase cDNAs and gene CYP7B1 J. Lipid Res. 40:1999;2195-2203.
9. Janowski B.A., Willy P.J., Devi T.R., Falck J.R., Mangelsdorf D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXRα Nature. 383:1996;728-731.
10. Toll A., Shoda J., Axelson M., Sjövall J., Wikvall K. 7α -Hydroxylation of 26-hydroxycholesterol, 3β -hydroxy-5-cholestenoic acid and 3β -hydroxy-5-cholenoic acid by cytochrome P-450 in pig liver microsomes FEBS Lett. 296:1992;73-76.
11. Schwarz M., Lund E.G., Lathe R., Björkhem I., Russell D.W. Identification and characterization of a mouse oxysterol. 7α -hydroxylase cDNA J. Biol. Chem. 272:1997;23995-24001.
12. Norlin M., Wikvall K. Biochemical characterization of the. 7α -hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes Biochim. Biophys. Acta. 1390:1998;269-281.
13. Norlin M., Toll A., Björkhem I., Wikvall K. 24-hydroxycholesterol is a substrate for hepatic cholesterol. 7α -hydroxylase (CYP7A) J. Lipid Res. 41:2000;1629-1639.
14. Norlin M., Andersson U., Björkhem I., Wikvall K. Oxysterol. 7α -hydroxylase activity by cholesterol 7α -hydroxylase (CYP7A) J. Biol. Chem. 275:2000;34046-34053.
15. Martin K.O., Reiss A.B., Lathe R., Javitt N.B. 7α -Hydroxylation of 27-hydroxycholesterol: biologic role in the regulation of cholesterol synthesis J. Lipid Res. 38:1997;1053-1058.
16. Axelson M., Larsson O. 27-Hydroxylated low density lipoprotein (LDL) cholesterol can be converted to. 7α,27-dihydroxy-4-cholesten-3-one (cytosterone) before suppressing cholesterol production in normal human fibroblasts. Evidence that an altered metabolism of ldl cholesterol can underlie a defective feedback control in malignant cells J. Biol. Chem. 271:1996;12724-12736.
17. Weihua Z., Lathe R., Warner M., Gustafsson J.Å. An endocrine pathway in the prostate, ERβ, AR, 5α -androstane- 3β, 17β -diol, and CYP7B1, regulates prostate growth Proc. Natl. Acad. Sci. USA. 99:2002;13589-13594.
18. Wu Z., Chiang J.Y. Transcriptional regulation of human oxysterol. 7α -hydroxylase gene (CYP7B1) by Sp1 Gene. 272:2001;191-197.
19. Pandak W.M., Hylemon P.B., Ren S., Marques D., Gil G., Redford K., Mallonee D., Vlahcevic Z.R. Regulation of oxysterol. 7α -hydroxylase (CYP7B1) in primary cultures of rat hepatocytes Hepatology. 35:2002;1400-1408.
20. Zhang M., Chiang J.Y. Transcriptional regulation of the human sterol. 12α -hydroxylase gene (CYP8B1): roles of hepatocyte nuclear factor 4α in mediating bile acid repression J. Biol. Chem. 276:2001;41690-41699.
21. DeBose-Boyd R.A., Ou J., Goldstein J.L., Brown M.S. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. Proc. Natl. Acad. Sci. USA. 98:2001;1477-1482.
22. del Castillo-Olivares A., Gil G. Differential effects of sterol regulatory binding protein 1 and 2 on sterol. 12α -hydroxylase. SREBP-2 suppresses the sterol 12α -hydroxylase promoter J. Biol. Chem. 277:2002;6750-6757.
23. Osborne T.F. Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. J. Biol. Chem. 275:2000;32379-32382.
24. Gunther M., Laithier M., Brison O. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. Mol. Cell. Biochem. 210:2000;131-142.
25. Sakai J., Rawson R.B. The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport. Curr. Opin. Lipidol. 12:2001;261-266.
26. Repa J.J., Lund E.G., Horton J.D., Leitersdorf E., Russell D.W., Dietschy J.M., Turley S.D. Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding. J. Biol. Chem. 275:2000;39685-39692.
27. Stulnig T.M., Steffensen K.R., Gao H., Reimers M., Dahlman-Wright K., Schuster G.U., Gustafsson J.Å. Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol. Pharmacol. 62:2002;1299-1305.
28. Repa J.J., Liang G., Ou J., Bashmakov Y., Lobaccaro J.M., Shimomura I., Shan B., Brown M.S., Goldstein J.L., Mangelsdorf D.J. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ Genes Dev. 14:2000;2819-2830.
29. Setchell K.D., Schwarz M., O'Connell N.C., Lund E.G., Davis D.L., Lathe R., Thompson H.R., Weslie Tyson R., Sokol R.J., Russell D.W. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol. 7α -hydroxylase gene causes severe neonatal liver disease J. Clin. Invest. 102:1998;1690-1703.