2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48

Journal of Experimental Medicine

Volumn 188, Issue 11, 1998, Pages 2083-2090

  Brown, Marion H ^a   Boles, Kent ^b   Van Der Merwe, P Anton ^a   Kumar, Vinay ^c   Mathew, Porunelloor A ^b   Barclay, A Neil ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

2B4; CD48; Ligand; Natural killer cell; T cell

Indexed keywords

CD2 ANTIGEN; CD48 ANTIGEN; CELL SURFACE PROTEIN; IMMUNOGLOBULIN; LIGAND; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; GENETIC ENGINEERING; LIGAND BINDING; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULINS; KILLER CELLS, NATURAL; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES;

EID: 0031743839     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.11.2083     Document Type: Article

References (42)

1. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe. 1997. The Leucocyte Antigen Factsbook. 2nd ed. Academic Press Ltd., London. 613 pp.
2. Preston, S., G.J. Wright, K. Starr, A.N. Barclay, and M.H. Brown. 1997. The leukocyte/neuron cell surface antigen OX2 binds to a ligand on macrophages. Eur. J. Immunol. 27: 1911-1918.
3. Hunig, T. 1985. The cell surface molecule recognized by the erythrocyte receptor of T lymphocytes. Identification and partial characterization using a monoclonal antibody. J. Exp. Med. 162:890-901.
4. Selvaraj, P., M.L. Plunkett, M. Dustin, M.E. Sanders, S. Shaw, and T.A. Springer. 1987. The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3. Nature. 326: 400-403.
5. Kato, K., M. Koyanaga, H. Okada, T. Takanashi, Y.W. Wong, A.F. Williams, K. Okumura, and H. Yagita. 1992. CD48 is a counter-receptor for mouse CD2 and involved in T cell activation. J. Exp. Med. 176:1241-1249.
6. 2-terminal domain of rat CD2 binds rat CD48 with a low affinity and binding does not require glycosylation of CD2. Eur. J. Immunol. 23:1373-1377.
7. Davis, S.J., and P.A. van der Merwe. 1996. The structure and ligand interactions of CD2: implications for T cell function. Immunol. Today. 17:177-187.
8. de la Fuente, M.A., P. Pizcueta, M. Nadal, J. Bosch, and P. Engel. 1997. CD84 leukocyte antigen is a new member of the Ig superfamily. Blood. 90:2398-2405.
9. Wong, Y.W., A.F. Williams, S.F. Kingsmore, and M.F. Selclin. 1990. Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3. J. Exp. Med. 171:2115-2130.
10. Garni-Wagner, B.A., A. Purohit, P.A. Mathew, M. Bennett, and V. Kumar. 1993. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells. J. Immunol. 151:60-70.
11. Schuhmachers, G., K. Ariizumi, P.A. Mathew, M. Bennett, V. Kumar, and A. Takashima. 1995. 2B4, a new member of the immunoglobulin gene superfamily, is expressed on murine dendritic epidermal T cells and plays a functional role in their killing of skin tumors. J. Investig. Dermatol. 105:592-596.
12. Schuhmachers, G., K. Ariizumi, P.A. Mathew, M. Bennett, V. Kumar, and A. Takashima. 1995. Activation of murine epidermal gamma delta T cells through surface 2B4. Eur. J. Immunol. 25:1117-1120.
13. Mathew, P.A., B.A. Garni-Wagner, K. Land, A. Takashima, E. Stoneman, M. Bennett, and V. Kumar. 1993. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J. Immunol. 151:5328-5337.
14. Sewell, W.A., M.H. Brown, M.J. Owen, P.J. Fink, C.A. Kozak, and M.J. Crumpton. 1987. The murine homologue of the T lymphocyte CD2 antigen: molecular cloning, chromosome assignment and cell surface expression. Eur. J. Immunol. 17:1015-1020.
15. van der Merwe, P.A., and A.N. Barclay. 1994. Transient intercellular adhesion: the importance of weak protein-protein interactions. Trends Biochem. Sci. 19:354-358.
16. Brown, M.H., S. Preston, and A.N. Barclay. 1995. A sensitive assay for detecting low-affinity interactions at the cell surface reveals no additional ligands for the adhesion pair rat CD2 and CD48. Eur. J. Immunol. 25:3222-3228.
17. Altman J.D., P.A.H. Moss, P.J.R. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMichael, and M.M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:94-96.
18. Schatz, P.J. 1993. Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: a 13 residue consensus peptide specifies biotinylation in Escherichia coli. Biotechnology. 11:1138-1143.
19. Yagita, H., T. Nakamura, H. Karasuyama, and K. Okumura. 1989. Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells. Proc. Natl. Acad. Sci. USA. 86:645-649.
20. Korinek, V., I. Stefanova, P. Angelisova, I. Hilgert, and V. Horejsi. 1991. The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1. Immunogenetics. 33:108-112.
21. Yokoyama, S., D. Staunton, R. Fisher, M. Amiot, J.J. Fortin, and D.A. Thorley-Lawson. 1991. Expression of the Blast-1 activation/adhesion molecule and its identification as CD48. J. Immunol. 146:2192-2200.
22. Brown, M.H., and A.N. Barclay. 1994. Expression of immunoglobulin and scavenger receptor superfamily domains as chimeric proteins with domains 3 and 4 of CD4 for ligand analysis. Protein Eng. 7:515-521.
23. Al-Shamkhani, A., S. Mallett, M.H. Brown, W. James, and A.N. Barclay. 1997. Affinity and kinetics of the interaction between soluble trimenc OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells. J. Biol. Chem. 272:5275-5282.
24. Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
25. McAlister, M.S.B., M.H. Brown, A.N. Barclay, A.C. Willis, I.D. Campbell, and P.C. Driscoll. 1998. Structural studies of the CD5 antigen. Eur. J. Biochem. 257:131-141.
26. van der Merwe, P.A., M.H. Brown, S.J. Davis, and A.N. Barclay. 1993. Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48. EMBO J. 12:4945-4954.
27. Davis, S.J., S. Ikemizu, M.W. Wild, and P.A. van der Merwe. 1998. CD2 and the nature of protein interactions mediating cell-cell recognition. Immunol. Rev. 163:217-236.
28. van der Merwe, P.A., A.N. Barclay, D.W. Mason, E.A. Davies, B.P. Morgan, M. Tone, A.K.C. Krishnam, C. Ianelli, and S.J. Davis. 1994. Human cell adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59. Biochemistry. 33:10149-10160.
29. Chavin, K.D., L. Qin, J. Lin, J. Woodward, P. Baliga, K. Kato, H. Yagita, and J.S. Bromberg. 1994. Anti-CD48 (murine CD2 ligand) mAbs suppress cell-mediated immunity in vivo. Int. Immunol. 6:701-709.
30. Qin, L., K.D. Chavin, J. Lin, H. Yagita, and J.S. Bromberg. 1994. Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. J. Exp. Med. 179:341-346.
31. Ianelli, C.J., C.M. Edson, and D.A. Thorley-Lawson. 1997. A ligand for human CD48 on epithelial cells. J. Immunol. 159: 3910-3920.
32. Sandrin, M.S., E. Mouhtouris, H.A. Vaughan, H.S. Warren, and C.R. Parish. 1993. CD48 is a low affinity ligand for human CD2.J. Immunol. 151:4606-4613.
33. Arulanandam, A.R., P. Moingeon, M.F. Concino, M.A. Recny, K. Kato, H. Yagita, S. Koyasu, and E.L. Reinherz. 1993. A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: divergence of CD2 ligands during the evolution of humans and mice. J. Exp. Med. 177:1439-1450.
34. van der Merwe, P.A., P.N. McNamee, E.A. Davies, A.N. Barclay, and S.J. Davis. 1995. Topology of the CD2-CD48 cell-adhesion molecule complex: implications for antigen recognition by T cells. Curr. Biol. 5:74-84.
35. Fan, Q.R., L. Mosyak, C.C. Winter, N. Wagtmann, E.O. Long, and D.C. Wiley. 1997. Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors [published erratum 390:315]. Nature. 389:96-100.
36. Lanier, L.L., B. Corliss, and J.H. Phillips. 1997. Arousal and inhibition of human NK cells. Immunol. Rev. 155:145-154.
37. Spruyt, L.L., M.J. Glennie, A.D. Beyers, and A.F. Williams. 1991. Signal transduction by the CD2 antigen in T cells and natural killer cells: requirement for expression of a functional T cell receptor or binding of antibody Fc to the Fc receptor, FcγRIIIA (CD16). J. Exp. Med. 174:1407-1415.
38. Thompson, C.B., and J.P. Allison. 1997. The emerging role of CTLA-4 as an immune attenuator. Immunity. 7:445-450.
39. van der Merwe, P.A., D.L. Bodian, S. Daenke, P. Linsley, and S.J. Davis. 1997. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J. Exp. Med. 185:393-403.
40. Reiser, H. 1997. Role of CD48 molecule in lymphocyte activation. Immunology. 92:IS46.
41. Killeen, N., S.G. Stuart, and D.R. Littman. 1992. Development and function of T cells in mice with a disrupted CD2 gene. EMBO J. 11:4329-4336.
42. Teh, S.J., N. Killeen, A. Tarakhovsky, D.R. Littman, and H.S. Teh. 1997. CD2 regulates the positive selection and function of antigen-specific CD4-CD8+ T cells. Blood. 89: 1308-1318.