p53, apoptosis and axon-guidance molecules

Cell Death and Differentiation

Volumn 12, Issue 8, 2005, Pages 1057-1065

  Arakawa, H ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Apoptosis; Cancer; Netrin 1; p53; Tumor suppressor; UNC5B

Indexed keywords

EPHRIN RECEPTOR B2; NETRIN; NETRIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; PROTEIN P75; RECEPTOR PROTEIN; ROUNDABOUT RECEPTOR; SEMAPHORIN; SEMAPHORIN 3B; SEMAPHORIN 3F; SLIT2 PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; CARCINOGENESIS; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; HUMAN; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; AXONS; HUMANS; NERVE TISSUE PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 23044446171     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401601     Document Type: Review

References (89)

1. Vogelstein B, Lane D and Levine AJ (2000) Surfing the p53 network. Nature 408: 307-310
2. Vousden KH (2002) Live or let die: the cell's response to p53. Nat. Rev. Cancer 2: 594-604
3. Nakamura Y (2004) Isolation of p53-target genes and their functional analysis. Cancer Sci. 95: 7-11
4. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y and Taya Y (2000) p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phophorylated p53. Cell 102: 849-862
5. Vousden KH (2000) p53: Death star. Cell 103: 691-694
6. Yu TW and Bargmann CI (2001) Dynamic regulation of axon guidance. Nat. Neurosci. 4: 1169-1176
7. Bredesen DE, Mehlen P and Rabizaheh S (2004) Apoptosis and dependence receptors: a molecular basis for cellular addiction. Physiol. Rev. 84: 411-430
8. Mehlen P and Bredesen DE (2004) The dependence receptor hypothesis. Apoptosis 9: 37-49
9. Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS and Bredesen DE (1998) The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395: 801-804
10. Llambi F, Causeret F, Bloch-Gallego E and Mehlen P (2001) Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J. 20: 2715-2722
11. Tanikawa C, Matsuda K, Fukuda S, Nakamura Y and Arakawa H (2003) p53RDL1 regulates p53-dependent apoptosis. Nat. Cell Biol. 5: 216-223
12. El-Deiry W, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer W, Kinzler KW and Vogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825
13. Miyashita T and Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human BAX gene. Cell 80: 293-299
14. Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR and Kley N (1995) Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377: 646-649
15. Nishimori H, Shiratsuchi T, Urano T, Kimura Y, Kiyono K, Tatsumi K, Yoshida S, Ono M, Kuwano M, Nakamura Y and Tokino T (1997) A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. Oncogene 15: 2145-2150
16. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B and Fornance AJ (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597
17. Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, Takei Y and Nakamura Y (2000) A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 404: 42-49
18. Barak Y, Juven T, Haffner R and Oren M (1993) Mdm2 expression is induced by wild type p53 activity. EMBO J. 12: 461-468
19. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T and Tanaka N (2000) Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288: 1053-1058
20. Nakano K and Vousden KH (2001) PUMA, a novel pro-apoptotic gene, is induced by p53. Mol. Cell 7: 683-692
21. Yu J, Zhang L, Hwang PM, Kinzler KW and Vogelstein B (2001) PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7: 673-682
22. Moroni MC, Hickman ES, Denchi EL, Caprara G, Colli E, Cecconi F, Muller H and Helin K (2001) Apaf-1 is a key transcriptional target for E2F and p53. Nat. Cell Biol. 3: 552-558
23. Polyak K, Xia Y, Zweier JL, Kinzler KW and Vogelstein B (1997) A model for p53-induced apoptosis. Nature 389: 300-305
24. Donald SP, Sun XY, Hu CA, Yu J, Mei JM, Valle D and Phang JM (2001) Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species. Cancer Res. 61: 1810-1815
25. Yoon KA, Nakamura Y and Arakawa H (2004) Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. J. Hum. Genet. 49: 134-140
26. Hwang PM, Bunz F, Yu J, Rago C, Chan TA, Murphy MP, Kelso GF, Smith RA, Kinzler KW and Vogelstein B (2001) Ferredocin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat. Med. 7: 1111-1117
27. Iiizumi M, Arakawa H, Mori T, Ando A and Nakamura Y (2002) Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex. Cancer Res. 62: 1246-1250
28. Chipuk JE, Kuwano T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M and Green DR (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303: 1010-1014
29. Owen-Schaub LB, Zhang W, Cusack JC, Angelo LS, Santee SM, Fujiwara T, Roth JA, Deisseroth AB, Zhang WW, Kruzel E and Radinsky R (1995) Wild-type human p53 and temperature sensitive mutant induce Fas/APO-1 expression. Mol. Cell. Biol. 15: 3032-3040
30. Wu GS, Bums TF, McDonald III ER, Jiang W, Meng R, Krantz ID, Kao G, Gan DD, Zhou JY, Muschel R, Hamilton SR, Spinner NB, Markowitz S, Wu G and El-Deiry WS (1997) KILLER/DR5 is a DNA damage inducible p53-regulated death receptor gene. Nat. Genet. 17: 141-143
31. Fei P, Bernhard EJ and El-Deiry WS (2002) Tissue-specific induction of p53-targets in vivo. Cancer Res. 62: 7316-7327
32. Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL and Tessier-Lavigne M (1997) Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386: 833-838
33. Tessier-Lavigne M and Goodman CS (1996) The molecular biology of axon guidance. Science 274: 1123-1133
34. Mehlen P and Bredesen DE (2003) Meeting report: cellular dependence - old concept, new mechanisms. Sci. STKE 2003: pe55
35. Williams ME, Strickland P, Watanabe K and Hinck L (2003) UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NARGE. J. Biol. Chem. 278: 17483-17490
36. Hedgecook EM, Culotti JG and Hall DH (1990) The unc-5, unc-6 and unc-40 genes guide circumferential migration of pioneer axons and mesodermal cells on the epidermis of C. elegans. Neuron 2: 61-85
37. Ishii N, Wadsworth WG, Stern BD, Culotti JG and Hedgecook EM (1992) UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9: 873-881
38. Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM and Tessier-Lavigne M (1994) The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78: 409-424
39. Kennedy TE, Serafini T, de la Torre JR and Tessier-Lavigne M (1994) Netrins are diffusible chemotropic factors for commissural axons in the embryonal spinal cord. Cell 78: 425-435
40. Chan SS, Zheng H, Su MW, Wilk R, Killeen MT, Hedgecock EM and Culotti JG (1996) UNC40, a C. elegans homolog of DCC (deleted in colorectal cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87: 187-195
41. Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC and Tessier-Lavigne M (1996) Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87: 1001-1014
42. Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M and Stein E (1999) A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts Netrin-induced growth cone attraction to repulsion. Cell 97: 927-941
43. Wang JJ, Rabizadeh S, Tasinato A, Sperandio S, Ye X, Green M, Assa-Munt N, Spencer D and Bredesen DE. (2000) Dimerization-dependent block of the proapoptotic effect of p75/NTR. J. Neurosci. Res. 60: 587-593
44. Liu J, Yao F, Wu R, Morgan M, Thorburn A, Finley Jr RL and Chen YQ (2002) Mediation of the DCC apoptotic signal by DIP13alpha. J. Biol. Chem. 277: 26281-26285
45. Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA and Testa JR (1999) Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 18: 4891-4898
46. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR and Greenberg ME (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275: 661-665
47. Hemmings BA (1997) Akt signaling: linking membrane events to life and death decisions. Science 275: 628-630
48. Sabbatini P and McCormick F (1999) Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated transcriptional dependent apoptosis. J. Biol. Chem. 274: 24263-24269
49. Yamaguchi A, Tamatani M, Matsuzaki H, Namikawa K, Kiyama H, Vitek MP, Mitsuda N and Tohyama M (2001) Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J. Biol. Chem. 276: 5256-5364
50. Mazelin L, Bernet A, Bonod-Bidaud C, Pays L, Arnaud S, Gespach C, Bredesen DE, Scoazec JY and Mehlen P (2004) Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431: 80-84
51. Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT and Fearon ER (1999) Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Cell Growth Differ. 10: 35-42
52. Latil A, Chene L, Cochant-Priollet B, Mangin P, Fournier G, Berthon P and Cussenot O (2003) Quantification of expression of netrins, slits and their receptors in human prostate tumors. Int. J. Cancer 103: 306-315
53. Kimura T, Takeda S, Sagiya Y, Gotoh M, Nakamura Y and Arakawa H (2003) Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Nat. Genet. 34: 440-445
54. Adimoolam S and Ford JM (2002) p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene. Proc. Natl. Acad. Sci. USA 99: 12985-12990
55. Hwang BJ, Ford JM, Hanawalt PC and Chu G (1999) Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair. Proc. Natl. Acad. Sci. USA 96: 424-428
56. Han HJ, Tokino T and Nakamura Y (1998) CSR, a scavenger receptor-like protein with a protective role against cellular damage caused by UV irradiation and oxidative stress. Hum. Mol. Genet. 7: 1039-1046
57. Vivanco I and Sawyers CL (2002) The phosphatidylinositol 3-kinase-Akt pathway in human cancer. Nat. Rev. Cancer 2: 489-501
58. Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B and Velculescu VE (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554
59. Arakawa H (2004) Netrin-1 and its receptors in tumorigenesis. Nat. Rev. Cancer 4: 978-987
60. Ochi K, Mori T, Toyama Y, Nakamura Y and Arakawa H (2002) Identification of semaphorin3B as a direct target of p53. Neoplasia 4: 82-87
61. Dohn M, Jiang J and Chen X (2001) Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis. Oncogene 20: 6503-6515
62. Sekido Y, Bader S, Latif F, Chen JY, Duh FM, Wei MH, Albanesi JP, Lee CC, Lerman MI and Minna JD (1996) Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. Proc. Natl. Acad. Sci. USA 93: 4120-4125
63. Kuroki T, Trapasso F, Yendamuri S, Matsuyama A, Alder H, Williams NN, Kaiser LR and Croce CM (2003) Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer. Cancer Res. 63: 3352-3355
64. Tomizawa Y, Sekido Y, Kondo M, Gao B, Yokota J, Roche J, Drabkin H, Lerman MI, Gazdar AF and Minna JD (2001) Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B. Proc. Natl. Acad. Sci. USA 98: 13954-13959
65. Tse C, Xiang RH, Bracht T and Naylor SL (2002) Human semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. Cancer Res. 62: 542-546
66. Xiang R, Davalos AR, Hensel CH, Zhou XJ, Tse C and Naylor SL (2002) Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice. Cancer Res. 62: 2637-2643
67. Kessler O, Shraga-Heled N, Lange T, Gutmann-Raviv N, Sabo E, Baruch L, Machluf M and Neufeld G (2004) Semaphorin-3F is an inhibitor of tumor angiogenesis. Cancer Res. 64: 1008-1015
68. Brambilla E, Constantin B, Drabkin H and Roche J (2000) Semaphorin SEMA3F localization in malignant human lung and cell lines: a suggested role in cell adhesion and cell migration. Am. J. Pathol. 156: 939-950
69. Lantuejoul S, Constantin B, Drabkin H, Brambilla C, Roche J and Brambilla E (2003) Expression of VEGF, semaphoring SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumors, and cell lines. J. Pathol. 200: 336-347
70. Dallol A, Morton D, Maher ER and Latif F (2003) SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells. Cancer Res. 63: 1054-1058
71. Dallol A, Da Silva NF, Viacava P, Minna JD, Bieche I, Maher ER and Latif F (2002) SLIT2, a human homologue of the Drosophila slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. Cancer Res. 62: 5874-5880
72. Huebner K (2001) Tumor suppressors on 3p: a neoclassic quartet. Proc. Natl. Acad. Sci. USA 98: 14763-14765
73. Dallol A, Forgacs E, Martinez A, Sekido Y, Walker R, Kishida T, Rabbitts P, Mahler ER, Minna JD and Latif F (2002) Tumour specific promoter region methylation of the human homologue of the Drosophila roundabout gene (ROBO1) in human cancers. Oncogene 21: 3020-3038
74. Sundaresan V, Chung G, Heppell-Parton A, Xiong J, Grundy C, Roberts I, James L, Cahn A, Bench A, Douglas J, Minna J, Sekido Y, Lerman M, Latif F, Bergh J, Li H, Lowe N, Ogilvie D and Rabbitts P (1998) Homozygous deletions at 3p12 in breast and lung cancer. Oncogene 17: 1723-1729
75. Ikegaki N, Tang XX, Liu XG, Biegel JA, Allen C, Yoshioka A, Sulman EP, Brodeur GM and Pleasure DE (1995) Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family. Hum. Mol. Genet. 4: 2033-2045
76. Huusko P, Ponciano-Jackson D, Wolf M, kiefer JA, Azorsa DO, Tuzmen S, Weaver D, Robbins C, Moses T, Allinen M, Hautaniemi S, Chen Y, Elkahloun A, Basik M, Bova GS, Bubendorf L, Lugli A, Sauter G, Schleutker J, Ozcelik H, Elowe S, Pawson T, Trent JM, Carpten JD, Kallioniemi OP and Mousses S (2004) Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat. Genet. 36: 979-983
77. Trusolino L and Comoglio PM (2002) Scatter-factor and semaphoring receptors: cell signaling for invasive growth. Nat. Rev. Cancer 2: 289-299
78. Tamagnone L and Comoglio PM (2004) To move or not to move? EMBO Rep. 5: 356-361
79. Nakada M, Niska JA, Miyamori H, McDonough WS, Wu J, Sato H and Berens ME (2004) The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. Cancer Res. 64: 3179-3185
80. Roush W (1998) Receptor links blood vessels, axons. Science 279: 2042
81. Liu ZJ and Herlyn M (2004) Slit-Robo: neuronal guides signal in tumor angiogenesis. Cancer Cell 4: 1-2
82. Wang B, Xiao Y, Ding BB, Zhang N, Yuan X, Gui L, Qian KX, Duan S, Chen Z, Rao Y and Geng JG (2004) Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell 4: 19-29
83. Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y and Ziv Y (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281: 1674-1677
84. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB and Siliciano JD (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 1677-1679
85. Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ and Mak TW (2000) DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287: 1824-1827
86. Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y and Lu H (2001) A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol. Cell 7: 283-292
87. Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y, Monden M and Nakamura Y (2001) p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol. Cell 8: 85-94
88. Shikama N, Lee CW, France S, Delavaine L, Lyon J, Krstic-Demonacos M and La Thangue NB (1999) A novel cofactor for p300 that regulates the p53 response. Mol. Cell 4: 365-376
89. Samuels-Lev Y, O'Connor DJ, Bergamaschi D, Trigiante G, Hsieh JK, Zhong S, Campargue I, Naumovski L, Crook T and Lu X (2001) ASPP proteins specifically stimulate the apoptotic function of p53. Mol. Cell 8: 781-794