Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5′-methylthioadenosine/S- adenosylhomocysteine nucleosidase

Journal of Biological Chemistry

Volumn 280, Issue 18, 2005, Pages 18274-18282

  Lee, Jeffrey E ^a,b   Singh, Vipender ^c   Evans, Gary B ^d   Tyler, Peter C ^d   Furneax, Richard H ^d   Cornell, Kenneth A ^e   Riscoe, Michael K ^f,g   Schramm, Vern L ^c   Howell, P Lynne ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d CALLAGHAN INNOVATION   (New Zealand)

^e BOISE STATE UNIVERSITY   (United States)

^f PORTLAND VA MEDICAL CENTER   (United States)

^g PORTLAND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMS; CRYSTAL STRUCTURE; ENZYMES; HYDROGEN BONDS; IONS; STRUCTURAL ANALYSIS;

ANALOGUE; AROMATIC SUBSTITUTIONS; CYSTEINE; TRANSITION STATE STRUCTURE;

ESCHERICHIA COLI;

5' METHYLTHIOADENOSINE; IMMUCILLIN H; NUCLEOSIDASE; PURINE NUCLEOSIDE PHOSPHORYLASE; S ADENOSYLHOMOCYSTEINE; 5'-METHYLTHIOADENOSINE; ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; DEOXYADENOSINE DERIVATIVE; ENZYME INHIBITOR; GLYCOSIDASE; NUCLEOSIDE; PYRIMIDINONE DERIVATIVE; PYRROLE DERIVATIVE;

AMINO ACID SUBSTITUTION; ANALYTIC METHOD; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME STRUCTURE; ESCHERICHIA COLI; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM;

ESCHERICHIA COLI;

DEOXYADENOSINES; ENZYME INHIBITORS; ESCHERICHIA COLI; MODELS, MOLECULAR; N-GLYCOSYL HYDROLASES; PYRIMIDINONES; PYRROLES; THIONUCLEOSIDES;

EID: 23944452200     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414471200     Document Type: Article

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