Transmembrane adapters: Attractants for cytoplasmic effectors

Immunological Reviews

Volumn 191, Issue , 2003, Pages 165-182

  Lindquist, Jonathan A ^a   Simeoni, Luca ^a   Schraven, Burkhart ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; GLYCOSPHINGOLIPID; PROTEIN SIT; PROTEIN TRAP; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

GENE EXPRESSION REGULATION; HUMAN; IMMUNOREGULATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE RECEPTOR GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; HUMANS; IMMEDIATE-EARLY PROTEINS; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; MONOMERIC GTP-BINDING PROTEINS; PHOSPHOPROTEINS; T-LYMPHOCYTES;

EID: 0037306143     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2003.00007.x     Document Type: Review

References (95)

1. Kabouridis PS, Janzen J, Magee AL, Ley SC. Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. Eur J Immunol 2000;30:954-963.
2. Harder T, Simons K. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur J Immunol 1999;29:556-562.
3. Gouy H, Deterre P, Debre P, Bismuth G. Cell calcium signaling via GM1 cell surface gangliosides in the human Jurkat T cell line. J Immunol 1994;152:3271-3281.
4. Webb Y, Hermida-Matsumoto L, Resh MD. Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids. J Biol Chem 2000;275:261-270.
5. Koegl M, Zlatkine P, Ley SC, Courtneidge SA, Magee AL. Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif. Biochem J 1994;303:749-753.
6. Yurchak LK, Sefton BM. Palmitoylation of either Cys-3 or Cys-5 is required for the biological activity of the Lck tyrosine protein kinase. Mol Cell Biol 1995;15:6914-6922.
7. Shenoy-Scaria AM, Dietzen DJ, Kwong J, Link DC, Lublin DM. Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae. J Cell Biol 1994;126:353-363.
8. Rodgers W, Crise B, Rose JK. Signals determining protein tyrosine kinase and glycosylphosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction. Mol Cell Biol 1994;14:5384-5391.
9. Peyron JF, Ferrua B, Fehlmann M. Activation of human T cells is associated with tyrosine phosphorylation of several cellular proteins. Cell Signal 1989;1:313-322.
10. June CH, Fletcher MC, Ledbetter JA, Samelson LE. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J Immunol 1990;144:1591-1599.
11. Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 1998;92:83-92.
12. Weber JR, et al. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adapter protein selectively expressed by T cells and natural killer cells. J Exp Med 1998;187:1157-1161.
13. Facchetti F, et al. Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions. Am J Pathol 1999;154:1037-1046.
14. Sarkar S. Tyrosine phosphorylation and translocation of LAT in platelets. FEBS Lett 1998;441:357-360.
15. Gibbins JM, et al. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin. J Biol Chem 1998;273:34437-34443.
16. Wange RL. LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways. Sci Signal Transduction Knowledge Environment 2000. http://stke.sciencemag.org/cgi/content/full/sigtrans;2000/63/re1.
17. Zhang W, Trible RP, Samelson LE. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 1998;9:239-246.
18. Lin J, Weiss A, Finco TS. Localization of LAT in glycolipid-enriched microdomains is required for T cell activation. J Biol Chem 1999;274:28861-28864.
19. Mege D, Di Bartolo V, Germain V, Tuosto L, Michel F, Acuto O. Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways. J Biol Chem 1996;271:32644-32652.
20. Williams BL, et al. Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol 1998;18:1388-1399.
21. Paz PE, Wang S, Clarke H, Lu X, Stokoe D, Abo A. Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. Biochem J 2001;356:461-471.
22. Sieh M, Batzer A, Schlessinger J, Weiss A. GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol Cell Biol 1994;14:4435-4442.
23. Welsh M, et al. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. Oncogene 1998;16:891-901.
24. Deckert M, Tartare-Deckert S, Hernandez J, Rottapel R, Altman A. Adapter function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation. Immunity 1998;9:595-605.
25. Boerth NJ, Sadler JJ, Bauer DE, Clements JL, Gheith SM, Koretzky GA. Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling. J Exp Med 2000;192:1047-1058.
26. Zhang W, et al. Essential role of LAT in T cell development. Immunity 1999;10:323-332.
27. Zhang W, Trible RP, Zhu M, Liu SK, McGlade CJ, Samelson LE. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. J Biol Chem 2000;275:23355-23361.
28. Lin J, Weiss A. Identification of the minimal tyrosine residues required for linker for activation of T cell function. J Biol Chem 2001;276:29588-29595.
29. Tsuchida M, Manthei ER, Knechtle SJ, Hamawy MM. CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation. Eur J Immunol 1999;29:2354-2359.
30. Perez-Villar JJ, et al. Phosphorylation of the linker for activation of T-cells by itk promotes recruitment of vav. Biochemistry 2002;41:10732-10740.
31. Sommers CL, Menon RK, Grinberg A, Zhang W, Samelson LE, Love PE. Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development. J Exp Med 2001;194:135-142.
32. Aguado E, et al. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 2002;296:2036-2040.
33. Sommers CL, et al. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 2002;296:2040-2043.
34. Kane LP, Hedrick SM. A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection. J Immunol 1996;156:4594-4601.
35. Ranger AM, Oukka M, Rengarajan J, Glimcher LH. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity 1998;9:627-635.
36. Villalba M, Hernandez J, Deckert M, Tanaka Y, Altman A. Vav modulation of the Ras/MEK/ERK signaling pathway plays a role in NFAT activation and CD69 up-regulation. Eur J Immunol 2000;30:1587-1596.
37. Ye ZS, Baltimore D. Binding of Vav to Grb2 through dimerization of Src homology 3 domains. Proc Natl Acad Sci USA 1994;91:12629-12633.
38. Tuosto L, Michel F, Acuto O. p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. J Exp Med 1996;184:1161-1166.
39. Bergman M, et al. The human p50csk tyrosine kinase phosphorylates p561ck at Tyr-505 and down regulates its catalytic activity. EMBO J 1992;11:2919-2924.
40. Okada M, Nada S, Yamanashi Y, Yamamoto T, Nakagawa H. CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J Biol Chem 1991;166:24249-24252.
41. Imamoto A, Soriano P. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell 1993;73:1117-1124.
42. Nada S, et al. Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell 1993;73:1125-1135.
43. Chow LM, Fournel M, Davidson D, Veillette A. Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk. Nature 1993;365:156-160.
44. Schmedt C, Saijo K, Niidome T, Kuhn R, Aizawa S, Tarakhovsky A. Csk controls antigen receptor-mediated development and selection of T-lineage cells. Nature 1998;394:901-904.
45. Schmedt C, Tarakhovsky A. Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk). J Exp Med 2001;193:815-826.
46. Brdicka T, et al. Phosphoprotein associated with glycosphingolipid-enriched micro-domains (PAG), a novel ubiquitously expressed transmembrane adapter protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med 2000;191:1591-1604.
47. Kawabuchi M, et al. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature 2000;404:999-1003.
48. Zeyda M, Staffler G, Horejsi V, Waldhausl W, Stulnig TM. LAT displacement from lipid rafts as molecular mechanism for inhibition of T cell signaling by polyunsaturated fatty acids. J Biol Chem 2002;277:28418-28423.
49. Reth M. Antigen receptor tail clue. Nature 1989;338:383-384.
50. Marie-Cardine A, Kirchgessner H, Schraven B. Molecular alterations of the Fyn-complex occur as late events of human T cell activation. Eur J Immunol 1999b;29:1175-1187.
51. Torgersen KM, et al. Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts. J Biol Chem 2001;276:29313-29318.
52. Cloutier JF, Chow LM, Veillette A. Requirement of the SH3 and SH2 domains for the inhibitory function of tyrosine protein kinase p50csk in T lymphocytes. Mol Cell Biol 1995;15:5937-5944.
53. Yasuda K, et al. Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. J Immunol 2002;169:2813-2817.
54. Itoh K, et al. Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly. J Immunol 2002;168:541-544.
55. Takeuchi S, Takayama Y, Ogawa A, Tamura K, Okada M. Transmembrane phosphoproteni Cbp positively regulates the activity of the carboxyl-terminal Src kinase, Csk. J Biol Chem 2000;275:29183-29186.
56. Ohtake H, Ichikawa N, Okada M, Yamashita T. Cutting edge: transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcepsilonRI. J Immunol 2002;168:2087-2090.
57. Eiseman E, Bolen JB. Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 1992;355:78-80.
58. Yamashita T, Mao SY, Metzger H. Aggregation of the high-affinity IgE receptor and enhanced activity of p53/p56lyn protein-tyrosine kinase. Proc Natl Acad Sci USA 1994;91:11251-11255.
59. Brdickova N, et al. Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. FEBS Lett 2001;507:133-136.
60. Cloutier JF, Veillette A. Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. EMBO J 1996;15:4909-4918.
61. Cloutier JF, Veillette A. Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase. J Exp Med 1999;189:111-121.
62. Gjorloff-Wingren A, Saxena M, Williams S, Hammi D, Mustelin T. Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP. Eur J Immunol 1999;29:3845-3854.
63. Marie-Cardine A, et al. SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. J Exp Med 1999;189:1181-1194.
64. Pfrepper KI, et al. Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). Eur J Immunol 2001;31:1825-1836.
65. Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E. Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT). Immunogenetics 2001;53:337-341.
66. Osborne BA. Transcriptional control of T cell development. Curr Opin Immunol 2000;12:301-306.
67. Izquierdo M, Leevers SJ, Marshall CJ, Cantrell D. p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes. J Exp Med 1993;178:1199-1208.
68. Rayter SI, Woodrow M, Lucas SC, Cantrell DA, Downward J. p21 ras mediates control of IL-2 gene promoter function in T cell activation. EMBO J 1992;11:4549-4556.
69. Nimnual AS, Yatsula BA, Bar-Sagi D. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science 1998;279:560-563.
70. Jacinto E, Werlen G, Karin M. Cooperation between Syk and Rac1 leads to synergistic INK activation in T lymphocytes. Immunity 1998;8:31-41.
71. Genot E, Cleverley S, Hennnig S, Cantrell D. Multiple p21ras effector pathways regulate nuclear factor of activated T cells. EMBO J 1996;15:3923-3933.
72. Gong Q, et al. Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nat Immunol 2001;2:29-36.
73. Cory GO, et al. Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways. J Immunol 1996;157:3791-3795.
74. Ganju RK, Brubaker SA, Chernock RID, Avraham S, Groopman JE. Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. J Biol Chem 2000;275:17263-17268.
75. Poe JC, Fujimoto M, Jansen PJ, Miller AS, Tedder TF. CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. J Biol Chem 2000;275:17420-17427.
76. Vidal M, et al. Differential interactions of the growth factor receptor-bound protein 2 N-SH3 domain with son of sevenless and dynamin. Potential role in the Ras-dependent signaling pathway. J Biol Chem 1998;273:5343-5348.
77. Lemay S, Davidson D, Latour S, Veillette A. Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. Mol Cell Biol 2000;20:2743-2754.
78. Bruyns E, et al. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane. J Exp Med 1998;188:561-575.
79. Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E. Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM). Immunogenetics 2000;51:154-158.
80. Cornelis F, et al. New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. Proc Natl Acad Sci USA 1998;95:10746-10750.
81. Huynh T, Wurch A, Bruyns E, Korinek V, Schraven B, Eichmann K. Developmentally regulated expression of the transmembrane adaptor protein trim in fetal and adult T cells. Scand J Immunol 2001;54:146-154.
82. Kirchgessner H, et al. The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med 2001;193:1269-1284.
83. Klausner RD, Donaldson JG, Lippincott-Schwartz J. Brefeldin A: insights into the control of membrane traffic and organelle structure. J Cell Biol 1992;116:1071-1080.
84. Toker A, Cantley LC. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 1997;387:673-676.
85. Berry D, Nash P, Liu S, Pawson T, McGlade C. A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling. Curr Biol 2002;12:1336-1341.
86. Fu C, Turck CW, Kurosaki T, Chan AC. BLNK: a central linker protein in B cell activation. Immunity 1998;9:93-103.
87. Wienands J, Schweikert J, Wollscheid B, Jumaa H, Nielsen PJ, Reth M. SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. J Exp Med 1998;188:791-795.
88. Jumaa H, Wollscheid B, Mitterer M, Wienands J, Reth M, Nielsen PJ. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity 1999;11:547-554.
89. Kurosaki T, Tsukada S. BLNK: connecting Syk and Btk to calcium signals. Immunity 2000;12:1-5.
90. Ishiai M, Kurosaki M, Inabe K, Chan AC, Sugamura K, Kurosaki T. Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane. J Exp Med 2000;192:847-856.
91. Wong J, Ishiai M, Kurosaki T, Chan AC. Functional complementation of BLNK by SLP-76 and LAT linker proteins. J Biol Chem 2000;275:33116-33122.
92. Brdicka T, et al. Non-T cell activation Linker (NTAL): A transmembrane adaptor protein involved in immunoreceptor signaling. J E.xp Med 2002;196:1617-1626.
93. Engels N, Wollscheid B, Wienands J. Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha. Eur J Immunol 2001;31:2126-2134.
94. Kabak S, et al. The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol Cell Biol 2002;22:2524-2535.
95. Zhu M, Janssen E, Leung K, Zhang W. Molecular cloning of a novel gene encoding a membrane-associated adapter protein (LAX) in lymphocyte signaling. J Biol Chem 2002;277:46151-46158.