Characteristics of the heterologously expressed human lanosterol 14α-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents

Yeast

Volumn 15, Issue 9, 1999, Pages 755-763

  Lamb, David C ^a   Kelly, Diane E ^a   Waterman, Michael R ^b   Stromstedt, Maria ^b   Rozman, Damjana ^c   Kelly, Steven L ^a  

^a ABERYSTWYTH UNIVERSITY   (United Kingdom)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Azole antifungals; Inhibition; Resistance; Sterol demethylase

Indexed keywords

ANTIFUNGAL AGENT; ENZYME; ITRACONAZOLE; KETOCONAZOLE; PYRROLE DERIVATIVE; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

ARTICLE; CANDIDA ALBICANS; DEMETHYLATION; ENZYMATIC ASSAY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME PURIFICATION; HUMAN; NONHUMAN; PRIORITY JOURNAL;

ANTIFUNGAL AGENTS; BINDING SITES; CANDIDA ALBICANS; CARBON MONOXIDE; CYTOCHROME P-450 ENZYME SYSTEM; FORMIC ACIDS; HUMANS; INHIBITORY CONCENTRATION 50; ITRACONAZOLE; KETOCONAZOLE; KINETICS; LIGANDS; OXIDOREDUCTASES; RECOMBINANT PROTEINS; SPECTRUM ANALYSIS; TITRIMETRY;

CANDIDA ALBICANS;

EID: 0033618146     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0061(19990630)15:9<755::AID-YEA417>3.0.CO;2-8     Document Type: Article

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