NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily

Journal of Experimental Medicine

Volumn 189, Issue 5, 1999, Pages 787-795

  Cantoni, Claudia ^a,b   Bottino, Cristina ^a   Vitale, Massimo ^a   Pessino, Anna ^a,b   Augugliaro, Raffaella ^a,b   Malaspina, Angela ^a   Parolini, Silvia ^c   Moretta, Lorenzo ^a,b   Moretta, Alessandro ^b   Biassoni, Roberto ^a  

^a CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Activating receptor; cDNA; Immunoglobulin superfamily; Natural cytotoxicity; Natural killer cells

Indexed keywords

COMPLEMENTARY DNA; IMMUNOGLOBULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE PROTEIN;

ADOPTIVE TRANSFER; ARTICLE; CELL FUNCTION; CYTOLYSIS; CYTOTOXICITY; HUMAN; HUMAN CELL; KILLER CELL; MOLECULAR CLONING; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; TARGET CELL; TUMOR CELL;

AMINO ACID SEQUENCE; ANIMALS; CELL COMPARTMENTATION; CHROMOSOMES, HUMAN, PAIR 6; CLONING, MOLECULAR; CONSERVED SEQUENCE; COS CELLS; CYTOTOXICITY, IMMUNOLOGIC; DNA, COMPLEMENTARY; HUMANS; IMMUNOGLOBULINS; KILLER CELLS, NATURAL; LYMPHOCYTE SUBSETS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY;

EID: 0033103860     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.5.787     Document Type: Article

References (27)

1. Moretta, A., R. Biassoni, C. Bottino, D. Pende, M. Vitale, A. Poggi, M.C. Mingari, and L. Moretta. 1997. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol. Rev. 155:105-117.
2. Sivori, S., M. Vitale, L. Morelli, L. Sanseverino, R. Augugliaro, C. Bottino, L. Moretta, and A. Moretta. 1997. p46, a novel natural killer cell-specific surface molecule that mediates cell activation. J. Exp. Med. 186:1129-1136.
3. Vitale, M., C. Bottino, S. Sivori, L. Sanseverino, R. Castriconi, E. Marcenaro, R. Augugliaro, L. Moretta, and A. Moretta. 1998. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells is involved in non-major histocompatibility complex-restricted tumor cell lysis J. Exp. Med. 187:2065-2072.
4. Ferrini, S., S. Miescher, M.R. Zocchi, V. Von Fliedner, and A. Moretta. 1987. Phenotypic and functional characterization of recombinant interleukin-2 (rIL-2)-induced killer cells: analysis at the population and the clonal level. J. Immunol. 138:1297-1302.
5. Rosenberg, S.A., and M.T. Lotze. 1986. Cancer immunotherapy-2 and interleukin-2-activated lymphocytes. Annu. Rev. Immunol. 4:681-709.
6. Grimm, E. 1982. Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin-2-activated autologous human peripheral blood lymphocytes. J. Exp. Med. 155:1823-1841.
7. Pessino, A., S. Sivori, C. Bottino, A. Malaspina, L. Morelli, L. Moretta, R. Biassoni, and A. Moretta. 1998. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J. Exp. Med. 188:953-960.
8. Biassoni, R., S. Ferrini, I. Prigione, A. Moretta, and E.O. Long. 1988. CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon-gene. J. Immunol. 140:1685-1689.
9. Brakenhoff, R.H., M. Gerretsen, E.M.C. Knippels, M. van Dijk, H. van Essen, D.O. Weghuis, R.J. Sinke, G.B. Snow, and G.A.M.S. van Dongen. 1995. The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. J. Cell Biol. 129:1677-1689.
10. Lanier, L.L., B.C. Corliss, W. Jun, C. Leong, and J.H. Phillips. 1998. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature. 391:703-707.
11. Pende, D., R. Biassoni, C. Cantoni, S. Verdiani, M. Falco, C. Di Donato, L. Accame, C. Bottino, A. Moretta, and L. Moretta. 1996. The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer. J. Exp. Med. 184:505-518.
12. Chelly, J., J.-C. Kaplan, P. Maire, S. Gautron, and A. Kahn. 1988. Transcription of the dystrophin gene in human muscle and non muscle tissues. Nature. 333:858-860.
13. Pessino, A., B. Sparatore, M. Patrone, M. Passalacqua, E. Melloni, and S. Pontremoli. 1994. Differential expression of protein kinase C isoform genes in three murine erythroleukemia cell variants: implication for chemical induced differentiation. Biochem. Biophys. Res. Commun. 204:461-467.
14. Maniatis, T., E.F. Fritsch, and J. Sambrook. 1982. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 545 pp.
15. Vivier, E., N. Rochet, M. Ackerly, J. Petrini, H. Levine, J. Daley, and P. Anderson. 1992. Signaling function of reconstituted CD 16:ζ:γ receptor complex isoforms. Int. Immunol. 4:1313-1323.
16. Olcese, L., A. Cambiaggi, G. Semenzato, C. Bottino, A. Moretta, and E. Vivier. 1997. Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by Natural Killer cells. J. Immunol. 158:5083-5086.
17. Williams, A.F., and A.N. Barclay. 1988. The immunoglobulin superfamily-domains for cell surface recognition. Annu. Rev. Immunol. 6:381-405.
18. Krajici, P., K.H. Grzesschik, A.H. Geurts van Kessel, B. Olaisen, and P. Brandtzaeg. 1991. The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization. Hum. Genet. 87:642-648.
19. Jentoft, N. 1990. Why are proteins glycosylated? Trends. Biochem. Sci. 15:291-294.
20. Hansen, J.E., O. Lund, J. Engelbrecht, H. Bohr, J.O. Nielsen, J.-E.S. Hansen, and S. Brunak. 1995. Prediction of O-glycosylation of mammalian proteins: specificity patterns of UDP-GalNAc:-polypeptide N-acetylgalactosaminyl-transferase. Biochem. J. 308:801-813.
21. Renard, V., A. Cambiaggi, F. Vély, M. Bléry, L. Olcese, S. Olivero, M. Bouchet, and E. Vivier. 1997. Transduction of cytotoxic signals in natural killer cells: a general model of fine tuning between activatory and inhibitory pathways in lymphocytes. Immunol. Rev. 155:205-221.
22. Klingmuller, U., U. Lorenz, L.C. Cantley, B.G. Neel, and H.F. Lodish. 1995. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell. 80:729-738.
23. Yi, T., and J.N. Ihle. 1993. Association of hematopoietic cell phosphatase with c-kit after stimulation with c-kit ligand. Mol. Cell. Biol. 13:3350-3358.
24. Yi, T., L.-F. Mui, G. Krystal, and J.N. Ihle. 1993. Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor β chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis. Mol. Cell. Biol. 13:7577-7586.
25. Jackson, D.G., D.N.J. Hart, G. Starling, and J.I. Bell. 1992. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. Eur.J. Immunol. 22:1157-1163.
26. Samaridis, J., and M. Colonna. 1997. Cloning of novel immunoglobulin superfamily receptor expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. Eur. J. Immunol. 27:660-665.
27. Borges, L., M.-L. Hsu, N. Fanger, M. Kubin, and D. Cosman. 1997. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. J. Immunol. 159:5192-5196.