Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases

Biochemistry

Volumn 38, Issue 40, 1999, Pages 13147-13154

  Miles, Robert W ^a   Tyler, Peter C ^b   Evans, Gary B ^b   Furneaux, Richard H ^b   Parkin, David W ^b,c   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CALLAGHAN INNOVATION   (New Zealand)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; NUCLEOSIDASE; RIBITOL;

ARTICLE; CRITHIDIA FASCICULATA; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; MICHAELIS CONSTANT; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

ANIMALS; CRITHIDIA FASCICULATA; ENZYME INHIBITORS; GUANOSINE; HYDROGEN BONDING; INOSINE; MACROMOLECULAR SUBSTANCES; N-GLYCOSYL HYDROLASES; PROTOZOAN PROTEINS; PURINES; PYRIMIDINONES; PYRROLES; RIBITOL; RIBOSE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

CRITHIDIA FASCICULATA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0032834001     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990829u     Document Type: Article

References (21)

1. Berens, R. L., Marr, J. J., LaFon, S. W., and Nelson, D. J. (1981) Mol. Biochem. Parasitol. 3, 187-196.
2. Berens, R. L., Krug, E. C., and Marr, J. J. (1995) in Biochemistry and Molecular Biology of Parasites (Marr, J. J., and Müller, M., Eds.) pp 89-117, Academic Press, New York.
3. Parkin, D. W., Horenstein, B. A., Abdulah, D. R., Estupiñán, B., and Schramm, V. L. (1991) J. Biol. Chem. 266, 20658-20665.
4. Estupiñán, B., and Schramm, V. L. (1994) J. Biol. Chem. 269, 23068-23073.
5. Parkin, D. W. (1996) J. Biol. Chem. 271, 21713-21719.
6. Mazzella, L. J., Parkin, D. W., Tyler, P. C., Furneaux, R. H., and Schramm, V. L. (1996) J. Am. Chem. Soc. 118, 2111-2112.
7. Schramm, V. L. (1997) Curr. Opin. Chem. Biol. 1, 323-331.
8. Horenstein, B. A., Parkin, D. W., Estupiñán, B., and Schramm, V. L. (1991) Biochemistry 30, 10788-10795.
9. Horenstein, B. A., and Schramm, V. L. (1993) Biochemistry 32, 7089-7097.
10. Gopaul, D. N., Meyer, S. L., Degano, M., Sacchettini, J. C., and Schramm, V. L. (1996) Biochemistry 35, 5963-5970.
11. Parkin, D. W., Limberg, G., Tyler, P. C., Furneaux, R. H., Chen, X.-Y., and Schramm, V. L. (1997) Biochemistry 36, 3528-3534.
12. Degano, M., Almo, S., Sacchettini, J. C., and Schramm, V. L. (1998) Biochemistry 37, 6277-6285.
13. Degano, M., Gopaul, D. N., Scapin, G., Schramm, V. L., and Sacchettini, J. C. (1996) Biochemistry 35, 5971-5981.
14. Pellé, R., Schramm, V. L., and Parkin, D. W. (1998) J. Biol. Chem. 273, 2118-2126.
15. Bagdassarian, C. K., Schramm, V. L., and Schwartz, S. D. (1996) J. Am. Chem. Soc. 118, 8825-8836.
16. Horenstein, B. A., Zabinski, R. F., and Schramm, V. L. (1993) Tetrahedron Lett. 34, 7213-7216.
17. Furneaux, R. H., Limberg, G., Tyler, P. C., and Schramm, V. L. (1997) Tetrahedron 53, 2915-2930.
18. Miles, R. W., Tyler, P. C., Furneaux, R. H., Bagdassarian, C. K., and Schramm, V. L. (1998) Biochemistry 37, 8615-8621.
19. Morrison, J. F., and Walsh, C. T. (1988) Adv. Enzymol. Relat. Areas Mol. Biol. 61, 201-301.
20. Li, C. M., Tyler, P. C., Furneaux, R. H., Kicska, G., Xu, Y., Grubmeyer, C., Girvin, M. E., and Schramm, V. L. (1999) Nat. Struct. Biol. (in press).
21. Parkin, D. W., and Schramm, V. L. (1995) Biochemistry 34, 13961-13966.