Alveolar wall apoptosis causes lung destruction and emphysematous changes

American Journal of Respiratory Cell and Molecular Biology

Volumn 28, Issue 5, 2003, Pages 555-562

  Aoshiba, Kazutetsu ^a   Yokohori, Naoko ^a   Nagai, Atsushi ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; NODULARIN; REAGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DESTRUCTION; CONTROLLED STUDY; EMPHYSEMA; ENDOTHELIUM CELL; EPITHELIUM CELL; GENETIC TRANSFECTION; LUNG ALVEOLUS WALL; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PH; PROTEIN FUNCTION; RAT;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; BRONCHOALVEOLAR LAVAGE FLUID; CASPASE 3; CASPASES; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; ELASTIN; EMPHYSEMA; HUMANS; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED C57BL; PANCREATIC ELASTASE; PULMONARY ALVEOLI; RATS; TRANSFECTION;

ANIMALIA; MURINAE;

EID: 0038070219     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2002-0090OC     Document Type: Article

References (25)

1. American Thoracic Society. 1995. Definitions, epidemiology, pathophysiology, and staging. Am. J. Respir. Crit. Care Med. 152:s78-s83.
2. Murray, C. J. L., and A. D. Lopez. 1996. Evidence-based health policy: lessons from the global burden of disease study. Science 274:740-743.
3. Snider, G. L. 1989. Chronic obstructive pulmonary disease: risk factors, pathophysiology, and pathogenesis. Annu. Rev. Med. 40:411-429.
4. Kasahara, Y., R. M. Tuder, L. Taraseviciene-Stewart, T. D. Le Cras, S. Abman, P. K. Hirth, J. Waltenberger, and N. F. Voelkel. 2000. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J. Clin. Invest. 106:1311-1319.
5. Shapiro, S. D. 2000. Vascular atrophy and VEGFR-2 signaling: old theories of pulmonary emphysema meet new data. J. Clin. Invest. 106:1309-1310.
6. Kasahara, Y., R. M. Tuder, C. D. Cool, D. A. Lynch, S. C. Flores, and N. F. Voelkel. 2001. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am. J. Respir. Crit. Care Med. 163:737-744.
7. Segura-Valdez, L., A. Pardo, M. Gaxiola, B. D. Uhal, C. Becerril, and M. Selman. 2000. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest 117:684-694.
8. Morris, M. C., J. Depollier, J. Mery, F. Heitz, and G. Divita. 2001. A peptide carrier for the delivery of biologically active proteins into mammalian ceils. Nat. Biotech. 19:1173-1176.
9. Dobbs, L. G., E. F. Geppert, M. C. Williams, R. D. Greenleaf, and R. J. Mason. 1980. Metabolic properties and ultrastructure of alveolar type II cells isolated with elastase. Biochim. Biophys. Acta 618:510-523.
10. Kikkawa, Y., and K. Yoneda. 1974. The type II epithelial cell of the lung: I. Method of isolation. Lab. Invest. 30:76-84.
11. Saetta, M., R. J. Shiner, G. E. Angus, W. D. Kim, N.-S. Wang, M. King, H. Ghezzo, and M. G. Cosio. 1985. Destructive index: a measurement of lung parenchymal destruction in smokers. Am. Rev. Respir. Dis. 131:764-769.
12. Senior, R. M., G. L. Griffin, C. J. Fliszar, S. D. Shapiro, G. I. Goldberg, and H. G. Welgus. 1991. Human 92- and 72-kilodalton type IV collagenases are elastases. J. Biol. Chem. 266:7870-7875.
13. Fladmark, K.E., O. T. Brustugun, R. Hovland, R. Bøe, B. T. Gjertsen, B. Zhivotovsky, and G. Døskeland. 1999. Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors. Cell Death Differ. 11:1099-1108.
14. Shoshani, T., A. Faerman. I. Mett, E. Zelin, T. Tenne, S. Gorodin, Y. Moshel, S. Elbaz, A. Budanov, A. Chajut, H. Kalinski, I. Kamer, A. Rozen, O. Mor, E. Keshet, D. Leshkowitz, P. Einat, R. Skaliter, and E. Feinstein. 2002. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol. Cell. Biol. 22:2283-2293.
15. 2 induces apoptosis of bovine bronchial epithelial cells in vitro. Life Sci. 64:2489-2496.
16. Saetta, M., S. Baraldo, L. Corbino, G. Turato, F. Braccioni, F. Rea, G. Cavallesco, G. Tropean, C. E. Mapp, P. Maestrelli, A. Ciccia, and L. M. Fabbri. 1999. CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 160:711-717.
17. Zhao, M. Q., M. K. Amir, W. R. Rice, and R. I. Enelow. 2001. Type II pneumocyte-CDS+ T-cell interactions: relationship between target cell cytotoxicity and activation. Am. J. Respir. Cell Mol. Biol. 25:362-369.
18. Chapman, H. A., R. J. Riese, and G.-P. Shi. 1997. Emerging roles for cysteine proteases in human biology. Annu. Rev. Physiol. 59:63-88.
19. Turk, B., D. Turk, and V. Turk. 2000. Lysosomal cysteine proteases: more than scavengers. BBA 1477:98-111.
20. Reddy, V. Y., Q.-Y. Zhang, and S. J. Weiss. 1995. Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsin B, L, and S, by human monocyte-derived macrophages. Proc. Natl. Acad. Sci. USA 92:3849-3853.
21. Sukhova, G. K., G.-P. Shi, D. I. Simon, H. A. Chapman, and P. Libby. 1998. Expression of the elastolytic cathepsin S and K in human atheroma and regulation of their production in smooth muscle cells. J. Clin. Invest. 102:576-583.
22. Foghsgaard, L., D. Wissing, D. Mauch, U. Lademann, L. Bastholm, M. Boes, F. Elling, M. Leist, and M. Jäättelä. 2001. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J. Cell Biol. 153:999-1010.
23. Bühling, F., A. Gerber, C. Häckel, S. Krüger, T. Köhnlein, D. Brömme, D. Reinhold, S. Ansorge, and T. Welte. 1999. Expression of cathepsin K in lung epithelial cells. Am. J. Respir. Cell Mol. Biol. 20:612-619.
24. Bossard, M. J., T. A. Tomaszek, S. K. Thompson, B. Y. Amegadzie, C. R. Hanning, C. Jones, J. T. Kurdyla, D. E. McNulty, F. H. Drake, M. Gowen, and M. A. Levy. 1996 Proteolytic activity of human osteoclast cathepsin K. J. Biol. Chem. 271:12517-12524.
25. 2, a matrix protein-degrading cysteine protease expressed in osteoclasts. J. Biol. Chem. 271:2126-2132.