Cutting edge: T cell-specific adapter protein inhibits T cell activation by modulating Lck activity

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 2927-2931

  Sundvold, V ^a   Torgersen, K M ^a   Post, N H ^a   Marti, F ^a   King, P D ^a   Rottingen, J A ^a   Spurkland, A ^a   Lea, T ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD3; PHOSPHOTRANSFERASE; PROTEIN; T CELL SPECIFIC ADAPTER PROTEIN; UNCLASSIFIED DRUG; ANTIGEN T CELL RECEPTOR, ZETA CHAIN; CARRIER PROTEIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; ISOENZYME; LAT PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEIN; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; SH2D2A PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SLP 76 SIGNAL TRANSDUCING ADAPTOR PROTEINS; SLP-76 SIGNAL TRANSDUCING ADAPTOR PROTEINS; TYROSINE; ZAP70 PROTEIN, HUMAN;

ARTICLE; CALCIUM MOBILIZATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION; BIOSYNTHESIS; CALCIUM SIGNALING; DOWN REGULATION; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; INTRACELLULAR FLUID; LYMPHOCYTE ACTIVATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROMOTER REGION; SRC HOMOLOGY DOMAIN; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CALCIUM SIGNALING; CARRIER PROTEINS; DOWN-REGULATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; INTRACELLULAR FLUID; ISOENZYMES; JURKAT CELLS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MEMBRANE PROTEINS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES; TRANSFECTION; TYROSINE; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0034664756     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.2927     Document Type: Article

References (35)

1. Signal transduction by lymphocyte antigen receptors
2. Complex complexes: Signaling at the TCR
3. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function
4. A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells
5. GRB2 and phospholipase C-γ1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation
6. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling
7. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
8. T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/ phospholipase C-γl-binding phosphotyrosyl protein pp36/38
9. Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLCγ 1 SH2 domains
10. LAT is required for TCR-mediated activation of PLCγl and the Ras pathway
11. Adaptor proteins in lymphocyte antigen-receptor signaling
12. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line
13. Essential role of LAT in T cell development
14. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cb1-deficient mice
15. The Cb1 proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation
16. The product of the proto-oncogene c-cbl: A negative regulator of the Syk tyrosine kinase
17. A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells
18. 292 negative regulatory phosphorylation site of ZAP-70
19. Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells
20. Molecular cloning of a T cell-specific adapter protein containing an src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites
21. The complete sequences of plasmids pFNeo and pMHNeo: Convenient expression vectors for high level expression of eukaryotic genes in hematopoietic cell lines
22. Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production
23. Signal transmission between the plasma membrane, and the nucleus of T lymphocytes
24. Transcriptional regulation of the IL-2 gene
25. Thapsigargin reveals evidence for fMLP-insensitive calcium pools in human leukocytes
26. Quantitative analysis of cytosolic free calcium oscillations in neutrophils by mathematical modelling
27. 2+ indicators with greatly improved fluorescence properties
28. Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK
29. Uncoupling of nonreceptor tyrosine kinases from PLC-γl in an SLP-76-deficient T cell
30. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76
31. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
32. F2(Pmp)2-TAMζ3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling
33. Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation
34. Activation of p56(lck) through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation
35. Mutational analysis of Lck in CD45-negative T cells: Dominant role of tyrosine 394 phosphorylation in kinase activity