Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 33, Issue 3, 2005, Pages 231-247

  Suzuki, Tomoko ^b   Moraes, Theo J ^b   Vachon, Eric ^b   Ginzberg, Hedy H ^b   Huang, Tsun Tsao ^b   Matthay, Michael A ^b   Hollenberg, Morley D ^b   Marshall, John ^b   McCulloch, Christopher A G ^b   Abreu, Maria Teresa Herrera ^b   Chow, Chung Wai ^b   Downey, Gregory P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NONE

Author keywords

Acute lung injury; Inflammation; Proteinases; Signal transduction

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; ELASTASE; HISTONE; LEUKOCYTE ELASTASE; PEPTIDE; PROTEIN KINASE B; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 1 ACTIVATING PEPTIDE; RECEPTOR BLOCKING AGENT; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; THROMBIN; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOL; DNA STRAND BREAKAGE; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NICK END LABELING; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN DNA BINDING; RESPIRATORY EPITHELIUM; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

APOPTOSIS; CASPASE 3; CASPASE 9; CASPASES; CELLS, CULTURED; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKOCYTE ELASTASE; MITOCHONDRIA; OLIGOPEPTIDES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, PAR-1; RESPIRATORY DISTRESS SYNDROME, ADULT; RESPIRATORY MUCOSA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 24344498989     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2005-0109OC     Document Type: Article

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