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Volumn 80, Issue 7, 2005, Pages 947-958

The JAK2V617F tyrosine kinase mutation in myeloproliferative disorders: Status report and immediate implications for disease classification and diagnosis

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; JANUS KINASE 2; PROTEIN TYROSINE KINASE; STAT PROTEIN; JAK2 PROTEIN, HUMAN; ONCOPROTEIN; PHENYLALANINE; VALINE;

EID: 21344444103     PISSN: 00256196     EISSN: None     Source Type: Journal    
DOI: 10.4065/80.7.947     Document Type: Article
Times cited : (114)

References (176)
  • 1
    • 0001639195 scopus 로고
    • Some speculations on the myeloproliferative syndromes
    • Dameshek W. Some speculations on the myeloproliferative syndromes. Blood. 1951;6:372-375.
    • (1951) Blood , vol.6 , pp. 372-375
    • Dameshek, W.1
  • 2
    • 0028069002 scopus 로고
    • The chronic myeloid leukaemias: Guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia: Proposals by the French-American-British Cooperative Leukaemia Group
    • Bennett JM, Catovsky D, Daniel MT, et al. The chronic myeloid leukaemias: guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia: proposals by the French-American-British Cooperative Leukaemia Group. Br J Haematol. 1994;87:746-754.
    • (1994) Br J Haematol , vol.87 , pp. 746-754
    • Bennett, J.M.1    Catovsky, D.2    Daniel, M.T.3
  • 3
    • 0036786901 scopus 로고    scopus 로고
    • The World Health Organization (WHO) classification of the myeloid neoplasms
    • Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002;100:2292-2302.
    • (2002) Blood , vol.100 , pp. 2292-2302
    • Vardiman, J.W.1    Harris, N.L.2    Brunning, R.D.3
  • 4
    • 0038798485 scopus 로고    scopus 로고
    • Chronic basophilic leukemia: A distinict clinico-pathologic entity?
    • Pardanani AD, Morice WG, Hoyer JD, Tefferi A. Chronic basophilic leukemia: a distinict clinico-pathologic entity? Eur J Haematol. 2003;71:18-22.
    • (2003) Eur J Haematol , vol.71 , pp. 18-22
    • Pardanani, A.D.1    Morice, W.G.2    Hoyer, J.D.3    Tefferi, A.4
  • 5
    • 84900349377 scopus 로고    scopus 로고
    • Classification of myeloproliferative disorders: From Dameshek towards a semi-molecular system
    • In press
    • Tefferi A, Gilliland DG. Classification of myeloproliferative disorders: from Dameshek towards a semi-molecular system. Best Pract Res Clin Haematol. In press.
    • Best Pract Res Clin Haematol
    • Tefferi, A.1    Gilliland, D.G.2
  • 6
    • 0026075627 scopus 로고
    • Clonality in myeloproliferative disorders: Analysis by means of the polymerase chain reaction
    • Gilliland DG, Blanchard KL, Levy J, Perrin S, Bunn HF. Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction. Proc Natl Acad Sci USA. 1991;88:6848-6852.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 6848-6852
    • Gilliland, D.G.1    Blanchard, K.L.2    Levy, J.3    Perrin, S.4    Bunn, H.F.5
  • 8
    • 0015918608 scopus 로고
    • Clonal origin of chronic myelocytic leukemia
    • Barr RD, Fialkow PJ. Clonal origin of chronic myelocytic leukemia. N Engl J Med. 1973;289:307-309.
    • (1973) N Engl J Med , vol.289 , pp. 307-309
    • Barr, R.D.1    Fialkow, P.J.2
  • 10
    • 0017653321 scopus 로고
    • Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage
    • Fialkow PJ, Jacobson RJ, Papayannopoulou T. Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med. 1977;63:125-130.
    • (1977) Am J Med , vol.63 , pp. 125-130
    • Fialkow, P.J.1    Jacobson, R.J.2    Papayannopoulou, T.3
  • 11
    • 0018079901 scopus 로고
    • Chronic myelocytic leukemia: Origin of some lymphocytes from leukemic stem cells
    • Fialkow PJ, Denman AM, Jacobson RJ, Lowenthal MN. Chronic myelocytic leukemia: origin of some lymphocytes from leukemic stem cells. J Clin Invest. 1978;62:815-823.
    • (1978) J Clin Invest , vol.62 , pp. 815-823
    • Fialkow, P.J.1    Denman, A.M.2    Jacobson, R.J.3    Lowenthal, M.N.4
  • 12
    • 0017812507 scopus 로고
    • Agnogenic myeloid metaplasia: A clonal proliferation of hematopoietic stem cells with secondary myelofibrosis
    • Jacobson RJ, Salo A, Fialkow PJ. Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis. Blood. 1978;51:189-194.
    • (1978) Blood , vol.51 , pp. 189-194
    • Jacobson, R.J.1    Salo, A.2    Fialkow, P.J.3
  • 14
    • 0019818299 scopus 로고
    • Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell
    • Fialkow PJ, Faguet GB, Jacobson RJ, Vaidya K, Murphy S. Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood. 1981;58:916-919.
    • (1981) Blood , vol.58 , pp. 916-919
    • Fialkow, P.J.1    Faguet, G.B.2    Jacobson, R.J.3    Vaidya, K.4    Murphy, S.5
  • 15
    • 0037372287 scopus 로고    scopus 로고
    • Both B and T lymphocytes may be clonally involved in myelofibrosis with myeloid metaplasia
    • Reeder TL, Bailey RJ, Dewald GW, Tefferi A. Both B and T lymphocytes may be clonally involved in myelofibrosis with myeloid metaplasia. Blood. 2003;101:1981-1983.
    • (2003) Blood , vol.101 , pp. 1981-1983
    • Reeder, T.L.1    Bailey, R.J.2    Dewald, G.W.3    Tefferi, A.4
  • 16
    • 17344366356 scopus 로고    scopus 로고
    • Molecular genetics of human leukemia
    • Gilliland DG. Molecular genetics of human leukemia. Leukemia. 1998;12(suppl 1:S7-S12.
    • (1998) Leukemia , vol.12 , Issue.SUPPL. 1
    • Gilliland, D.G.1
  • 17
    • 72849159485 scopus 로고
    • Chromosome studies on normal and leukemic human leukocytes
    • Nowell PC, Hungerford DA. Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst. 1960;25:85-109.
    • (1960) J Natl Cancer Inst , vol.25 , pp. 85-109
    • Nowell, P.C.1    Hungerford, D.A.2
  • 18
    • 0020333906 scopus 로고
    • A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
    • de Klein A, van Kessel AG, Grosveld G, et al. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982;300:765-767.
    • (1982) Nature , vol.300 , pp. 765-767
    • Klein, A.1    Van Kessel, A.G.2    Grosveld, G.3
  • 19
    • 0021346853 scopus 로고
    • Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
    • Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell. 1984;36:93-99.
    • (1984) Cell , vol.36 , pp. 93-99
    • Groffen, J.1    Stephenson, J.R.2    Heisterkamp, N.3    De Klein, A.4    Bartram, C.R.5    Grosveld, G.6
  • 20
    • 0021811764 scopus 로고
    • Structural organization of the bcr gene and its role in the Ph′ translocation
    • Heisterkamp N, Stam K, Groffen J, de Klein A, Grosveld G. Structural organization of the bcr gene and its role in the Ph′ translocation. Nature. 1985; 315:758-761.
    • (1985) Nature , vol.315 , pp. 758-761
    • Heisterkamp, N.1    Stam, K.2    Groffen, J.3    De Klein, A.4    Grosveld, G.5
  • 21
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
    • Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science. 1990;247:1079-1082.
    • (1990) Science , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3    Witte, O.N.4
  • 22
    • 0025187837 scopus 로고
    • Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ ABL [published correction appears in Proc Natl Acad Sci USA. 1990;87:9072]
    • Kelliher MA, McLaughlin J, Witte ON, Rosenberg N. Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ ABL [published correction appears in Proc Natl Acad Sci USA. 1990;87:9072]. Proc Natl Acad Sci USA. 1990;87:6649-6653.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6649-6653
    • Kelliher, M.A.1    McLaughlin, J.2    Witte, O.N.3    Rosenberg, N.4
  • 23
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science. 1990;247:824-830.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 24
    • 0025766195 scopus 로고
    • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner
    • Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON. BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell. 1991;66:161-171.
    • (1991) Cell , vol.66 , pp. 161-171
    • Pendergast, A.M.1    Muller, A.J.2    Havlik, M.H.3    Maru, Y.4    Witte, O.N.5
  • 25
    • 0029669975 scopus 로고    scopus 로고
    • The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ ABL and p210BCR/ABL to the phosphatidylinositol- 3′ kinase pathway
    • Sattler M, Salgia R, Okuda K, et al. The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ ABL and p210BCR/ABL to the phosphatidylinositol-3′ kinase pathway. Oncogene. 1996;12:839-846.
    • (1996) Oncogene , vol.12 , pp. 839-846
    • Sattler, M.1    Salgia, R.2    Okuda, K.3
  • 26
    • 0023410428 scopus 로고
    • In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome
    • McLaughlin J, Chianese E, Witte ON. In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome. Proc Natl Acad Sci USA. 1987;84:6558-6562.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6558-6562
    • McLaughlin, J.1    Chianese, E.2    Witte, O.N.3
  • 28
    • 0344987881 scopus 로고    scopus 로고
    • A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
    • Cools J, DeAngelo DJ, Gotlib J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 2003;348:1201-1214.
    • (2003) N Engl J Med , vol.348 , pp. 1201-1214
    • Cools, J.1    Deangelo, D.J.2    Gotlib, J.3
  • 29
    • 8644263305 scopus 로고    scopus 로고
    • FIP1L1-PDGFRA fusion: Prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia
    • Pardanani A, Brockman SR, Paternoster SF, et al. FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia. Blood. 2004;104:3038-3045.
    • (2004) Blood , vol.104 , pp. 3038-3045
    • Pardanani, A.1    Brockman, S.R.2    Paternoster, S.F.3
  • 30
    • 0027359443 scopus 로고
    • Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
    • Furitsu T, Tsujimura T, Tono T, et al. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest. 1993; 92:1736-1744.
    • (1993) J Clin Invest , vol.92 , pp. 1736-1744
    • Furitsu, T.1    Tsujimura, T.2    Tono, T.3
  • 31
    • 0032456567 scopus 로고    scopus 로고
    • Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: A possible explanation for divergent clinical behavior
    • Buttner C, Henz BM, Welker P, Sepp NT, Grabbe J. Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: a possible explanation for divergent clinical behavior. J Invest Dermatol. 1998;111:1227-1231.
    • (1998) J Invest Dermatol , vol.111 , pp. 1227-1231
    • Buttner, C.1    Henz, B.M.2    Welker, P.3    Sepp, N.T.4    Grabbe, J.5
  • 32
    • 0028856070 scopus 로고
    • Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder
    • Nagata H, Worobec AS, Oh CK, et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci USA. 1995;92:10560-10564.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10560-10564
    • Nagata, H.1    Worobec, A.S.2    Oh, C.K.3
  • 33
    • 0038204191 scopus 로고    scopus 로고
    • Flt-3 and c-kit mutation studies in a spectrum of chronic myeloid disorders including systemic mast cell disease
    • Pardanani A, Reeder TL, Kimlinger TK, et al. Flt-3 and c-kit mutation studies in a spectrum of chronic myeloid disorders including systemic mast cell disease. Leuk Res. 2003;27:739-742.
    • (2003) Leuk Res , vol.27 , pp. 739-742
    • Pardanani, A.1    Reeder, T.L.2    Kimlinger, T.K.3
  • 34
    • 13044305857 scopus 로고    scopus 로고
    • Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis
    • Longley BJ Jr, Metcalfe DD, Tharp M, et al. Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis. Proc Natl Acad Sci USA. 1999;96:1609-1614.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1609-1614
    • Longley Jr., B.J.1    Metcalfe, D.D.2    Tharp, M.3
  • 35
    • 0028224348 scopus 로고
    • Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
    • Golub TR, Barker GF, Lovett M, Gilliland DG. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell. 1994;77:307-316.
    • (1994) Cell , vol.77 , pp. 307-316
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3    Gilliland, D.G.4
  • 36
    • 0031864246 scopus 로고    scopus 로고
    • Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor β receptor (PDGFβR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2)
    • Ross TS, Bernard OA, Berger R, Gilliland DG. Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor β receptor (PDGFβR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2). Blood. 1998;91:4419-4426.
    • (1998) Blood , vol.91 , pp. 4419-4426
    • Ross, T.S.1    Bernard, O.A.2    Berger, R.3    Gilliland, D.G.4
  • 37
    • 0035889128 scopus 로고    scopus 로고
    • Rabaptin-5 is a novel fusion partner to platelet-derived growth factor β receptor in chronic myelomonocytic leukemia
    • Magnusson MK, Meade KE, Brown KE, et al. Rabaptin-5 is a novel fusion partner to platelet-derived growth factor β receptor in chronic myelomonocytic leukemia. Blood. 2001;98:2518-2525.
    • (2001) Blood , vol.98 , pp. 2518-2525
    • Magnusson, M.K.1    Meade, K.E.2    Brown, K.E.3
  • 38
    • 18344404198 scopus 로고    scopus 로고
    • Fusion of H4/D10S170 to the platelet-derived growth factor receptor beta in BCR-ABL-negative myeloproliferative disorders with a t(5;10)(q33;q21)
    • Kulkarni S, Heath C, Parker S, et al. Fusion of H4/D10S170 to the platelet-derived growth factor receptor beta in BCR-ABL-negative myeloproliferative disorders with a t(5;10)(q33;q21). Cancer Res. 2000;60:3592-3598.
    • (2000) Cancer Res , vol.60 , pp. 3592-3598
    • Kulkarni, S.1    Heath, C.2    Parker, S.3
  • 39
    • 0035877975 scopus 로고    scopus 로고
    • H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor β gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22)
    • Schwaller J, Anastasiadou E, Cain D, et al. H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor β gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22). Blood. 2001;97:3910-3918.
    • (2001) Blood , vol.97 , pp. 3910-3918
    • Schwaller, J.1    Anastasiadou, E.2    Cain, D.3
  • 40
    • 0344826038 scopus 로고    scopus 로고
    • Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: Involvement of PDGFRB and response to imatinib
    • Wilkinson K, Velloso ER, Lopes LF, et al. Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. Blood. 2003;102:4187-4190.
    • (2003) Blood , vol.102 , pp. 4187-4190
    • Wilkinson, K.1    Velloso, E.R.2    Lopes, L.F.3
  • 41
    • 0030669455 scopus 로고    scopus 로고
    • Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution
    • Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. Blood. 1997;90:4271-4277.
    • (1997) Blood , vol.90 , pp. 4271-4277
    • Abe, A.1    Emi, N.2    Tanimoto, M.3    Terasaki, H.4    Marunouchi, T.5    Saito, H.6
  • 42
    • 0036202529 scopus 로고    scopus 로고
    • Myeloproliferative disorders with translocations of chromosome 5q31-35: Role of the platelet-derived growth factor receptor beta
    • Steer EJ, Cross NC. Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor beta. Acta Haematol. 2002;107:113-122.
    • (2002) Acta Haematol , vol.107 , pp. 113-122
    • Steer, E.J.1    Cross, N.C.2
  • 43
    • 0346186282 scopus 로고    scopus 로고
    • Novel translocations that disrupt the platelet-derived growth factor receptor beta (PDGFRB) gene in BCR-ABL-negative chronic myeloproliferative disorders
    • Baxter EJ, Kulkarni S, Vizmanos JL, et al. Novel translocations that disrupt the platelet-derived growth factor receptor beta (PDGFRB) gene in BCR-ABL-negative chronic myeloproliferative disorders. Br J Haematol. 2003;120:251-256.
    • (2003) Br J Haematol , vol.120 , pp. 251-256
    • Baxter, E.J.1    Kulkarni, S.2    Vizmanos, J.L.3
  • 44
    • 18344395028 scopus 로고    scopus 로고
    • Chronic eosinophilic leukaemia presenting with erythroderma, mild eosinophilia and hyper-IgE: Clinical, immunological and cytogenetic features and therapeutic approach: A case report
    • Granjo E, Lima M, Lopes JM, et al. Chronic eosinophilic leukaemia presenting with erythroderma, mild eosinophilia and hyper-IgE: clinical, immunological and cytogenetic features and therapeutic approach: a case report. Acta Haematol. 2002;107:108-112.
    • (2002) Acta Haematol , vol.107 , pp. 108-112
    • Granjo, E.1    Lima, M.2    Lopes, J.M.3
  • 45
    • 0037103624 scopus 로고    scopus 로고
    • Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
    • Apperley JF, Gardembas M, Melo JV, et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N Engl J Med. 2002; 347:481-487.
    • (2002) N Engl J Med , vol.347 , pp. 481-487
    • Apperley, J.F.1    Gardembas, M.2    Melo, J.V.3
  • 46
    • 0036098784 scopus 로고    scopus 로고
    • Receptor tyrosine kinase mutations in myeloid neoplasms
    • Gupta R, Knight CL, Bain BJ. Receptor tyrosine kinase mutations in myeloid neoplasms. Br J Haematol. 2002;117:489-508.
    • (2002) Br J Haematol , vol.117 , pp. 489-508
    • Gupta, R.1    Knight, C.L.2    Bain, B.J.3
  • 47
    • 5644271514 scopus 로고    scopus 로고
    • p53-binding protein 1 is fused to the platelet-derived growth factor receptor β in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder
    • Grand FH, Burgstaller S, Kuhr T, et al. p53-Binding protein 1 is fused to the platelet-derived growth factor receptor β in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder. Cancer Res. 2004;64:7216-7219.
    • (2004) Cancer Res , vol.64 , pp. 7216-7219
    • Grand, F.H.1    Burgstaller, S.2    Kuhr, T.3
  • 48
    • 0035159831 scopus 로고    scopus 로고
    • Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: The first fusion gene involving BCR but not ABL
    • Fioretos T, Panagopoulos I, Lassen C, et al. Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL. Genes Chromosomes Cancer. 2001;32:302-310.
    • (2001) Genes Chromosomes Cancer , vol.32 , pp. 302-310
    • Fioretos, T.1    Panagopoulos, I.2    Lassen, C.3
  • 49
    • 0037216062 scopus 로고    scopus 로고
    • Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3)
    • Guasch G, Popovici C, Mugneret F, et al. Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3). Blood. 2003;101:286-288.
    • (2003) Blood , vol.101 , pp. 286-288
    • Guasch, G.1    Popovici, C.2    Mugneret, F.3
  • 50
    • 84905515146 scopus 로고    scopus 로고
    • Identification of four new translocations involving FGFR1 in myeloid disorders
    • Sohal J, Chase A, Mould S, et al. Identification of four new translocations involving FGFR1 in myeloid disorders. Genes Chromosomes Cancer. 2001;32:155-163.
    • (2001) Genes Chromosomes Cancer , vol.32 , pp. 155-163
    • Sohal, J.1    Chase, A.2    Mould, S.3
  • 51
    • 0030797764 scopus 로고    scopus 로고
    • Molecular characterization of the t(8;13)(p11;q12) translocation associated with an atypical myeloproliferative disorder: Evidence for three discrete loci involved in myeloid leukemias on 8p11
    • Still IH, Chernova O, Hurd D, Stone RM, Cowell JK. Molecular characterization of the t(8;13)(p11;q12) translocation associated with an atypical myeloproliferative disorder: evidence for three discrete loci involved in myeloid leukemias on 8p11. Blood. 1997;90:3136-3141.
    • (1997) Blood , vol.90 , pp. 3136-3141
    • Still, I.H.1    Chernova, O.2    Hurd, D.3    Stone, R.M.4    Cowell, J.K.5
  • 52
    • 17344373285 scopus 로고    scopus 로고
    • FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome
    • Xiao S, Nalabolu SR, Aster JC, et al. FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. Nat Genet. 1998;18:84-87.
    • (1998) Nat Genet , vol.18 , pp. 84-87
    • Xiao, S.1    Nalabolu, S.R.2    Aster, J.C.3
  • 54
    • 14444277275 scopus 로고    scopus 로고
    • T(6;8), t(8;9) and t(8;13) translocations associated with stem cell myeloproliferative disorders have close or identical breakpoints in chromosome region 8p11-12
    • Chaffanet M, Popovici C, Leroux D, et al. t(6;8), t(8;9) and t(8;13) translocations associated with stem cell myeloproliferative disorders have close or identical breakpoints in chromosome region 8p11-12. Oncogene. 1998;16:945-949.
    • (1998) Oncogene , vol.16 , pp. 945-949
    • Chaffanet, M.1    Popovici, C.2    Leroux, D.3
  • 55
    • 6844255886 scopus 로고    scopus 로고
    • The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP
    • Smedley D, Hamoudi R, Clark J, et al. The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP. Hum Mol Genet. 1998;7:637-642.
    • (1998) Hum Mol Genet , vol.7 , pp. 637-642
    • Smedley, D.1    Hamoudi, R.2    Clark, J.3
  • 56
    • 0032510791 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)
    • Popovici C, Adelaide J, Ollendorff V, et al. Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13). Proc Natl Acad Sci USA. 1998;95:5712-5717.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5712-5717
    • Popovici, C.1    Adelaide, J.2    Ollendorff, V.3
  • 57
    • 0032170974 scopus 로고    scopus 로고
    • Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome
    • Reiter A, Sohal J, Kulkarni S, et al. Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome. Blood. 1998;92:1735-1742.
    • (1998) Blood , vol.92 , pp. 1735-1742
    • Reiter, A.1    Sohal, J.2    Kulkarni, S.3
  • 58
    • 0032910745 scopus 로고    scopus 로고
    • The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome
    • Kulkarni S, Reiter A, Smedley D, Goldman JM, Cross NC. The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome. Genomics. 1999;55:118-121.
    • (1999) Genomics , vol.55 , pp. 118-121
    • Kulkarni, S.1    Reiter, A.2    Smedley, D.3    Goldman, J.M.4    Cross, N.C.5
  • 59
    • 0037093259 scopus 로고    scopus 로고
    • NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15) [published correction appears in Blood. 2002;100:1132]
    • Rosati R, La Starza R, Veronese A, et al. NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15) [published correction appears in Blood. 2002;100:1132]. Blood. 2002;99:3857-3860.
    • (2002) Blood , vol.99 , pp. 3857-3860
    • Rosati, R.1    La Starza, R.2    Veronese, A.3
  • 60
    • 0029010203 scopus 로고
    • Myeloproliferative disorder associated with 8p11 translocations
    • Aguiar RC, Macdonald D, Mason PJ, Cross NC, Goldman JM. Myeloproliferative disorder associated with 8p11 translocations [letter]. Blood. 1995; 86:834-835.
    • (1995) Blood , vol.86 , pp. 834-835
    • Aguiar, R.C.1    Macdonald, D.2    Mason, P.J.3    Cross, N.C.4    Goldman, J.M.5
  • 61
    • 0029913153 scopus 로고    scopus 로고
    • Chronic myelomonocytic leukaemia with t(8;9)(p11;q34) in childhood: An example of the 8p11 myeloproliferative disorder?
    • Nakayama H, Inamitsu T, Ohga S, et al. Chronic myelomonocytic leukaemia with t(8;9)(p11;q34) in childhood: an example of the 8p11 myeloproliferative disorder? Br J Haematol. 1996;92:692-695.
    • (1996) Br J Haematol , vol.92 , pp. 692-695
    • Nakayama, H.1    Inamitsu, T.2    Ohga, S.3
  • 62
    • 0030054857 scopus 로고    scopus 로고
    • A young child with acquired t(8;9)(p11;q34): Additional proof that 8p11 is involved in mixed myeloid/T lymphoid malignancies
    • van den Berg H, Kroes W, van der School CE, et al. A young child with acquired t(8;9)(p11;q34): additional proof that 8p11 is involved in mixed myeloid/T lymphoid malignancies [letter]. Leukemia. 1996;10:1252-1253.
    • (1996) Leukemia , vol.10 , pp. 1252-1253
    • Berg, H.1    Kroes, W.2    Van Der School, C.E.3
  • 63
    • 19944432120 scopus 로고    scopus 로고
    • 8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes
    • Belloni E, Trubia M, Gasparini P, et al. 8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes. Genes Chromosomes Cancer. 2005;42:320-325.
    • (2005) Genes Chromosomes Cancer , vol.42 , pp. 320-325
    • Belloni, E.1    Trubia, M.2    Gasparini, P.3
  • 64
    • 0033558253 scopus 로고    scopus 로고
    • The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
    • Popovici C, Zhang B, Gregoire MJ, et al. The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. Blood. 1999;93:1381-1389.
    • (1999) Blood , vol.93 , pp. 1381-1389
    • Popovici, C.1    Zhang, B.2    Gregoire, M.J.3
  • 65
    • 11044238012 scopus 로고    scopus 로고
    • Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: Two further cases
    • Vizmanos JL, Hernandez R, Vidal MJ, et al. Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases. Hematol J. 2004;5:534-537.
    • (2004) Hematol J , vol.5 , pp. 534-537
    • Vizmanos, J.L.1    Hernandez, R.2    Vidal, M.J.3
  • 66
    • 1942422114 scopus 로고    scopus 로고
    • Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome
    • Grand EK, Grand FH, Chase AJ, et al. Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. Genes Chromosomes Cancer. 2004;40:78-83.
    • (2004) Genes Chromosomes Cancer , vol.40 , pp. 78-83
    • Grand, E.K.1    Grand, F.H.2    Chase, A.J.3
  • 67
    • 0038278866 scopus 로고    scopus 로고
    • Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia
    • Tartaglia M, Niemeyer CM, Fragale A, et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet. 2003;34:148-150.
    • (2003) Nat Genet , vol.34 , pp. 148-150
    • Tartaglia, M.1    Niemeyer, C.M.2    Fragale, A.3
  • 68
    • 0032125716 scopus 로고    scopus 로고
    • Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1
    • Side LE, Emanuel PD, Taylor B, et al. Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1. Blood. 1998;92:267-272.
    • (1998) Blood , vol.92 , pp. 267-272
    • Side, L.E.1    Emanuel, P.D.2    Taylor, B.3
  • 69
    • 0030045594 scopus 로고    scopus 로고
    • Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
    • Largaespada DA, Brannan CI, Jenkins NA, Copeland NG. Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia. Nat Genet. 1996;12:137-143.
    • (1996) Nat Genet , vol.12 , pp. 137-143
    • Largaespada, D.A.1    Brannan, C.I.2    Jenkins, N.A.3    Copeland, N.G.4
  • 70
    • 12144286410 scopus 로고    scopus 로고
    • Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis
    • Loh ML, Vattikuti S, Schubbert S, et al. Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. Blood. 2004;103:2325-2331.
    • (2004) Blood , vol.103 , pp. 2325-2331
    • Loh, M.L.1    Vattikuti, S.2    Schubbert, S.3
  • 71
    • 1642489095 scopus 로고    scopus 로고
    • Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia
    • Gitler AD, Kong Y, Choi JK, Zhu Y, Pear WS, Epstein JA. Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. Pediatr Res. 2004;55:581-584.
    • (2004) Pediatr Res , vol.55 , pp. 581-584
    • Gitler, A.D.1    Kong, Y.2    Choi, J.K.3    Zhu, Y.4    Pear, W.S.5    Epstein, J.A.6
  • 72
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ, Scott LM, Campbell PJ, et al, Cancer Genome Project. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365:1054-1061.
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3
  • 73
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C, Ugo V, Le Couedic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005; 434:1144-1148.
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3
  • 74
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352:1779-1790.
    • (2005) N Engl J Med , vol.352 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3
  • 75
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7:387-397.
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3
  • 76
    • 20744460045 scopus 로고    scopus 로고
    • Identification of an acquired JAK2 mutation in polycythemia vera
    • April 29 [Epub ahead of print]
    • Zhao R, Xing S, Li Z, et al. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem. April 29, 2005 [Epub ahead of print].
    • (2005) J Biol Chem
    • Zhao, R.1    Xing, S.2    Li, Z.3
  • 77
    • 21344440357 scopus 로고    scopus 로고
    • The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and the myelodysplastic syndrome
    • April 28 [Epub ahead of print]
    • Steensma DP, Dewald GW, Lasho TL, et al. The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and the myelodysplastic syndrome. Blood. April 28, 2005 [Epub ahead of print].
    • (2005) Blood
    • Steensma, D.P.1    Dewald, G.W.2    Lasho, T.L.3
  • 78
    • 21344467318 scopus 로고    scopus 로고
    • Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
    • paper, prepublished online May 26 ; DOI 10.1182/blood-2005-03-1320
    • Jones AV, Kreil S, Zoi K, et al. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood. First edition paper, prepublished online May 26, 2005; DOI 10.1182/blood-2005-03-1320. Available at: www.bloodjournal.org/cgi/reprint/2005-03-1320v1.pdf. Accessibility verified May 31, 2005.
    • (2005) Blood. First Edition
    • Jones, A.V.1    Kreil, S.2    Zoi, K.3
  • 79
    • 1642323740 scopus 로고    scopus 로고
    • Protein kinase inhibitors: Insights into drug design from structure
    • Noble ME, Endicott JA, Johnson LN. Protein kinase inhibitors: insights into drug design from structure. Science. 2004;303:1800-1805.
    • (2004) Science , vol.303 , pp. 1800-1805
    • Noble, M.E.1    Endicott, J.A.2    Johnson, L.N.3
  • 80
    • 0028149381 scopus 로고
    • The coordinated action of protein tyrosine phosphatases and kinases in cell signaling
    • Sun H, Tonks NK. The coordinated action of protein tyrosine phosphatases and kinases in cell signaling. Trends Biochem Sci. 1994;19:480-485.
    • (1994) Trends Biochem Sci , vol.19 , pp. 480-485
    • Sun, H.1    Tonks, N.K.2
  • 81
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature. 2001; 411:355-365.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 82
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2000; 103:211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 83
    • 0034693799 scopus 로고    scopus 로고
    • The protein tyrosine kinase family of the human genome
    • Robinson DR, Wu YM, Lin SF. The protein tyrosine kinase family of the human genome. Oncogene. 2000;19:5548-5557.
    • (2000) Oncogene , vol.19 , pp. 5548-5557
    • Robinson, D.R.1    Wu, Y.M.2    Lin, S.F.3
  • 84
    • 0034693871 scopus 로고    scopus 로고
    • Janus kinases: Components of multiple signaling pathways
    • Rane SG, Reddy EP. Janus kinases: components of multiple signaling pathways. Oncogene. 2000;19:5662-5679.
    • (2000) Oncogene , vol.19 , pp. 5662-5679
    • Rane, S.G.1    Reddy, E.P.2
  • 86
    • 13544256790 scopus 로고    scopus 로고
    • Src protein-tyrosine kinase structure and regulation
    • Roskoski R Jr. Src protein-tyrosine kinase structure and regulation. Biochem Biophys Res Commun. 2004;324:1155-1164.
    • (2004) Biochem Biophys Res Commun , vol.324 , pp. 1155-1164
    • Roskoski Jr., R.1
  • 87
    • 0036391801 scopus 로고    scopus 로고
    • The Abl family kinases: Mechanisms of regulation and signaling
    • Pendergast AM. The Abl family kinases: mechanisms of regulation and signaling. Adv Cancer Res. 2002;85:51-100.
    • (2002) Adv Cancer Res , vol.85 , pp. 51-100
    • Pendergast, A.M.1
  • 88
    • 0037071409 scopus 로고    scopus 로고
    • JAKs, STATs and Src kinases in hematopoiesis
    • Rane SG, Reddy EP. JAKs, STATs and Src kinases in hematopoiesis. Oncogene. 2002;21:3334-3358.
    • (2002) Oncogene , vol.21 , pp. 3334-3358
    • Rane, S.G.1    Reddy, E.P.2
  • 89
    • 0034693878 scopus 로고    scopus 로고
    • Regulation of cell death by the Abl tyrosine kinase
    • Wang JY. Regulation of cell death by the Abl tyrosine kinase. Oncogene. 2000;19:5643-5650.
    • (2000) Oncogene , vol.19 , pp. 5643-5650
    • Wang, J.Y.1
  • 90
    • 0032863261 scopus 로고    scopus 로고
    • The Janus kinase family of protein tyrosine kinases and their role in signaling
    • Yeh TC, Pellegrini S. The Janus kinase family of protein tyrosine kinases and their role in signaling. Cell Mol Life Sci. 1999;55;1523-1534.
    • (1999) Cell Mol Life Sci , vol.55 , pp. 1523-1534
    • Yeh, T.C.1    Pellegrini, S.2
  • 92
    • 0036560577 scopus 로고    scopus 로고
    • Oncogenic tyrosine kinases and the DNA-damage response
    • Skorski T. Oncogenic tyrosine kinases and the DNA-damage response. Nat Rev Cancer. 2002;2:351-360.
    • (2002) Nat Rev Cancer , vol.2 , pp. 351-360
    • Skorski, T.1
  • 93
    • 0031622702 scopus 로고    scopus 로고
    • Signaling via JAK tyrosine kinases: Growth hormone receptor as a model system
    • Carter-Su C, Smit LS. Signaling via JAK tyrosine kinases: growth hormone receptor as a model system. Recent Prog Horm Res. 1998;53:61-82.
    • (1998) Recent Prog Horm Res , vol.53 , pp. 61-82
    • Carter-Su, C.1    Smit, L.S.2
  • 94
    • 0038820386 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription proteins in leukemias
    • Benekli M, Baer MR, Baumann H, Wetzler M. Signal transducer and activator of transcription proteins in leukemias. Blood. 2003;101:2940-2954.
    • (2003) Blood , vol.101 , pp. 2940-2954
    • Benekli, M.1    Baer, M.R.2    Baumann, H.3    Wetzler, M.4
  • 95
    • 0036731485 scopus 로고    scopus 로고
    • Stats: Transcriptional control and biological impact
    • Levy DE, Darnell JE Jr. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol. 2002;3:651-662.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell Jr., J.E.2
  • 96
    • 0032966863 scopus 로고    scopus 로고
    • Negative regulation of the JAK/STAT pathway
    • Starr R, Hilton DJ. Negative regulation of the JAK/STAT pathway. Bioessays. 1999;21:47-52.
    • (1999) Bioessays , vol.21 , pp. 47-52
    • Starr, R.1    Hilton, D.J.2
  • 97
    • 0242468041 scopus 로고    scopus 로고
    • Regulation of JAK-STAT signalling in the immune system
    • Shuai K, Liu B. Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol. 2003;3:900-911.
    • (2003) Nat Rev Immunol , vol.3 , pp. 900-911
    • Shuai, K.1    Liu, B.2
  • 98
    • 0034703097 scopus 로고    scopus 로고
    • CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
    • Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem. 2000;275:29338-29347.
    • (2000) J Biol Chem , vol.275 , pp. 29338-29347
    • Sasaki, A.1    Yasukawa, H.2    Shouda, T.3    Kitamura, T.4    Dikic, I.5    Yoshimura, A.6
  • 99
    • 0033755417 scopus 로고    scopus 로고
    • Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B
    • Stofega MR, Herrington J, Billestrup N, Carter-Su C. Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B. Mol Endocrinol. 2000;14:1338-1350.
    • (2000) Mol Endocrinol , vol.14 , pp. 1338-1350
    • Stofega, M.R.1    Herrington, J.2    Billestrup, N.3    Carter-Su, C.4
  • 100
    • 15244350510 scopus 로고    scopus 로고
    • Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line
    • Melzner I, Bucur AJ, Bruderlein S, et al. Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line. Blood. 2005;105:2535-2542.
    • (2005) Blood , vol.105 , pp. 2535-2542
    • Melzner, I.1    Bucur, A.J.2    Bruderlein, S.3
  • 101
    • 0032076542 scopus 로고    scopus 로고
    • Jak2 is essential for signaling through a variety of cytokine receptors
    • Parganas E, Wang D, Stravopodis D, et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998;93:385-395.
    • (1998) Cell , vol.93 , pp. 385-395
    • Parganas, E.1    Wang, D.2    Stravopodis, D.3
  • 102
    • 10644224189 scopus 로고    scopus 로고
    • Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
    • Krempler A, Qi Y, Triplett AA, Zhu J, Rui H, Wagner KU. Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice. Genesis. 2004;40:52-57.
    • (2004) Genesis , vol.40 , pp. 52-57
    • Krempler, A.1    Qi, Y.2    Triplett, A.A.3    Zhu, J.4    Rui, H.5    Wagner, K.U.6
  • 103
    • 0030953788 scopus 로고    scopus 로고
    • The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells
    • Sakai I, Kraft AS. The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells. J Biol Chem. 1997;272:12350-12358.
    • (1997) J Biol Chem , vol.272 , pp. 12350-12358
    • Sakai, I.1    Kraft, A.S.2
  • 104
    • 0029164841 scopus 로고
    • Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
    • Macchi P, Villa A, Giliani S, et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature. 1995; 377:65-68.
    • (1995) Nature , vol.377 , pp. 65-68
    • Macchi, P.1    Villa, A.2    Giliani, S.3
  • 105
    • 0030852328 scopus 로고    scopus 로고
    • Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
    • Peeters P, Raynaud SD, Cools J, et al. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood. 1997;90:2535-2540.
    • (1997) Blood , vol.90 , pp. 2535-2540
    • Peeters, P.1    Raynaud, S.D.2    Cools, J.3
  • 106
    • 15444339209 scopus 로고    scopus 로고
    • A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
    • Lacronique V, Boureux A, Valle VD, et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science. 1997;278:1309-1312.
    • (1997) Science , vol.278 , pp. 1309-1312
    • Lacronique, V.1    Boureux, A.2    Valle, V.D.3
  • 107
    • 0035980056 scopus 로고    scopus 로고
    • TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3′-kinase/protein kinase B signaling pathway
    • Nguyen MH, Ho JM, Beattie BK, Barber DL. TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3′-kinase/protein kinase B signaling pathway. J Biochem. 2001;276:32704-32713.
    • (2001) J Biochem , vol.276 , pp. 32704-32713
    • Nguyen, M.H.1    Ho, J.M.2    Beattie, B.K.3    Barber, D.L.4
  • 108
    • 0037103262 scopus 로고    scopus 로고
    • TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/ Jun kinase (SAPK/JNK), and p38 signaling pathways
    • Ho JM, Nguyen MH, Dierov JK, et al. TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/ Jun kinase (SAPK/JNK), and p38 signaling pathways. Blood. 2002;100:1438-1448.
    • (2002) Blood , vol.100 , pp. 1438-1448
    • Ho, J.M.1    Nguyen, M.H.2    Dierov, J.K.3
  • 109
    • 0033639119 scopus 로고    scopus 로고
    • Stat5 is essential for the myelo- And lymphoproliferative disease induced by TEL/JAK2
    • Schwaller J, Parganas E, Wang D, et al. Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. Mol Cell. 2000;6:693-704.
    • (2000) Mol Cell , vol.6 , pp. 693-704
    • Schwaller, J.1    Parganas, E.2    Wang, D.3
  • 110
    • 20144389913 scopus 로고    scopus 로고
    • The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2
    • Reiter A, Walz C, Watmore A, et al. The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2. Cancer Res. 2005;65:2662-2667.
    • (2005) Cancer Res , vol.65 , pp. 2662-2667
    • Reiter, A.1    Walz, C.2    Watmore, A.3
  • 111
    • 0028938172 scopus 로고
    • An amino acid substitution in the Drosophila hopTum-1 Jak kinase causes leukemia-like hematopoietic defects
    • Luo H, Hanratty WP, Dearolf CR. An amino acid substitution in the Drosophila hopTum-1 Jak kinase causes leukemia-like hematopoietic defects. EMBO J. 1995;14:1412-1420.
    • (1995) EMBO J , vol.14 , pp. 1412-1420
    • Luo, H.1    Hanratty, W.P.2    Dearolf, C.R.3
  • 112
    • 0016391236 scopus 로고
    • Bone-marrow responses in polycythemia vera
    • Prchal JF, Axelrad AA. Bone-marrow responses in polycythemia vera [letter]. N Engl J Med. 1974;290:1382.
    • (1974) N Engl J Med , vol.290 , pp. 1382
    • Prchal, J.F.1    Axelrad, A.A.2
  • 113
    • 0017347539 scopus 로고
    • Polycythemia vera: Hormonal modulation of erythropoiesis in vitro
    • Golde DW, Bersch N, Cline MJ. Polycythemia vera: hormonal modulation of erythropoiesis in vitro. Blood. 1977;49:399-405.
    • (1977) Blood , vol.49 , pp. 399-405
    • Golde, D.W.1    Bersch, N.2    Cline, M.J.3
  • 114
    • 0017755475 scopus 로고
    • Erythroid colony formation by polycythemia vera bone marrow in vitro: Dependence on erythropoietin
    • Zanjani ED, Lutton JD, Hoffman R, Wasserman LR. Erythroid colony formation by polycythemia vera bone marrow in vitro: dependence on erythropoietin. J Clin Invest. 1977;59:841-848.
    • (1977) J Clin Invest , vol.59 , pp. 841-848
    • Zanjani, E.D.1    Lutton, J.D.2    Hoffman, R.3    Wasserman, L.R.4
  • 115
    • 0842309105 scopus 로고    scopus 로고
    • Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera
    • Ugo V, Marzac C, Teyssandier I, et al. Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera. Exp Hematol. 2004;32:179-187.
    • (2004) Exp Hematol , vol.32 , pp. 179-187
    • Ugo, V.1    Marzac, C.2    Teyssandier, I.3
  • 116
    • 0033050680 scopus 로고    scopus 로고
    • A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and StatS inactivation
    • Arcasoy MO, Harris KW, Forget BG. A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and StatS inactivation. Exp Hematol. 1999;27:63-74.
    • (1999) Exp Hematol , vol.27 , pp. 63-74
    • Arcasoy, M.O.1    Harris, K.W.2    Forget, B.G.3
  • 117
    • 0028956353 scopus 로고
    • Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
    • Klingmuller U, Lorenz U, Cantley LC, Neel BG, Lodish HF. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell. 1995;80:729-738.
    • (1995) Cell , vol.80 , pp. 729-738
    • Klingmuller, U.1    Lorenz, U.2    Cantley, L.C.3    Neel, B.G.4    Lodish, H.F.5
  • 118
    • 0030764557 scopus 로고    scopus 로고
    • Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency
    • Shultz LD, Rajan TV, Greiner DL. Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol. 1997;15:302-307.
    • (1997) Trends Biotechnol , vol.15 , pp. 302-307
    • Shultz, L.D.1    Rajan, T.V.2    Greiner, D.L.3
  • 119
    • 0023720556 scopus 로고
    • Megakaryocytic colony formation in polycythaemia vera and secondary erythrocytosis
    • Juvonen E, Partanen S, Ikkala E, Ruutu T. Megakaryocytic colony formation in polycythaemia vera and secondary erythrocytosis. Br J Haematol. 1988;69:441-444.
    • (1988) Br J Haematol , vol.69 , pp. 441-444
    • Juvonen, E.1    Partanen, S.2    Ikkala, E.3    Ruutu, T.4
  • 120
    • 0023261950 scopus 로고
    • Colony formation by megakaryocytic progenitors in essential thrombocythaemia
    • Juvonen E, Partanen S, Ruutu T. Colony formation by megakaryocytic progenitors in essential thrombocythaemia. Br J Haematol. 1987;66:161-164.
    • (1987) Br J Haematol , vol.66 , pp. 161-164
    • Juvonen, E.1    Partanen, S.2    Ruutu, T.3
  • 121
    • 0024591426 scopus 로고
    • Endogenous megakaryocyte colonies from peripheral blood in precursor cell cultures of patients with myeloproliferative disorders
    • Battegay EJ, Thomssen C, Nissen C, Gudat F, Speck B. Endogenous megakaryocyte colonies from peripheral blood in precursor cell cultures of patients with myeloproliferative disorders. Eur J Haematol. 1989;42:321-326.
    • (1989) Eur J Haematol , vol.42 , pp. 321-326
    • Battegay, E.J.1    Thomssen, C.2    Nissen, C.3    Gudat, F.4    Speck, B.5
  • 122
    • 0028934253 scopus 로고
    • Endogenous megakaryocyte and erythroid colony formation from blood in essential thrombocythaemia
    • Florensa L, Besses C, Woessner S, et al. Endogenous megakaryocyte and erythroid colony formation from blood in essential thrombocythaemia. Leukemia. 1995;9:271-273.
    • (1995) Leukemia , vol.9 , pp. 271-273
    • Florensa, L.1    Besses, C.2    Woessner, S.3
  • 123
    • 0034669997 scopus 로고    scopus 로고
    • Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia
    • Axelrad AA, Eskinazi D, Correa PN, Amato D. Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia. Blood. 2000;96:3310-3321.
    • (2000) Blood , vol.96 , pp. 3310-3321
    • Axelrad, A.A.1    Eskinazi, D.2    Correa, P.N.3    Amato, D.4
  • 124
    • 0025975727 scopus 로고
    • Polycythemia vera blood burst-forming units-erythroid are hypersensitive to interleukin-3
    • Dai CH, Krantz SB, Means RT Jr, Horn ST, Gilbert HS. Polycythemia vera blood burst-forming units-erythroid are hypersensitive to interleukin-3. J Clin Invest. 1991;87:391-396.
    • (1991) J Clin Invest , vol.87 , pp. 391-396
    • Dai, C.H.1    Krantz, S.B.2    Means Jr., R.T.3    Horn, S.T.4    Gilbert, H.S.5
  • 125
    • 0027502621 scopus 로고
    • Circulating megakaryocyte progenitors in myeloproliferative disorders are hypersensitive to interleukin-3
    • Kobayashi S, Teramura M, Hoshino S, Motoji T, Oshimi K, Mizoguchi H. Circulating megakaryocyte progenitors in myeloproliferative disorders are hypersensitive to interleukin-3. Br J Haematol. 1993;83:539-544.
    • (1993) Br J Haematol , vol.83 , pp. 539-544
    • Kobayashi, S.1    Teramura, M.2    Hoshino, S.3    Motoji, T.4    Oshimi, K.5    Mizoguchi, H.6
  • 126
    • 0028045069 scopus 로고
    • Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: Studies in an improved serum-free medium
    • Correa PN, Eskinazi D, Axelrad AA. Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: studies in an improved serum-free medium. Blood. 1994;83:99-112.
    • (1994) Blood , vol.83 , pp. 99-112
    • Correa, P.N.1    Eskinazi, D.2    Axelrad, A.A.3
  • 127
    • 0028068120 scopus 로고
    • In vitro sensitivity of human erythroid progenitors to hemopoietic growth factors: Studies on primary and secondary polycythemia
    • Montagna C, Massaro P, Morali F, Foa P, Maiolo AT, Eridani S. In vitro sensitivity of human erythroid progenitors to hemopoietic growth factors: studies on primary and secondary polycythemia. Haematologica. 1994;79:311-318.
    • (1994) Haematologica , vol.79 , pp. 311-318
    • Montagna, C.1    Massaro, P.2    Morali, F.3    Foa, P.4    Maiolo, A.T.5    Eridani, S.6
  • 128
    • 0026667283 scopus 로고
    • Polycythemia vera, II: Hypersensitivity of bone marrow erythroid, granulocyte-macrophage, and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony-stimulating factor
    • Dai CH, Krantz SB, Dessypris EN, Means RT Jr, Horn ST, Gilbert HS. Polycythemia vera, II: hypersensitivity of bone marrow erythroid, granulocyte-macrophage, and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony-stimulating factor. Blood. 1992;80:891-899.
    • (1992) Blood , vol.80 , pp. 891-899
    • Dai, C.H.1    Krantz, S.B.2    Dessypris, E.N.3    Means Jr., R.T.4    Horn, S.T.5    Gilbert, H.S.6
  • 129
    • 0028261196 scopus 로고
    • Polycythaemia vera, III: Burst-forming units-erythroid (BFU-E) response to stem cell factor and c-kit receptor expression
    • Dai CH, Krantz SB, Green WF, Gilbert HS. Polycythaemia vera, III: burst-forming units-erythroid (BFU-E) response to stem cell factor and c-kit receptor expression. Br J Haematol. 1994;86:12-21.
    • (1994) Br J Haematol , vol.86 , pp. 12-21
    • Dai, C.H.1    Krantz, S.B.2    Green, W.F.3    Gilbert, H.S.4
  • 130
    • 4243228153 scopus 로고    scopus 로고
    • Hypersensitivity of polycythemia vera megakaryocytic progenitors to thrombopoietin
    • Abstract 363
    • Martin JM, Gandhi YK, Jackson WR, Dessypris EN. Hypersensitivity of polycythemia vera megakaryocytic progenitors to thrombopoietin [abstract]. Blood. 1996;88(suppl 1):94a. Abstract 363.
    • (1996) Blood , vol.88 , Issue.SUPPL. 1
    • Martin, J.M.1    Gandhi, Y.K.2    Jackson, W.R.3    Dessypris, E.N.4
  • 131
    • 0035811544 scopus 로고    scopus 로고
    • Alterations of the insulin-like growth factor system in patients with polycythemia vera
    • Michl P, Spoettl G, Engelhardt D, Weber MM. Alterations of the insulin-like growth factor system in patients with polycythemia vera. Mol Cell Endocrinol. 2001;181:189-197.
    • (2001) Mol Cell Endocrinol , vol.181 , pp. 189-197
    • Michl, P.1    Spoettl, G.2    Engelhardt, D.3    Weber, M.M.4
  • 132
    • 0034982338 scopus 로고    scopus 로고
    • STAT3 is constitutively active in some patients with Polycythemia rubra vera
    • Röder S, Steimle C, Meinhardt G, Pahl HL. STAT3 is constitutively active in some patients with Polycythemia rubra vera. Exp Hematol. 2001;29:694-702.
    • (2001) Exp Hematol , vol.29 , pp. 694-702
    • Röder, S.1    Steimle, C.2    Meinhardt, G.3    Pahl, H.L.4
  • 133
    • 0035383807 scopus 로고    scopus 로고
    • Increased expression of the INK4a/ARF locus in polycythemia vera
    • Dai C, Krantz SB. Increased expression of the INK4a/ARF locus in polycythemia vera. Blood. 2001;97:3424-3432.
    • (2001) Blood , vol.97 , pp. 3424-3432
    • Dai, C.1    Krantz, S.B.2
  • 134
    • 0036214521 scopus 로고    scopus 로고
    • PRL activates the cyclin D1 promoter via the Jak2/Stat pathway
    • Brockman JL, Schroeder MD, Schuler LA. PRL activates the cyclin D1 promoter via the Jak2/Stat pathway. Mol Endocrinol. 2002;16:774-784.
    • (2002) Mol Endocrinol , vol.16 , pp. 774-784
    • Brockman, J.L.1    Schroeder, M.D.2    Schuler, L.A.3
  • 136
    • 0033597715 scopus 로고    scopus 로고
    • Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- Mice: A direct role for Stat5 in Bcl-X(L) induction
    • Socolovsky M, Fallon AE, Wang S, Brugnara C, Lodish HF. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell. 1999;98:181-191.
    • (1999) Cell , vol.98 , pp. 181-191
    • Socolovsky, M.1    Fallon, A.E.2    Wang, S.3    Brugnara, C.4    Lodish, H.F.5
  • 137
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. 1999;10:105-115.
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1    Landowski, T.H.2    Oshiro, M.M.3
  • 138
    • 20444426803 scopus 로고    scopus 로고
    • Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
    • February 10, [Epub ahead of print]
    • Tong W, Zhang J, Lodish HF. Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood. February 10, 2005 [Epub ahead of print].
    • (2005) Blood
    • Tong, W.1    Zhang, J.2    Lodish, H.F.3
  • 139
    • 0021956939 scopus 로고
    • Evidence for the involvement of B lymphoid cells in polycythemia vera and essential thrombocythemia
    • Raskind WH, Jacobson R, Murphy S, Adamson JW, Fialkow PJ. Evidence for the involvement of B lymphoid cells in polycythemia vera and essential thrombocythemia. J Clin Invest. 1985;75:1388-1390.
    • (1985) J Clin Invest , vol.75 , pp. 1388-1390
    • Raskind, W.H.1    Jacobson, R.2    Murphy, S.3    Adamson, J.W.4    Fialkow, P.J.5
  • 140
    • 0020054075 scopus 로고
    • In vitro studies of human pluripotential hematopoietic progenitors in polycythemia vera: Direct evidence of stem cell involvement
    • Ash RC, Detrick RA, Zanjani ED. In vitro studies of human pluripotential hematopoietic progenitors in polycythemia vera: direct evidence of stem cell involvement. J Clin Invest. 1982;69:1112-1118.
    • (1982) J Clin Invest , vol.69 , pp. 1112-1118
    • Ash, R.C.1    Detrick, R.A.2    Zanjani, E.D.3
  • 141
    • 0036191941 scopus 로고    scopus 로고
    • Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera
    • Kralovics R, Guan Y, Prchal JT. Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera. Exp Hematol. 2002;30:229-236.
    • (2002) Exp Hematol , vol.30 , pp. 229-236
    • Kralovics, R.1    Guan, Y.2    Prchal, J.T.3
  • 143
    • 0016794111 scopus 로고
    • Gd(-) Abrami: A deficient G-6PD variant with hemizygous expression in blood cells of a woman with primary myelofibrosis
    • Kahn A, Bernard JF, Cottreau D, Marie J, Boivin P. Gd(-) Abrami: a deficient G-6PD variant with hemizygous expression in blood cells of a woman with primary myelofibrosis. Humangenetik. 1975;30:41-46.
    • (1975) Humangenetik , vol.30 , pp. 41-46
    • Kahn, A.1    Bernard, J.F.2    Cottreau, D.3    Marie, J.4    Boivin, P.5
  • 144
    • 0028362575 scopus 로고
    • Clonality in chronic myeloproliferative disorders defined by X-chromosome linked probes: Demonstration of heterogeneity in lineage involvement
    • Tsukamoto N, Morita K, Maehara T, et al. Clonality in chronic myeloproliferative disorders defined by X-chromosome linked probes: demonstration of heterogeneity in lineage involvement. Br J Haematol. 1994;86:253-258.
    • (1994) Br J Haematol , vol.86 , pp. 253-258
    • Tsukamoto, N.1    Morita, K.2    Maehara, T.3
  • 145
    • 0034988764 scopus 로고    scopus 로고
    • Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia
    • Tefferi A, Mesa RA, Schroeder G, Hanson CA, Li CY. Dewald GW. Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia. Br J Haematol. 2001;113:763-771.
    • (2001) Br J Haematol , vol.113 , pp. 763-771
    • Tefferi, A.1    Mesa, R.A.2    Schroeder, G.3    Hanson, C.A.4    Li, C.Y.5    Dewald, G.W.6
  • 146
    • 0036439588 scopus 로고    scopus 로고
    • Exploring polycythaemia vera with fluorescence in situ hybridization: Additional cryptic 9p is the most frequent abnormality detected
    • Najfeld V, Montella L, Scalise A, Fruchtman S. Exploring polycythaemia vera with fluorescence in situ hybridization: additional cryptic 9p is the most frequent abnormality detected. Br J Haematol. 2002;119:558-566.
    • (2002) Br J Haematol , vol.119 , pp. 558-566
    • Najfeld, V.1    Montella, L.2    Scalise, A.3    Fruchtman, S.4
  • 147
    • 0036376905 scopus 로고    scopus 로고
    • Cytogenetic and molecular genetic aspects of essential thrombocythemia
    • Steensma DP, Tefferi A. Cytogenetic and molecular genetic aspects of essential thrombocythemia. Acta Haematol. 2002;108:55-65.
    • (2002) Acta Haematol , vol.108 , pp. 55-65
    • Steensma, D.P.1    Tefferi, A.2
  • 148
    • 0035723703 scopus 로고    scopus 로고
    • Comparison of peripheral blood interphase cytogenetics with bone marrow karyotype analysis in myelofibrosis with myeloid metaplasia
    • Tefferi A, Meyer RG, Wyatt WA, Dewald GW. Comparison of peripheral blood interphase cytogenetics with bone marrow karyotype analysis in myelofibrosis with myeloid metaplasia. Br J Haematol. 2001;115:316-319.
    • (2001) Br J Haematol , vol.115 , pp. 316-319
    • Tefferi, A.1    Meyer, R.G.2    Wyatt, W.A.3    Dewald, G.W.4
  • 149
    • 2542468674 scopus 로고    scopus 로고
    • Is fluorescence in situ hybridization a useful method in diagnosis of polycythemia vera patients?
    • Zamora L, Espinet B, Florensa L, et al. Is fluorescence in situ hybridization a useful method in diagnosis of polycythemia vera patients? Cancer Genet Cytogenet. 2004;151:139-145.
    • (2004) Cancer Genet Cytogenet , vol.151 , pp. 139-145
    • Zamora, L.1    Espinet, B.2    Florensa, L.3
  • 150
    • 0037765522 scopus 로고    scopus 로고
    • Molecular cytogenetics of polycythaemia vera: Lack of occult rearrangements detectable by 20q LSP screening, CGH, and M-FISH
    • Gribble SM, Reid AG, Bench AJ, et al. Molecular cytogenetics of polycythaemia vera: lack of occult rearrangements detectable by 20q LSP screening, CGH, and M-FISH [letter]. Leukemia. 2003;17:1419-1421.
    • (2003) Leukemia , vol.17 , pp. 1419-1421
    • Gribble, S.M.1    Reid, A.G.2    Bench, A.J.3
  • 152
    • 0035351213 scopus 로고    scopus 로고
    • Polycythemia vera: Analysis of DNA from blood granulocytes using comparative genomic hybridization
    • Westwood NB, Gruszka-Westwood AM, Atkinson S, Pearson TC. Polycythemia vera: analysis of DNA from blood granulocytes using comparative genomic hybridization. Haematologica. 2001;86:464-469.
    • (2001) Haematologica , vol.86 , pp. 464-469
    • Westwood, N.B.1    Gruszka-Westwood, A.M.2    Atkinson, S.3    Pearson, T.C.4
  • 153
    • 0041940289 scopus 로고    scopus 로고
    • Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders
    • Kralovics R, Buser AS, Teo SS, et al. Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders. Blood. 2003;102:1869-1871.
    • (2003) Blood , vol.102 , pp. 1869-1871
    • Kralovics, R.1    Buser, A.S.2    Teo, S.S.3
  • 154
    • 0035045092 scopus 로고    scopus 로고
    • Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation
    • Lindauer K, Loerting T, Liedl KR, Kroemer RT. Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation. Protein Eng. 2001;14:27-37.
    • (2001) Protein Eng , vol.14 , pp. 27-37
    • Lindauer, K.1    Loerting, T.2    Liedl, K.R.3    Kroemer, R.T.4
  • 155
    • 0034012330 scopus 로고    scopus 로고
    • Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
    • Saharinen P, Takaluoma K, Silvennoinen O. Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol Cell Biol. 2000;20:3387-3395.
    • (2000) Mol Cell Biol , vol.20 , pp. 3387-3395
    • Saharinen, P.1    Takaluoma, K.2    Silvennoinen, O.3
  • 156
    • 0037033012 scopus 로고    scopus 로고
    • The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
    • Saharinen P, Silvennoinen O. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem. 2002;277:47954-47963.
    • (2002) J Biol Chem , vol.277 , pp. 47954-47963
    • Saharinen, P.1    Silvennoinen, O.2
  • 157
    • 2442642830 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling
    • Feener EP, Rosario F, Dunn SL, Stancheva Z, Myers MG Jr. Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol. 2004;24:4968-4978.
    • (2004) Mol Cell Biol , vol.24 , pp. 4968-4978
    • Feener, E.P.1    Rosario, F.2    Dunn, S.L.3    Stancheva, Z.4    Myers Jr., M.G.5
  • 158
    • 17144369135 scopus 로고    scopus 로고
    • Identification of 1,2,3,4.5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation
    • Sandberg EM, Ma X, He K, Frank SJ, Ostrov DA, Sayeski PP. Identification of 1,2,3,4.5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation. J Med Chem. 2005;48:2526-2533.
    • (2005) J Med Chem , vol.48 , pp. 2526-2533
    • Sandberg, E.M.1    Ma, X.2    He, K.3    Frank, S.J.4    Ostrov, D.A.5    Sayeski, P.P.6
  • 159
    • 2942748413 scopus 로고    scopus 로고
    • The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity
    • van den Akker E, van Dijk TB, Schmidt U, et al. The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity. Biol Chem. 2004;385:409-413.
    • (2004) Biol Chem , vol.385 , pp. 409-413
    • Akker, E.1    Van Dijk, T.B.2    Schmidt, U.3
  • 160
    • 0033861096 scopus 로고    scopus 로고
    • JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells
    • De Vos J, Jourdan M, Tarte K, Jasmin C, Klein B. JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells. Br J Haematol. 2000;109:823-828.
    • (2000) Br J Haematol , vol.109 , pp. 823-828
    • De Vos, J.1    Jourdan, M.2    Tarte, K.3    Jasmin, C.4    Klein, B.5
  • 162
    • 0037308442 scopus 로고    scopus 로고
    • Polycythemia vera: A comprehensive review and clinical recommendations
    • Tefferi A. Polycythemia vera: a comprehensive review and clinical recommendations. Mayo Clin Proc. 2003;78:174-194.
    • (2003) Mayo Clin Proc , vol.78 , pp. 174-194
    • Tefferi, A.1
  • 163
    • 0013019263 scopus 로고    scopus 로고
    • Thrombocytosis and essential thrombocythemia
    • Michelson AD, ed. Amsterdam, the Netherlands: Academic Press
    • Tefferi A. Thrombocytosis and essential thrombocythemia. In: Michelson AD, ed. Platelets. Amsterdam, the Netherlands: Academic Press; 2002: 667-679.
    • (2002) Platelets , pp. 667-679
    • Tefferi, A.1
  • 164
    • 20544457318 scopus 로고    scopus 로고
    • Red cell mass and plasma volume measurements in polycythemia: Evaluation of performance and practical utility
    • May 11 [Epub ahead of print]
    • Sirhan S, Fairbanks VF, Tefferi A. Red cell mass and plasma volume measurements in polycythemia: evaluation of performance and practical utility. Cancer. May 11, 2005 [Epub ahead of print].
    • (2005) Cancer
    • Sirhan, S.1    Fairbanks, V.F.2    Tefferi, A.3
  • 165
    • 18844436219 scopus 로고    scopus 로고
    • Management of patients with polycythaemia vera: Results of a survey among Swedish haematologists
    • Andreasson B, Lofvenberg E, Westin J. Management of patients with polycythaemia vera: results of a survey among Swedish haematologists. Eur J Haematol. 2005;74:489-495.
    • (2005) Eur J Haematol , vol.74 , pp. 489-495
    • Andreasson, B.1    Lofvenberg, E.2    Westin, J.3
  • 167
    • 19644392085 scopus 로고    scopus 로고
    • Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis
    • Mossuz P, Girodon F, Donnard M, et al. Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis. Haematologica. 2004;89:1194-1198.
    • (2004) Haematologica , vol.89 , pp. 1194-1198
    • Mossuz, P.1    Girodon, F.2    Donnard, M.3
  • 168
    • 0035106628 scopus 로고    scopus 로고
    • Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders
    • Prchal JT. Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders. Semin Hematol. 2001;38(1, suppl 2):10-20.
    • (2001) Semin Hematol , vol.38 , Issue.1 SUPPL. 2 , pp. 10-20
    • Prchal, J.T.1
  • 169
    • 11144290067 scopus 로고    scopus 로고
    • Diagnostic impact of bone marrow histopathology in polycythemia vera (PV)
    • Thiele J, Kvasnicka HM. Diagnostic impact of bone marrow histopathology in polycythemia vera (PV). Histol Histopathol. 2005;20:317-328.
    • (2005) Histol Histopathol , vol.20 , pp. 317-328
    • Thiele, J.1    Kvasnicka, H.M.2
  • 170
    • 0035115281 scopus 로고    scopus 로고
    • Polycythemia rubra vera versus secondary polycythemias: A clinicopathological evaluation of distinctive features in 199 patients
    • Thiele J, Kvasnicka HM, Muehlhausen K, Walter S, Zankovich R, Diehl V. Polycythemia rubra vera versus secondary polycythemias: a clinicopathological evaluation of distinctive features in 199 patients. Pathol Res Pract. 2001;197:77-84.
    • (2001) Pathol Res Pract , vol.197 , pp. 77-84
    • Thiele, J.1    Kvasnicka, H.M.2    Muehlhausen, K.3    Walter, S.4    Zankovich, R.5    Diehl, V.6
  • 172
    • 0035675028 scopus 로고    scopus 로고
    • Comparison of four serum-free, cytokine-free media for analysis of endogenous erythroid colony growth in polycythemia vera and essential thrombocythemia
    • Dobo I, Mossuz P, Campos L, et al. Comparison of four serum-free, cytokine-free media for analysis of endogenous erythroid colony growth in polycythemia vera and essential thrombocythemia. Hematol J. 2001;2:396-403.
    • (2001) Hematol J , vol.2 , pp. 396-403
    • Dobo, I.1    Mossuz, P.2    Campos, L.3
  • 173
    • 2642609475 scopus 로고    scopus 로고
    • Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera
    • Moliterno AR, Hankins WD, Spivak JL. Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera. N Engl J Med. 1998;338:572-580.
    • (1998) N Engl J Med , vol.338 , pp. 572-580
    • Moliterno, A.R.1    Hankins, W.D.2    Spivak, J.L.3
  • 174
    • 0034661898 scopus 로고    scopus 로고
    • Immunohistochemical staining for megakaryocyte c-mpl may complement morphologic distinction between polycythemia vera and secondary erythrocytosis
    • Tefferi A, Yoon SY, Li CY. Immunohistochemical staining for megakaryocyte c-mpl may complement morphologic distinction between polycythemia vera and secondary erythrocytosis. Blood. 2000;96:771-772.
    • (2000) Blood , vol.96 , pp. 771-772
    • Tefferi, A.1    Yoon, S.Y.2    Li, C.Y.3
  • 175
    • 0242663394 scopus 로고    scopus 로고
    • Quantification of PRV-1 mRNA distinguishes polycythemia vera from secondary erythrocytosis
    • Klippel S, Strunck E, Temerinac S, et al. Quantification of PRV-1 mRNA
    • (2003) Blood , vol.102 , pp. 3569-3574
    • Klippel, S.1    Strunck, E.2    Temerinac, S.3
  • 176
    • 4944243980 scopus 로고    scopus 로고
    • Platelet-rich plasma serotonin levels in chronic myeloproliferative disorders: Evaluation of diagnostic use and comparison with the neutrophil PRV-1 assay
    • Koch CA, Lasho TL, Tefferi A. Platelet-rich plasma serotonin levels in chronic myeloproliferative disorders: evaluation of diagnostic use and comparison with the neutrophil PRV-1 assay. Br J Haematol. 2004;127:34-39.
    • (2004) Br J Haematol , vol.127 , pp. 34-39
    • Koch, C.A.1    Lasho, T.L.2    Tefferi, A.3


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