A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1

Molecular Cell

Volumn 7, Issue 2, 2001, Pages 283-292

  Keller, David M ^a   Zeng, Xiaoya ^a   Wang, Yun ^b   Zhang, Qing Hong ^a   Kapoor, Mini ^c   Shu, Hongjun ^b   Goodman, Richard ^a   Lozano, Guillermina ^c   Zhao, Yingming ^b   Lu, Hua ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE II; ELONGATION FACTOR; PROTEIN FACT; PROTEIN HSPT16; PROTEIN P53; PROTEIN SERINE KINASE; PROTEIN SUBUNIT; STRUCTURE SPECIFIC RECOGNITION PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; ENZYME SPECIFICITY; GAMMA IRRADIATION; GENE ACTIVATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; ULTRAVIOLET IRRADIATION;

ANIMALIA; MAMMALIA;

EID: 17744384255     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00176-9     Document Type: Article

References (59)

1. Enhanced phosphorylation of p53 by ATM in response to DNA damage
2. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
3. DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site
4. Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin
5. p53 phosphorylation and association with murine double minute 2, c-Jun NH2-terminal kinase, p14ARF, and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation
6. Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage
7. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
8. 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro
9. Prolonged p53 protein accumulation in trichothiodystrophy fibroblasts dependent on unrepaired pyrimidine dimers on the transcribed strands of cellular genes
10. Initiation inhibition and reinitiation of the synthesis of heterogenous nuclear RNA in living cells
11. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53
12. The complexity of p53 modulation: Emerging patterns from divergent signals
13. Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal
14. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
15. HMG domain proteins: Architectural elements in the assembly of nucleoprotein structures
16. CK2: A protein kinase in need of control
17. Mutation of phosphoserine 389 affects p53 function in vivo
18. Monoclonal antibodies specific for simian virus 40 tumor antigens
19. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
20. p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389
21. Regulation of the specific DNA binding function of p53
22. Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation
23. Participation of p53 protein in the cellular response to DNA damage
24. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
25. The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53
26. Identification of p53 as a sequence-specific DNA-binding protein
27. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells
28. Regulation of p53 in response to DNA damage
29. p53, the cellular gatekeeper for growth and division
30. Quality control by DNA repair
31. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
32. Blockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosis
33. Inhibition of RNA polymerase II as a trigger for the p53 response
34. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
35. Human TAFII31 protein is a transcriptional coactivator of the p53 protein
36. Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
37. The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro
38. Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389
39. The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II
40. MAP kinase pathways activated by stress: The p38 MAPK pathway
41. Introduction: p53 - The first twenty years
42. FACT, a factor that facilitates transcript elongation through nucleosomes
43. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins
44. Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53
45. DNA damage activates p53 through a phosphorylation-acetylation cascade
46. Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase
47. The inhibition by DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells
48. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
49. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
50. Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1
51. Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents
52. Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression
53. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
54. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
55. UV-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle
56. Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription
57. Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53
58. The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis