Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools

Nature Genetics

Volumn 34, Issue 4, 2003, Pages 440-445

  Kimura, Takashi ^a,b   Takeda, Satoshi ^c   Sagiya, Yoji ^a   Gotoh, Mitsukazu ^b   Nakamura, Yusuke ^a   Arakawa, Hirofumi ^a,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^c OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^d NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEOTIDE; GENE PRODUCT; PROTEIN P53; PROTEIN P53R2; RIBONUCLEOTIDE REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATTENUATION; CELL IMMORTALIZATION; CONTROLLED STUDY; DISEASE SEVERITY; DNA REPAIR; EMBRYO; EMBRYO CELL; ENZYME SUBUNIT; FIBROBLAST; GENE; GENE INDUCTION; GENETIC TRANSCRIPTION; GROWTH RETARDATION; KIDNEY FAILURE; MORTALITY; MOUSE; MULTIPLE ORGAN FAILURE; NICK END LABELING; NONHUMAN; NULL ALLELE; OXIDATIVE STRESS; PRIORITY JOURNAL; RRM2B GENE; SPONTANEOUS MUTATION;

ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; DEOXYRIBONUCLEOTIDES; DNA REPAIR; FEMALE; GENES, P53; KIDNEY; KIDNEY FAILURE, CHRONIC; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPLE ORGAN FAILURE; MUTATION; OXIDATIVE STRESS; RIBONUCLEOTIDE REDUCTASES;

ANIMALIA;

EID: 0042166135     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1212     Document Type: Article

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