Involvement of Na+ channels in pain pathways

Trends in Pharmacological Sciences

Volumn 22, Issue 1, 2001, Pages 27-31

  Baker, M D ^a   Wood, J N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; HALOTHANE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SODIUM ION; TETRODOTOXIN;

ACTION POTENTIAL; ANALGESIA; BIODIVERSITY; CHANNEL GATING; DRUG TARGETING; EXCITABILITY; HUMAN; INFLAMMATION; KNOCKOUT GENE; MEMBRANE DEPOLARIZATION; NERVE FIBER TRANSECTION; NERVE INJURY; NONHUMAN; PAIN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SENSORY NERVE; SPINAL GANGLION;

ACTION POTENTIALS; ANESTHETICS, INHALATION; ANESTHETICS, LOCAL; ANIMALS; HALOTHANE; HUMANS; NEURONS, AFFERENT; PAIN; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 0035151069     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01585-6     Document Type: Review

References (42)

1. Ionic currents in the somatic membrane of rat dorsal root ganglion neurons. I. Sodium currents
2. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons
3. Three types of sodium channels in adult rat dorsal root ganglion neurons
4. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia
5. Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia
6. Spinal sensory neurons express multiple sodium channel α-subunit mRNAs
7. Sodium channels and pain
8. Cellular and molecular biology of sodium channel β-subunits: Therapeutic implications for pain?
9. Cloning, localization, and functional expression of sodium channel β1A subunits
10. β3: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics
11. Functional analysis of the mouse Scn8a sodium channel
12. Sodium channel β-subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell - Cell contact
13. Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones
14. Electrophysiological properties of neurons in intact rat dorsal root ganglia classified by conduction velocity and action potential duration
15. A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties
16. Chimeric study of sodium channels from rat skeletal and cardiac muscle
17. A tetrodotoxin-resistant sodium channel expressed by C-fibre-associated sensory neurons
18. A single serine residue confers tetrodotoxin insensitivity on the rat sensory-neuron-specific sodium channel SNS
19. + current components
20. A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia
21. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
22. + channel in rat dorsal root ganglion neurons and their blockade by halothane
23. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down regulated after axotomy
24. A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild type small primary sensory neurons
25. + currents by lidocaine and bupivacaine reduce firing frequency in DRG neurons
26. Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction
27. Mechanisms of action of lidocaine and quinidine on action potential duration in rabbit cardiac Purkinje-fibers - An effect on steady-state sodium currents
28. + current by local anaesthetics in rat large sensory neurones
29. Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea
30. Electrophysiological evidence for tetrodotoxin-resistant sodium channels in slowly conducting dural sensory fibers
31. Distribution of the tetrodotoxin resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions
32. Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro
33. + current in nociceptors
34. PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat DRG neurones via the cAMP-protein kinase A cascade
35. cAMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS
36. Novel classes of responsive and unresponsive C nociceptors in human skin
37. Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model
38. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy
39. Potent analgesic effects of GDNF in neuropathic pain states
40. II-deficient mice
41. α-SNS produces the slow TTX-resistant sodium current in large cutaneous afferent DRG neurons
42. v2/NaG channel is involved in control of salt-intake behavior in the CNS