Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1

Biochemical Journal

Volumn 375, Issue 1, 2003, Pages 99-109

  Chalmers, Claire J ^a,b   Balmanno, Kathryn ^a   Hadfield, Kathryn ^a   Ley, Rebecca ^a   Cook, Simon J ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Apoptosis; Bim; Extracellular signal related kinase (ERK); Protease activated receptor 1 (PAR1); Protein kinase B (PKB); Thrombin

Indexed keywords

CELLS; ENZYME INHIBITION; GENES; RNA; TOXIC MATERIALS;

FIBROBLASTS;

ENZYMES;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; BCL 2 INTERACTING MEDIATOR OF CELL DEATH PROTEIN; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BCL 2 BINDING PROTEIN, BIM; BCL-2-BINDING PROTEIN, BIM; CARRIER PROTEIN; ETOPOSIDE; MEMBRANE PROTEIN; ONCOPROTEIN; PROTEIN KINASE C; THROMBIN RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FIBROBLAST; GENE EXPRESSION; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SERUM; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL LINE; CULTURE MEDIUM; DRUG ANTAGONISM; GENETICS; METABOLISM; PROTEIN SYNTHESIS;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CELL LINE; CELL SURVIVAL; CULTURE MEDIA, SERUM-FREE; ETOPOSIDE; GENE EXPRESSION REGULATION; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PERTUSSIS TOXIN; PROTEIN BIOSYNTHESIS; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS; RECEPTOR, PAR-1; RECEPTORS, THROMBIN; SIGNAL TRANSDUCTION; THROMBIN;

EID: 0141905920     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030346     Document Type: Article

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