Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes

Molecular Pharmacology

Volumn 65, Issue 5, 2004, Pages 1302-1312

  Shenoy, Sarita D ^a   Spencer, Thomas A ^b   Mercer Haines, Nancy A ^a   Abdolalipour, Masumeh ^a   Wurster, William L ^a   Runge Morris, Melissa ^a   Kocarek, Thomas A ^a,c  

^a WAYNE STATE UNIVERSITY   (United States)

^b Dartmouth College   (United States)

^c Inst of Environ Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(3,3' BITHIOPHEN 5 YL)METHOXY] N (6,6 DIMETHYL 2 HEPTEN 4 YNYL) N ETHYLBENZYLAMINE; 3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; [4' (6 ALLYLMETHYLAMINOHEXYLOXY) 2' FLUOROPHENYL](4 BROMOPHENYL)METHANONE FUMARATE; BIBX 79; CHOLESTEROL; CYTOCHROME P450 3A; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LANOSTEROL SYNTHASE; MESSENGER RNA; MEVALONIC ACID; N (4 CHLOROBENZOYL) N METHYL(4 DIMETHYLAMINOMETHYLPHENYL)CYCLOHEXYLAMINE; PRAVASTATIN; PREGNANE X RECEPTOR; RO 488071; SQUALENE MONOOXYGENASE; SQUALENE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; ZARAGOZIC ACID A;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; DRUG EFFECT; ENZYME INHIBITION; EXPERIMENTAL MOUSE; EXPERIMENTAL RAT; LIVER CELL; LIVER CELL CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZOPHENONES; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; ENZYME INDUCTION; HEPATOCYTES; INTRAMOLECULAR TRANSFERASES; MALE; MICE; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SQUALENE; TRANSFECTION;

EID: 2142703819     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.5.1302     Document Type: Article

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