Analgesic dose-response relationship of ibuprofen 50, 100, 200, and 400 mg after surgical removal of third molars: A single-dose, randomized, placebo-controlled, and double-blind study of 304 patients

Journal of Clinical Pharmacology

Volumn 38, Issue 5, 1998, Pages 447-454

  Schou, Søren ^a,b   Nielsen, Henrik ^b   Nattestad, Anders ^a,b   Hillerup, Søren ^c   Ritzau, Martin ^d,e   Branebjerg, Poul Erik ^f   Bugge, Christine ^f   Skoglund, Lasse A ^g  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^d Esbjerg University Hospital   (Denmark)

^e AARHUS UNIVERSITY   (Denmark)

^f Nycomed Denmark   (Denmark)

^g UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO;

ADULT; ANALGESIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENTAL SURGERY; DIARRHEA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED DISEASE; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLAR TOOTH; NAUSEA; ORAL DRUG ADMINISTRATION; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL; TOOTH EXTRACTION; VERTIGO;

EID: 0031966496     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1998.tb04452.x     Document Type: Article

References (23)

1. Cooper SA, Needle SE, Kruger GO: Comparative analgesic potency of aspirin and ibuprofen. J Oral Surg 1977;35:898-903.
2. Winter L, Bass E, Recant B, Cahaly JF: Analgesic activity of ibuprofen (Motrin) in postoperative oral surgical pain. Oral Surg Oral Med Oral Pathol 1978;45:159-166.
3. Shapiro SS, Diem K: The effect of ibuprofen in the treatment of dysmenorrhea. Curr Ther Res 1981;30:327-334.
4. Vogel RI, Gross JI: The effects of nonsteroidal anti-inflammatory analgesics on pain after periodontal surgery. J Am Dent Assoc 1984;109:731-734.
5. Jain AK, Ryan JR, McMahon FG, Kuebel JO, Walters PJ, Noveck C: Analgesic efficacy of low-dose ibuprofen in dental extraction pain. Pharmacotherapy 1986;6:318-322.
6. Forbes JA, Beaver WT, Jones KF, Kehm CJ, Smith WK, Gongloff CM, et al: Effect of caffeine on ibuprofen analgesia in postoperative oral surgery pain. Clin Pharmacol Ther 1991;49:674-684.
7. Hersh EV, Cooper S, Betts N, Wedell D, MacAfee K, Quinn P, et al: Single dose and multidose analgesic study of ibuprofen and meclofenamate sodium after third molar surgery. Oral Surg Oral Med Oral Pathol 1993;76:680-687.
8. Seymour RA, Ward-Booth P, Kelly PJ: Evaluation of different doses of soluble ibuprofen and ibuprofen tablets in postoperative dental pain. Br J Oral Maxillofac Surg 1996;34:110-114.
9. Owens WD, Felts JA, Spitznagel EL Jr: ASA physical status classifications: a study of consistency of ratings. Anesthesiology 1978;49:239-243.
10. Cooper SA, Beaver WT: A model to evaluate mild analgesics in oral surgery outpatients. Clin Pharmacol Ther 1976;20:241-250.
11. Cooper SA, Breen JF, Giuliani RL: The relative efficacy of indoprofen compared with opioid-analgesic combinations. J Oral Surg 1981;39:21-25.
12. Bakshi R, Frenkel G, Dietlein G, Meurer-Witt B, Schneider B, Sinterhauf U: A placebo-controlled comparative evaluation of diclofenac dispersible versus ibuprofen in postoperative pain after third molar surgery. J Clin Pharmacol 1994;34:225-230.
13. Sriwatanakul K, Lasagna L, Cox C: Evaluation of current clinical trial methodology in analgesimetry based on experts' opinions and analysis of several analgesic studies. Clin Pharmacol Ther 1983;34:277-283.
14. Seymour RA, Blair GS, Wyatt FAR: Post-operative dental pain and analgesic efficacy. Br J Oral Surg 1983;21:290-297.
15. Laska EM, Sunshine A, Marrero I, Olson N, Siegel C, McCormick N: The correlation between blood levels of ibuprofen and clinical analgesic response. Clin Pharmacol Ther 1986;40:1-7.
16. Littmann GS, Walker BR, Schneider BE: Reassessment of verbal and visual analog ratings in analgesic studies. Clin Pharmacol Ther 1985;38:16-23.
17. Boström ÅAS, Forbes JA, Adolfsson C, Beaver WT, Bell WE: Evaluation of bromfenac and ibuprofen for pain after orthopedic surgery. Pharmacotherapy 1994;14:305-313.
18. Bloomfield SS, Barden TP, Mitchell J: Comparative efficacy of ibuprofen and aspirin in episiotomy pain. Clin Pharmacol Ther 1974;15:565-570.
19. Mehlisch DR, Sollecito WA, Helfrick JF, Leibold DG, Markowitz R, Schow CE, et al: Multicenter clinical trial of ibuprofen and acetaminophen in the treatment of postoperative dental pain. J Am Dent Assoc 1990;121:257-263.
20. Ahlström U, Bakshi R, Nilsson P, Wåhlander L: The analgesic efficacy of diclofenac dispersible and ibuprofen in postoperative pain after dental extraction. Eur J Clin Pharmacol 1993;44:587-588.
21. Quiding H, Grimstad J, Rusten K, Stubhaug A, Bremnes J, Breivik H: Ibuprofen plus codeine, ibuprofen, and placebo in a single- and multidose cross-over comparison for coxarthrosis pain. Pain 1992;50:303-307.
22. Busson M: Update on ibuprofen (review article). J Int Med Res 1986;14:53-62.
23. Halpern SM, Fitzpatrick R, Volans GN: Ibuprofen toxicity: a review of adverse reactions and overdose. Adverse Drug React Toxicol Rev 1993;12:107-128.