Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase

EMBO Reports

Volumn 4, Issue 4, 2003, Pages 425-431

  Shao, Yuan ^a   Elly, Chris ^a   Liu, Yun Cai ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE; INTEGRIN; RAP PROTEIN; UBIQUITIN PROTEIN LIGASE; CBL PROTEIN; RAP1 PROTEIN; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL CELL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MODIFICATION; ENZYME REGULATION; ENZYME STABILITY; MEMBRANE TRANSPORT; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; THYMOCYTE; UBIQUITINATION;

ANIMALS; CELL ADHESION; CELL LINE; CELLS, CULTURED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GTP-BINDING PROTEINS; HUMANS; LIGASES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ONCOGENE PROTEIN V-CBL; RAP1 GTP-BINDING PROTEINS; RECOMBINANT PROTEINS; RETROVIRIDAE PROTEINS, ONCOGENIC; T-LYMPHOCYTES; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA;

EID: 0037900000     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.embor813     Document Type: Article

References (24)

1. Bachmaier, K. et al. (2000) Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature, 403, 211-216.
2. Bos, J.L. (1998) All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral. EMBO J., 17, 6776-6782.
3. Boussiotis, V.A., Freeman, G.J., Berezovskaya, A., Barber, D.L. & Nadler, L.M. (1997) Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science, 278, 124-128.
4. Carey, K.D. et al. (2000) CD28 and the tyrosine kinase Lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1. Mol. Cell. Biol., 20, 8409-8419.
5. Chiang, S.H. et al. (2001) Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature, 410, 944-948.
6. Deng, L. et al. (2000) Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell, 103, 351-361.
7. Elly, C. et al. (1999) Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Oncogene, 18, 1153-1162.
8. Fang, D. & Liu, Y.-C. (2001) Proteolysis-independent regulation of phosphatidylinositol 3-kinase by Cbl-b-mediated ubiquitylation in T cells. Nature Immunol., 2, 870-875.
9. Genot, E. & Cantrell, D.A. (2000) Ras regulation and function in lymphocytes. Curr. Opin. Immunol., 12, 289-294.
10. Hershko, A. & Ciechanover, A. (1998) The ubiquitin system. Annu. Rev. Biochem., 67, 425-479.
11. Hoppe, T., Matuschewski, K., Rape, M., Schlenker, S., Ulrich, H.D. & Jentsch, S. (2000) Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. Cell, 102, 577-586.
12. Joazeiro, C.A., Wing, S.S., Huang, H., Leverson, J.D., Hunter, T. & Liu, Y.C. (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science, 286, 309-312.
13. Kaiser, P., Flick, K., Wittenberg, C. & Reed, S.I. (2000) Regulation of transcription by ubiquitylation without proteolysis: Cdc34/SCF (Met30)-mediated inactivation of the transcription factor Met4. Cell, 102, 303-314.
14. Knudsen, B.S., Feller, S.M. & Hanafusa, H. (1994) Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk. J. Biol. Chem., 269, 32781-32787.
15. Levkowitz, G. et al. (1999) Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol. Cell, 4, 1029-1040.
16. Liu, Y.-C. & Gu, H. (2002) Cbl and Cbl-b in T-cell regulation. Trends Immunol., 23, 140-143.
17. Murphy, M.A. et al. (1998) Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol. Cell. Biol., 18, 4872-4882.
18. Naramura, M., Kole, H.K., Hu, R.-J. & Gu, H. (1998) Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc. Natl Acad. Sci. USA, 95, 15547-15552.
19. Naramura, M., Jang, I.K., Kole, H., Huang, F, Haines, D. & Gu, H. (2002) c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced-TCR down-modulation. Nature Immunol., 3, 1192-1199.
20. Reedquist, K.A. & Bos, J.L. (1998) Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes. J. Biol. Chem., 273, 4944-4949.
21. Schmitt, J.M. & Stork, P.J. (2002) PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1. Mol. Cell, 9, 85-94.
22. Sebzda, E., Bracke, M., Tugal, T., Hogg, N. & Cantrell, D.A. (2002) Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signalling. Nature Immunol., 3, 251-258.
23. Thien, C.B. & Langdon, W.Y. (2001) Cbl: many adaptations to regulate protein tyrosine kinases. Nature Rev. Mol. Cell Biol., 2, 294-307.
24. Wang, H.Y. et al. (2001) Cbl promotes ubiquitination of the T cell receptor-ζ through an adaptor function of Zap-70. J. Biol. Chem., 276, 26004-26011.