The dialogue between human natural killer cells and dendritic cells

Current Opinion in Immunology

Volumn 17, Issue 3, 2005, Pages 306-311

  Moretta, Alessandro ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; CD56 ANTIGEN; CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PADGEM PROTEIN; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANCHORAGE INDEPENDENT GROWTH; BONE MARROW CELL; CELL INTERACTION; CELL MATURATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOLYSIS; DENDRITIC CELL; HOST RESISTANCE; HUMAN; HUMORAL IMMUNITY; IMMUNOSTIMULATION; INNATE IMMUNITY; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TARGET CELL DESTRUCTION; THYROID PARAFOLLICULAR CELL; UPREGULATION;

ANIMALS; CELL COMMUNICATION; DENDRITIC CELLS; HUMANS; KILLER CELLS, NATURAL;

EID: 18844416664     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2005.03.004     Document Type: Review

References (49)

1. A. Moretta, C. Bottino, M.C. Mingari, R. Biassoni, and L. Moretta What is a natural killer cell? Nat Immunol 3 2002 6 8
2. C.A. Janeway Jr., and R. Medzhitov Innate immune recognition Annu Rev Immunol 20 2002 197 216
3. C.A. Biron Activation and function of natural killer cell responses during viral infections Curr Opin Immunol 9 1997 24 34
4. A. Moretta Natural killer cells and dendritic cells: rendezvous in abused tissues Nat Rev Immunol 2 2002 957 965
5. L. Zitvogel Dendritic and Natural Killer Cells Cooperate in the Control/Switch of Innate Immunity J Exp Med 195 2002 F9 F14
6. G. Ferlazzo, and C. Munz NK cell compartements and their activation by dendritic cells J Immunol 172 2004 1333 1339
7. A. Moretta, C. Bottino, M. Vitale, D. Pende, R. Biassoni, M.C. Mingari, and L. Moretta Receptors for HLA-class I molecules in human Natural Killer cells Annu Rev Immunol 14 1996 619 648
8. E.O. Long Regulation of immune responses through inhibitory receptors Annu Rev Immunol 17 1999 875 904
9. M. Lopez-Botet, M. Llano, F. Navarro, and T. Bellon NK cell recognition of non-classical HLA class I molecules Semin Immunol 12 2000 109 119
10. C. Vilches, and P. Parham KIR: diverse, rapidly evolving receptors of innate and adaptive immunity Annu Rev Immunol 20 2002 217 251
11. A. Moretta, C. Bottino, M. Vitale, D. Pende, C. Cantoni, M.C. Mingari, R. Biassoni, and L. Moretta Activating receptors and co-receptors involved in human natural killer cell-mediated cytolysis Annu Rev Immunol 19 2001 197 223
12. A. Cerwenka, and L.L. Lanier Ligands for natural killer cell receptors: redundancy or specificity Immunol Rev 181 2001 158 169
13. D.H. Raulet Roles of the NKG2D immunoreceptor and its ligands Nat Rev Immunol 3 2003 781 790
14. E. Marcenaro, R. Augugliaro, M. Falco, R. Castriconi, S. Parolini, S. Sivori, E. Romeo, R. Millo, L. Moretta, C. Bottino, and A. Moretta CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity Eur J Immunol 33 2003 3367 3376
15. A. Shibuya, D. Campbell, C. Hannum, H. Yssel, K. Franz-Bacon, T. McClanahan, T. Kitamura, J. Nicholl, G.R. Sutherland, L.L. Lanier, and J.H. Phillips DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes Immunity 4 1996 573 581
16. Bottino C, Castriconi R, Moretta L, Moretta A: Cellular ligands for activating NK receptors. Trends Immunol 2005, in press. A timely overview on what is presently known on activating NK receptor-ligand interactions.
17. M. Falco, E. Marcenaro, E. Romeo, F. Bellora, D. Marras, F. Vely, G. Ferracci, L. Moretta, A. Moretta, and C. Bottino Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells Eur J Immunol 34 2004 1663 1672
18. R.M. Flaig, S. Stark, and C. Waltzl Cutting edge: NTB-A activates NK cells via homophilic interaction J Immunol 172 2004 6524 6527
19. C. Bottino, R. Castriconi, D. Pende, P. Rivera, M. Nanni, B. Carnemolla, C. Cantoni, J. Grassi, S. Marcenaro, and N. Reymond Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule J Exp Med 198 2003 557 567 This study demonstrates that DNAM-1 can function as an activating NK receptor and identifies its ligands as the two nectins PVR and Nectin-2. Human NK cells, via DNAM-1, recognize and become activated by nectins expressed on tumour cells of different histotypes.
20. ••]. It identifies the interaction between DNAM-1 and PVR as a crucial event in monocyte migration through endothelial junctions.
21. S. Sivori, M. Falco, M. Della Chiesa, S. Carlomagno, M. Vitale, L. Moretta, and A. Moretta CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumours and dendritic cells Proc Natl Acad Sci USA 101 2004 10116 10121 This paper demonstrates that human NK cells express Toll-like receptors 3 and 9 when exposed to DC-derived IL-12. Upon interaction with their ligands they activate NK cells by inducing both cytolytic activity and cytokine production.
22. ••], shows a TLR3-dependent, direct NK-cell activation.
23. •], describes the TLR3-dependent NK-cell activation. The role of p38 MAPK in the activation process is also demonstrated.
24. S. Akira, and K. Takeda Toll-like receptor signalling Nat Rev Immunol 4 2004 499 511
25. M. Cella, D. Jarrossay, F. Facchetti, O. Alebardi, H. Nakajima, A. Lanzavecchia, and M. Colonna Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon Nat Med 5 1999 919 923
26. D. Piccioli, S. Sbrana, E. Melandri, and N.M. Valiante Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells J Exp Med 195 2002 335 341
27. G. Ferlazzo, M.L. Tsang, L. Moretta, G. Melioli, R.M. Steinman, and C. Munz Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells J Exp Med 195 2002 343 351
28. F. Gerosa, B. Baldani-Guerra, C. Nisii, V. Marchesini, G. Carra, and G. Trinchieri Reciprocal activating interaction between NK cells and dendritic cells J Exp Med 195 2002 327 333
29. C. Borg, A. Jalil, D. Laderach, K. Maruyama, H. Wakasugi, S. Charrier, B. Ryffel, A. Cambi, C. Figdor, and W. Vainchenker NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs Blood 104 2004 3267 3275
30. M.A. Cooper, T.A. Fehniger, and M.A. Caligiuri The biology of human natural killer-cell subsets Trends Immunol 22 2001 633 640
31. G. Ferlazzo, M. Pack, D. Thomas, C. Paludan, D. Schmid, T. Strowig, G. Bougras, W.A. Muller, L. Moretta, and C. Munz Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs Proc Natl Acad Sci USA 101 2004 16606 16611 This study demonstrates a role for IL-15 bound to the surface of myeloid DCs that are in the process of inducting both NK-cell proliferation and survival.
32. C. Munz, T. Dao, G. Ferlazzo, M.A. de Cos, K. Goodman, and J.W. Young Mature myeloid dendritic cell subsets have distinct roles for activation and viability of circulating human natural killer cells Blood 105 2005 266 273
33. V. Supajatura, H. Ushio, A. Nakao, S. Akira, K. Okumura, C. Ra, and H. Ogawa Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity J Clin Invest 109 2002 1351 1359
34. H. Nagase, S. Okugawa, Y. Ota, M. Yamaguchi, H. Tomizawa, K. Matsushima, K. Ohta, K. Yamamoto, and K. Hirai Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand J Immunol 171 2003 3977 3982
35. T. Bjerke, M. Gaustadnes, S. Nielsen, L.P. Nielsen, P.O. Schiotz, N. Rudiger, C.M. Reimert, R. Dahl, I. Christensen, and L.K. Poulsen Human blood eosinophils produce and secrete interleukin 4 Respir Med 90 1996 271 277
36. E. Marcenaro, M. Della Chiesa, F. Bellora, S. Parolini, R. Millo, L. Moretta, and A. Moretta IL12 or IL4 prime human Natural Killer cells to mediate functionally divergent interactions with dendritic cells or tumours J Immunol 174 2005 3992 3998 This study shows that the exposure of NK cells to distinct cytokine milieu during the early stages of inflammation has an important impact on the subsequent ability of NK cells to promote the editing program of myeloid DCs towards the generation of Th1 responses.
37. M. Della Chiesa, S. Sivori, R. Castriconi, E. Marcenaro, and A. Moretta Pathogen induced-private conversations between natural killer and dendritic cells Trends Microbiol 13 2005 128 136 A review tracing the interactions between NK and DC in the context of pathogen infections.
38. R. Castriconi, C. Cantoni, M. Della Chiesa, M. Vitale, E. Marcenaro, R. Conte, R. Biassoni, C. Bottino, L. Moretta, and A. Moretta TGFβ1 inhibits expression of the NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells Proc Natl Acad Sci USA 100 2003 4120 4125
39. - cells as the human NK cell subset that displays cytolytic activity against immature DCs. The article also shows that killing is due to downregulation of surface HLA-E on DCs.
40. M.A. Cooper, T.A. Fehniger, A. Fuchs, M. Colonna, and M.A. Caligiuri NK cell and DC interactions Trends Immunol 25 2004 47 52 A timely review on the interactions between NK cells and DCs.
41. R.B. Mailliard, Y.I. Son, R. Redlinger, P.T. Coates, A. Giermasz, P.A. Morel, W.J. Storkus, and P. Kalinski Dendritic cells mediate NK cell help for Th1 and CTL responses: two-signal requirement for the induction of NK cell helper function J Immunol 171 2003 2366 2373
42. A. Martin-Fontecha, L.L. Thomsen, S. Brett, C. Gerard, M. Lipp, A. Lanzavecchia, and F. Sallusto Induced recruitment of NK cells to lymph nodes provides IFN-γ for Th1 priming Nat Immunol 5 2004 1260 1265 This outstanding study shows that NK cells can be recruited to lymph nodes by CCR7-independent mechanisms and that, by releasing IFNγ, they play a crucial role in the early phases of T-cell priming.
43. P. Byrne, P. McGuirk, S. Todryk, and KH.G. Mills Depletion of NK cells results in disseminating lethal infection with Bordetella pertussis associated with a reduction of antigen-specific Th1 and enhancement of Th2, but not Tr1 Eur J Immunol 34 2004 2579
44. T.A. Fehniger, M.A. Cooper, G.J. Nuovo, M. Cella, F. Facchetti, M. Colonna, and M.A. Caligiuri CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity Blood 101 2003 3052 3057 This paper analyzes the distribution, phenotype and function of human NK cells that populate secondary lymphoid tissues.
45. ••] , analyzes NK cells in secondary lymphoid organs. It also provides evidence that these cells might de novo acquire KIRs at their surface.
46. M. Vitale, M. Della Chiesa, S. Carlomagno, C. Romagnani, A. Thiel, L. Moretta, and A. Moretta The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells Eur J Immunol 34 2004 1715 1722 This study shows that both NK cell proliferation and production of IFN-γ upon interaction with DCs are confined to the small NK subset expressing high surface densities of CD56 and lacking CD16.
47. A. Langenkamp, M. Messi, A. Lanzavecchia, and F. Sallusto Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells Nat Immunol 1 2000 311 316
48. H. Jonuleit, K. Wiedemann, G. Muller, J. Degwert, U. Hoppe, J. Knop, and A.H. Enk Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: a role for IL-15 in attraction of T cells J Immunol 158 1997 2610 2615
49. M. Jinushi, T. Takehara, T. Tatsumi, T. Kanto, V. Groh, T. Spies, T. Suzuki, T. Miyagi, and N. Hayashi Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection J Immunol 171 2003 5423 5429