Different checkpoints in human NK-cell activation

Trends in Immunology

Volumn 25, Issue 12, 2004, Pages 670-676

  Moretta, Lorenzo ^a,b   Bottino, Cristina ^a   Pende, Daniela ^c   Vitale, Massimo ^c   Mingari, Maria Cristina ^b,c   Moretta, Alessandro ^b  

^a G GASLINI INSTITUTE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2D;

CELL DIFFERENTIATION; CELL KILLING; HLA SYSTEM; HUMAN; MOLECULE; NATURAL KILLER CELL; REVIEW; TARGET CELL; TUMOR CELL;

ANIMALS; CELL DIFFERENTIATION; CELL MEMBRANE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KILLER CELLS, NATURAL; LIGANDS; MICE; MODELS, IMMUNOLOGICAL; RECEPTORS, IMMUNOLOGIC;

EID: 7644223692     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2004.09.008     Document Type: Review

References (62)

1. Trinchieri, G. (1989) Biology of natural killer cells. Adv. Immunol. 47, 187-176
2. L. Moretta Human NK cells: origin, clonality, specificity and receptors Adv. Immunol. 55 1994 341 380
3. H.G. Ljunggren, and K. Kärre In search of the 'missing self'. MHC molecules and NK cell recognition Immunol. Today 11 1990 237 244
4. L. Moretta Allorecognition by NK cells: nonself or no self? Immunol. Today 13 1992 300 306
5. W.M. Yokoyama, and W.E. Seaman The ly49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex Annu. Rev. Immunol. 11 1993 613 635
6. + natural killer cells. Role in cell activation and regulation of cytolytic function J. Exp. Med. 171 1990 695 714
7. A. Moretta Identification of four subsets of human CD3-CD16+ NK cells by the expression of clonally distributed functional surface molecules. Correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition J. Exp. Med. 172 1990 1589 1598
8. E. Ciccone Involvement of HLA class I alleles in NK cell specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2) J. Exp. Med. 176 1992 963 971
9. A. Moretta p58 molecules as putative receptors for MHC class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities J. Exp. Med. 178 1993 597 604
10. N. Wagtmann Molecular clones of the p58 natural killer cell receptor reveal Ig-related molecules with diversity in both the extra- and intracellular domains Immunity 2 1995 439 449
11. M. Colonna, and J. Samaridis Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells Science 268 1995 405 408
12. M. Vitale Physical and functional independency of p70 and p58 cell receptors for HLA-class I. Their role in the definition of different groups of alloreactive NK cell clones Proc. Natl. Acad. Sci. U. S. A. 93 1996 1453 1457
13. D. Pende The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140 kD disulphide-linked dimer J. Exp. Med. 184 1996 505 518
14. M. Lopez-Botet Structure and function of the CD94 C-type lectin receptor complex involved in the recognition of HLA-class I molecules Immunol. Rev. 155 1997 165 174
15. V.M. Braud HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C Nature 391 1998 795 799
16. M. Colonna A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells J. Exp. Med. 186 1997 1809 1818
17. M.C. Mingari Cytolytic T lymphocytes displaying natural killer (NK)-like activity. Expression of NK-related functional receptors for HLA-class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production Int. Immunol. 7 1995 697 703
18. + T lymphocyte subsets that express HLA-class I specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations Proc. Natl. Acad. Sci. U. S. A. 93 1996 12433 12438
19. L. Moretta NK-CTL, a novel HLA-E-restricted T cell subset Trends Immunol. 24 2003 136 143
20. H. Ikeda Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor Immunity 6 1997 199 208
21. E. Vivier, and N. Anfossi Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future Nat. Rev. Immunol. 4 2004 190 198
22. S. Ugolini Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells Nat. Immunol. 2 2001 430 435
23. E.O. Long Regulation of immune responses through inhibitory receptors Annu. Rev. Immunol. 17 1999 875 904
24. C. Vilches, and P. Parham KIR: diverse, rapidly evolving receptors of innate and adaptive immunity Annu. Rev. Immunol. 20 2002 217 251
25. J. Trowsdale Genetic and functional relationships between MHC and NK receptor genes Immunity 15 2001 363 374
26. A. Moretta Receptors for HLA-class I-molecules in human natural killer cells Annu. Rev. Immunol. 14 1996 619 648
27. H.G. Shilling Genetic control of human NK cell repertoire J. Immunol. 169 2002 239 247
28. S. Sivori Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation Proc. Natl. Acad. Sci. U. S. A. 99 2002 4526 4531
29. S. Parolini X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells J. Exp. Med. 192 2000 337 346
30. C. Bottino NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of NK cells to kill EBV-infected B cells in X-linked lymphoproliferative disease J. Exp. Med. 194 2001 235 246
31. L. Ruggeri Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants Science 295 2002 2097 2100
32. A. Velardi NK cells: a lesson from mismatched hematopoietic transplantation Trends Immunol. 23 2002 438 444
33. K. Kärre A perfect mismatch Science 295 2002 2029 2031
34. A. Alcami, and U.H. Koszinowski Viral mechanisms of immune evasion Immunol. Today 21 2000 447 455
35. C.A. Biron Activation and function of natural killer cell responses during viral infections Curr. Opin. Immunol. 9 1997 24 34
36. M.S. Malnati Peptide specificity in the recognition of MHC class I by natural killer cell clones Science 267 1995 1016 1018
37. J. Michaelsson A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition J. Exp. Med. 196 2002 1399 1402
38. F. Garrido Implications for immunosurveillance of altered HLA-class I phenotypes in human tumours Immunol. Today 18 1997 89 95
39. D. Pende The susceptibility to natural killer cell-mediated lysis of HLA-class I positive melanomas reflects the expression of insufficient amounts of different HLA-class I alleles Eur. J. Immunol. 28 1998 2384 2394
40. A. Moretta Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis Annu. Rev. Immunol. 19 2001 197 223
41. L. Moretta, and A. Moretta Unravelling the NK cell function: triggering and inhibitory human NK receptors EMBO J. 23 2004 255 259
42. M. Vitale Identification of NKp80, a novel triggering molecule expressed by human natural killer cells Eur. J. Immunol. 31 2001 233 242
43. A. Shibuya DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes Immunity 4 1996 573 581
44. C. Bottino Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule J. Exp. Med. 198 2003 557 567
45. E. Marcenaro CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity Eur. J. Immunol. 33 2003 3367 3376
46. S. Sivori NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh of cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells Eur. J. Immunol. 29 1999 1656 1666
47. G. Ferlazzo Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells J. Exp. Med. 195 2002 343 351
48. A. Moretta Natural killer cells and dendritic cells: rendezvous in abused tissues Nat. Rev. Immunol. 2 2002 957 964
49. R.T. Costello Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukaemia Blood 99 2002 3661 3667
50. R. Castriconi TGFβ1 inhibits surface expression of natural killer (NK)p30 and NKG2D triggering NK receptors: consequences for the NK-mediated killing of dendritic cells Proc. Natl. Acad. Sci. U. S. A. 100 2003 4120 4125
51. D. Mavilio Natural killer cell in HIV-1 infections: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates Proc. Natl. Acad. Sci. U.S. A. 100 2003 15011 15016
52. Vitale, C. et al. The corticosteroid-induced inhibitory effect on NK cell function reflects downregulation and/or dysfunction of triggering receptors involved in natural cytotoxicity. Eur. J. Immunol. (in press)
53. V. Groh Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium Proc. Natl. Acad. Sci. U. S. A. 93 1996 12445 12450
54. D. Cosman ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor Immunity 14 2001 123 133
55. D. Pende Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity Cancer Res. 62 2002 6178 6186
56. N. Reymond DNAM-1 and PVR act as regulators of monocyte migration through endothelial junctions J. Exp. Med. 199 2004 1331 1341
57. R. Castriconi Identification of 4Ig-B7-H3 as a novel neuroblastoma- associated molecule that exerts a protective role from natural killer cell-mediated lysis Proc. Natl. Acad. Sci. U. S. A. 101 2004 12640 12645
58. A. Poggi p40, a novel surface molecule involved in the regulation of the non-MHC restricted cytolytic activity in humans Eur. J. Immunol. 25 1995 369 376
59. M. Falco Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family which functions as an inhibitory receptor in human natural killer cells J. Exp. Med. 190 1999 793 801
60. C. Cantoni Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human natural killer cells Eur. J. Immunol. 29 1999 3148 3159
61. M. Vitale A The small CD56bright CD16- natural killer subset is selectively responsible for both cell proliferation and interferon-γ production upon interaction with dendritic cells Eur. J. Immunol. 34 2004 1715 1722
62. S. Sivori CpG and dsRNA trigger human NK cells via TLR. Induction of cytokine release and of cytolytic activity against tumors and immature DC Proc. Natl. Acad. Sci. U. S. A. 101 2004 10116 10121