메뉴 건너뛰기




Volumn 353, Issue 9149, 1999, Pages 307-314

COX-2 inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; ETODOLAC; FLURBIPROFEN; IBUPROFEN; MELOXICAM; NABUMETONE; NAPROXEN; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; ROFECOXIB; UNCLASSIFIED DRUG;

EID: 0033031331     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(98)12154-2     Document Type: Review
Times cited : (1100)

References (75)
  • 1
    • 0025005862 scopus 로고
    • The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes
    • Fu JY, Masferrer JL, Seibert K, Raz A, Needlemann P The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem. 265:1990;16737-16740.
    • (1990) J Biol Chem , vol.265 , pp. 16737-16740
    • Fu, J.Y.1    Masferrer, J.L.2    Seibert, K.3    Raz, A.4    Needlemann, P.5
  • 2
    • 0025871150 scopus 로고
    • TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
    • Kujubu DA, Fletcher BS, Varnum BC, Lim RW, Herschman HR TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem. 266:1991;12866-12872.
    • (1991) J Biol Chem , vol.266 , pp. 12866-12872
    • Kujubu, D.A.1    Fletcher, B.S.2    Varnum, B.C.3    Lim, R.W.4    Herschman, H.R.5
  • 3
    • 0028009093 scopus 로고
    • The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1
    • Picot D, Loll PJ, Garavito RM The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature. 367:1994;243-249.
    • (1994) Nature , vol.367 , pp. 243-249
    • Picot, D.1    Loll, P.J.2    Garavito, R.M.3
  • 4
    • 0029911267 scopus 로고    scopus 로고
    • The structure of human cyclooxygenase-2; Conservation and flexibility of the NSAID binding site
    • Luong C, Miller A, Barnett J, Chow J, Ramasha C, Browner MF The structure of human cyclooxygenase-2; conservation and flexibility of the NSAID binding site. Nat Struct Biol. 3:1996;927-933.
    • (1996) Nat Struct Biol , vol.3 , pp. 927-933
    • Luong, C.1    Miller, A.2    Barnett, J.3    Chow, J.4    Ramasha, C.5    Browner, M.F.6
  • 5
    • 0032488630 scopus 로고    scopus 로고
    • Investigation of the binding of isoform-selective inhibitors to prostaglandin endoperoxide synthases using fluorescence spectroscopy
    • Lanzo CA, Beechem JM, Talley J, Marnett LJ Investigation of the binding of isoform-selective inhibitors to prostaglandin endoperoxide synthases using fluorescence spectroscopy. Biochemistry. 37:1998;217-226.
    • (1998) Biochemistry , vol.37 , pp. 217-226
    • Lanzo, C.A.1    Beechem, J.M.2    Talley, J.3    Marnett, L.J.4
  • 6
    • 0029899186 scopus 로고    scopus 로고
    • A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors
    • Gierse J, McDonald J, Hauser S, Rangwala S, Seibert K A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J Biol Chem. 271:1996;15810-15814.
    • (1996) J Biol Chem , vol.271 , pp. 15810-15814
    • Gierse, J.1    McDonald, J.2    Hauser, S.3    Rangwala, S.4    Seibert, K.5
  • 8
    • 0025160887 scopus 로고
    • Anti-inflammatory and safety profile of DuP697, a novel orally effective prostaglandin synthesis inhibiton
    • Gans KR, Galbraith W, Roman RJet al. Anti-inflammatory and safety profile of DuP697, a novel orally effective prostaglandin synthesis inhibiton. J Pharmacol Exp Ther. 254:1990;180-207.
    • (1990) J Pharmacol Exp Ther , vol.254 , pp. 180-207
    • Gans, K.R.1    Galbraith, W.2    Roman, R.J.3
  • 9
    • 0002008747 scopus 로고    scopus 로고
    • Differential inhibition of COX-1 and COX-2 by NSAIDs: A summary of results obtained using various test systems
    • In: Vane J, Botting J, eds. Dordrecht: Kluwer Academic Publishers
    • Pairet M, Van Ryn J, Mauz A, et al. Differential inhibition of COX-1 and COX-2 by NSAIDs: a summary of results obtained using various test systems. In: Vane J, Botting J, eds. Selective COX-2 inhibitors: pharmacology, clinical effects and therapeutic potential. Dordrecht: Kluwer Academic Publishers, 1997; 3: 27-46.
    • (1997) Selective COX-2 Inhibitors: Pharmacology, Clinical Effects and Therapeutic Potential , vol.3 , pp. 27-46
    • Pairet, M.1    Van Ryn, J.2    Mauz, A.3
  • 10
    • 0000016609 scopus 로고    scopus 로고
    • COX-1 expression in human gastric mucosa infected with Helicobacter pylori: Constitutive or induced?
    • Jackson LM, Wu K, Mahida YRet al. COX-1 expression in human gastric mucosa infected with Helicobacter pylori: constitutive or induced? Gastroenterology. 114:1998;A160.
    • (1998) Gastroenterology , vol.114 , pp. 160
    • Jackson, L.M.1    Wu, K.2    Mahida, Y.R.3
  • 12
    • 0031456454 scopus 로고    scopus 로고
    • Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs
    • Patrignani P, Panara MR, Sciulli MG, Santini G, Renda G, Patrono C Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs. J Physiol Pharmacol. 48:1997;623-631.
    • (1997) J Physiol Pharmacol , vol.48 , pp. 623-631
    • Patrignani, P.1    Panara, M.R.2    Sciulli, M.G.3    Santini, G.4    Renda, G.5    Patrono, C.6
  • 13
    • 0030876026 scopus 로고    scopus 로고
    • A double-blind, randomized trial to compare meloxicam 15 mg with diclofenac 100 mg in the treatment of osteoarthritis of the knee
    • Goeithe HS, Lund B, Distel MR, Bluhmki E A double-blind, randomized trial to compare meloxicam 15 mg with diclofenac 100 mg in the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage. 15:1997;283-288.
    • (1997) Osteoarthritis Cartilage , vol.15 , pp. 283-288
    • Goeithe, H.S.1    Lund, B.2    Distel, M.R.3    Bluhmki, E.4
  • 14
    • 0029870734 scopus 로고    scopus 로고
    • A double-blind study to compare the efficacy and safety of meloxicam 15 mg with piroxicam 20 mg in patients with osteoarthritis of the hip
    • Linden B, Distel M, Bluhmki E. A double-blind study to compare the efficacy and safety of meloxicam 15 mg with piroxicam 20 mg in patients with osteoarthritis of the hip. Br J Rheumatol 1996; 35 (suppl 1): 35-38.
    • (1996) Br J Rheumatol , vol.35 , Issue.1 SUPPL , pp. 35-38
    • Linden, B.1    Distel, M.2    Bluhmki, E.3
  • 15
    • 0029868836 scopus 로고    scopus 로고
    • Meloxicam in osteoarthritis: A six months, double-blind comparison with diclofenac sodium
    • Hosie J, Distel M, Bluhmki E. Meloxicam in osteoarthritis: a six months, double-blind comparison with diclofenac sodium. Br J Rheumatol 1996; 35 (suppl 1): 39-43.
    • (1996) Br J Rheumatol , vol.35 , Issue.1 SUPPL , pp. 39-43
    • Hosie, J.1    Distel, M.2    Bluhmki, E.3
  • 16
    • 0030899926 scopus 로고    scopus 로고
    • Efficacy and tolerability of meloxicam versus piroxicam in patients with osteoarthritis of the hip or knee: A six-month double-blind study
    • Hosie J, Distel M, Bluhmki E Efficacy and tolerability of meloxicam versus piroxicam in patients with osteoarthritis of the hip or knee: a six-month double-blind study. Clin Drug Invest. 13:1997;175-184.
    • (1997) Clin Drug Invest , vol.13 , pp. 175-184
    • Hosie, J.1    Distel, M.2    Bluhmki, E.3
  • 17
    • 0029865433 scopus 로고    scopus 로고
    • A six months double-blind trial to compare the efficacy and safety of meloxicam 7·5 mg daily and naproxen 750 mg daily in patients with rheumatoid arthritis
    • Wojtulewski JA, Schattenkirchner M, Barcelo P, et al. A six months double-blind trial to compare the efficacy and safety of meloxicam 7·5 mg daily and naproxen 750 mg daily in patients with rheumatoid arthritis. Br J Rheumatol 1996; 35 (suppl 1): 22-28.
    • (1996) Br J Rheumatol , vol.35 , Issue.1 SUPPL , pp. 22-28
    • Wojtulewski, J.A.1    Schattenkirchner, M.2    Barcelo, P.3
  • 18
    • 0029866403 scopus 로고    scopus 로고
    • A four-week, double-blind, parallel-group study to compare the gastrointestinal effects of meloxicam 7·5 mg, meloxicam 15 mg, piroxicam 20 mg and placebo by means of faecal blood loss, endoxcopy and symptoms evaluation in healthy volunteer
    • Patoia I, Santucci I, Furno Pet al. A four-week, double-blind, parallel-group study to compare the gastrointestinal effects of meloxicam 7·5 mg, meloxicam 15 mg, piroxicam 20 mg and placebo by means of faecal blood loss, endoxcopy and symptoms evaluation in healthy volunteer. Br J Rheumatol. 35:1996;61-67.
    • (1996) Br J Rheumatol , vol.35 , pp. 61-67
    • Patoia, I.1    Santucci, I.2    Furno, P.3
  • 19
    • 0029979358 scopus 로고    scopus 로고
    • Global analysis of safety of a new NSAID, meloxicam
    • Distel M, Mueller C, Bluhmki E, et al. Global analysis of safety of a new NSAID, meloxicam. Br J Rheumatol 1996; 35 (suppl 1): 68-77.
    • (1996) Br J Rheumatol , vol.35 , Issue.1 SUPPL , pp. 68-77
    • Distel, M.1    Mueller, C.2    Bluhmki, E.3
  • 20
    • 0031685519 scopus 로고    scopus 로고
    • Gastrointestinal tolerabability of the COX-2 inhibitor, meloxicam, in osteoarthritis patients: The meloxicam large scale internatinal study safety assessment (MELISSA)
    • Hawkey C, Kahan A, Steinbruck Ket al. Gastrointestinal tolerabability of the COX-2 inhibitor, meloxicam, in osteoarthritis patients: the meloxicam large scale internatinal study safety assessment (MELISSA). Br J Rheumatol. 37:1998;937-945.
    • (1998) Br J Rheumatol , vol.37 , pp. 937-945
    • Hawkey, C.1    Kahan, A.2    Steinbruck, K.3
  • 21
    • 0031696493 scopus 로고    scopus 로고
    • Improvement in gastrointestinal tolerabilityof the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: Results of the safety and efficacy large-scale evaluation of COX-inhibiting therapies (SELECT) trial in osteoarthritis
    • Dequeker J, Hawkey C, Kahan Aet al. Improvement in gastrointestinal tolerabilityof the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: results of the safety and efficacy large-scale evaluation of COX-inhibiting therapies (SELECT) trial in osteoarthritis. Br J Rheumatol. 37:1998;946-951.
    • (1998) Br J Rheumatol , vol.37 , pp. 946-951
    • Dequeker, J.1    Hawkey, C.2    Kahan, A.3
  • 22
    • 0028122558 scopus 로고
    • Nimesulide: An update on its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy
    • Davis R, Brogden RN Nimesulide: an update on its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 48:1994;431-454.
    • (1994) Drugs , vol.48 , pp. 431-454
    • Davis, R.1    Brogden, R.N.2
  • 23
    • 0028846183 scopus 로고
    • Activity of nimesulide on constitutive and inducible cyclooxygenases
    • Tavares IA, Bishai PM, Bennett A Activity of nimesulide on constitutive and inducible cyclooxygenases. Arzneimittelforschung. 45:1995;1093-1095.
    • (1995) Arzneimittelforschung , vol.45 , pp. 1093-1095
    • Tavares, I.A.1    Bishai, P.M.2    Bennett, A.3
  • 24
    • 0002656782 scopus 로고    scopus 로고
    • Risk of hospitalisation for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs
    • Garcia Rodriguez LA, Cattaruzzi C, Troncon MG, Agostinis L Risk of hospitalisation for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs. Arch Intern Med. 158:1998;33-39.
    • (1998) Arch Intern Med , vol.158 , pp. 33-39
    • Garcia Rodriguez, L.A.1    Cattaruzzi, C.2    Troncon, M.G.3    Agostinis, L.4
  • 25
    • 0029088821 scopus 로고
    • Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1
    • Glaser K, Sung ML, O'Neill Ket al. Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1. Eur J Pharmacol. 281:1995;107-111.
    • (1995) Eur J Pharmacol , vol.281 , pp. 107-111
    • Glaser, K.1    Sung, M.L.2    O'Neill, K.3
  • 26
    • 0029145880 scopus 로고
    • NSAIDs, COX-2 inhibitors, and the gut
    • Hallyar J, Bjarnason I NSAIDs, COX-2 inhibitors, and the gut. Lancet. 346:1995;521-522.
    • (1995) Lancet , vol.346 , pp. 521-522
    • Hallyar, J.1    Bjarnason, I.2
  • 28
    • 85030353261 scopus 로고    scopus 로고
    • Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2
    • in press
    • Brooks P, Emery P, Evans J, et al Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2. Br J Rheumatol (in press).
    • Br J Rheumatol
    • Brooks, P.1    Emery, P.2    Evans, J.3
  • 29
    • 13444266910 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-y]benzenesulfonamide (SC-58635, celecoxib)
    • Penning TD, Talley JJ, Bertenshaw SRet al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-y]benzenesulfonamide (SC-58635, celecoxib). J Med Chem. 40:1997;1347-1365.
    • (1997) J Med Chem , vol.40 , pp. 1347-1365
    • Penning, T.D.1    Talley, J.J.2    Bertenshaw, S.R.3
  • 31
    • 0030787861 scopus 로고    scopus 로고
    • Outcome of specific COX-2 inhibition in rheumatoid arthritis
    • Lipsky PE, Isakson PC Outcome of specific COX-2 inhibition in rheumatoid arthritis. J Rheumatol. 24:1997;9-14.
    • (1997) J Rheumatol , vol.24 , pp. 9-14
    • Lipsky, P.E.1    Isakson, P.C.2
  • 32
    • 0001793772 scopus 로고    scopus 로고
    • A study of the platelet effects of SC-58635, a novel COX-2-selective inhibitor
    • Mengle-Gaw L, Hubbard RC, Karim A, et al. A study of the platelet effects of SC-58635, a novel COX-2-selective inhibitor. Arthritis Rheum 1997; 40 (suppl 9): S93.
    • (1997) Arthritis Rheum , vol.40 , Issue.9 SUPPL
    • Mengle-Gaw, L.1    Hubbard, R.C.2    Karim, A.3
  • 34
    • 33646124789 scopus 로고    scopus 로고
    • SC-58635, a highly selective inhibitor of COX-2, is an effective analgesic in an acute post surgical pain model
    • ANOTHER NAME
    • Hubbard RC, Mehlisch DR, ANOTHER NAME, et al. SC-58635, a highly selective inhibitor of COX-2, is an effective analgesic in an acute post surgical pain model. J Invest Med 1996; 44: 293A.
    • (1996) J Invest Med , vol.44
    • Hubbard, R.C.1    Mehlisch, D.R.2
  • 35
    • 33748975407 scopus 로고    scopus 로고
    • Analgesic efficacy and plasma levels of a highly selective inhibitor of COX-2 (SC-58635; SC) in patients with post-surgical dental pain
    • Mehlisch DR, Hubbard RCet al. Analgesic efficacy and plasma levels of a highly selective inhibitor of COX-2 (SC-58635; SC) in patients with post-surgical dental pain. Clin Pharmacol Ther. 61:1997;195.
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 195
    • Mehlisch, D.R.1    Hubbard, R.C.2
  • 36
    • 0031680203 scopus 로고    scopus 로고
    • Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor
    • Simon LS, Lanza FLet al. Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor. Arthritis Rheum. 41:1998;1591-1602.
    • (1998) Arthritis Rheum , vol.41 , pp. 1591-1602
    • Simon, L.S.1    Lanza, F.L.2
  • 37
    • 0001114183 scopus 로고    scopus 로고
    • Efficacy, tolerability, and safety of celecoxib, a specific COX-2 inhibitor, in osteoarthritis
    • Hubbard RC, Geiss GS, Woods EM, Yu JS, Zhao W. Efficacy, tolerability, and safety of celecoxib, a specific COX-2 inhibitor, in osteoarthritis. Rheumatol Eur 1998; 27 (suppl 1): 118.
    • (1998) Rheumatol Eur , vol.27 , Issue.1 SUPPL , pp. 118
    • Hubbard, R.C.1    Geiss, G.S.2    Woods, E.M.3    Yu, J.S.4    Zhao, W.5
  • 38
    • 0001114183 scopus 로고    scopus 로고
    • Safety and efficacy of celecoxib, a specific COX-2 inhibitor
    • Geiss GS, Hubbard RC, Callison DA, Yu S, Zhao W. Safety and efficacy of celecoxib, a specific COX-2 inhibitor. Rheumatol Eur 1998; 27 (suppl 1): 118.
    • (1998) Rheumatol Eur , vol.27 , Issue.1 SUPPL , pp. 118
    • Geiss, G.S.1    Hubbard, R.C.2    Callison, D.A.3    Yu, S.4    Zhao, W.5
  • 39
    • 0001114183 scopus 로고    scopus 로고
    • Endoscopic and tolerability, results from a study of celecoxib, a specific COX-2 inhibitor, in patients with rheumatoid arthritis
    • Geiss GS, Stead H, Morant SV, Nandin R, Hubbard RC. Endoscopic and tolerability, results from a study of celecoxib, a specific COX-2 inhibitor, in patients with rheumatoid arthritis. Rheumatol Eur 1998; 27 (suppl 1): 118.
    • (1998) Rheumatol Eur , vol.27 , Issue.1 SUPPL , pp. 118
    • Geiss, G.S.1    Stead, H.2    Morant, S.V.3    Nandin, R.4    Hubbard, R.C.5
  • 40
    • 0000204747 scopus 로고    scopus 로고
    • Effect of celecoxib, a novel COX-2 inhibitor, on health-related quality of life of patients with osteoarthritis of the knee
    • Zhao SZ, Hatoum HT, Hubbard ACet al. Effect of celecoxib, a novel COX-2 inhibitor, on health-related quality of life of patients with osteoarthritis of the knee. Arthritis Rheum. 40:1997;S88.
    • (1997) Arthritis Rheum , vol.40 , pp. 88
    • Zhao, S.Z.1    Hatoum, H.T.2    Hubbard, A.C.3
  • 41
    • 0000036055 scopus 로고    scopus 로고
    • A pilot endoscopic study of the gastroduodenal effects of SC-58635, a novel COX-2-selective inhibitor
    • Lanza FL, Rack MF, Callison DA, et al. A pilot endoscopic study of the gastroduodenal effects of SC-58635, a novel COX-2-selective inhibitor. Gastroenterology 1997; 112 (suppl 4): A194.
    • (1997) Gastroenterology , vol.112 , Issue.4 SUPPL
    • Lanza, F.L.1    Rack, M.F.2    Callison, D.A.3
  • 42
    • 0006731970 scopus 로고    scopus 로고
    • Inhibition of the cyclooxygenase-2 isoform by rofecoxib is sufficient for analgesic efficacy in the dental pain model
    • in press
    • Ehrich EW, Dallob A, De Lepeleire I, et al. Inhibition of the cyclooxygenase-2 isoform by rofecoxib is sufficient for analgesic efficacy in the dental pain model Clin Pharm Ther (in press).
    • Clin Pharm Ther
    • Ehrich, E.W.1    Dallob, A.2    De Lepeleire, I.3
  • 43
    • 0001230668 scopus 로고    scopus 로고
    • Demonstration of specific COX-2 inhibition by MK966 (Vioxx) in humans with supratherapeutic doses
    • Depre M, Ehrich E, DeLepeleire I, et al. Demonstration of specific COX-2 inhibition by MK966 (Vioxx) in humans with supratherapeutic doses. Rheumatol Eur 1998; 27 (suppl 1).
    • (1998) Rheumatol Eur , vol.27 , Issue.1 SUPPL
    • Depre, M.1    Ehrich, E.2    DeLepeleire, I.3
  • 44
    • 0001867832 scopus 로고    scopus 로고
    • Efficacy of MK-966, a highly selective inhibitor of COX-2, in the treatment of postoperative dental pain
    • Ehrich E, Mehlisch D, Perkins S, et al. Efficacy of MK-966, a highly selective inhibitor of COX-2, in the treatment of postoperative dental pain. Arthritis Rheum 1996; 39 (suppl 9): S81.
    • (1996) Arthritis Rheum , vol.39 , Issue.9 SUPPL
    • Ehrich, E.1    Mehlisch, D.2    Perkins, S.3
  • 45
    • 0000598098 scopus 로고    scopus 로고
    • Ex vivo assay of COX-2 inhibition predicts analgesic efficacy in post-surgical dental pain with MK-966
    • Mehlisch DR, Mills S, Sandler Met al. Ex vivo assay of COX-2 inhibition predicts analgesic efficacy in post-surgical dental pain with MK-966. Clin Pharmacol Ther. 63:1998;139.
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 139
    • Mehlisch, D.R.1    Mills, S.2    Sandler, M.3
  • 46
    • 0000010956 scopus 로고    scopus 로고
    • Antipyretic activity of a selective cyclooxygenase (COX)-2 inhibitor, MK-0966
    • Schwartz J, Mukhopadhyay S, McBride Ket al. Antipyretic activity of a selective cyclooxygenase (COX)-2 inhibitor, MK-0966. Clin Pharmacol Ther. 63:1998;167.
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 167
    • Schwartz, J.1    Mukhopadhyay, S.2    McBride, K.3
  • 47
    • 0000750985 scopus 로고    scopus 로고
    • MK-966, a highly selective COX-2 inhibitor, was effective in the treatment of osteoarthritis (OA) of the knee and hip in a six-week placebo controlled study
    • Ehrich E, Schnitzer T, Kivitz A, et al. MK-966, a highly selective COX-2 inhibitor, was effective in the treatment of osteoarthritis (OA) of the knee and hip in a six-week placebo controlled study. Arthritis Rheum 1997; 40 (suppl 9): S85.
    • (1997) Arthritis Rheum , vol.40 , Issue.9 SUPPL
    • Ehrich, E.1    Schnitzer, T.2    Kivitz, A.3
  • 48
    • 0001305554 scopus 로고    scopus 로고
    • MK-0966, a specific COX-2 inhibitor, has clinical efficacy comparable to ibuprofen in the treatment of knee and hip osteoarthritis (OA) in a six-week controlled clinical trial
    • Saag K, Fisher C, McKay J, et al. MK-0966, a specific COX-2 inhibitor, has clinical efficacy comparable to ibuprofen in the treatment of knee and hip osteoarthritis (OA) in a six-week controlled clinical trial. Arthritis Rheum 1998; 41 (suppl 9): S84.
    • (1998) Arthritis Rheum , vol.41 , Issue.9 SUPPL
    • Saag, K.1    Fisher, C.2    McKay, J.3
  • 49
    • 0001305554 scopus 로고    scopus 로고
    • MK-0966, a specific COX-2 inhibitor, has clinical efficacy comparable to diclofenac in the treatment of knee and hip osteoarthritis (OA) in a 26-week controlled clinical trial
    • Cannon G, Caldwell J, Holt P, et al. MK-0966, a specific COX-2 inhibitor, has clinical efficacy comparable to diclofenac in the treatment of knee and hip osteoarthritis (OA) in a 26-week controlled clinical trial. Arthritis Rheum 1998; 41 (suppl 9): S83.
    • (1998) Arthritis Rheum , vol.41 , Issue.9 SUPPL
    • Cannon, G.1    Caldwell, J.2    Holt, P.3
  • 51
    • 0000036055 scopus 로고    scopus 로고
    • Selective inhibition of cyclooxygenase-2 (COX-2) with MK-0966 (250 mg qd) is associated with less gastroduodenal damage than aspirin (ASA) 650 mg qid or ibuprofen (IBU) 800 mg tid
    • Lanza F, Simon T, Quan Het al. Selective inhibition of cyclooxygenase-2 (COX-2) with MK-0966 (250 mg qd) is associated with less gastroduodenal damage than aspirin (ASA) 650 mg qid or ibuprofen (IBU) 800 mg tid. Gastroenterology. 112:1997;A194.
    • (1997) Gastroenterology , vol.112 , pp. 194
    • Lanza, F.1    Simon, T.2    Quan, H.3
  • 52
    • 0013654553 scopus 로고    scopus 로고
    • Effects of a novel cyclooxygenase (COX)-2 inhibitor on gastric mucosal prostaglandin (PG) synthesis in healthy humans
    • Cryer B, Gottesdiener MD, Gertz B, Hsieh P, Dallob A, Feldman M Effects of a novel cyclooxygenase (COX)-2 inhibitor on gastric mucosal prostaglandin (PG) synthesis in healthy humans. Am J Gastroenterol. 93:1998;A104.
    • (1998) Am J Gastroenterol , vol.93 , pp. 104
    • Cryer, B.1    Gottesdiener, M.D.2    Gertz, B.3    Hsieh, P.4    Dallob, A.5    Feldman, M.6
  • 53
    • 0000402103 scopus 로고    scopus 로고
    • COX-2 specific inhibition with MK-0966 or 50 mg qd over 4 weeks does not increase fecal blood loss: A controlled study with placebo and ibuprofen 800 mg tid
    • Hunt R, Bowen B, James Cet al. COX-2 specific inhibition with MK-0966 or 50 mg qd over 4 weeks does not increase fecal blood loss: a controlled study with placebo and ibuprofen 800 mg tid. Am J Gastroenterol. 93:1998;A247.
    • (1998) Am J Gastroenterol , vol.93 , pp. 247
    • Hunt, R.1    Bowen, B.2    James, C.3
  • 54
    • 0000402105 scopus 로고    scopus 로고
    • COX-2 specific inhibition with MK-0966 25 or 50 mg qd does not increase intestinal permeability: A controlled study with placebo and indomethacin 50 mg tid
    • Bjarnason I, Sigthorssen G, Crane Ret al. COX-2 specific inhibition with MK-0966 25 or 50 mg qd does not increase intestinal permeability: a controlled study with placebo and indomethacin 50 mg tid. Am J Gastroenterol. 93:1998;A246.
    • (1998) Am J Gastroenterol , vol.93 , pp. 246
    • Bjarnason, I.1    Sigthorssen, G.2    Crane, R.3
  • 55
    • 85030351273 scopus 로고    scopus 로고
    • Clinical trials of COX-2 inhibitors
    • In: Vane J, ed. London: William Harvey Press
    • Smolen J. Clinical trials of COX-2 inhibitors. In: Vane J, ed. The promise of specific COX-2 inhibition by novel agents. London: William Harvey Press 1998: 21.
    • (1998) The Promise of Specific COX-2 Inhibition by Novel Agents , pp. 21
    • Smolen, J.1
  • 56
    • 0005216311 scopus 로고    scopus 로고
    • A new class of potent, orally active and selective COX-2 inhibitor-preclinical pharmacology
    • Chan CC, Boyce S, Brideau C, et al. A new class of potent, orally active and selective COX-2 inhibitor-preclinical pharmacology. Inflamm Res 1997; 46 (suppl 3): S242.
    • (1997) Inflamm Res , vol.46 , Issue.3 SUPPL
    • Chan, C.C.1    Boyce, S.2    Brideau, C.3
  • 57
    • 0031113915 scopus 로고    scopus 로고
    • Review article: COX-II inhibitors - A new generation of safer NSAIDs?
    • Donnelly MT, Hawkey CJ Review article: COX-II inhibitors - a new generation of safer NSAIDs? Aliment Pharmacol Ther. 11:1997;227-236.
    • (1997) Aliment Pharmacol Ther , vol.11 , pp. 227-236
    • Donnelly, M.T.1    Hawkey, C.J.2
  • 58
    • 0032006784 scopus 로고    scopus 로고
    • Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis
    • Kawamori T, Rao CV Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res. 58:1998;409-412.
    • (1998) Cancer Res , vol.58 , pp. 409-412
    • Kawamori, T.1    Rao, C.V.2
  • 59
    • 85030353059 scopus 로고    scopus 로고
    • Cyclooxygenase 2 expression is increased in frontal cortex of Alzheimer's disease brain
    • in press
    • Pasinette GM, Aisen PS. Cyclooxygenase 2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience (in press).
    • Neuroscience
    • Pasinette, G.M.1    Aisen, P.S.2
  • 60
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • McGeer PL, Schulzer M, McGeer EG Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology. 47:1996;425-432.
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 62
    • 0031052116 scopus 로고    scopus 로고
    • Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
    • Mizuno H, Sakamoto C, Matsuda K Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology. 112:1997;387-397.
    • (1997) Gastroenterology , vol.112 , pp. 387-397
    • Mizuno, H.1    Sakamoto, C.2    Matsuda, K.3
  • 63
    • 0031884213 scopus 로고    scopus 로고
    • Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats
    • Schmassmann A, Peskar BM, Stettler Cet al. Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. Br J Pharmacol. 123:1998;795-804.
    • (1998) Br J Pharmacol , vol.123 , pp. 795-804
    • Schmassmann, A.1    Peskar, B.M.2    Stettler, C.3
  • 64
    • 0032510378 scopus 로고    scopus 로고
    • A comparison of omeprazole and misoprostol for treating and preventing ulcers associated with non-steroidal anti-inflammatory drugs
    • Hawkey CJ, Jeffrey AK, Szczepanski Let al. A comparison of omeprazole and misoprostol for treating and preventing ulcers associated with non-steroidal anti-inflammatory drugs. N Engl J Med. 338:1998;727-734.
    • (1998) N Engl J Med , vol.338 , pp. 727-734
    • Hawkey, C.J.1    Jeffrey, A.K.2    Szczepanski, L.3
  • 65
    • 0032510315 scopus 로고    scopus 로고
    • A comparison of omeprazole and ranitidine for treating and preventing ulcers associated with non-steroidal anti-inflammatory drugs
    • Yeomans ND, Tulassay Z, Juhasz Let al. A comparison of omeprazole and ranitidine for treating and preventing ulcers associated with non-steroidal anti-inflammatory drugs. N Engl J Med. 338:1998;719-726.
    • (1998) N Engl J Med , vol.338 , pp. 719-726
    • Yeomans, N.D.1    Tulassay, Z.2    Juhasz, L.3
  • 66
    • 0028034970 scopus 로고
    • Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction
    • Harris RC, McKanna JA, Akai Y, Jacobson HR, Dubois RN, Breyer MD Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest. 94:1994;2504-2510.
    • (1994) J Clin Invest , vol.94 , pp. 2504-2510
    • Harris, R.C.1    McKanna, J.A.2    Akai, Y.3    Jacobson, H.R.4    Dubois, R.N.5    Breyer, M.D.6
  • 67
    • 0027973091 scopus 로고
    • Effects of some naturally occurring prostanoids and some cyclooxygenase inhibitors on the contraction of the human uterine segment in vivo
    • Crankshaw, DJ, Dyal R. Effects of some naturally occurring prostanoids and some cyclooxygenase inhibitors on the contraction of the human uterine segment in vivo. Can J Physiol Pharmacol 1994; 870-74.
    • (1994) Can J Physiol Pharmacol , pp. 870-874
    • Crankshaw, D.J.1    Dyal, R.2
  • 68
    • 0031034814 scopus 로고    scopus 로고
    • Hypoxia induces cyclooxygenase-2 via the NF-KappaB pbs transcription facts in human vascular endothelial cells
    • Schmedtje JF Jr., Ji YS, Liu WL, DuBois RN, Runge MJ Hypoxia induces cyclooxygenase-2 via the NF-KappaB pbs transcription facts in human vascular endothelial cells. J Biol Chem. 272:1997;601-608.
    • (1997) J Biol Chem , vol.272 , pp. 601-608
    • Schmedtje J.F., Jr.1    Ji, Y.S.2    Liu, W.L.3    Dubois, R.N.4    Runge, M.J.5
  • 69
    • 0031749806 scopus 로고    scopus 로고
    • Cyclooxygenase-1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
    • Wallace JL, Bak A, McKnight W, Asfaha S, Sharka KA, MacNaughton WK Cyclooxygenase-1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity. Gastroenterology. 115:1998;101-109.
    • (1998) Gastroenterology , vol.115 , pp. 101-109
    • Wallace, J.L.1    Bak, A.2    McKnight, W.3    Asfaha, S.4    Sharka, K.A.5    MacNaughton, W.K.6
  • 71
    • 0001508538 scopus 로고    scopus 로고
    • Nitric oxide donating flurbiprofen (HCT 1026) causes less endoscopic damage in healthy volunteers than flurbiprofen
    • Donnelly MT, Stack WA, Courtauld EM, Garlick N, Del Soldato P, Hawkey CJ Nitric oxide donating flurbiprofen (HCT 1026) causes less endoscopic damage in healthy volunteers than flurbiprofen. Gastroenterology. 114:1998;A107.
    • (1998) Gastroenterology , vol.114 , pp. 107
    • Donnelly, M.T.1    Stack, W.A.2    Courtauld, E.M.3    Garlick, N.4    Del Soldato, P.5    Hawkey, C.J.6
  • 73
    • 0029100370 scopus 로고
    • A nitirc oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats
    • Elliott SN, McKnight W, Cirino G, Wallace JL A nitirc oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology. 109:1995;524-530.
    • (1995) Gastroenterology , vol.109 , pp. 524-530
    • Elliott, S.N.1    McKnight, W.2    Cirino, G.3    Wallace, J.L.4
  • 74
    • 0000421812 scopus 로고    scopus 로고
    • NSAIDs and CagA positive H pylori but not CagA negative H pylori as independent risk factors for bleeding peptic ulcers
    • Stack WA, Hawkey GM, Atherton JCet al. NSAIDs and CagA positive H pylori but not CagA negative H pylori as independent risk factors for bleeding peptic ulcers. Gastroenterology. 114:1998;A294.
    • (1998) Gastroenterology , vol.114 , pp. 294
    • Stack, W.A.1    Hawkey, G.M.2    Atherton, J.C.3
  • 75
    • 0029162250 scopus 로고
    • Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs: A randomized, double-blind, placebo-controlled trial
    • Silverstein FE, Graham DY, Senior JRet al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 123:1995;241-249.
    • (1995) Ann Intern Med , vol.123 , pp. 241-249
    • Silverstein, F.E.1    Graham, D.Y.2    Senior, J.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.