Activation of NK cells and T cells by NKG2D, a receptor for stress- inducible MICA

Science

Volumn 285, Issue 5428, 1999, Pages 727-729

  Bauer, Stefan ^a,c   Groh, Veronika ^a   Wu, Jun ^b   Steinle, Alexander ^a   Phillips, Joseph H ^b   Lanier, Lewis L ^b   Spies, Thomas ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; NATURAL KILLER CELL RECEPTOR NKG2D;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOLYSIS; EPITHELIUM TUMOR; LYMPHOCYTE ACTIVATION; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; ANTIGEN SPECIFICITY; CD8+ T LYMPHOCYTE; CELL ACTIVATION; EFFECTOR CELL; HUMAN; INNATE IMMUNITY; MAJOR HISTOCOMPATIBILITY COMPLEX; T LYMPHOCYTE ACTIVATION;

CYTOTOXICITY, IMMUNOLOGIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; JURKAT CELLS; KILLER CELLS, NATURAL; LIGANDS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; MEMBRANE PROTEINS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033618504     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.285.5428.727     Document Type: Article

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33. Supported by the Deutsche Forschungsgemeinschaft (S.B.) and NIH grants PO1 CA18221 and RO1 Al30581. DNAX is supported by Schering Plough Corporation. We thank D. Morris, S. Willie, and R. Strong for help in the production and purification of sMICA; R. Rhinehart for technical assistance; D. Geraghty for mAb 3D12; M. Robertson for the NKL cell line; D. Schatz for the RDA protocol; and A. Grandea for suggestions.