메뉴 건너뛰기




Volumn 100, Issue 1, 2005, Pages 7-13

Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis

Author keywords

Activating NK receptors; Cellular ligands; Inhibitory NK receptors; Innate immunity; NK cells

Indexed keywords

HLA ANTIGEN CLASS 1; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2D; TRANSFORMING GROWTH FACTOR BETA;

EID: 24344505476     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2005.07.004     Document Type: Review
Times cited : (104)

References (63)
  • 1
    • 0024792513 scopus 로고
    • Biology of natural killer cells
    • G. Trinchieri Biology of natural killer cells Adv Immunol 47 1989 187 276
    • (1989) Adv Immunol , vol.47 , pp. 187-276
    • Trinchieri, G.1
  • 2
    • 18844416664 scopus 로고    scopus 로고
    • The dialogue between human natural killer cells and dendritic cells
    • A. Moretta The dialogue between human natural killer cells and dendritic cells Curr Opin Immunol 17 2005 306 311
    • (2005) Curr Opin Immunol , vol.17 , pp. 306-311
    • Moretta, A.1
  • 6
    • 11144299492 scopus 로고    scopus 로고
    • NK cell recognition
    • L.L. Lanier NK cell recognition Annu Rev Immunol 23 2005 225 274
    • (2005) Annu Rev Immunol , vol.23 , pp. 225-274
    • Lanier, L.L.1
  • 7
    • 14944355535 scopus 로고    scopus 로고
    • Class I molecules and KIRs in human history, health and survival
    • P.M.H.C. Parham Class I molecules and KIRs in human history, health and survival Nat Rev Immunol 5 2005 201 214
    • (2005) Nat Rev Immunol , vol.5 , pp. 201-214
    • Parham, P.M.H.C.1
  • 9
    • 0025267879 scopus 로고
    • A novel surface antigen expressed by a subset of human CD3-CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function
    • A. Moretta, G. Tambussi, C. Bottino, G. Tripodi, A. Merli, E. Ciccone, G. Pantaleo, and L. Moretta A novel surface antigen expressed by a subset of human CD3-CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function J Exp Med 171 1990 695 714
    • (1990) J Exp Med , vol.171 , pp. 695-714
    • Moretta, A.1    Tambussi, G.2    Bottino, C.3    Tripodi, G.4    Merli, A.5    Ciccone, E.6    Pantaleo, G.7    Moretta, L.8
  • 10
    • 0025677333 scopus 로고
    • Identification of four subsets of human CD3-CD16+ NK cells by the expression of clonally distributed functional surface molecules. Correlation between subset assignement of NK clones and ability to mediate specific alloantigen recognition
    • A. Moretta, C. Bottino, D. Pende, G. Tripodi, G. Tambussi, O. Viale, A. Orengo, M. Barbaresi, A. Merli, E. Ciccone, and L. Moretta Identification of four subsets of human CD3-CD16+ NK cells by the expression of clonally distributed functional surface molecules. Correlation between subset assignement of NK clones and ability to mediate specific alloantigen recognition J Exp Med 172 1990 1589 1598
    • (1990) J Exp Med , vol.172 , pp. 1589-1598
    • Moretta, A.1    Bottino, C.2    Pende, D.3    Tripodi, G.4    Tambussi, G.5    Viale, O.6    Orengo, A.7    Barbaresi, M.8    Merli, A.9    Ciccone, E.10    Moretta, L.11
  • 11
    • 0027284452 scopus 로고
    • P58 molecules as putative receptors for MHC class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities
    • A. Moretta, M. Vitale, C. Bottino, A.M. Orengo, L. Morelli, R. Augugliaro, M. Barbaresi, E. Ciccone, and L. Moretta p58 molecules as putative receptors for MHC class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities J Exp Med 178 1993 597 604
    • (1993) J Exp Med , vol.178 , pp. 597-604
    • Moretta, A.1    Vitale, M.2    Bottino, C.3    Orengo, A.M.4    Morelli, L.5    Augugliaro, R.6    Barbaresi, M.7    Ciccone, E.8    Moretta, L.9
  • 12
    • 0027410441 scopus 로고
    • The Ly49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: The NK gene complex
    • W.M. Yokoyama, and W.E. Seaman The Ly49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex Annu Rev Immunol 11 1993 613 635
    • (1993) Annu Rev Immunol , vol.11 , pp. 613-635
    • Yokoyama, W.M.1    Seaman, W.E.2
  • 14
    • 0025300414 scopus 로고
    • In search of the "missing self". MHC molecules and NK cell recognition
    • H.G. Ljunggren, and K. Kärre In search of the "missing self". MHC molecules and NK cell recognition Immunol Today 11 1990 237 244
    • (1990) Immunol Today , vol.11 , pp. 237-244
    • Ljunggren, H.G.1    Kärre, K.2
  • 16
    • 4744373672 scopus 로고    scopus 로고
    • The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules: Implications for tumor immune escape
    • I. Algarra, A. Garcia-Lora, T. Cabrera, F. Ruiz-Cabello, and F. Garrido The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules: implications for tumor immune escape Cancer Immunol Immunother 53 2004 904 910
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 904-910
    • Algarra, I.1    Garcia-Lora, A.2    Cabrera, T.3    Ruiz-Cabello, F.4    Garrido, F.5
  • 17
    • 0033831421 scopus 로고    scopus 로고
    • Viral mechanisms of immune evasion
    • A. Alcami, and U.H. Koszinowski Viral mechanisms of immune evasion Immunol Today 21 2000 447 455
    • (2000) Immunol Today , vol.21 , pp. 447-455
    • Alcami, A.1    Koszinowski, U.H.2
  • 18
    • 22444439740 scopus 로고    scopus 로고
    • Viral evasion of NK-cell activation
    • Rajagopalan S, Long EO. Viral evasion of NK-cell activation. Trends Immunol 2005;26:403-5.
    • (2005) Trends Immunol , vol.26 , pp. 403-405
    • Rajagopalan, S.1    Long, E.O.2
  • 19
    • 1542359026 scopus 로고    scopus 로고
    • Natural killer cell receptors for major histocompatibility complex class I and related molecules in cytomegalovirus infection
    • M. Lopez-Botet, A. Angulo, and M. Guma Natural killer cell receptors for major histocompatibility complex class I and related molecules in cytomegalovirus infection Tissue Antigens 63 2004 195 203
    • (2004) Tissue Antigens , vol.63 , pp. 195-203
    • Lopez-Botet, M.1    Angulo, A.2    Guma, M.3
  • 20
    • 11144279169 scopus 로고    scopus 로고
    • Viral modulation of NK cell immunity
    • M.B. Lodoen, and L.L. Lanier Viral modulation of NK cell immunity Nat Rev Microbiol 3 2005 59 69
    • (2005) Nat Rev Microbiol , vol.3 , pp. 59-69
    • Lodoen, M.B.1    Lanier, L.L.2
  • 22
    • 0031879322 scopus 로고    scopus 로고
    • The susceptibility to natural killer cell-mediated lysis of HLA class I-positive melanomas reflects the expression of insufficient amounts of different HLA class I alleles
    • D. Pende, L. Accame, L. Pareti, A. Mazzocchi, A. Moretta, G. Parmiani, and L. Moretta The susceptibility to natural killer cell-mediated lysis of HLA class I-positive melanomas reflects the expression of insufficient amounts of different HLA class I alleles Eur J Immunol 28 1998 2384 2394
    • (1998) Eur J Immunol , vol.28 , pp. 2384-2394
    • Pende, D.1    Accame, L.2    Pareti, L.3    Mazzocchi, A.4    Moretta, A.5    Parmiani, G.6    Moretta, L.7
  • 23
    • 0033007567 scopus 로고    scopus 로고
    • Regulation of immune responses through inhibitory receptors
    • E.O. Long Regulation of immune responses through inhibitory receptors Annu Rev Immunol 17 1999 875 904
    • (1999) Annu Rev Immunol , vol.17 , pp. 875-904
    • Long, E.O.1
  • 24
    • 0034808022 scopus 로고    scopus 로고
    • Genetic and functional relationships between MHC and NK receptor genes
    • J. Trowsdale Genetic and functional relationships between MHC and NK receptor genes Immunity 15 2001 363 374
    • (2001) Immunity , vol.15 , pp. 363-374
    • Trowsdale, J.1
  • 25
    • 0036215134 scopus 로고    scopus 로고
    • KIR: Diverse, rapidly evolving receptors of innate and adaptive immunity
    • C. Vilches, and P. Parham KIR: diverse, rapidly evolving receptors of innate and adaptive immunity Annu Rev Immunol 20 2002 217 251
    • (2002) Annu Rev Immunol , vol.20 , pp. 217-251
    • Vilches, C.1    Parham, P.2
  • 26
    • 4444243490 scopus 로고    scopus 로고
    • Killer immunoglobulin-like receptors
    • L. Moretta, and A. Moretta Killer immunoglobulin-like receptors Curr Opin Immunol 16 2004 626 633
    • (2004) Curr Opin Immunol , vol.16 , pp. 626-633
    • Moretta, L.1    Moretta, A.2
  • 29
    • 0037007090 scopus 로고    scopus 로고
    • Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation
    • S. Sivori, M. Falco, E. Marcenaro, S. Parolini, R. Biasson, C. Bottino, L. Moretta, and A. Moretta Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation Proc Natl Acad Sci USA 99 2002 4526 4531
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 4526-4531
    • Sivori, S.1    Falco, M.2    Marcenaro, E.3    Parolini, S.4    Biasson, R.5    Bottino, C.6    Moretta, L.7    Moretta, A.8
  • 30
    • 0031743839 scopus 로고    scopus 로고
    • 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48
    • M.H. Brown, K. Boles, P.A. van der Merwe, V. Kumar, P.A. Mathew, and A.N. Barclay 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48 J Exp Med 188 1998 2083 2090
    • (1998) J Exp Med , vol.188 , pp. 2083-2090
    • Brown, M.H.1    Boles, K.2    Van Der Merwe, P.A.3    Kumar, V.4    Mathew, P.A.5    Barclay, A.N.6
  • 33
    • 0036716947 scopus 로고    scopus 로고
    • NK cells: A lesson from mismatched hematopoietic transplantation
    • A. Velardi, L. Ruggeri, A. Moretta, and L. Moretta NK cells: a lesson from mismatched hematopoietic transplantation Trends Immunol 23 2002 438 444
    • (2002) Trends Immunol , vol.23 , pp. 438-444
    • Velardi, A.1    Ruggeri, L.2    Moretta, A.3    Moretta, L.4
  • 34
    • 20144385362 scopus 로고    scopus 로고
    • Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: Evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)
    • D. Pende, G.M. Spaggiari, S. Marcenaro, S. Martini, P. Rivera, A. Capobianco, M. Falco, E. Lanino, I. Pierri, R. Zambello, A. Bacigalupo, M.C. Mingari, A. Moretta, and L. Moretta Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112) Blood 105 2005 2066 2073
    • (2005) Blood , vol.105 , pp. 2066-2073
    • Pende, D.1    Spaggiari, G.M.2    Marcenaro, S.3    Martini, S.4    Rivera, P.5    Capobianco, A.6    Falco, M.7    Lanino, E.8    Pierri, I.9    Zambello, R.10    Bacigalupo, A.11    Mingari, M.C.12    Moretta, A.13    Moretta, L.14
  • 37
    • 0034117882 scopus 로고    scopus 로고
    • Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis
    • A. Moretta, R. Biassoni, C. Bottino, M.C. Mingari, and L. Moretta Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis Immunol Today 21 2000 228 234
    • (2000) Immunol Today , vol.21 , pp. 228-234
    • Moretta, A.1    Biassoni, R.2    Bottino, C.3    Mingari, M.C.4    Moretta, L.5
  • 38
    • 3042569008 scopus 로고    scopus 로고
    • Learning how to discriminate between friends and enemies, a lesson from natural killer cells
    • C. Bottino, L. Moretta, D. Pende, M. Vitale, and A. Moretta Learning how to discriminate between friends and enemies, a lesson from natural killer cells Mol Immunol 41 2004 569 575
    • (2004) Mol Immunol , vol.41 , pp. 569-575
    • Bottino, C.1    Moretta, L.2    Pende, D.3    Vitale, M.4    Moretta, A.5
  • 40
    • 0032494190 scopus 로고    scopus 로고
    • Molecular cloning of NKp46: A novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity
    • A. Pessino, S. Sivori, C. Bottino, A. Malaspina, L. Morelli, L. Moretta, R. Biassoni, and A. Moretta Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity J Exp Med 188 1998 953 960
    • (1998) J Exp Med , vol.188 , pp. 953-960
    • Pessino, A.1    Sivori, S.2    Bottino, C.3    Malaspina, A.4    Morelli, L.5    Moretta, L.6    Biassoni, R.7    Moretta, A.8
  • 42
    • 0032526860 scopus 로고    scopus 로고
    • NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells is involved in non-MHC restricted tumor cell lysis
    • M. Vitale, C. Bottino, S. Sivori, L. Sanseverino, R. Castriconi, R. Marcenaro, R. Augugliaro, L. Moretta, and A. Moretta NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells is involved in non-MHC restricted tumor cell lysis J Exp Med 187 1998 2065 2072
    • (1998) J Exp Med , vol.187 , pp. 2065-2072
    • Vitale, M.1    Bottino, C.2    Sivori, S.3    Sanseverino, L.4    Castriconi, R.5    Marcenaro, R.6    Augugliaro, R.7    Moretta, L.8    Moretta, A.9
  • 43
    • 0033103860 scopus 로고    scopus 로고
    • NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily
    • C. Cantoni, C. Bottino, M. Vitale, A. Pessino, R. Augugliaro, A. Malaspina, S. Parolini, L. Moretta, A. Moretta, and R. Biassoni NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily J Exp Med 189 1999 787 796
    • (1999) J Exp Med , vol.189 , pp. 787-796
    • Cantoni, C.1    Bottino, C.2    Vitale, M.3    Pessino, A.4    Augugliaro, R.5    Malaspina, A.6    Parolini, S.7    Moretta, L.8    Moretta, A.9    Biassoni, R.10
  • 44
    • 0032945045 scopus 로고    scopus 로고
    • NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells
    • S. Sivori, D. Pende, C. Bottino, E. Marcenaro, A. Pessino, R. Biassoni, L. Moretta, and A. Moretta NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells Eur J Immunol 29 1999, May 1656 1666
    • (1999) Eur J Immunol , vol.29 , pp. 1656-1666
    • Sivori, S.1    Pende, D.2    Bottino, C.3    Marcenaro, E.4    Pessino, A.5    Biassoni, R.6    Moretta, L.7    Moretta, A.8
  • 46
    • 0033618504 scopus 로고    scopus 로고
    • Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    • S. Bauer, V. Groh, J. Wu, A. Steinle, J.H. Phillips, L.L. Lanier, and T. Spies Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA Science 285 1999 727 729
    • (1999) Science , vol.285 , pp. 727-729
    • Bauer, S.1    Groh, V.2    Wu, J.3    Steinle, A.4    Phillips, J.H.5    Lanier, L.L.6    Spies, T.7
  • 47
    • 0033536068 scopus 로고    scopus 로고
    • Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB
    • V. Groh, R. Rhinehart, H. Secrist, S. Bauer, K.H. Grabstein, and T. Spies Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB Proc Natl Acad Sci USA 96 1999 6879 6884
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6879-6884
    • Groh, V.1    Rhinehart, R.2    Secrist, H.3    Bauer, S.4    Grabstein, K.H.5    Spies, T.6
  • 48
    • 0035099068 scopus 로고    scopus 로고
    • ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
    • D. Cosman, J. Mullberg, C.L. Sutherland, W. Chin, R. Armitage, W. Fanslow, M. Kubin, and N.J. Chalupny ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor Immunity 14 2001 123 133
    • (2001) Immunity , vol.14 , pp. 123-133
    • Cosman, D.1    Mullberg, J.2    Sutherland, C.L.3    Chin, W.4    Armitage, R.5    Fanslow, W.6    Kubin, M.7    Chalupny, N.J.8
  • 49
    • 0036604988 scopus 로고    scopus 로고
    • Lymphocyte activation via NKG2D: Towards a new paradigm in immune recognition?
    • E. Vivier, E. Tomasello, and P. Paul Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? Curr Opin Immunol 14 2002 306 311
    • (2002) Curr Opin Immunol , vol.14 , pp. 306-311
    • Vivier, E.1    Tomasello, E.2    Paul, P.3
  • 50
    • 0142197631 scopus 로고    scopus 로고
    • Roles of the NKG2D immunoreceptor and its ligands
    • D.H. Raulet Roles of the NKG2D immunoreceptor and its ligands Nat Rev Immunol 3 2003 781 790
    • (2003) Nat Rev Immunol , vol.3 , pp. 781-790
    • Raulet, D.H.1
  • 51
    • 0037515740 scopus 로고    scopus 로고
    • NKG2D ligands: Unconventional MHC class I-like molecules exploited by viruses and cancer
    • A. Cerwenka, and L.L. Lanier NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer Tissue Antigens 61 2003 335 343
    • (2003) Tissue Antigens , vol.61 , pp. 335-343
    • Cerwenka, A.1    Lanier, L.L.2
  • 56
    • 0141650530 scopus 로고    scopus 로고
    • The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44)
    • A. De Maria, M. Fogli, P. Costa, G. Murdaca, F. Puppo, D. Mavilio, A. Moretta, and L. Moretta The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44) Eur J Immunol 33 2003 2410 2418
    • (2003) Eur J Immunol , vol.33 , pp. 2410-2418
    • De Maria, A.1    Fogli, M.2    Costa, P.3    Murdaca, G.4    Puppo, F.5    Mavilio, D.6    Moretta, A.7    Moretta, L.8
  • 59
    • 0036829733 scopus 로고    scopus 로고
    • Major histocompatibility complex class I-related chain a and UL16-binding protein expression on tumor cell lines of different histotypes: Analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
    • D. Pende, P. Rivera, S. Marcenaro, C.C. Chang, R. Biassoni, R. Conte, M. Kubin, D. Cosman, S. Ferrone, L. Moretta, and A. Moretta Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity Cancer Res 62 2002 6178 6186
    • (2002) Cancer Res , vol.62 , pp. 6178-6186
    • Pende, D.1    Rivera, P.2    Marcenaro, S.3    Chang, C.C.4    Biassoni, R.5    Conte, R.6    Kubin, M.7    Cosman, D.8    Ferrone, S.9    Moretta, L.10    Moretta, A.11
  • 61
    • 10844246498 scopus 로고    scopus 로고
    • Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: Critical role of DNAX accessory molecule-1-poliovirus receptor interaction
    • R. Castriconi, A. Dondero, M.V. Corrias, E. Lanino, D. Pende, L. Moretta, C. Bottino, and A. Moretta Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction Cancer Res 64 2004 9180 9184
    • (2004) Cancer Res , vol.64 , pp. 9180-9184
    • Castriconi, R.1    Dondero, A.2    Corrias, M.V.3    Lanino, E.4    Pende, D.5    Moretta, L.6    Bottino, C.7    Moretta, A.8
  • 63
    • 4344656536 scopus 로고    scopus 로고
    • Commentary, Regulated equilibrium between opposite signals: A general paradigm for T cell function?
    • A. Moretta, and C. Bottino Commentary, Regulated equilibrium between opposite signals: a general paradigm for T cell function? Eur J Immunol 34 2004 2084 2088
    • (2004) Eur J Immunol , vol.34 , pp. 2084-2088
    • Moretta, A.1    Bottino, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.