Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: Effects on development, reproduction, and microsomal cytochrome P450

Journal of Pharmacology and Experimental Therapeutics

Volumn 312, Issue 1, 2005, Pages 35-43

  Wu, Lin ^a   Gu, Jun ^a   Cui, Huadong ^a   Zhang, Qing Yu ^a   Behr, Melissa ^a   Fang, Cheng ^a   Weng, Yan ^a   Kluetzman, Kerri ^a   Swiatek, Pamela J ^a,b   Yang, Weizhu ^a   Kaminsky, Laurence ^a   Ding, Xinxin ^a,c  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b VAN ANDEL RESEARCH INSTITUTE   (United States)

^c WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; MICROSOME ENZYME; PARACETAMOL; PENTOBARBITAL; PROGESTERONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; TESTOSTERONE;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; COPULATION; DEVELOPMENTAL DISORDER; DRUG CLEARANCE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME DEFICIENCY; FATTY LIVER; FEMALE; FEMALE INFERTILITY; GENE DISRUPTION; GENE EXPRESSION; GENOTYPE; HEART WEIGHT; HOMOZYGOTE; KIDNEY MASS; LETHALITY; LIVER MICROSOME; LUNG WEIGHT; MALE; MOUSE; NONHUMAN; ORGAN DISTRIBUTION; PHENOTYPE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROTEIN EXPRESSION; REPRODUCTION; TESTOSTERONE BLOOD LEVEL; TRANSGENIC MOUSE;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE SILENCING; HORMONES; INTRONS; KIDNEY; LIVER; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, TRANSGENIC; MICROSOMES; NADPH-FERRIHEMOPROTEIN REDUCTASE; PENTOBARBITAL; REPRODUCTION;

EID: 19944426178     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.073353     Document Type: Article

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