COX-dependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites

Pharmacology and Therapeutics

Volumn 107, Issue 2, 2005, Pages 139-154

  Burian, Maria ^a   Geisslinger, Gerd ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Antinociceptive effects; Hyperalgesia; NSAIDs

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CYCLOOXYGENASE 2; FLURBIPROFEN; FORMALDEHYDE; FREUND ADJUVANT; IBUPROFEN; INDOMETACIN; KETOROLAC; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PHOSPHOLIPASE A2; PROSTACYCLIN; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROSTANOID; THROMBOXANE A2; ZOMEPIRAC;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; AUTONOMIC NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID ANALYSIS; CLINICAL FEATURE; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REGULATION; HYPERALGESIA; NOCICEPTION; NONHUMAN; PAIN ASSESSMENT; PAIN THRESHOLD; PAW EDEMA; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN INDUCTION; REVIEW; SENSITIZATION; SENSORY NERVE CONDUCTION; TOOTH EXTRACTION; TOOTH PAIN;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CENTRAL NERVOUS SYSTEM; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; MEMBRANE PROTEINS; NOCICEPTORS; PERIPHERAL NERVOUS SYSTEM; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS;

EID: 21344458578     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2005.02.004     Document Type: Review

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