A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase

Journal of Experimental Medicine

Volumn 197, Issue 4, 2003, Pages 503-513

  Thien, Christine B F ^a   Scaife, Robin M ^a   Papadimitriou, John M ^a   Murphy, Maria A ^b   Bowtell, David D L ^b   Langdon, Wallace Y ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

CD3; CD5; Rac; SH2 domain; T cell receptor

Indexed keywords

CBL PROTEIN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CELL PROTEIN; MUTANT PROTEIN; PHOSPHOPROTEIN; PHOSPHOTYROSINE; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; RAC PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME REGULATION; FEMALE; GENE MUTATION; KNOCKOUT MOUSE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, CD5; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BINDING SITES; CAENORHABDITIS ELEGANS PROTEINS; FEMALE; HELMINTH PROTEINS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MUTATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; RAC GTP-BINDING PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ANTIGEN, T-CELL; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES; THYMUS GLAND; UBIQUITIN-PROTEIN LIGASES; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0037450822     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021498     Document Type: Article

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