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Volumn 15, Issue 6, 2003, Pages 668-676

Negative selection and autoimmunity

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AUTOIMMUNE REGULATOR; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 0242491039     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2003.09.013     Document Type: Review
Times cited : (63)

References (98)
  • 2
    • 0037459321 scopus 로고    scopus 로고
    • Signaling life and death in the thymus: Timing is everything
    • Werlen G., Hausmann B., Naeher D., Palmer E. Signaling life and death in the thymus: timing is everything. Science. 299:2003;1859-1863.
    • (2003) Science , vol.299 , pp. 1859-1863
    • Werlen, G.1    Hausmann, B.2    Naeher, D.3    Palmer, E.4
  • 4
    • 0023724209 scopus 로고
    • Positive and negative selection of an antigen receptor on T cells in transgenic mice
    • Sha W.C., Nelson C.A., Newberry R.D., Kranz D.M., Russell J.H., Loh D.Y. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature. 336:1988;73-76.
    • (1988) Nature , vol.336 , pp. 73-76
    • Sha, W.C.1    Nelson, C.A.2    Newberry, R.D.3    Kranz, D.M.4    Russell, J.H.5    Loh, D.Y.6
  • 5
    • 0024577093 scopus 로고
    • The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice
    • White J., Herman A., Pullen A.M., Kubo R., Kappler J.W., Marrack P. The Vβ-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell. 56:1989;27-35.
    • (1989) Cell , vol.56 , pp. 27-35
    • White, J.1    Herman, A.2    Pullen, A.M.3    Kubo, R.4    Kappler, J.W.5    Marrack, P.6
  • 6
    • 0025184378 scopus 로고
    • Distinct sequence of negative or positive selection implied by thymocyte T cell receptor densities
    • Ohashi P.S., Pircher H., Bürki K., Zinkernagel R.M., Hengartner H. Distinct sequence of negative or positive selection implied by thymocyte T cell receptor densities. Nature. 346:1990;861-863.
    • (1990) Nature , vol.346 , pp. 861-863
    • Ohashi, P.S.1    Pircher, H.2    Bürki, K.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 7
    • 0025761241 scopus 로고
    • Lower receptor avidity required for thymic clonal deletion than for effector T cell function
    • Pircher H., Hoffmann Rohrer U., Moskophidis D., Zinkernagel R.M., Hengartner H. Lower receptor avidity required for thymic clonal deletion than for effector T cell function. Nature. 351:1991;482-485.
    • (1991) Nature , vol.351 , pp. 482-485
    • Pircher, H.1    Hoffmann Rohrer, U.2    Moskophidis, D.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 8
    • 0029835390 scopus 로고    scopus 로고
    • Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
    • Laufer T.M., DeKoning J., Markowitz J.S., Lo D., Glimcher L.H. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature. 383:1996;81-85.
    • (1996) Nature , vol.383 , pp. 81-85
    • Laufer, T.M.1    Dekoning, J.2    Markowitz, J.S.3    Lo, D.4    Glimcher, L.H.5
  • 10
    • 0036279191 scopus 로고    scopus 로고
    • Failure of HY-specific thymocytes to escape negative selection by receptor editing
    • Buch T., Rieux-Laucat F., Förster I., Rajewsky K. Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity. 16:2002;707-718.
    • (2002) Immunity , vol.16 , pp. 707-718
    • Buch, T.1    Rieux-Laucat, F.2    Förster, I.3    Rajewsky, K.4
  • 11
    • 0033984819 scopus 로고    scopus 로고
    • Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, ld3
    • Rivera R.R., Johns C.P., Quan J., Johnson R.S., Murre C. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, ld3. Immunity. 12:2000;17-26.
    • (2000) Immunity , vol.12 , pp. 17-26
    • Rivera, R.R.1    Johns, C.P.2    Quan, J.3    Johnson, R.S.4    Murre, C.5
  • 12
    • 1842291572 scopus 로고    scopus 로고
    • Crucial role of Jak3 in negative selection of self-reactive T cells
    • Saijo K., Park S.Y., Ishida Y., Arase H., Saito T. Crucial role of Jak3 in negative selection of self-reactive T cells. J. Exp. Med. 185:1997;351-356.
    • (1997) J. Exp. Med. , vol.185 , pp. 351-356
    • Saijo, K.1    Park, S.Y.2    Ishida, Y.3    Arase, H.4    Saito, T.5
  • 13
    • 0344631673 scopus 로고    scopus 로고
    • Role of IL-12 in intrathymic negative selection
    • Ludviksson B.R., Ehrhardt R.O., Strober W. Role of IL-12 in intrathymic negative selection. J. Immunol. 163:1999;4349-4359.
    • (1999) J. Immunol. , vol.163 , pp. 4349-4359
    • Ludviksson, B.R.1    Ehrhardt, R.O.2    Strober, W.3
  • 14
    • 0033118752 scopus 로고    scopus 로고
    • The role of cytokine receptor signaling in lymphocyte development
    • Baird A.M., Gerstein R.M., Berg L.J. The role of cytokine receptor signaling in lymphocyte development. Curr. Opin. Immunol. 11:1999;157-166.
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 157-166
    • Baird, A.M.1    Gerstein, R.M.2    Berg, L.J.3
  • 15
    • 0031587826 scopus 로고    scopus 로고
    • Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
    • Akashi K., Kondo M., von Freeden-Jeffry U., Murray R., Weissman I.L. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell. 89:1997;1033-1041.
    • (1997) Cell , vol.89 , pp. 1033-1041
    • Akashi, K.1    Kondo, M.2    Von Freeden-Jeffry, U.3    Murray, R.4    Weissman, I.L.5
  • 18
    • 0037103223 scopus 로고    scopus 로고
    • Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo
    • A clear and excellent study, using glucocorticoid receptor knockout thymocytes, showing that anti-TCR treatment in vivo is not a model for negative selection.
    • Brewer J.A., Kanagawa O., Sleckman B.P., Muglia L.J. Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J. Immunol. 169:2002;1837-1843 A clear and excellent study, using glucocorticoid receptor knockout thymocytes, showing that anti-TCR treatment in vivo is not a model for negative selection.
    • (2002) J. Immunol. , vol.169 , pp. 1837-1843
    • Brewer, J.A.1    Kanagawa, O.2    Sleckman, B.P.3    Muglia, L.J.4
  • 19
    • 0029907408 scopus 로고    scopus 로고
    • Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death
    • Lerner A., Clayton L.K., Mizoguchi E., Ghendler Y., van Ewijk W., Koyasu S., Bhan A.K., Reinherz E.L. Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death. EMBO J. 15:1996;5876-5887.
    • (1996) EMBO J. , vol.15 , pp. 5876-5887
    • Lerner, A.1    Clayton, L.K.2    Mizoguchi, E.3    Ghendler, Y.4    Van Ewijk, W.5    Koyasu, S.6    Bhan, A.K.7    Reinherz, E.L.8
  • 20
    • 0025250455 scopus 로고
    • Tolerogenicity of thymic epithelium
    • Webb S.R., Sprent J. Tolerogenicity of thymic epithelium. Eur. J. Immunol. 20:1990;2525-2528.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 2525-2528
    • Webb, S.R.1    Sprent, J.2
  • 21
    • 0026587483 scopus 로고
    • Clonal deletion induced by either thymic epithelium or lymphohemopoietic cells at different stages of class I restricted T cell ontogeny
    • Speiser D.E., Pircher H., Ohashi P.S., Kyburz D., Hengartner H., Zinkernagel R.M. Clonal deletion induced by either thymic epithelium or lymphohemopoietic cells at different stages of class I restricted T cell ontogeny. J. Exp. Med. 175:1992;1277-1283.
    • (1992) J. Exp. Med. , vol.175 , pp. 1277-1283
    • Speiser, D.E.1    Pircher, H.2    Ohashi, P.S.3    Kyburz, D.4    Hengartner, H.5    Zinkernagel, R.M.6
  • 22
    • 0036222578 scopus 로고    scopus 로고
    • Cellular environment and freedom of gene expression
    • Pietropaolo M., Giannoukakis N., Trucco M. Cellular environment and freedom of gene expression. Nat. Immunol. 3:2002;335-336.
    • (2002) Nat. Immunol. , vol.3 , pp. 335-336
    • Pietropaolo, M.1    Giannoukakis, N.2    Trucco, M.3
  • 23
    • 0028301977 scopus 로고
    • T-cell tolerance toward a transgenic β-cell antigen and transcription of endogenous pancreatic genes in thymus
    • Jolicoeur C., Hanahan D., Smith K.M. T-cell tolerance toward a transgenic β-cell antigen and transcription of endogenous pancreatic genes in thymus. Proc. Natl. Acad. Sci. U.S.A. 91:1994;6707-6711.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 6707-6711
    • Jolicoeur, C.1    Hanahan, D.2    Smith, K.M.3
  • 24
    • 0030796631 scopus 로고    scopus 로고
    • Pancreatic gene expression in rare cells of thymic medulla: Evidence for functional contribution to T cell tolerance
    • Smith K.M., Olson D.C., Hirose R., Hanahan D. Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance. Int. Immunol. 9:1997;1355-1365.
    • (1997) Int. Immunol. , vol.9 , pp. 1355-1365
    • Smith, K.M.1    Olson, D.C.2    Hirose, R.3    Hanahan, D.4
  • 25
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski J., Schulte A., Kyewski B., Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2:2001;1032-1039.
    • (2001) Nat. Immunol. , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 27
    • 0346599403 scopus 로고    scopus 로고
    • The Finnish-German APECED Consortium: An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 1997, 17:399-403.
    • The Finnish-German APECED Consortium: An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 1997, 17:399-403.
  • 30
    • 0037084784 scopus 로고    scopus 로고
    • Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
    • This is the first report to describe the phenotype of Aire-deficient mice.
    • Ramsey C., Winqvist O., Puhakka L., Halonen M., Moro A., Kämpe O., Eskelin P., Pelto-Huikko M., Peltonen L. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11:2002;397-409 This is the first report to describe the phenotype of Aire-deficient mice.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 397-409
    • Ramsey, C.1    Winqvist, O.2    Puhakka, L.3    Halonen, M.4    Moro, A.5    Kämpe, O.6    Eskelin, P.7    Pelto-Huikko, M.8    Peltonen, L.9
  • 31
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • This is the first report to describe the phenotype of Aire-deficient mice, with interesting data showing that Aire regulates the expression of a variety of tissue-specific genes in MECs. This gives a clear insight into the tolerance defects in these animals and correlates well with the reported autoimmune disease progression.
    • Anderson M.S., Venanzi E.S., Klein L., Chen Z., Berzins S.P., Turley S.J., von Boehmer H., Bronson R., Dierich A., Benoist C., Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science. 298:2002;1395-1401 This is the first report to describe the phenotype of Aire-deficient mice, with interesting data showing that Aire regulates the expression of a variety of tissue-specific genes in MECs. This gives a clear insight into the tolerance defects in these animals and correlates well with the reported autoimmune disease progression.
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3    Chen, Z.4    Berzins, S.P.5    Turley, S.J.6    Von Boehmer, H.7    Bronson, R.8    Dierich, A.9    Benoist, C.10    Mathis, D.11
  • 32
    • 0037383758 scopus 로고    scopus 로고
    • Aire regulates negative selection of organ-specific T cells
    • This is the first study to show that Aire plays a direct role in thymic tolerance. The authors used a double transgenic model of mice bearing a TCR transgene specific for HEL and another transgene, InsHEL, that expressed HEL in the β-islets and systemically.
    • Liston A., Lesage S., Wilson J., Peltonen L., Goodnow C.C. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4:2003;350-354 This is the first study to show that Aire plays a direct role in thymic tolerance. The authors used a double transgenic model of mice bearing a TCR transgene specific for HEL and another transgene, InsHEL, that expressed HEL in the β-islets and systemically.
    • (2003) Nat. Immunol. , vol.4 , pp. 350-354
    • Liston, A.1    Lesage, S.2    Wilson, J.3    Peltonen, L.4    Goodnow, C.C.5
  • 33
    • 0025873567 scopus 로고
    • Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice
    • Zhou T., Bluethmann H., Eldridge J., Brockhaus M., Berry K., Mountz J.D. Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice. J. Immunol. 147:1991;466-474.
    • (1991) J. Immunol. , vol.147 , pp. 466-474
    • Zhou, T.1    Bluethmann, H.2    Eldridge, J.3    Brockhaus, M.4    Berry, K.5    Mountz, J.D.6
  • 34
    • 0028485743 scopus 로고
    • The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
    • Singer G.G., Abbas A.K. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity. 1:1994;365-371.
    • (1994) Immunity , vol.1 , pp. 365-371
    • Singer, G.G.1    Abbas, A.K.2
  • 37
    • 0031883138 scopus 로고    scopus 로고
    • TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection
    • Page D.M., Roberts E.M., Peschon J.J., Hedrick S.M. TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection. J. Immunol. 160:1998;120-133.
    • (1998) J. Immunol. , vol.160 , pp. 120-133
    • Page, D.M.1    Roberts, E.M.2    Peschon, J.J.3    Hedrick, S.M.4
  • 38
    • 0032482160 scopus 로고    scopus 로고
    • A role for Fas in negative selection of thymocytes in vivo
    • Kishimoto H., Surh C.D., Sprent J. A role for Fas in negative selection of thymocytes in vivo. J. Exp. Med. 187:1998;1427-1438.
    • (1998) J. Exp. Med. , vol.187 , pp. 1427-1438
    • Kishimoto, H.1    Surh, C.D.2    Sprent, J.3
  • 39
    • 0034541174 scopus 로고    scopus 로고
    • The TNF receptor family member CD30 is not essential for negative selection
    • DeYoung A.L., Duramad O., Winoto A. The TNF receptor family member CD30 is not essential for negative selection. J. Immunol. 165:2000;6170-6173.
    • (2000) J. Immunol. , vol.165 , pp. 6170-6173
    • Deyoung, A.L.1    Duramad, O.2    Winoto, A.3
  • 42
    • 0037446641 scopus 로고    scopus 로고
    • LIGHT (a cellular ligand for Herpes virus entry mediator and lymphotoxin receptor)-mediated thymocyte deletion is dependent on the interaction between TCR and MHC/self-peptide
    • Wang J., Fu Y.-X. LIGHT (a cellular ligand for Herpes virus entry mediator and lymphotoxin receptor)-mediated thymocyte deletion is dependent on the interaction between TCR and MHC/self-peptide. J. Immunol. 170:2003;3986-3993.
    • (2003) J. Immunol. , vol.170 , pp. 3986-3993
    • Wang, J.1    Fu, Y.-X.2
  • 45
    • 0032472916 scopus 로고    scopus 로고
    • A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
    • Newton K., Harris A.W., Bath M.L., Smith K.G.C., Strasser A. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J. 17:1998;706-718.
    • (1998) EMBO J. , vol.17 , pp. 706-718
    • Newton, K.1    Harris, A.W.2    Bath, M.L.3    Smith, K.G.C.4    Strasser, A.5
  • 48
    • 0030698056 scopus 로고    scopus 로고
    • Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus
    • Alam A., Braun M.Y., Hartgers F., Lesage S., Cohen L., Hugo P., Denis F., Sekaly R.P. Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus. J. Exp. Med. 186:1997;1503-1512.
    • (1997) J. Exp. Med. , vol.186 , pp. 1503-1512
    • Alam, A.1    Braun, M.Y.2    Hartgers, F.3    Lesage, S.4    Cohen, L.5    Hugo, P.6    Denis, F.7    Sekaly, R.P.8
  • 51
    • 0034655149 scopus 로고    scopus 로고
    • Caspase enzyme activity is not essential for apoptosis during thymocyte development
    • Doerfler P., Forbush K.A., Perlmutter R.M. Caspase enzyme activity is not essential for apoptosis during thymocyte development. J. Immunol. 164:2000;4071-4079.
    • (2000) J. Immunol. , vol.164 , pp. 4071-4079
    • Doerfler, P.1    Forbush, K.A.2    Perlmutter, R.M.3
  • 52
    • 0035942178 scopus 로고    scopus 로고
    • Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation
    • Conte D., Liston P., Wong J.W., Wright K.E., Korneluk R.G. Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation. Proc. Natl. Acad. Sci. U.S.A. 98:2001;5049-5054.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 5049-5054
    • Conte, D.1    Liston, P.2    Wong, J.W.3    Wright, K.E.4    Korneluk, R.G.5
  • 55
    • 0037514517 scopus 로고    scopus 로고
    • A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection
    • Buhlmann J.E., Elkin S.K., Sharpe A.H. A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection. J. Immunol. 170:2003;5421-5428.
    • (2003) J. Immunol. , vol.170 , pp. 5421-5428
    • Buhlmann, J.E.1    Elkin, S.K.2    Sharpe, A.H.3
  • 56
    • 0037148840 scopus 로고    scopus 로고
    • BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    • This study shows that Bim influences thymocyte survival and is upregulated upon TCR ligation of thymocytes.
    • Bouillet P., Purton J.F., Godfrey D.I., Zhang L.-C., Coultas L., Puthalakath H., Pellegrini M., Cory S., Adams J.M., Strasser A. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature. 415:2002;922-926 This study shows that Bim influences thymocyte survival and is upregulated upon TCR ligation of thymocytes.
    • (2002) Nature , vol.415 , pp. 922-926
    • Bouillet, P.1    Purton, J.F.2    Godfrey, D.I.3    Zhang, L.-C.4    Coultas, L.5    Puthalakath, H.6    Pellegrini, M.7    Cory, S.8    Adams, J.M.9    Strasser, A.10
  • 57
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet P., Metcalf D., Huang D.C.S., Tarlinton D.M., Kay T.W.H., Köntgen F., Adams J.M., Strasser A. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science. 286:1999;1735-1738.
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.C.S.3    Tarlinton, D.M.4    Kay, T.W.H.5    Köntgen, F.6    Adams, J.M.7    Strasser, A.8
  • 58
    • 0033746263 scopus 로고    scopus 로고
    • Cell death control in lymphocytes
    • Newton K., Strasser A. Cell death control in lymphocytes. Adv. Immunol. 76:2001;179-226.
    • (2001) Adv. Immunol. , vol.76 , pp. 179-226
    • Newton, K.1    Strasser, A.2
  • 59
    • 0035876483 scopus 로고    scopus 로고
    • BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
    • Zong W.X., Lindsten T., Ross A.J., MacGregor G.R., Thompson C.B. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev. 15:2001;1481-1486.
    • (2001) Genes Dev. , vol.15 , pp. 1481-1486
    • Zong, W.X.1    Lindsten, T.2    Ross, A.J.3    Macgregor, G.R.4    Thompson, C.B.5
  • 60
    • 0034786019 scopus 로고    scopus 로고
    • BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
    • Cheng E.H., Wei M.C., Weiler S., Flavell R.A., Mak T.W., Lindsten T., Korsmeyer S.J. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell. 8:2001;705-711.
    • (2001) Mol. Cell , vol.8 , pp. 705-711
    • Cheng, E.H.1    Wei, M.C.2    Weiler, S.3    Flavell, R.A.4    Mak, T.W.5    Lindsten, T.6    Korsmeyer, S.J.7
  • 61
    • 0036794390 scopus 로고    scopus 로고
    • Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
    • This paper shows that Bak and Bax contribute to thymocyte death.
    • Rathmell J.C., Lindsten T., Zong W.-X., Cinalli R.M., Thompson C.B. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat. Immunol. 3:2002;932-939 This paper shows that Bak and Bax contribute to thymocyte death.
    • (2002) Nat. Immunol. , vol.3 , pp. 932-939
    • Rathmell, J.C.1    Lindsten, T.2    Zong, W.-X.3    Cinalli, R.M.4    Thompson, C.B.5
  • 62
    • 0030449990 scopus 로고    scopus 로고
    • Baxα perturbs T cell development and affects cell cycle entry of T cells
    • Brady H.J.M., Gil-Gomez G., Kirberg J., Berns A.J.M. Baxα perturbs T cell development and affects cell cycle entry of T cells. EMBO J. 15:1996;6991-7001.
    • (1996) EMBO J. , vol.15 , pp. 6991-7001
    • Brady, H.J.M.1    Gil-Gomez, G.2    Kirberg, J.3    Berns, A.J.M.4
  • 67
    • 0033136288 scopus 로고    scopus 로고
    • Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors
    • Pallard C., Stegmann A.P.A., van Kleffens T., Smart F., Venkitaraman A., Spits H. Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity. 10:1999;525-535.
    • (1999) Immunity , vol.10 , pp. 525-535
    • Pallard, C.1    Stegmann, A.P.A.2    Van Kleffens, T.3    Smart, F.4    Venkitaraman, A.5    Spits, H.6
  • 68
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • Karin M., Lin A. NF-κB at the crossroads of life and death. Nat. Immunol. 3:2002;221-227.
    • (2002) Nat. Immunol. , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 69
    • 18344393786 scopus 로고    scopus 로고
    • Peptide-induced negative selection of thymocytes activates transcription of an NF-κB inhibitor
    • These exciting studies show that expression of a newly identified IκB family member is induced upon signals for thymocyte negative selection.
    • Fiorini E., Schmitz I., Marissen W.E., Osborm S.L., Touma M., Sasada T., Reche P.A., Tibaldi E.V., Hussey R.E., Kruisbeek A.M., et al. Peptide-induced negative selection of thymocytes activates transcription of an NF-κB inhibitor. Mol. Cell. 9:2002;637-648 These exciting studies show that expression of a newly identified IκB family member is induced upon signals for thymocyte negative selection.
    • (2002) Mol. Cell , vol.9 , pp. 637-648
    • Fiorini, E.1    Schmitz, I.2    Marissen, W.E.3    Osborm, S.L.4    Touma, M.5    Sasada, T.6    Reche, P.A.7    Tibaldi, E.V.8    Hussey, R.E.9    Kruisbeek, A.M.10
  • 70
    • 0033053791 scopus 로고    scopus 로고
    • A transcriptional regulator Rel is essential for antigen receptor-mediated stimulation of mature T cells but dispensable for positive and negative selection of thymocytes and T cell apoptosis
    • Strasser A., Grumont R.J., Stanley M.L., Gerondakis S. A transcriptional regulator Rel is essential for antigen receptor-mediated stimulation of mature T cells but dispensable for positive and negative selection of thymocytes and T cell apoptosis. Eur. J. Immunol. 29:1999;928-935.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 928-935
    • Strasser, A.1    Grumont, R.J.2    Stanley, M.L.3    Gerondakis, S.4
  • 71
    • 0028817585 scopus 로고
    • Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family
    • Weih F., Carrasco D., Durham S.K., Barton D.S., Rizzo C.A., Rysek R.-P., Lira S.A., Bravo R. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell. 80:1995;331-340.
    • (1995) Cell , vol.80 , pp. 331-340
    • Weih, F.1    Carrasco, D.2    Durham, S.K.3    Barton, D.S.4    Rizzo, C.A.5    Rysek, R.-P.6    Lira, S.A.7    Bravo, R.8
  • 76
    • 0032191837 scopus 로고    scopus 로고
    • Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
    • Sugawara T., Moriguchi T., Nishida E., Takahama Y. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes. Immunity. 9:1998;565-574.
    • (1998) Immunity , vol.9 , pp. 565-574
    • Sugawara, T.1    Moriguchi, T.2    Nishida, E.3    Takahama, Y.4
  • 81
    • 0034720881 scopus 로고    scopus 로고
    • A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity
    • Werlen G., Hausmann B., Palmer E. A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity. Nature. 406:2000;422-426.
    • (2000) Nature , vol.406 , pp. 422-426
    • Werlen, G.1    Hausmann, B.2    Palmer, E.3
  • 82
    • 0035500758 scopus 로고    scopus 로고
    • Duration and strength of extracellular signal-regulated kinase signals are altered during positive versus negative thymocyte selection
    • Mariathasan S., Zakarian A., Bouchard D., Ohashi P.S. Duration and strength of extracellular signal-regulated kinase signals are altered during positive versus negative thymocyte selection. J. Immunol. 167:2001;4966-4973.
    • (2001) J. Immunol. , vol.167 , pp. 4966-4973
    • Mariathasan, S.1    Zakarian, A.2    Bouchard, D.3    Ohashi, P.S.4
  • 83
    • 0033994221 scopus 로고    scopus 로고
    • Degree of ERK activation influences both positive and negative thymocyte selection
    • Mariathasan S., Ho S.S.N., Zakarian A., Ohashi P.S. Degree of ERK activation influences both positive and negative thymocyte selection. Eur. J. Immunol. 30:2000;1060-1068.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1060-1068
    • Mariathasan, S.1    Ho, S.S.N.2    Zakarian, A.3    Ohashi, P.S.4
  • 85
    • 0027976193 scopus 로고
    • Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77
    • Liu Z.-G., Smith S.W., McLaughlin K.A., Schwartz L.M., Osborne B.A. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature. 281:1994;284.
    • (1994) Nature , vol.281 , pp. 284
    • Liu, Z.-G.1    Smith, S.W.2    Mclaughlin, K.A.3    Schwartz, L.M.4    Osborne, B.A.5
  • 86
    • 0028008513 scopus 로고
    • Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas
    • Woronicz J.D., Calnan B., Ngo V., Winoto A. Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature. 367:1994;277-281.
    • (1994) Nature , vol.367 , pp. 277-281
    • Woronicz, J.D.1    Calnan, B.2    Ngo, V.3    Winoto, A.4
  • 87
    • 0028807837 scopus 로고
    • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection
    • Calnan B.J., Szychowski S., Chan F.K.M., Cado D., Winoto A. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity. 3:1995;273-282.
    • (1995) Immunity , vol.3 , pp. 273-282
    • Calnan, B.J.1    Szychowski, S.2    Chan, F.K.M.3    Cado, D.4    Winoto, A.5
  • 88
    • 0029914914 scopus 로고    scopus 로고
    • Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
    • Zhou T., Cheng J., Yang Z., Liu C., Su X., Bluethmann H., Mountz J.D. Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells. J. Exp. Med. 183:1996;1879-1892.
    • (1996) J. Exp. Med. , vol.183 , pp. 1879-1892
    • Zhou, T.1    Cheng, J.2    Yang, Z.3    Liu, C.4    Su, X.5    Bluethmann, H.6    Mountz, J.D.7
  • 89
    • 0037728615 scopus 로고    scopus 로고
    • HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis
    • Dequiedt et al. show here that a histone deacetylase is expressed at the DP stage of thymocyte development, and plays a role in TCR-mediated death.
    • Dequiedt F., Kasler H., Fischle W., Kiermer V., Weinstein M., Herndier B.G., Verdin E. HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity. 18:2003;687-698 Dequiedt, et al. show here that a histone deacetylase is expressed at the DP stage of thymocyte development, and plays a role in TCR-mediated death.
    • (2003) Immunity , vol.18 , pp. 687-698
    • Dequiedt, F.1    Kasler, H.2    Fischle, W.3    Kiermer, V.4    Weinstein, M.5    Herndier, B.G.6    Verdin, E.7
  • 90
    • 0035175577 scopus 로고    scopus 로고
    • A defect in central tolerance in NOD mice
    • Kishimoto H., Sprent J. A defect in central tolerance in NOD mice. Nat. Immunol. 2:2001;1025-1031.
    • (2001) Nat. Immunol. , vol.2 , pp. 1025-1031
    • Kishimoto, H.1    Sprent, J.2
  • 94
    • 0036595050 scopus 로고    scopus 로고
    • T-cell signalling and autoimmunity: Molecular mechanisms of disease
    • Ohashi P.S. T-cell signalling and autoimmunity: molecular mechanisms of disease. Nat. Rev. Immunol. 2:2002;427-438.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 427-438
    • Ohashi, P.S.1
  • 96
    • 0042969051 scopus 로고    scopus 로고
    • Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage
    • Trigueros C., Hozumi K., Silva-Santos B., Bruno L., Hayday A.C., Owen M.J., Pennington D.J. Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage. Eur. J. Immunol. 33:2003;1968-1977.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 1968-1977
    • Trigueros, C.1    Hozumi, K.2    Silva-Santos, B.3    Bruno, L.4    Hayday, A.C.5    Owen, M.J.6    Pennington, D.J.7
  • 97
    • 0042697001 scopus 로고    scopus 로고
    • Efficient T cell receptor-mediated apoptosis in nonobese diabetic mouse thymocytes
    • Villunger A., Marsden V.S., Strasser A. Efficient T cell receptor-mediated apoptosis in nonobese diabetic mouse thymocytes. Nat. Immunol. 4:2003;717.
    • (2003) Nat. Immunol. , vol.4 , pp. 717
    • Villunger, A.1    Marsden, V.S.2    Strasser, A.3


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